Biological research for nursing最新文献

{"title":"The Causal Relationship Between Chronic Pain and Frailty: A Two-Sample Mendelian Randomization Study.","authors":"Shuo Wang, Jing Han, Qingyan Wang, Qing Li, Yanze Cui","doi":"10.1177/10998004251361789","DOIUrl":"10.1177/10998004251361789","url":null,"abstract":"<p><p><b>Objective:</b> Frailty and chronic pain are closely related, but the causal relationship between them needs to be further explored with high-level evidence. Mendelian randomization (MR) was used to analyse the bidirectional causal relationship between nine chronic pain disorders and two frailty indicators in this study. <b>Methods:</b> We used Causal Analysis Using Summary Effect Estimates (CAUSE) as the primary method of analysis. The inverse-variance-weighted, simple model, weighted model, penalized weighted median and MR‒Egger regression methods were used to evaluate the robustness of the results. <b>Results:</b> The frailty index (FI) was significantly associated with the number of chronic pain sites (multisite chronic pain, MCP, <i>p</i>_adjust < .001) and the risk of chronic widespread pain (CWP, <i>p</i>_adjust < .001). The Fried frailty score (FFS) was significantly associated with MCP (<i>p</i>_adjust < .001), the risk of CWP (<i>p</i>_adjust < .001) and chronic back pain (<i>p</i>_adjust = .031). In the reverse analysis, both MCP and CWP were significantly positively associated with the FI (<i>p</i>_adjust < .001; <i>p</i>_adjust = .003) and FFS (<i>p</i>_adjust < .001; <i>p</i>_adjust = .009). <b>Conclusions:</b> This study revealed a bidirectional causal relationship between frailty and chronic pain, with the number of pain sites playing a key role. This finding has significant implications for effectively managing frailty and chronic pain in older adults.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"630-639"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and Adiposity Outcomes in School-Age Children with Overweight and Obesity.","authors":"Shao-Yu Tsai, Yi-Ching Tung, Chuen-Min Huang, Shu-Yu Kuo, Chien-Chang Lee","doi":"10.1177/10998004251339743","DOIUrl":"10.1177/10998004251339743","url":null,"abstract":"<p><p><b>Purpose:</b> To examine four dimensions of sleep (timing, quality, quantity, and variability) and their association with adiposity outcomes in a community sample of school-age children with overweight and obesity. <b>Design</b>: A cross-sectional actigraphic study. <b>Methods:</b> 246 school-age children aged 6-9 years with overweight or obesity were recruited from 10 public elementary schools in Taipei, Taiwan. Children's sleep was objectively assessed over a 7-day period using a wrist actigraph. Adiposity outcomes, including BMI, BMI-for-age z-score, and percent body fat, were computed based on measured weight, height, and skinfold thickness following standardized procedures. Associations between sleep and child adiposity outcomes were examined using bivariate and multiple linear regression analyses. <b>Results:</b> In the bivariate analyses, later sleep onset time was correlated with greater percent body fat (<i>p =</i> .01); shorter daily sleep duration was correlated with higher BMI and percent body fat (both <i>p <</i> .05); greater variability in daily sleep duration was correlated with higher BMI, BMI-for-age z-score, and percent body fat (all <i>p <</i> .05). In multiple linear regression analyses, variability in daily sleep duration was the only sleep characteristic that showed a statistically significant association with percent body fat in children (b = 2.36; 95% CI: 0.28 to 4.43; <i>p =</i> .02). <b>Conclusions:</b> Overweight and obesity treatment interventions targeting child weight management should prioritize the assessment and promotion of children's sleep regularity. Future randomized controlled trials are needed to investigate the impact of maintaining a more consistent sleep pattern on measures of adiposity in school-age children with overweight and obesity.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"592-600"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in DNA Methylation Associated With Psychobehavioral Interventions: A Scoping Literature Review.","authors":"Karen L Saban, Linda Janusek, Paula de la Pena, Sueyeon Lee, Dina Tell, Herbert Mathews, Alexandra L Nowak, Alexandria Nyembwe, Jacquelyn Y Taylor","doi":"10.1177/10998004251346179","DOIUrl":"10.1177/10998004251346179","url":null,"abstract":"<p><p><b>Background:</b> DNA methylation (DNAm) is an epigenetic process of addition or reduction of methyl groups to genes that modify gene expression and can alter the physiological response to psychological stress. DNAm associated with psychological stress is malleable, making it a prime target for psychobehavioral interventions. Research is beginning to examine changes in DNAm in response to psychobehavioral interventions, such as mindfulness-based stress reduction, cognitive behavioral therapy, and yoga. A better understanding of the current evidence may provide direction for future research. <b>Objective:</b> The purpose of this scoping review is to summarize current studies, identify knowledge gaps, and make recommendations for further research related to examining alterations in DNAm in response to psychobehavioral interventions. <b>Methods:</b> A scoping review was conducted based on the methods recommended by Arksey and O'Malley (2005). Studies examining response of blood or saliva DNAm to psychobehavioral interventions in adult humans were reviewed. <b>Results:</b> Twenty-one studies met the inclusion criteria. Although many studies were inadequately powered, several reported differences in DNAm in response to a psychobehavioral intervention across a variety of genes, including genes related to stress and inflammation. However, the studies varied with respect to participant health status, type and duration of psychobehavioral interventions evaluated, biospecimens examined, and method of DNA analysis. <b>Conclusions:</b> The evaluation of DNAm in response to psychobehavioral interventions is a growing area of research. Future research is needed to address design limitations of existing investigations, evaluate the biological importance of observations, and link the DNAm response to physiological and psychological outcomes of the interventions.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"666-682"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12571133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Eight Weeks of Aerobic Exercise and Spirulina Supplementation on Some Liver Enzymes, Body Composition, and Cardiorespiratory Fitness in Overweight and Obese Adult Women.","authors":"Haniyeh Akbarzadeh Khadari, Rokhsare Fazolahzade Mousavi, Ladan Hosseini Abrishami","doi":"10.1177/10998004251340024","DOIUrl":"10.1177/10998004251340024","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to evaluate the effects of eight weeks of aerobic exercise and spirulina supplementation on liver enzymes, body composition, and cardiorespiratory fitness in overweight and obese women. <b>Methods:</b> A randomized, double-blind, placebo-controlled trial was conducted involving 36 overweight and obese adult women (body mass index [BMI] ≥ 25 kg/m², aged 25-40 years) randomly assigned to four groups: placebo with aerobic exercise, spirulina with aerobic exercise, spirulina-only, and placebo-only. Interventions included aerobic training three times per week (40-50 minutes/session) and a twice-daily dose (each 500 mg) of Spirulina or placebo for eight weeks. Outcomes were assessed at baseline and post-intervention, including liver enzyme levels (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), body composition (BMI, body fat percentage, waist-to-hip ratio (WHR)), and VO_2max using validated protocols. <b>Results:</b> Significant within-group improvements in ALT, AST, body weight, BMI, WHR, and VO₂max were observed in the aerobic training and spirulina groups, either alone or combined (<i>p <</i> .001). The aerobic training + placebo group demonstrated the greatest reduction in body weight and BMI, while spirulina-alone showed significant ALT and AST reductions. VO_2max improved in all intervention groups, but post hoc analysis revealed no significant between-group differences. <b>Conclusion:</b> Aerobic exercise and spirulina supplementation independently and synergistically improve liver function, body composition, and cardiorespiratory fitness in overweight and obese women. Combining these interventions may offer a holistic approach to managing obesity-related health risks. Further research is essential to elucidate the underlying mechanisms and optimize intervention strategies for diverse populations.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"601-611"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of 6 Weeks of Dynamic Neuromuscular Stabilization Exercises on Motor Control, Cardiovascular Fitness, and Respiratory Performance in Overweight and Obese Women.","authors":"Sara Binabaji, Nasser Mohammad Rahimi, Mahdi Esfahani","doi":"10.1177/10998004251337451","DOIUrl":"10.1177/10998004251337451","url":null,"abstract":"<p><p><b>Background:</b> Obesity is linked to impairments in motor control, cardiovascular fitness, and respiratory function. Dynamic Neuromuscular Stabilization (DNS) aims to enhance core stability, diaphragmatic breathing, and neuromuscular coordination. This study investigated the effects of a 6-week DNS program on these functional outcomes in overweight and obese women. <b>Methods:</b> Thirty-six participants (aged 35-50 years, BMI: 25-34 kg/m²) were randomly assigned to either an experimental group (<i>n</i> = 18), which underwent DNS training, or a control group (<i>n</i> = 18), which received no intervention. The DNS program consisted of six weekly sessions (three supervised, three home-based), emphasizing core stabilization, diaphragmatic breathing, and neuromuscular coordination. Motor control (lumbar movement control tests), cardiovascular fitness (two-minute step test), and respiratory performance (breath-hold time, respiratory rate, and respiratory muscle strength) were assessed before and after the intervention. <b>Results:</b> The DNS group demonstrated significant improvements compared to the control group, with notable increases in motor control scores (<i>p <</i> .001) and cardiovascular fitness (<i>p <</i> .001). Additionally, inspiratory and expiratory breath-hold times (<i>p <</i> .001 for both), respiratory rate (<i>p <</i> .001), and maximum inspiratory and expiratory pressures (<i>p <</i> .001) showed substantial enhancements. No significant changes were observed in the control group. <b>Conclusion:</b> A 6-week DNS exercise program significantly improved motor control, cardiovascular fitness, and respiratory performance in overweight and obese women. These findings support DNS training as an effective intervention for enhancing core stability, breathing efficiency, and neuromuscular coordination, with potential applications in rehabilitation and health promotion.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"581-591"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Microbiology of Healthcare-Associated Infections in Neurosurgery Department: A Cross-Sectional Study.","authors":"Renata Jabłońska, Paweł Sokal, Magdalena Zając, Agnieszka Królikowska, Karolina Filipska-Blejder, Irena Wrońska, Robert Ślusarz","doi":"10.1177/10998004251336748","DOIUrl":"10.1177/10998004251336748","url":null,"abstract":"<p><p><b>Objective:</b> Hospital-acquired infections (HAIs) present a significant challenge in neurosurgical settings. This study aimed to assess the prevalence, risk factors, and clinical impact of HAIs in a neurosurgery department. <b>Methods:</b> A retrospective cross-sectional study was conducted on 5474 patients hospitalized in <i>a</i> neurosurgery <i>department</i> (2019-2023). HAIs were diagnosed in 93 patients (2.7%), accounting for 147 infections. The final cohort included 273 patients: 93 with HAIs and 181 matched controls (age, sex, mortality). Demographic, clinical, and microbiological data were analyzed. Nutritional status was assessed using the Nutritional Risk Screening (NRS, 2002) and consciousness was assessed using the Glasgow Coma Scale (GCS). Infections were classified according to Centers for Disease Control and Prevention (CDC) criteria. <b>Results:</b> The most frequent HAIs were pneumonia (PN, 18.3%), bloodstream infections (BSI, 16.2%), and surgical site infections (SSI, 16.3%). Malnutrition (NRS ≥3) was significantly more common in infected patients (65.6% vs. 11%, <i>p</i> < .001). Patients with GCS ≤8 had higher rates of PN (44.7%) and urinary tract infections (UTI, 32.5%) (<i>p</i> = .004), while GCS 13-15 was linked to SSI (91.7%). HAIs occurred more frequently after emergency procedures (57.8% vs. 30%, <i>p</i> < .0001). Hospital stay was significantly longer in infected patients (40 vs. 5.4 days, <i>p</i> = .001). <i>Klebsiella pneumoniae</i> (15.1%) and <i>Staphylococcus aureus</i> (11.5%) were the most common. Age and sex were not significant risk factors. <b>Conclusion:</b> HAIs in neurosurgical patients are associated with malnutrition and procedural urgency. Targeted infection control, early nutrition support, and antimicrobial stewardship are essential to improving outcomes.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"544-557"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Perceived Stress, Glucocorticoids Receptors, and Corticotropin-Releasing Hormone Gene Expression During Pregnancy.","authors":"Marlene Brennen, Ruth Tappen, Vanessa Johnson","doi":"10.1177/10998004251336366","DOIUrl":"10.1177/10998004251336366","url":null,"abstract":"<p><p>The preterm birth rate and the maternal mortality rate are 1.6 and 2.6 times higher for Black women than for White women, respectively, in the United States. This disproportionate difference in maternal health outcomes is a notable health inequity. The purpose of this study was to evaluate the influence of perceived stress, and glucocorticoid receptors (GR) on histone acetylation (HAT) of the corticotropin-releasing hormone (CRH) gene between non-Hispanic Black and non-Hispanic White women in their second trimester of pregnancy. This study used a cross-sectional design to analyze secondary, deidentified data including peripheral blood monocyte cells, from a prior study. The study sample consisted of 32 non-Hispanic Black women and 73 non-Hispanic White women from the parent study. A four-step hierarchical linear regression analysis was used to analyze the influence of race, perceived stress, and GR on the HAT of the CRH gene. The hierarchical linear regression analysis found that race, perceived stress, and GR significantly predicted the HAT of the CRH. GR explained 41.33% of the variation in HAT CRH of the gene, and age plus race explained an additional 3.56% of the variation in HAT CRH of the gene. The findings of this study suggest that perceived stress and GR among young Black women were associated with higher levels of HAT of the CRH gene, which may contribute to adverse pregnancy outcomes such as preeclampsia and preterm birth. These findings highlight stress-related factors contributing to maternal morbidity, and the need for a comprehensive approach to improving prenatal healthcare.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"525-534"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between the Neutrophil-To-lymphocyte Ratio and Health-related Behaviors and Factors in Rural Adults With and Without Cardiometabolic Disease.","authors":"Hsiang-Ting Lu, Yu-Chih Lin, Tung-Jung Huang, Mei-Yen Chen","doi":"10.1177/10998004251336478","DOIUrl":"10.1177/10998004251336478","url":null,"abstract":"<p><p>BackgroundComplete blood count (CBC) is a commonly used and cost-effective blood test in health screenings; however, its potential as a biomarker for early detection of chronic diseases remains underutilized. Previous studies have shown that the neutrophil-to-lymphocyte ratio (NLR) is associated with systemic inflammation and is correlated with cardiometabolic diseases (CMDs). Unhealthy lifestyles can trigger inflammatory responses and contribute to the progression of CMDs. This study aimed to explore the association between NLR levels, cardiometabolic risks, and health-related behaviors.MethodsA community-based, cross-sectional study was conducted in collaboration with a local hospital as part of an annual health screening for rural adults. The study outcomes included CMDs, health-related behaviors, and NLR levels. A multivariable quantile regression model, adjusted for confounding factors, was used to identify factors associated with NLR levels.ResultsA total of 11,220 participants were enrolled. CMDs prevalence was 25.8%, with hypertension and diabetes being most common. Nearly half of participants reported insufficient exercise, low water intake, and inadequate oral hygiene. Higher NLR was significantly associated with CMDs (<i>p</i> for trend <0.001). Older age (<i>p</i> < .01) and living alone (<i>p</i> < .01) were linked to higher NLR, while adequate water intake (<i>p</i> < .05) and regular exercise (<i>p</i> < .01) were associated with lower NLR levels.ConclusionsRural adults demonstrated a high prevalence of CMDs and inadequate health-related behaviors, which were associated with elevated NLR levels. Implementing NLR-guided lifestyle modifications and tailored health promotion programs may serve as innovative strategies to mitigate the progression of CMDs.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"535-543"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Functional Training on Physical Function, Cardiorespiratory Fitness, and Quality of Life in Older Women: A 6-Week Randomized Controlled Trial.","authors":"Akram Dashti, Nasser Mohammad Rahimi, Amin Azimkhani","doi":"10.1177/10998004251337063","DOIUrl":"10.1177/10998004251337063","url":null,"abstract":"<p><p><b>Background:</b> Functional training is increasingly recognized for its potential to improve physical function and quality of life (QoL) in older adults. This randomized controlled trial examined the effects of a six-week functional training program on physical function, cardiorespiratory fitness, and QoL in older women. <b>Methods:</b> Fifty older women (mean age: 63.5 ± 3.7 years) were randomly assigned to a functional training group (<i>n</i> = 25) or a control group (<i>n</i> = 25). The intervention group participated in a six-week functional training program (six sessions per week), while the control group maintained usual daily activities. Outcomes included dynamic balance (TUG test), flexibility, muscle strength, walking speed, cardiorespiratory fitness (two-minute step test), and QoL. <b>Results:</b> Functional training significantly improved dynamic balance, lower body flexibility, lower body strength, walking speed, and aerobic endurance (<i>p</i> < .05 for all). QoL significantly increased in the functional training group across all domains, as well as overall scores (<i>p</i> < .05). However, the control group experienced declines in some measures. <b>Conclusion:</b> Functional training is a safe and effective intervention for improving physical function, cardiorespiratory fitness, and QoL in older women. The significant enhancements in physical and mental health highlight its value in promoting independence and well-being in aging populations. Future studies should explore its long-term benefits and scalability.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"570-580"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Glycemic Variability in Patients With Intracerebral Hemorrhage and Neurological Deterioration.","authors":"Lichun Lu, Xiangyi Yin, Chen Wang, Xianlan Meng, Gongbo Li, Wenyu Zhu","doi":"10.1177/10998004251344888","DOIUrl":"10.1177/10998004251344888","url":null,"abstract":"<p><p><b>Background:</b> Glycemic variability and its management hold significant prognostic implications in clinical practice for patient outcomes. The aim of this study is to analyze the correlation between glycemic variability and the deterioration of neurological function in patients with intracerebral hemorrhage (ICH), to provide evidence-based support for the treatment and care of clinical ICH patients. <b>Methods:</b> Patients with ICH admitted to our hospital between January 2022 and August 2024 were subjected to the National Institutes of Health Stroke Scale (NIHSS) scoring upon admission and discharge. A comparative analysis of baseline characteristics and glycemic variability parameters was conducted. <b>Results:</b> A total of 156 patients with ICH were included. The incidence of neurological deterioration in ICH patients was 30.8%. Correlation analysis revealed significant associations between age (r = 0.602), mean glucose levels (r = 0.623), Time in Range (TIR) (r = 0.589), Mean Amplitude of Glycemic Excursions (MAGE) (r = 0.608), and Large Amplitude of Glycemic Excursions (LAGE) (r = 0.634) with the occurrence of neurological deterioration. Logistic regression analysis identified age (OR = 2.512, 95%CI: 1.924-3.006), mean glucose (OR = 2.743, 95%CI: 2.101-3.286), TIR (OR = 3.204, 95%CI: 2.985-3.607), MAGE (OR = 3.029, 95%CI: 2.601-3.748), and LAGE (OR = 2.768, 95%CI: 2.245-3.103) as significant predictors of neurological deterioration in ICH patients. <b>Conclusion:</b> This finding underscores the critical importance of considering both chronological age and glycemic control metrics in the prognostic evaluation of ICH patients. Integrating these factors into clinical assessments may enhance the accuracy of predicting patient outcomes and guide tailored therapeutic strategies.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"612-619"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}