Biological research for nursing最新文献

{"title":"Neurological Post-Acute Sequelae of COVID-19 in Non-Hospitalized Patients: An Integrative Review.","authors":"Jose Carlos de Andrade Vieira Junior, Murilo Rossi Lima Sander, José Airton de Oliveira Matos, André de Macêdo Medeiros, Flávio Santos da Silva, Caio Augusto Martins Aires","doi":"10.1177/10998004251335968","DOIUrl":"https://doi.org/10.1177/10998004251335968","url":null,"abstract":"<p><p>The COVID-19 pandemic has had a significant impact on the global population. The infection, caused by SARS-CoV-2, presents with a variety of clinical manifestations, from asymptomatic cases to more severe forms, including a variety of neurological symptoms, such as fatigue, weakness, brain fog, paresthesias, dysautonomia, anosmia, and dysgeusia. Additionally, the disease is associated with the long COVID syndrome, in which there is persistence of the effects and symptoms of the acute phase. In recent years the literature has shown relevant data on long COVID, but there is still a need to deepen the knowledge about these long term manifestations. Thus, the present study aimed to describe the main neurological sequelae resulting from SARS-CoV-2 infection in non-hospitalized population during the long phase of the disease, gathering scientific evidence through an integrative review of the prevalence of symptoms, patient profile, duration and severity of sequelae, risk factors, comorbidities, and possible nervous system structural damage. The PubMed/Medline database was used with descriptors and, at the end of the screening process with predefined inclusion and exclusion criteria, 22 studies were included. A group of neurological symptoms associated with long COVID was identified: myalgia, dysgeusia, memory alterations, olfactory dysfunction, dizziness, and pain. Most patients presented multiple symptoms that lasted for more than one year with a significant impact on quality of life. The main risk factors were dyslipidemia, age, ethnicity, muscle/ joint pain, and sex. This review highlights the importance of further studies on the syndrome, its etiology, diagnosis, follow-up, and treatments.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251335968"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and Adiposity Outcomes in School-Age Children with Overweight and Obesity.","authors":"Shao-Yu Tsai, Yi-Ching Tung, Chuen-Min Huang, Shu-Yu Kuo, Chien-Chang Lee","doi":"10.1177/10998004251339743","DOIUrl":"https://doi.org/10.1177/10998004251339743","url":null,"abstract":"<p><p><b>Purpose:</b> To examine four dimensions of sleep (timing, quality, quantity, and variability) and their association with adiposity outcomes in a community sample of school-age children with overweight and obesity. <b>Design</b>: A cross-sectional actigraphic study. <b>Methods:</b> 246 school-age children aged 6-9 years with overweight or obesity were recruited from 10 public elementary schools in Taipei, Taiwan. Children's sleep was objectively assessed over a 7-day period using a wrist actigraph. Adiposity outcomes, including BMI, BMI-for-age z-score, and percent body fat, were computed based on measured weight, height, and skinfold thickness following standardized procedures. Associations between sleep and child adiposity outcomes were examined using bivariate and multiple linear regression analyses. <b>Results:</b> In the bivariate analyses, later sleep onset time was correlated with greater percent body fat (<i>p =</i> .01); shorter daily sleep duration was correlated with higher BMI and percent body fat (both <i>p <</i> .05); greater variability in daily sleep duration was correlated with higher BMI, BMI-for-age z-score, and percent body fat (all <i>p <</i> .05). In multiple linear regression analyses, variability in daily sleep duration was the only sleep characteristic that showed a statistically significant association with percent body fat in children (b = 2.36; 95% CI: 0.28 to 4.43; <i>p =</i> .02). <b>Conclusions:</b> Overweight and obesity treatment interventions targeting child weight management should prioritize the assessment and promotion of children's sleep regularity. Future randomized controlled trials are needed to investigate the impact of maintaining a more consistent sleep pattern on measures of adiposity in school-age children with overweight and obesity.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251339743"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Eight Weeks of Aerobic Exercise and Spirulina Supplementation on Some Liver Enzymes, Body Composition, and Cardiorespiratory Fitness in Overweight and Obese Adult Women.","authors":"Haniyeh Akbarzadeh Khadari, Rokhsare Fazolahzade Mousavi, Ladan Hosseini Abrishami","doi":"10.1177/10998004251340024","DOIUrl":"https://doi.org/10.1177/10998004251340024","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to evaluate the effects of eight weeks of aerobic exercise and spirulina supplementation on liver enzymes, body composition, and cardiorespiratory fitness in overweight and obese women. <b>Methods:</b> A randomized, double-blind, placebo-controlled trial was conducted involving 36 overweight and obese adult women (body mass index [BMI] ≥ 25 kg/m², aged 25-40 years) randomly assigned to four groups: placebo with aerobic exercise, spirulina with aerobic exercise, spirulina-only, and placebo-only. Interventions included aerobic training three times per week (40-50 minutes/session) and a twice-daily dose (each 500 mg) of Spirulina or placebo for eight weeks. Outcomes were assessed at baseline and post-intervention, including liver enzyme levels (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), body composition (BMI, body fat percentage, waist-to-hip ratio (WHR)), and VO_2max using validated protocols. <b>Results:</b> Significant within-group improvements in ALT, AST, body weight, BMI, WHR, and VO₂max were observed in the aerobic training and spirulina groups, either alone or combined (<i>p <</i> .001). The aerobic training + placebo group demonstrated the greatest reduction in body weight and BMI, while spirulina-alone showed significant ALT and AST reductions. VO_2max improved in all intervention groups, but post hoc analysis revealed no significant between-group differences. <b>Conclusion:</b> Aerobic exercise and spirulina supplementation independently and synergistically improve liver function, body composition, and cardiorespiratory fitness in overweight and obese women. Combining these interventions may offer a holistic approach to managing obesity-related health risks. Further research is essential to elucidate the underlying mechanisms and optimize intervention strategies for diverse populations.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251340024"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of 6 Weeks of Dynamic Neuromuscular Stabilization Exercises on Motor Control, Cardiovascular Fitness, and Respiratory Performance in Overweight and Obese Women.","authors":"Sara Binabaji, Nasser Mohammad Rahimi, Mahdi Esfahani","doi":"10.1177/10998004251337451","DOIUrl":"https://doi.org/10.1177/10998004251337451","url":null,"abstract":"<p><p><b>Background:</b> Obesity is linked to impairments in motor control, cardiovascular fitness, and respiratory function. Dynamic Neuromuscular Stabilization (DNS) aims to enhance core stability, diaphragmatic breathing, and neuromuscular coordination. This study investigated the effects of a 6-week DNS program on these functional outcomes in overweight and obese women. <b>Methods:</b> Thirty-six participants (aged 35-50 years, BMI: 25-34 kg/m²) were randomly assigned to either an experimental group (<i>n</i> = 18), which underwent DNS training, or a control group (<i>n</i> = 18), which received no intervention. The DNS program consisted of six weekly sessions (three supervised, three home-based), emphasizing core stabilization, diaphragmatic breathing, and neuromuscular coordination. Motor control (lumbar movement control tests), cardiovascular fitness (two-minute step test), and respiratory performance (breath-hold time, respiratory rate, and respiratory muscle strength) were assessed before and after the intervention. <b>Results:</b> The DNS group demonstrated significant improvements compared to the control group, with notable increases in motor control scores (<i>p <</i> .001) and cardiovascular fitness (<i>p <</i> .001). Additionally, inspiratory and expiratory breath-hold times (<i>p <</i> .001 for both), respiratory rate (<i>p <</i> .001), and maximum inspiratory and expiratory pressures (<i>p <</i> .001) showed substantial enhancements. No significant changes were observed in the control group. <b>Conclusion:</b> A 6-week DNS exercise program significantly improved motor control, cardiovascular fitness, and respiratory performance in overweight and obese women. These findings support DNS training as an effective intervention for enhancing core stability, breathing efficiency, and neuromuscular coordination, with potential applications in rehabilitation and health promotion.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251337451"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Functional Training on Physical Function, Cardiorespiratory Fitness, and Quality of Life in Older Women: A 6-Week Randomized Controlled Trial.","authors":"Akram Dashti, Nasser Mohammad Rahimi, Amin Azimkhani","doi":"10.1177/10998004251337063","DOIUrl":"https://doi.org/10.1177/10998004251337063","url":null,"abstract":"<p><p><b>Background:</b> Functional training is increasingly recognized for its potential to improve physical function and quality of life (QoL) in older adults. This randomized controlled trial examined the effects of a six-week functional training program on physical function, cardiorespiratory fitness, and QoL in older women. <b>Methods:</b> Fifty older women (mean age: 63.5 ± 3.7 years) were randomly assigned to a functional training group (<i>n</i> = 25) or a control group (<i>n</i> = 25). The intervention group participated in a six-week functional training program (six sessions per week), while the control group maintained usual daily activities. Outcomes included dynamic balance (TUG test), flexibility, muscle strength, walking speed, cardiorespiratory fitness (two-minute step test), and QoL. <b>Results:</b> Functional training significantly improved dynamic balance, lower body flexibility, lower body strength, walking speed, and aerobic endurance (<i>p</i> < .05 for all). QoL significantly increased in the functional training group across all domains, as well as overall scores (<i>p</i> < .05). However, the control group experienced declines in some measures. <b>Conclusion:</b> Functional training is a safe and effective intervention for improving physical function, cardiorespiratory fitness, and QoL in older women. The significant enhancements in physical and mental health highlight its value in promoting independence and well-being in aging populations. Future studies should explore its long-term benefits and scalability.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251337063"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant Impacts of the Body-Mass Index, Blood Pressure, Blood Glucose, and Ankle-Brachial Index on Peripheral Neuropathy Risk in Indonesian With Type 2 Diabetes: A Cross-Sectional Study.","authors":"Siti Fadlilah, Vivi Leona Amelia, Cyruz P Tuppal, Hui-Chen Rita Chang, Ching Wen Chang, Chia Ling Lin, Hsiu Ting Tsai","doi":"10.1177/10998004251336795","DOIUrl":"https://doi.org/10.1177/10998004251336795","url":null,"abstract":"<p><p><b>Background:</b> Diabetic peripheral neuropathy is associated with morbidity and mortality in people with diabetes mellitus. <b>Aims:</b> In this study, we determined relationships of the body-mass index (BMI), systolic blood pressure, diastolic blood pressure, fasting blood glucose, HbA1c, and ankle-brachial index (ABI) with diabetic peripheral neuropathy risk. <b>Methods:</b> A cross-sectional study was conducted with 1088 Indonesians and data collected using self-reported questionnaires, laboratory examinations, and physical examinations. Instruments included a digital scale, height measurement device, digital sphygmomanometer, Doppler ultrasound, 10-g monofilament, and a 128-Hz tuning fork. Data analysis used the Chi-square test, Fisher Exact, and multiple logistic regression test with significance <i>p <</i> .05. <b>Results:</b> The BMI (<i>p <</i> .001), blood pressure (<i>p <</i> .001), ABI (<i>p <</i> .001), fasting blood glucose (<i>p =</i> .016), and HbA1c (<i>p <</i> .001) were significantly related to peripheral neuropathy risk. The conditions of obesity, hypertension, high ABI, high fasting blood glucose, and high HbA1c significantly increased the risk of peripheral neuropathy. Moreover, participants with ≥4 co-occurring abnormal levels of the BMI, systolic blood pressure, diastolic blood pressure, fasting blood glucose, HbA1c, and ABI had significantly synergistically increased risks of peripheral neuropathy, and the more abnormal conditions there were, the higher the risk of peripheral neuropathy. <b>Conclusions:</b> Abnormalities of the BMI, blood pressure, fasting blood glucose, HbA1c, and ABI significantly and synergistically increased the risk of peripheral neuropathy and can be considered predictors of peripheral neuropathy. Nurses are expected to be aware of these predictors so that they can immediately take appropriate steps if they encounter abnormal conditions by optimizing their role as educators.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251336795"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for the Use of Commercial Wearables to Assess Sleep and Rest-Activity Rhythms.","authors":"Mackenzie Morrison, Jemima Adisa, Olivia Trimiar, John Norfleet, Mathias Basner, Makayla L Cordoza","doi":"10.1177/10998004251337065","DOIUrl":"https://doi.org/10.1177/10998004251337065","url":null,"abstract":"<p><p>Use of wearables, which can be considered as devices worn on the body that capture dimensions of health, are common in research. Wearables are useful as they can be employed in a number of environments for a variety of populations and can record over short or long time periods. Recent advancements in technology have significantly improved the accuracy of sensors and the algorithms used to interpret their data. Commercial wearables, such as fitness trackers, smartwatches, and smart rings have seen parallel advancements. Perhaps the most common application of wearables in research is for the assessment of sleep and rest-activity rhythms as most wearables include accelerometers, a sensor commonly used to infer sleep and activity from movement patterns. Commercial wearables are appealing for use in research due to their widespread use in the general population, real-time data syncing capabilities, affordability, and their user-friendly, consumer-oriented design and interfaces. There are, however, several important factors to consider when selecting a commercial wearable for use in research. These include device specifications (durability, price, unique features, etc.), data accessibility, and participant factors. Keeping these considerations in mind can assist in the collection of high-quality data that can ultimately be used to improve population outcomes. The purpose of this methodological review is to describe considerations for the use of commercially available wearables in research for the purposes of assessing sleep and rest-activity patterns.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251337065"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Perceived Stress, Glucocorticoids Receptors, and Corticotropin-Releasing Hormone Gene Expression During Pregnancy.","authors":"Marlene Brennen, Ruth Tappen, Vanessa Johnson","doi":"10.1177/10998004251336366","DOIUrl":"https://doi.org/10.1177/10998004251336366","url":null,"abstract":"<p><p>The preterm birth rate and the maternal mortality rate are 1.6 and 2.6 times higher for Black women than for White women, respectively, in the United States. This disproportionate difference in maternal health outcomes is a notable health inequity. The purpose of this study was to evaluate the influence of perceived stress, and glucocorticoid receptors (GR) on histone acetylation (HAT) of the corticotropin-releasing hormone (CRH) gene between non-Hispanic Black and non-Hispanic White women in their second trimester of pregnancy. This study used a cross-sectional design to analyze secondary, deidentified data including peripheral blood monocyte cells, from a prior study. The study sample consisted of 32 non-Hispanic Black women and 73 non-Hispanic White women from the parent study. A four-step hierarchical linear regression analysis was used to analyze the influence of race, perceived stress, and GR on the HAT of the CRH gene. The hierarchical linear regression analysis found that race, perceived stress, and GR significantly predicted the HAT of the CRH. GR explained 41.33% of the variation in HAT CRH of the gene, and age plus race explained an additional 3.56% of the variation in HAT CRH of the gene. The findings of this study suggest that perceived stress and GR among young Black women were associated with higher levels of HAT of the CRH gene, which may contribute to adverse pregnancy outcomes such as preeclampsia and preterm birth. These findings highlight stress-related factors contributing to maternal morbidity, and the need for a comprehensive approach to improving prenatal healthcare.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251336366"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between the Neutrophil-To-lymphocyte Ratio and Health-related Behaviors and Factors in Rural Adults With and Without Cardiometabolic Disease.","authors":"Hsiang-Ting Lu, Yu-Chih Lin, Tung-Jung Huang, Mei-Yen Chen","doi":"10.1177/10998004251336478","DOIUrl":"https://doi.org/10.1177/10998004251336478","url":null,"abstract":"<p><p>BackgroundComplete blood count (CBC) is a commonly used and cost-effective blood test in health screenings; however, its potential as a biomarker for early detection of chronic diseases remains underutilized. Previous studies have shown that the neutrophil-to-lymphocyte ratio (NLR) is associated with systemic inflammation and is correlated with cardiometabolic diseases (CMDs). Unhealthy lifestyles can trigger inflammatory responses and contribute to the progression of CMDs. This study aimed to explore the association between NLR levels, cardiometabolic risks, and health-related behaviors.MethodsA community-based, cross-sectional study was conducted in collaboration with a local hospital as part of an annual health screening for rural adults. The study outcomes included CMDs, health-related behaviors, and NLR levels. A multivariable quantile regression model, adjusted for confounding factors, was used to identify factors associated with NLR levels.ResultsA total of 11,220 participants were enrolled. CMDs prevalence was 25.8%, with hypertension and diabetes being most common. Nearly half of participants reported insufficient exercise, low water intake, and inadequate oral hygiene. Higher NLR was significantly associated with CMDs (<i>p</i> for trend <0.001). Older age (<i>p</i> < .01) and living alone (<i>p</i> < .01) were linked to higher NLR, while adequate water intake (<i>p</i> < .05) and regular exercise (<i>p</i> < .01) were associated with lower NLR levels.ConclusionsRural adults demonstrated a high prevalence of CMDs and inadequate health-related behaviors, which were associated with elevated NLR levels. Implementing NLR-guided lifestyle modifications and tailored health promotion programs may serve as innovative strategies to mitigate the progression of CMDs.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251336478"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Associations With Fatigue and Physical Function in Children With Cancer: A Pilot Study.","authors":"Janice S Withycombe, Jinbing Bai, Canhua Xiao, Ronald C Eldridge","doi":"10.1177/10998004251335639","DOIUrl":"https://doi.org/10.1177/10998004251335639","url":null,"abstract":"<p><p><b>Background:</b> Fatigue is a frequently reported symptom in children undergoing cancer treatment. Prior research shows an inverse relationship between fatigue and physical activity. Less is known about fatigue's relationship with physical function or the underlying biological mechanisms of fatigue. This study explored associations among fatigue, physical function, and associated metabolites. <b>Methods:</b> Children (7-18 years) provided serum samples and self-reports of fatigue and lower extremity physical function (mobility) using Pediatric Patient-Reported Outcomes Measurement Information System (PROMIS) surveys at two timepoints during cancer therapy. PROMIS scores were categorized as high/low per established cut points (high fatigue T <u>></u>47.5; high physical function T <u>></u>51.5). High-resolution liquid chromatography-mass spectrometry extracted 29 metabolites hypothesized a priori to be associated with fatigue or physical function. Descriptive statistics summarized PROMIS scores, and linear mixed effect models estimated metabolite associations adjusting for age, gender and steroid use. <b>Results:</b> Forty children participated (female, 53%; 7-12 years, 38%; 13-18 years 62%; Hodgkins Lymphoma, 33%; Acute Lymphoblastic/Lymphocytic Leukemia, 40%; Osteosarcoma, 10%; Other, 17%). Physical function and fatigue were inversely related: T1 (r = -0.64; <i>p <</i> .001) and T2 (r = -0.63; <i>p <</i> .001). One metabolite (indole-3-latic acid) differentiated between low and high fatigue. Five metabolites differentiated significantly between low and high physical function (4-Hydroxybenzoic acid, m-Coumaric acid, myoinositol, tryptophan, and tyrosine). <b>Conclusions:</b>These findings substantiate prior studies showing metabolites, particularly amino acids, significantly associated with fatigue and physical function. All significant metabolites were associated with the gut microbiome. Physical function was inversely corelated with fatigue providing another potential intervention for fatigue management.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251335639"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}