Biological research for nursing最新文献

{"title":"Impact of <i>IL6</i> and <i>IL10</i> Genotype on Cytokines and Preeclampsia in a Pregnant Multi-Ethnic Cohort of Women With Overweight and Obesity.","authors":"Jennifer Woo, Michelle Pearce, Ryan Hulla, Yvette P Conley, McKenzie K Jancsura","doi":"10.1177/10998004261445879","DOIUrl":"https://doi.org/10.1177/10998004261445879","url":null,"abstract":"<p><p>IntroductionAn imbalance between pro- and anti-inflammatory factors is implicated in the pathogenesis of preeclampsia (PE). Although <i>IL10</i> (rs1800896) and <i>IL6</i> (rs1800795) genotypes are known to influence circulating cytokine levels, their associations with longitudinal inflammatory profiles across pregnancy have not been well characterized.MethodsWe conducted a retrospective case-control study to longitudinally compare nine pro- and four anti-inflammatory cytokines across pregnancy based on <i>IL6</i> and <i>IL10</i> genotype. The cohort included 111 women with overweight/obesity (37 with PE; 74 without PE), matched 2:1, and predominantly Black (72%). Separate 3 × 3 mixed multivariate analyses of variance (MANOVAs) assessed interactions between <i>IL6</i> or <i>IL10</i> genotype (between-subjects' factor) and pregnancy trimester (within-subjects factor). Pro- and anti-inflammatory cytokines were analyzed in separate models for each genotype. Due to the exploratory nature of the study and the examination of clinical relevance, statistical significance was set at <i>p =</i> .10.ResultsPro-inflammatory cytokine levels changed over pregnancy (<i>p <</i> .05) but were not associated with <i>IL6</i> or <i>IL10</i> genotype (all <i>p ></i> .10). Anti-inflammatory cytokine levels also varied across pregnancy (<i>p</i> < .05). <i>IL6</i> genotype was not associated with anti-inflammatory cytokine levels (<i>p ></i> .10). In contrast, <i>IL10</i> genotype was significantly associated with differences in anti-inflammatory cytokine levels across genotypes (V = 0.22, F (8,162) = 2.48, <i>p =</i> .014, η_<i>p</i>² = 0.11) and demonstrated an interaction effect with pregnancy trimester (V = 0.28, F (16,154) = 1.56, <i>p =</i> .087, η_<i>p</i>² = 0.14).Conclusion<i>IL10</i> genotype may influence circulating anti-inflammatory cytokines across pregnancy and, as such, may contribute to preeclampsia by influencing anti-inflammatory cytokine expression across pregnancy.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261445879"},"PeriodicalIF":2.1,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiome and Psychoneurological Symptoms Among Patients With Colorectal Cancer and Their Caregivers: A Pilot Study.","authors":"Yufen Lin, Zahra A Barandouzi, Madelyn C Houser, Canhua Xiao, Olatunji B Alese, Sindile Mathebula, Jinbing Bai, Olumide Gbolahan, Deborah W Bruner","doi":"10.1177/10998004261447509","DOIUrl":"https://doi.org/10.1177/10998004261447509","url":null,"abstract":"<p><p><b>Purpose:</b> Survivorship in colorectal cancer (CRC) is often accompanied by co-occurring psychoneurological symptoms (PNS, e.g., fatigue, depression, pain), which negatively affect quality of life. Caregivers of individuals with CRC also experience PNS due to caregiving burdens, amplifying distress across the dyad. PNS may be influenced by the activity of the gut microbes. The purpose of this pilot study was to examine gut microbiome diversity and composition, and their association with PNS in CRC patients and their caregivers. <b>Methods:</b> Baseline data from a technology-based dyadic intervention were included in this analysis. Eleven patients and eight caregivers provided stool samples and completed PROMIS measures of PNS at baseline. Gut microbiome profiles were assessed using 16S rRNA gene sequencing. Alpha and beta diversity metrics and differential abundance analyses were used to characterize the gut microbiome and examine its associations with PNS. <b>Results:</b> Patients exhibited significantly lower microbial alpha diversity than caregivers in the full sample (<i>p</i> = 0.033). Dyadic comparisons identified 92 differentially abundant taxa, with patients showing depletion of short-chain fatty acid-producing taxa and enrichment of opportunistic taxa. Microbiome-symptom models revealed significant interactions by group (patient vs. caregiver) and taxa-level effects, with patients showing stronger positive associations between microbial alterations and higher PNS severity. <b>Conclusions:</b> CRC patients actively on chemotherapy demonstrated reduced diversity and depletion of beneficial taxa that may contribute to heightened PNS. Caregivers, despite healthier profiles, reported substantial symptom burden that were linked to gut microbiome features, highlighting dyadic interdependence and the potential for microbiome-targeted, dyadic interventions in survivorship care.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261447509"},"PeriodicalIF":2.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender, Inflammation, and Cognition Affect the Sleep Trajectories of Subarachnoid Hemorrhage Survivors.","authors":"Chiyoung Lee, Hilaire J Thompson, Susan M McCurry, Suyoung Kwon, Suah Park, Lalipat Phianhasin, Calvin Huynh, Theo K Bammler, Kyra J Becker, Maria Bleil, Michael R Levitt, Eeeseung Byun","doi":"10.1177/10998004261444672","DOIUrl":"https://doi.org/10.1177/10998004261444672","url":null,"abstract":"<p><p>Longitudinal trajectories of sleep in subarachnoid hemorrhage (SAH) survivors are not well known. We identified subgroups of SAH survivors based on distinct trajectories of sleep during the first 6 months post-SAH and compared sociodemographic characteristics, clinical characteristics, inflammatory biomarkers (Toll-like receptor 4, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and IL-6), and symptom-related characteristics (depression/anxiety, fatigue, sleep quality, and cognition) among the subgroups. We conducted a 6-month longitudinal study of 40 SAH survivors (mean age = 56.0). Multi-trajectory latent class growth analysis identified salient patient groupings based on the trajectories of sleep parameters-sleep efficiency (SE), sleep onset latency (SOL), wake after sleep onset (WASO), and total sleep time (TST)-assessed using actigraphy at 2, 3, and 6 months. Two trajectory groups were identified: Group 1 (n = 24; \"high SE/short SOL/short WASO/adequate TST\") and Group 2 (n = 16; \"low SE/long SOL/long WASO/insufficient TST\"). The mean scores of all sleep parameters remained stable across months 2, 3, and 6 in both groups, except for SOL, which decreased in Group 2, but remained higher than that of Group 1. Individuals in Group 1 (vs. Group 2) were more likely to be female and had lower levels of TNF-α and IL-6 on days 3 and 4 post-SAH, respectively. Individuals in Group 1 (vs. Group 2) performed better on immediate memory, visuospatial/constructional ability, attention, and delayed memory tasks at 2 months. Distinct sleep trajectory groups were identified among SAH survivors; however, further studies with larger samples are needed to validate and better characterize these patterns.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261444672"},"PeriodicalIF":2.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biobehavioral and Interpersonal Predictors of Cognitive Impairment in Older Adults With Type 2 Diabetes: A Systematic Review of Cohort Studies.","authors":"Min Jung Kim, Bohyun Kim","doi":"10.1177/10998004261444978","DOIUrl":"https://doi.org/10.1177/10998004261444978","url":null,"abstract":"<p><p>The type 2 diabetes-cognitive decline link is a potent independent risk factor for cognitive impairment and dementia. However, preventive strategies often neglect diabetes-specific risks, and reviews generally rely on cross-sectional data. This systematic review of observational cohort studies was conducted to synthesize longitudinal evidence on the multidimensional predictors of cognitive impairment in older adults with type 2 diabetes. PubMed, CINAHL, PsycINFO, and Cochrane Library were searched. Included studies followed older adults with type 2 diabetes for at least six months and evaluated biological, behavioral, psychological, or interpersonal predictors of cognitive impairment. Data were narratively synthesized and study quality was assessed using the Newcastle-Ottawa Scale. Forty-three studies met the inclusion criteria. Biological predictors were the most extensively studied (n = 31). Nine studies addressed behavioral factors, two examined social and environmental predictors, and no studies investigated psychological factors. Higher HbA1c levels, glucose variability, severe hypoglycemia, vascular complications, and inflammatory/metabolic markers significantly predicted higher cognitive impairment risk. Poor diet, low physical activity, and sleep disorders were associated with cognitive decline. Social determinants of health and limited social contact were linked to higher dementia risk, although evidence remains sparse. This review highlights the critical need to prioritize modifiable predictors, especially diabetes-specific biological markers and health behaviors, to prevent or delay cognitive impairment in older adults with type 2 diabetes. Future research should focus on developing individualized, multidimensional preventive interventions that incorporate behavioral and contextual factors. Additionally, validated multifactorial risk prediction models are needed to identify high-risk populations and inform tailored care.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261444978"},"PeriodicalIF":2.1,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol Analysis Using a Novel Method of Saliva Collection: Method and Application in Preterm Infants.","authors":"Marliese Dion Nist, Nicole Cistone, Claire Packer, Abigail B Shoben, Christine A Fortney, Rita H Pickler","doi":"10.1177/10998004261438483","DOIUrl":"https://doi.org/10.1177/10998004261438483","url":null,"abstract":"<p><p>Preterm infants experience frequent stressors that activate the hypothalamic-pituitary-adrenal (HPA) axis. Cortisol can be readily quantified in saliva samples, but sufficient saliva volumes are difficult to collect from preterm infants. We report the development and validation of a novel method to collect saliva using flocked polyester swabs and the application of this method in a study of preterm infants. Saliva samples, collected from adult participants (<i>N</i> = 24), were divided and processed as \"standard\" aliquots and aliquots absorbed by and extracted from flocked polyester swabs. Cortisol levels in \"standard\" and \"swab\" aliquots were compared. We then collected saliva samples from preterm infants (<i>N</i> = 31) using flocked polyester swabs to measure HPA responses to routine, clustered nursing care. Saliva samples were collected from each infant prior to caregiving, 30-min after caregiving, and 60-min after caregiving. Aliquots from the same adult were highly correlated. Sufficient volumes of saliva were extracted from 91 of 93 infant swabs (98%). Changes in cortisol levels from baseline to 30-min and 60-min after caregiving were negatively associated with acute procedural stress, quantified using the Neonatal Infant Stressor Scale. The change in cortisol level from baseline to 60-min after caregiving was negatively associated with caregiving duration. Further research is needed to understand the relationship between caregiving stress exposure and HPA axis responses in preterm infants and to identify the myriad factors that may influence this association. Flocked polyester swabs offer a viable option for the collection of sufficient volumes of saliva to support this research.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261438483"},"PeriodicalIF":2.1,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Interactions and Cell Aging Dynamics in Postpartum Women.","authors":"Nourit Houminer-Klepar, Shiran Bord, Elissa Epel, Jue Lin, Shlomi Sagi, Orna Baron-Epel","doi":"10.1177/10998004251397544","DOIUrl":"10.1177/10998004251397544","url":null,"abstract":"<p><p><b>Introduction:</b> Psychosocial stressors are linked with declined physical and psychological health, and short telomere length (TL). While positive social interactions have been linked to improved postpartum physical and mental health, little research has explored the longitudinal effects of psychosocial stressors and telomere dynamics in the sensitive postpartum period. This study aimed to examine the effect of positive and negative social interactions on TL among first-time mothers during the first year postpartum. <b>Methods:</b> A cohort of 103 first-time mothers from Northern Israel completed validated measures assessing social support, marital satisfaction, and depressive symptoms, and provided blood samples for leukocyte TL analysis. Hierarchical linear and logistic regressions, adjusting for covariates, examined the association between social interactions and change in TL. <b>Results:</b> We observed three patterns of telomere dynamics over the year: telomere shortening, moderate telomere lengthening, and relatively high telomere lengthening in the lower, medium, and upper tertiles of change in TL, respectively, used as our categorical outcome. Hierarchical logistic regressions analyses revealed that mothers with higher marital satisfaction had a 4-fold greater likelihood of substantial telomere lengthening (OR = 3.997, 95%CI [1.345, 11.876] <i>p =</i> .013), remaining significant after correction for multiple comparisons. Negative social interactions showed initial associations (OR = 0.332, 95%CI [0.114, 0.971] <i>p =</i> .044) but did not maintain significance after multiple comparison adjustment. <b>Discussion:</b> Marital satisfaction showed a robust association with telomere lengthening postpartum, representing the most consistent finding. Social relationships, particularly intimate partnership quality, may be important in the postpartum period, not just for mental health but for biological aging indices.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"205-217"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>APOE</i> ε4 Allele and Methylation Patterns Linked to Cardiovascular Outcomes in Women With Breast Cancer.","authors":"Emily K Mewborn, Myeong-Ga Cho, Kirk I Erickson, Catherine M Bender, Yvette Conley","doi":"10.1177/10998004251385243","DOIUrl":"10.1177/10998004251385243","url":null,"abstract":"<p><p>DNA methylation affects gene expression. While the Apolipoprotein E (<i>APOE</i>) genotype impacts cardiovascular risk, <i>APOE</i> methylation impact remains unknown, particularly in women with breast cancer (BC). This study explored associations of <i>APOE</i> methylation with hypertension history and cardiovascular fitness (CVF) and whether <i>APOE</i> genotype and methylation moderate exercise effects over 6 months. This study leveraged data from a 6-month exercise randomized clinical trial in postmenopausal women with BC. Using peripheral blood, methylation M-values (Illumina Infinium Methylation EPIC Beadchip) and 13 CpG sites within and 2kb 5' and 3' to <i>APOE</i> were abstracted post data quality checks. Outcome variables: self-reported hypertension and CVF (peak oxygen consumed per kilogram per minute [VO₂max/kg/min] and peak metabolic equivalents [METs] through graded exercise testing). Participants completed 150 min/week of aerobic exercise or usual care for 6 months. Logistic and linear regression examined associations between CpG M-values and hypertension, VO₂max/kg/min and METs. Baseline M-value and <i>APOE</i> genotype were interaction terms for longitudinal analyses. This study included 102 women (Mean = 62 yrs). <i>APOE</i>ε4 carriers had increased methylation of cg06750524 (<i>p =</i> 0.04) and cg19514613 (<i>p =</i> 0.03), but lower methylation of cg21879725 (<i>p =</i> 0.04). Increased cg06750524 methylation was associated with higher hypertension odds (<i>p =</i> 0.022, OR = 2.813) and lower VO₂max/kg/min and METs (<i>p =</i> 0.005). Increased cg05501958 methylation (M = 4.539, SD = 0.17) was associated with lower hypertension odds (<i>p =</i> 0.02, OR = 0.035) and higher VO₂max/kg/min and METs (<i>p =</i> 0.022). Neither <i>APOE ε4</i> nor baseline methylation moderated exercise effects. <i>APOE</i> methylation, differentially by ε4 carriage, may impact cardiovascular outcomes and serve as a biomarker of risk in women with BC.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"177-186"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12664574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Infant Massage in Neonates With Hyperbilirubinemia Receiving Phototherapy: A Systematic Review and Meta-Analysis.","authors":"Zübeyde Ezgi Erçelik, Diler Aydin Yilmaz","doi":"10.1177/10998004251385121","DOIUrl":"10.1177/10998004251385121","url":null,"abstract":"<p><p>Most infants are diagnosed with hyperbilirubinemia in the first day of life. Although phototherapy is the most common treatment used in hyperbilirubinemia, different alternative therapies such as massage are also used. This systematic review and meta-analysis was designed to evaluate the effect of massage on serum bilirubin levels, defecation frequency, and length of hospital stay in neonates with hyperbilirubinemia receiving phototherapy. A review of randomized controlled trials published in English from 2008 to November 2023 was conducted using PubMed-Medline, Academic Search Ultimate-EBSCOhost, Web of Science, and Scopus databases. From 217 identified trials, six randomized controlled studies were included, with a total sample of 394 term infants. Infant massage was effective in increasing defecation frequency (MD: 0.52, 95% CI: Min: 0.29- Max: 0.76, <i>p <</i> 0.0001), reducing serum bilirubin levels on the 3rd and 4th days (MD: -1.19, 95% CI: Min: -1.50- Max: -0.89, <i>p <</i> 0.0001) (MD:-2.33, 95% CI: Min: -2.88- Max: -1.79, <i>p <</i> 0.0001), and shortening hospital stay (MD:-13.66, 95% CI: Min: -16.74- Max: -10.59, <i>p <</i> 0.0001). This systematic review and meta-analysis suggest that infant massage is a safe and effective intervention for term neonates with hyperbilirubinemia, contributing to a shorter hospital stay by lowering serum bilirubin levels and increasing defecation frequency.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"274-282"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric Acid, BMI, and Neutrophil Lymphocyte Ratio Mediate the Relationship Between Soft Drink Consumption and Systolic Blood Pressure: A Nationwide Structural Equation Model Pathways Among Adolescents and Young Adults Across Indonesia.","authors":"Maria Dyah Kurniasari, Ferry Fredy Karwur, Kristiawan Prasetyo Agung Nugroho, Farida Sonya Mangma, Elisa Esa Naftali","doi":"10.1177/10998004251406291","DOIUrl":"10.1177/10998004251406291","url":null,"abstract":"<p><p><b>Background:</b> Adolescent hypertension is an emerging global issue, with metabolic and inflammatory dysregulation potentially preceding cardiovascular disease. Increasing soft drinks and fast food consumption has been associated with obesity and metabolic imbalance. However, the biological pathways connecting these dietary behaviours to blood pressure remain weakly understood in Indonesian adolescents. <b>Objectives:</b> To investigate mediating effects of body mass index, uric acid, and neutrophil-to-lymphocyte ratio on relationship between soft-drink and fast-food consumption and systolic blood pressure among Indonesian adolescents and young adults. <b>Methods:</b> A nationwide, community-based cross-sectional study was conducted among 500 adolescents aged 10-24 years, representing Indonesia's major ethnic regions. Dietary intake was assessed using semi-quantitative food frequency questionnaire. Clinical measurements included body mass index, uric acid, neutrophil-to-lymphocyte ratio, and systolic blood pressure. Bivariate and multivariate analyses followed by mediation and multi-group analyses. <b>Results:</b> The mean systolic blood pressure was 110.84mmHg; soft-drink consumption correlated with uric acid, Body Mass Index, and systolic blood pressure (<i>p <</i> 0.001). In multiple regression, Body Mass Index (β = 0.36, <i>p <</i> 0.01) and soft drink-fast food consumption interaction (β = 0.27, <i>p <</i> 0.01) independently predicted systolic blood pressure. A significant indirect effect of soft-drink consumption on systolic blood pressure mediated by Body Mass Index, Neutrophil-to- Lymphocyte Ratio, and uric acid (β = 0.02, <i>p <</i> 0.05). Multi-group analysis indicated that effects of fast-food and soft-drink intake on body mass index and neutrophil-to-lymphocyte ratio did not differ significantly across gender or uric acid. <b>Conclusions:</b> Soft-drink consumption indirectly increases systolic blood pressure through metabolic and inflammatory mechanisms. Early nursing-led interventions that promote healthy diets, metabolic screening, and school-based health education are crucial to mitigating subclinical cardiovascular risk.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"230-241"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Research Landscape of Sleep Health in Nursing: A Bibliometric and Visualization Study.","authors":"Songül Çağlar","doi":"10.1177/10998004251397656","DOIUrl":"10.1177/10998004251397656","url":null,"abstract":"<p><p>This research intends to provide a comprehensive review of existing literature on sleep within the nursing field, employing bibliometric methods. A comprehensive analysis of the available literature concerning sleep in nursing was carried out through the Web of Science Core Collection (WoSCC) on October 20, 2025. The search terms \"sleep\" and \"nursing\" played a crucial role in identifying relevant research studies. VOSviewer was applied for bibliometric analysis and visualization to identify authors, journals, countries and display the keyword co-occurrence networks. A total of 2.456 publications focused on the topic of sleep were identified from 1991 to 2025. The dataset comprised predominantly research articles (2.296, 93.5%). These publications appeared in a total of 191 distinct academic journals and collectively received 103,025 citations over the analyzed period. The number of publications increased by an average of 6.83 units per year during the observed period (R² = 0.9622; p < 0.001). In the keyword co-occurrence network, \"sleep,\" \"sleep quality,\" and \"nursing\" keywords the highest frequency. The Journal of Clinical Nursing exhibited the highest publication output with 109 articles. The United States accounted for the largest share of publications. Development and Adaptation of Sleep Instruments in Nursing was performed on 14 measurement tools. This bibliometric study revealed the research points and trends in the field of sleep in nursing research. Future research should aim to strengthen international collaboration among nurse researchers, leveraging artificial intelligence tools and wearable technologies to effectively address sleep-related issues and enhance sleep quality.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"296-308"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}