Biological research for nursing最新文献

{"title":"Gut Microbiome Associations With Depressive Symptoms in Women With Gynecologic Cancer: A Longitudinal Study.","authors":"Zahra A Barandouzi, Tony Eng, Namita Khanna, Joseph Shelton, Isabelle Scott, Pretesh Patel, Jill Remick, Robyn Jin, Rebecca Meador, Deborah W Bruner","doi":"10.1177/10998004261461549","DOIUrl":"10.1177/10998004261461549","url":null,"abstract":"<p><p>About one-quarter of women diagnosed with gynecologic cancer experience depressive symptoms. While the precise mechanism remains unclear, little is known about the association between gut microbiota and depressive symptoms in gynecologic cancer. Thus, this study aimed to evaluate the associations between gut microbiota and depressive symptoms in women with gynecologic cancer over cancer treatment. Thirty-seven women with cervical or endometrial cancer were followed at pre-treatment (T0), 6-8 weeks (T1), and 6 months post-radiation (T2). Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Rectal swabs were collected at each visit and sequenced for the V4 region of the 16S rRNA gene. MaAsLin2 models evaluated cross-sectional associations between gut microbial taxa and depressive symptoms at each time point, whereas GEE models assessed longitudinal associations over the course of cancer treatment. The patients had an average age of 60 years, and 43% were Black. At baseline (T0), 24% of patients exhibited depressive symptoms, which decreased to 21% at T1 and further to 13% at T2. GEE models showed that lower α-diversity (Shannon index, p = 0.05), dissimilar β-diversity (Bray-Curtis distance, p = 0.02), and reduced abundance of the genus <i>Ruminococcus</i> (p = 0.02) were predictive factors associated with depressive symptoms throughout cancer treatment. Higher depressive symptoms were longitudinally associated with lower gut microbial Shannon diversity, dissimilar microbial community composition, and lower abundance of the genus <i>Ruminococcus</i>. Larger longitudinal studies using shotgun metagenomic sequencing are needed to validate these findings and further elucidate the microbial mechanisms underlying depressive symptoms in women with gynecologic cancers.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"560-571"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148260744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender, Inflammation, and Cognition Affect the Sleep Trajectories of Subarachnoid Hemorrhage Survivors.","authors":"Chiyoung Lee, Hilaire J Thompson, Susan M McCurry, Suyoung Kwon, Suah Park, Lalipat Phianhasin, Calvin Huynh, Theo K Bammler, Kyra J Becker, Maria Bleil, Michael R Levitt, Eeeseung Byun","doi":"10.1177/10998004261444672","DOIUrl":"10.1177/10998004261444672","url":null,"abstract":"<p><p>Longitudinal trajectories of sleep in subarachnoid hemorrhage (SAH) survivors are not well known. We identified subgroups of SAH survivors based on distinct trajectories of sleep during the first 6 months post-SAH and compared sociodemographic characteristics, clinical characteristics, inflammatory biomarkers (Toll-like receptor 4, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and IL-6), and symptom-related characteristics (depression/anxiety, fatigue, sleep quality, and cognition) among the subgroups. We conducted a 6-month longitudinal study of 40 SAH survivors (mean age = 56.0). Multi-trajectory latent class growth analysis identified salient patient groupings based on the trajectories of sleep parameters-sleep efficiency (SE), sleep onset latency (SOL), wake after sleep onset (WASO), and total sleep time (TST)-assessed using actigraphy at 2, 3, and 6 months. Two trajectory groups were identified: Group 1 (n = 24; \"high SE/short SOL/short WASO/adequate TST\") and Group 2 (n = 16; \"low SE/long SOL/long WASO/insufficient TST\"). The mean scores of all sleep parameters remained stable across months 2, 3, and 6 in both groups, except for SOL, which decreased in Group 2, but remained higher than that of Group 1. Individuals in Group 1 (vs. Group 2) were more likely to be female and had lower levels of TNF-α and IL-6 on days 3 and 4 post-SAH, respectively. Individuals in Group 1 (vs. Group 2) performed better on immediate memory, visuospatial/constructional ability, attention, and delayed memory tasks at 2 months. Distinct sleep trajectory groups were identified among SAH survivors; however, further studies with larger samples are needed to validate and better characterize these patterns.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"495-507"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial.","authors":"Carolyn Baratta Yucha","doi":"10.1177/10998004261436865","DOIUrl":"10.1177/10998004261436865","url":null,"abstract":"","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"493-494"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum Urinary Retention in Vaginal Delivery Women Under Epidural Analgesia: Risk Factors and Nursing Strategies.","authors":"Sujie Gu, Hong Shen, Huimin Shen","doi":"10.1177/10998004261452205","DOIUrl":"10.1177/10998004261452205","url":null,"abstract":"<p><p>The widespread use of epidural labor analgesia has introduced new challenges in postpartum bladder function management. Postpartum urinary retention (PUR) not only causes maternal discomfort but may also lead to bladder overdistension and long-term voiding dysfunction. This study aimed to investigate the incidence and risk factors for PUR in women undergoing vaginal delivery under epidural analgesia and to develop a predictive model for early identification of high-risk individuals. A retrospective case-control study was conducted on 1002 parturients who underwent vaginal delivery under epidural analgesia at our hospital from January 2024 to January 2026. Clinical data including demographic characteristics, labor parameters, obstetric interventions, analgesia-related factors, and neonatal outcomes were collected. The incidence of PUR was 6.4% (64/1002). Multivariate logistic regression identified five independent risk factors: prolonged second stage of labor (≥ 60 min, OR = 2.000, 95% CI: 1.182-3.384), episiotomy (OR = 2.801, 95% CI: 1.450-5.412), second-degree or higher perineal laceration (OR = 3.099, 95% CI: 1.542-6.229), prolonged epidural analgesia (≥ 300 min, OR = 1.600, 95% CI: 1.019-2.513), and macrosomia (≥ 4.0 kg, OR = 2.199, 95% CI: 1.186-4.077). The simplified scoring model (range 0-5) demonstrated good predictive performance with an area under the ROC curve of 0.789. Prolonged second stage of labor, episiotomy, severe perineal laceration, prolonged epidural analgesia, and macrosomia are independent risk factors for PUR in women undergoing vaginal delivery under epidural analgesia. The simplified scoring model based on these factors exhibits satisfactory predictive accuracy and may serve as a practical clinical tool for early identification of high-risk parturients.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"549-559"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurovascular Resilience and Autonomic Inertia: The Impact of Age and Sex on Intracranial Dynamics During Stress.","authors":"Alinne Alves Oliveira, Luciano Magno, Mansueto Gomes-Neto, Joanderson Felipe Soares Silva, Diego Rocha Cardoso, Mateus Argolo, Rafael Pereira","doi":"10.1177/10998004261447416","DOIUrl":"10.1177/10998004261447416","url":null,"abstract":"<p><p>Systemic vascular dynamics and autonomic nervous system (ANS) regulation are pivotal for maintaining cerebral homeostatic stability; however, the aging process and biological sex significantly modulate these neural feedback loops. This study investigated the neurobiological interaction between cardiac autonomic modulation and intracranial pulse waveform morphology (P2/P1 ratio) during isometric stress across distinct age and sex cohorts. We evaluated 320 individuals (184 women; 136 men), stratified into young (n = 151) and older adults (n = 169) groups. Heart rate variability (HRV) and intracranial pulse waveform morphology (P2/P1 ratio), monitored via non-invasive strain-gauge technology, were assessed at baseline, during a 1-min isometric handgrip challenge, and during a 5-min post-stress recovery, with data analyzed using a three-way ANOVA. Older adults exhibited significantly altered intracranial pulse waveform morphology (elevated P2/P1 ratio) and attenuated HRV compared to younger subjects, independent of sex. Importantly, we identified a phenomenon of \"sympathovagal lag\" in older adults, characterized by persistent sympathetic dominance (0V pattern) following stress cessation, contrasting with the rapid homeostatic recovery observed in younger individuals. Regarding sex, older women demonstrated the most compromised intracranial compensatory status despite maintaining higher parasympathetic tone. Aging is linked to significant autonomic inertia and diminished intracranial reserve; the prolonged post-stress sympathetic response in older age suggests a window of vulnerable cerebrovascular regulation, and our results establish the P2/P1 ratio as a reliable, non-invasive biomarker of age-associated neurophysiological dysregulation.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"516-524"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Relationships Between Systemic Inflammatory Markers and Urinary I-FABP in Preterm Infants: Evidence that Intestinal Inflammation Precedes Systemic Inflammation.","authors":"Noura El Habbal, Evgenia Jen Filatava, Samer Charbaji, Maya Gordon, Raina Fichorova, Katherine E Gregory","doi":"10.1177/10998004261451430","DOIUrl":"10.1177/10998004261451430","url":null,"abstract":"<p><p><b>Objective:</b> Preterm infants exhibit an aberrant inflammatory response, characterized by elevated intestinal and systemic inflammatory markers, and their relationship remains poorly understood in neonatal immunology. Our study aimed to examine the association and temporal relationship between intestinal and systemic inflammation. <b>Study Design:</b> This retrospective observational study included <i>n</i> = 74 infants who were born preterm (<34 weeks of gestation). Urine and blood samples were collected throughout the hospitalization period between 1-20 weeks of life. Urinary I-FABP (intestinal fatty acid binding protein) was measured as a marker of intestinal inflammation, and blood samples were analyzed for systemic inflammatory markers, including CRP, ICAM-1, IL-1β, IL-6, and IL-8. Unadjusted linear mixed-effects models were used to assess longitudinal trends and both concurrent and lagged associations between urinary I-FABP and systemic inflammatory markers. <b>Results:</b> Our longitudinal analyses revealed a significant decrease in levels of I-FABP (ß = -0.32, <i>p <</i> 0.001), IL-6 (ß = -0.03, <i>p</i> = 0.003), and IL-8 (ß = -0.11, <i>p <</i> 0.001), and a significant increase in levels of ICAM-1 (ß = 0.04, <i>p <</i> 0.001) over time. Within the same week, I-FABP was significantly associated with all systemic inflammatory markers except for CRP. Lagged associations between I-FABP levels measured one week before systemic biomarker assessment to determine whether intestinal inflammation temporally precedes systemic inflammation revealed significant positive associations with ICAM-1, IL-1β, and IL-8 (ß = 0.14, <i>p</i> = 0.008; ß = 0.15, <i>p</i> = 0.009; ß = 0.36, <i>p <</i> 0.001, respectively). <b>Conclusion:</b> Our exploratory study revealed significant associations between urinary I-FABP and systemic inflammatory markers, with intestinal inflammation preceding systemic inflammation. These findings suggest a potential temporal progression from intestinal to systemic inflammation, offering new insight into inflammatory dynamics and immune responses in preterm infants.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"538-548"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148221259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Progressive Muscle Relaxation on Sleep Quality, Serotonin, and Melatonin in Hospitalized Cardiac Patients: A Randomized Controlled Trial.","authors":"Tunç Eliş, Reva Balcı Akpınar, Zerrin Kutlu","doi":"10.1177/10998004261490059","DOIUrl":"https://doi.org/10.1177/10998004261490059","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of progressive muscle relaxation (PMR) on sleep quality and urinary 5-HIAA levels as an indicator of serotonin metabolism and urinary 6-HMS levels as an indicator of melatonin metabolism in hospitalized cardiac patients with sleep disturbances. This prospective, randomized, controlled trial included 60 patients diagnosed with heart failure or myocardial infarction. Patients in the intervention group received PMR in addition to routine care, whereas the control group received routine care alone. Sleep quality was assessed using the Richard-Campbell Sleep Scale (RCSS). Urinary concentrations of 5-HIAA and 6-HMS were measured as secondary outcomes. Data were analyzed using independent-samples <i>t</i>-tests, Mann-Whitney <i>U</i> tests, Wilcoxon signed-rank tests, and paired <i>t</i>-tests as appropriate, with statistical significance set at <i>p < 0.05</i>. Baseline RCSS scores were comparable between the intervention and control groups (21.0 ± 3.5 vs. 21.5 ± 3.0, <i>p</i> > 0.05). Following the intervention, the PMR group demonstrated a marked improvement in sleep quality compared with the control group (73.5 ± 8.2 vs. 25.0 ± 7.3, <i>p</i> < 0.001). Urinary 5-HIAA concentrations increased significantly in the PMR group (23.2 ± 1.9 to 42.4 ± 1.5), whereas concentrations decreased significantly in the control group. Similarly, urinary 6-HMS concentrations increased significantly following PMR (27.0 ± 2.3 to 48.4 ± 5.1), with significant between-group and within-group differences (<i>p</i> < 0.05). Progressive muscle relaxation significantly improved sleep quality and increased urinary concentrations of 5-HIAA and 6-HMS in patients with heart failure and myocardial infarction. These findings suggest that PMR may be an effective non-pharmacological nursing intervention for improving sleep and related neuroendocrine outcomes in hospitalized cardiac patients.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261490059"},"PeriodicalIF":2.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Discriminatory Ability of Body Mass Index, Percent Body Fat, Waist Circumference, and Waist-to-Height Ratio for Cardiometabolic Risk Among Korean Adults: A Cross-Sectional Study Using the Korea National Health and Nutrition Examination Survey (KNHANES) 2024.","authors":"Eunok Park","doi":"10.1177/10998004261484154","DOIUrl":"https://doi.org/10.1177/10998004261484154","url":null,"abstract":"<p><p>Obesity is a major risk factor for cardiometabolic disease, but which indicator best identifies elevated risk remains uncertain. This cross-sectional study compared the associations and discriminatory ability of body mass index (BMI), percent body fat (PBF), waist circumference (WC), and waist-to-height ratio (WHtR) for cardiometabolic risk among 2412 Korean adults aged 40-64 years, using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2024. Cardiometabolic risk (CMR) was defined as ≥ 2 of four factors: elevated blood pressure, hyperglycemia, hypertriglyceridemia, and low high-density lipoprotein cholesterol. Survey-weighted logistic regression and receiver operating characteristic analyses were adjusted for age and sex. All adiposity indicators were significantly associated with elevated CMR. Adjusted odds ratios per 1-SD increase were 2.40 (95% CI, 2.12-2.72) for BMI, 2.51 (2.19-2.87) for PBF, 2.84 (2.46-3.28) for WC, and 2.64 (2.32-3.00) for WHtR. WHtR had the highest AUC (0.780), statistically comparable to WC (0.776; Holm-adjusted <i>p</i> = .194) but significantly higher than BMI (0.766; <i>p</i> = .003) and PBF (0.752; <i>p</i> < .001). WC also had a higher AUC than PBF (<i>p</i> = .001), but not BMI (<i>p</i> = .098). Although differences in discriminatory ability were modest, WHtR may provide a practical, low-cost complementary measure for cardiometabolic risk assessment among Korean adults.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261484154"},"PeriodicalIF":2.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential microRNA Expression Reveals Sex-Specific Neuroinflammatory and Neurodegenerative Pathways in MS.","authors":"Stephanie Buxhoeveden, Theresa Swift-Scanlan, Amy Olex, Christiane Carter, Unsong Oh","doi":"10.1177/10998004261473903","DOIUrl":"https://doi.org/10.1177/10998004261473903","url":null,"abstract":"<p><p>Relapsing-remitting multiple sclerosis (RRMS) exhibits clear sex-based disparities: females have higher incidence and inflammatory activity, whereas males have lower incidence, yet experience an accelerated disease course of neurodegeneration and disability accumulation. MicroRNAs (miRNAs). Key epigenetic regulators of immune and neuronal pathways may contribute to these differences, but sex is rarely examined as a primary biological variable in MS miRNA research. This exploratory pilot study characterized sex-specific miRNA expression in treatment-naïve individuals with RRMS using samples from 46 participants (17 males and 17 females with RRMS; 6 male and 6 female healthy controls) obtained from the Accelerated Cure Project biorepository. miRNA expression was quantified using the NanoString nCounter Human v3 panel, and differential expression (<i>p <</i> 0.05, fold-change ≥1.3) was evaluated across four comparisons: Multiple sclerosis (MS) females vs. MS males; sex-matched MS vs. control groups; and female vs. male healthy controls. Distinct sex-biased miRNA signatures emerged. Males with RRMS demonstrated dysregulation of immune-associated miRNAs, including coordinated changes in the miR-29, miR-30, and miR-199 families. Females with RRMS exhibited consistent downregulation of miR-941 and differential expression of immune-associated miRNAs including miR-223-3p, miR-485-3p, and miR-199a-5p. Several immune-regulatory miRNAs, including miR-223-3p, miR-146a-5p, miR-196b-5p, and miR-183-5p, were differentially expressed in both healthy controls and disease-related comparisons, suggesting that sexually dimorphic immune regulatory programs may precede disease onset. These findings indicate that disease-associated miRNA alterations are superimposed on pre-existing sex-specific immune networks and underscore the importance of incorporating sex as a biological variable in biomarker discovery and precision medicine for MS.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261473903"},"PeriodicalIF":2.1,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum BDNF and S100 B Levels in Community-Dwelling Older Adults.","authors":"Ryuzo Orihashi, Takumi Shiraishi, Toru Murakawa-Hirachi, Hiroshi Tateishi, Yutaka Kunitake, Hiroko Kunitake, Yoshito Mizoguchi","doi":"10.1177/10998004261479322","DOIUrl":"https://doi.org/10.1177/10998004261479322","url":null,"abstract":"<p><p>Population aging has made the maintenance of cognitive function and mental health in older adults a major public health priority. Brain-derived neurotrophic factor (BDNF) and S100 calcium-binding protein B (S100 B) are biomarkers of brain health, reflecting neurotrophic support and neuroinflammatory activity, respectively. The objectives of this study were to examine the association (a) between serum BDNF and S100 B levels and (b) between these biomarkers and cognitive function and depression in community-dwelling older adults. This cross-sectional study included 95 community-dwelling adults aged ≥65 years living in rural Japan. Serum BDNF and S100 B levels were measured using enzyme-linked immunosorbent assays. Cognitive function and depressive symptoms were assessed using four instruments. Spearman's correlation analyses examined associations between the biomarkers and neuropsychological measures. Multiple regression analyses were performed using log10-transformed S100 B as the dependent variable and log10-transformed BDNF, age, sex, education, and BMI as independent variables. Serum BDNF levels were negatively correlated with serum S100 B levels (β = -0.509, <i>p</i> < 0.0001). This association remained significant across adjusted models (all <i>p</i> < 0.0001). Sensitivity analyses yielded consistent results. No associations were observed between serum BDNF or S100 B levels and cognitive function or depression. The inverse relationship between BDNF and S100 B suggests a link between neurotrophic and neuroinflammatory processes. Nursing interventions that enhance BDNF may also affect S100 B level, which may foster brain health in older adults.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004261479322"},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}