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Cytokines and Depressive Symptoms Among Adolescents. 细胞因子与青少年抑郁症状
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-02-04 DOI: 10.1177/10998004251318385
Cherry Y Leung, Sandra J Weiss
{"title":"Cytokines and Depressive Symptoms Among Adolescents.","authors":"Cherry Y Leung, Sandra J Weiss","doi":"10.1177/10998004251318385","DOIUrl":"10.1177/10998004251318385","url":null,"abstract":"<p><p><b>Background:</b> Inflammation has been linked to an increased risk of depression, but there is limited and conflicting research on the role of inflammatory markers in adolescent depression. The purpose of this study was to examine associations between cytokines TNF-α, IL-1β, IL-6, and IL-8 and depression among a community-based sample of adolescents (13-19 years of age). <b>Methods:</b> Salivary samples were self-collected by adolescents for assay of cytokines. The Patient Health Questionnaire-9 (PHQ-9) was used to measure depressive symptoms and clinical depression, where a score ≥11 indicated the threshold for experiencing clinical depression. Multiple linear and logistic regression models were used to examine the relationships between cytokines and depression, adjusting for age, sex, ethnicity, income, and body mass index. <b>Results:</b> The mean age of the 83 participants was 15.86 years. Eight participants screened positive for depression; the mean depressive symptom score was 5.11. Higher levels of IL-6 (Coef = 1.33, <i>p</i> < .001) and IL-8 (Coef = 0.69, <i>p =</i> .025) were associated with more frequent depressive symptoms while higher levels of TNF-α (OR = 2.50, <i>p =</i> .002), IL-1β (OR = 1.98, <i>p</i> = .001), and IL-8 (OR = 2.44, <i>p</i> = .008) were associated with greater odds of meeting criteria for clinical depression. <b>Conclusions:</b> Future research should focus on factors that induce higher cytokine levels and the mechanisms underlying their effects on depression. Cytokines assessed in this study may ultimately have implications as methods for depression screening or targets for biologic interventions to prevent and treat adolescent depression.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"400-410"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut Microbiome and Symptom Burden in Obese and Non-Obese Women Receiving Chemotherapy for Breast Cancer. 肥胖和非肥胖妇女接受乳腺癌化疗的肠道微生物组和症状负担。
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-02-10 DOI: 10.1177/10998004251318397
Catherine H Cherwin, Jemmie Hoang, Emily K Roberts, Ashutosh Mangalam
{"title":"Gut Microbiome and Symptom Burden in Obese and Non-Obese Women Receiving Chemotherapy for Breast Cancer.","authors":"Catherine H Cherwin, Jemmie Hoang, Emily K Roberts, Ashutosh Mangalam","doi":"10.1177/10998004251318397","DOIUrl":"10.1177/10998004251318397","url":null,"abstract":"<p><p><b>Purpose:</b> Obese women with breast cancer experience high symptom burden, poor quality of life, and increased mortality compared to non-obese women with breast cancer. Obesity-related changes to the bacteria of the gut, the GI microbiome, may be one such mechanism for these differences in outcomes. The purpose of this work is to report symptom burden and GI microbiome composition between obese and non-obese women with breast cancer to identify potential microbial influences for symptom severity. <b>Methods:</b> 59 women with breast cancer (26 obese, 33 non-obese) provided symptom reports using the Memorial Symptom Assessment Scale and stool samples for 16S analysis one week after receiving chemotherapy. Symptom reports were summarized and examined for differences based on obesity. Fecal microbiome analysis was compared between groups using alpha-diversity (Shannon index), beta-diversity (Principal Coordinate Analysis with weighted UniFrac distances), and LASSO analysis of abundance of bacterial species. <b>Results:</b> While symptom burden was high, it did not differ based on obesity status. Alpha- and beta-diversity did not find significant differences based on obesity, but LASSO analysis identified eight bacteria to be significantly enriched in obese participants: <i>Collinsella aerofacien</i>, <i>Prevotella 7</i>, <i>Coprobacillus cateniformis</i>, <i>Ruminococcus torques group</i>, <i>Agathobacter</i>, <i>Frisingicoccus</i>, <i>Roseburia inulinivorans</i>, and <i>Monoglobus pectinilyticus</i>. <b>Conclusions:</b> Identifying biologic mechanisms driving symptoms is necessary for the development of therapies to reduce cancer-related symptom burden. While obesity may alter the GI microbiome and influence symptom burden in women with breast cancer, these effects may be outweighed by the effects of chemotherapy on the gut.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"411-422"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The International Society of Nurses in Genetics (ISONG) 2024 World Congress: Generating Waves: Advancing Implementing Strategies from the Foundation of Genomic Nursing. 国际遗传学护士学会(ISONG) 2024年世界大会:产生浪潮:从基因组护理基础推进实施策略。
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-02-10 DOI: 10.1177/10998004251320593
Memnun Seven, Sandra Daack-Hirsch
{"title":"The International Society of Nurses in Genetics (ISONG) 2024 World Congress: Generating Waves: Advancing Implementing Strategies from the Foundation of Genomic Nursing.","authors":"Memnun Seven, Sandra Daack-Hirsch","doi":"10.1177/10998004251320593","DOIUrl":"10.1177/10998004251320593","url":null,"abstract":"","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"357-358"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clamping Catheter Versus Free Drainage for Patients With Neurogenic Bladder With Indwelling Urinary Catheter: A Meta-Analysis. 使用留置导尿管的神经源性膀胱患者夹闭导尿管与自由引流:一项 Meta 分析。
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-01-14 DOI: 10.1177/10998004241313393
Weiwei Cao, Min Lei, Yanfei Yu, Weizhen Cheng, Rong Huang, Kun Liu
{"title":"Clamping Catheter Versus Free Drainage for Patients With Neurogenic Bladder With Indwelling Urinary Catheter: A Meta-Analysis.","authors":"Weiwei Cao, Min Lei, Yanfei Yu, Weizhen Cheng, Rong Huang, Kun Liu","doi":"10.1177/10998004241313393","DOIUrl":"10.1177/10998004241313393","url":null,"abstract":"<p><p><b>Background:</b> In the clinical setting, individuals with neurogenic bladder dysfunction commonly utilize indwelling urinary catheters for urinary management. The comparative efficacy of catheter clamping versus continuous free drainage in this patient population is yet to be established. This meta-analysis aims to explore the efficacy and safety of catheter clamping versus natural drainage in patients with neurogenic bladder, to provide evidence to support the treatment and nursing care of these patients. <b>Methods:</b> Two researchers conducted a literature search in Clinicaltrials et al. databases for Randomized Controlled Trials (RCTs) comparing clamping of the catheter to free drainage in patients with neurogenic bladder who have indwelling urinary catheters. The RCT bias risk assessment tool recommended by the Cochrane Handbook was used for quality assessment. RevMan 5.3 software were used for meta-analysis. <b>Results:</b> A total of 8 RCTs involving 772 patients with neurogenic bladder were enrolled. Catheter clamping significantly increased the volume of first urination in patients [MD = 52.86, 95%CI (42.30, 63.41), <i>p <</i> .001]. The difference in time to first urination [SMD = 0.10, 95%CI (-0.68, 0.89), <i>p</i> = .80], residual urine volume [MD = -5.18, 95%CI (-17.27, 6.90), <i>p</i> = .40], incidence of urinary retention [MD = 1.07, 95%CI (0.30, 3.87), <i>p</i> = .92], the incidence of urinary tract infection [RR = 1.38, 95%CI (0.64, 2.97), <i>p</i> = .42] between the catheter clamping group and the natural drainage group were not statistically significant. The results of Egger's regression analysis indicated no evidence of statistical publication bias. <b>Conclusion:</b> In light of the existing body of evidence, the routine practice of catheter clamping in catheterized patients with neurogenic bladder is not recommended.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"359-370"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of the Gap Between 2-Hour Post-Load Plasma Glucose and Fasting Blood Glucose With All-Cause or Cardiovascular Mortality in US Normoglycemic Adults. 在美国血糖正常的成年人中,负荷后2小时血糖和空腹血糖与全因死亡率或心血管死亡率之间的关系
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-01-27 DOI: 10.1177/10998004251316688
Weiwei Liu, Zhiming Liu, Chen Ding, Jie Li, Haifeng Jiang
{"title":"Associations of the Gap Between 2-Hour Post-Load Plasma Glucose and Fasting Blood Glucose With All-Cause or Cardiovascular Mortality in US Normoglycemic Adults.","authors":"Weiwei Liu, Zhiming Liu, Chen Ding, Jie Li, Haifeng Jiang","doi":"10.1177/10998004251316688","DOIUrl":"10.1177/10998004251316688","url":null,"abstract":"<p><p>BackgroundThe gap between 2-hour post-load plasma glucose (2 h PG) and fasting blood glucose (FBG) has been shown to be informative of the risk of developing prediabetes and diabetes. We aimed to examine the significance of the gap between 2 h PG and FBG in relation to all-cause or cardiovascular disease (CVD) mortality in normoglycemic adults.Methods3611 normoglycemic participants from the 2005-2016 US National Health and Nutrition Examination Survey were included and dichotomized into the low (2 h PG ≤ FBG) and high post-load (2 h PG > FBG) groups. Associations of the gap between 2 h PG and FBG with all-cause or CVD mortality were evaluated with Kaplan-Meier curves, Cox proportional hazard ratio, and subgroup analysis.ResultsThe mean age was 38.80 years, with a male prevalence of 43.59%. Finally, 1746 (50.22%) and 1865 (49.78%) participants were categorized into the low and high post-load groups, respectively. During a median follow-up of 107 months, 130 deaths (36 CVD-related) occurred. Kaplan-Meier curves showed significantly higher all-cause and CVD mortality rates in the high post-load group compared with the low post-load group. The hazard ratio and 95% confidence interval for all-cause and CVD mortality in the high post-load group were 1.816 (1.149-2.870) and 2.302 (1.052-5.038), respectively, with the low post-load group as the reference. The results were robust and consistent in the sensitivity and subgroup analyses.ConclusionThe gap between 2 h PG and FBG may be potentially useful for predicting the risk of all-cause and CVD mortality in US normoglycemic adults.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"391-399"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
12-Year Physical Activity Trajectories and Epigenetic Age Acceleration Among Middle-Aged and Older Adults. 中老年人群12年体育活动轨迹与表观遗传年龄加速
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1177/10998004251334415
Tingting Liu, Yvette P Conley, Kirk I Erickson, Hongyu Miao, Colm G Connolly, Michael J Ormsbee, Changwei Li
{"title":"12-Year Physical Activity Trajectories and Epigenetic Age Acceleration Among Middle-Aged and Older Adults.","authors":"Tingting Liu, Yvette P Conley, Kirk I Erickson, Hongyu Miao, Colm G Connolly, Michael J Ormsbee, Changwei Li","doi":"10.1177/10998004251334415","DOIUrl":"10.1177/10998004251334415","url":null,"abstract":"<p><p><b>Purpose:</b> To examine the association between trajectories of physical activity (PA) over 12 years and epigenetic age acceleration (EAA) in 3600 middle-aged and older adults of the Health and Retirement Study. <b>Methods:</b> Latent variable mixture modeling identified subgroups with similar trajectories of vigorous, moderate, and light PA from 2004 to 2016. Six EAAs, including Horvath's age acceleration, Hannum's age acceleration, GrimAge acceleration, PhenoAge acceleration, DunedinPoAm acceleration, and ZhangAA were calculated by regressing epigenetic age on chronological age in 2016. Linear regression models tested associations of PA trajectories with EAAs, controlling for age, sex, race, education, smoking, alcohol consumption, and depression. <b>Results:</b> Five trajectories were identified for each PA type. Moderate and light PA trajectories were stable or slightly changed over time. In contrast, vigorous PA trajectories were either consistently low (27.2%), slightly increased at a low level (14.9%), decreased from moderate to low levels (25.9%), increased to a high level (11.9%), or consistently high (20.1%). Moderate PA trajectories were negatively associated with EAA across six epigenetic clocks (<i>p</i> < .01). Light PA trajectories were not associated with any EAA. Vigorous PA trajectories were associated with slower GrimAge acceleration (<i>p =</i> .004) and DunedinPoAm acceleration (<i>p =</i> .03). Participants that showed consistently high or increasing vigorous PA had slower EAA compared to those with consistently low vigorous PA. <b>Conclusion:</b> Moderate and vigorous, but not light, PA trajectories were associated with slower EAAs.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"442-452"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomic Associations With Fatigue and Physical Function in Children With Cancer: A Pilot Study. 代谢组学与癌症儿童疲劳和身体功能的关联:一项初步研究。
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-04-19 DOI: 10.1177/10998004251335639
Janice S Withycombe, Jinbing Bai, Canhua Xiao, Ronald C Eldridge
{"title":"Metabolomic Associations With Fatigue and Physical Function in Children With Cancer: A Pilot Study.","authors":"Janice S Withycombe, Jinbing Bai, Canhua Xiao, Ronald C Eldridge","doi":"10.1177/10998004251335639","DOIUrl":"10.1177/10998004251335639","url":null,"abstract":"<p><p><b>Background:</b> Fatigue is a frequently reported symptom in children undergoing cancer treatment. Prior research shows an inverse relationship between fatigue and physical activity. Less is known about fatigue's relationship with physical function or the underlying biological mechanisms of fatigue. This study explored associations among fatigue, physical function, and associated metabolites. <b>Methods:</b> Children (7-18 years) provided serum samples and self-reports of fatigue and lower extremity physical function (mobility) using Pediatric Patient-Reported Outcomes Measurement Information System (PROMIS) surveys at two timepoints during cancer therapy. PROMIS scores were categorized as high/low per established cut points (high fatigue T <u>></u>47.5; high physical function T <u>></u>51.5). High-resolution liquid chromatography-mass spectrometry extracted 29 metabolites hypothesized a priori to be associated with fatigue or physical function. Descriptive statistics summarized PROMIS scores, and linear mixed effect models estimated metabolite associations adjusting for age, gender and steroid use. <b>Results:</b> Forty children participated (female, 53%; 7-12 years, 38%; 13-18 years 62%; Hodgkins Lymphoma, 33%; Acute Lymphoblastic/Lymphocytic Leukemia, 40%; Osteosarcoma, 10%; Other, 17%). Physical function and fatigue were inversely related: T1 (r = -0.64; <i>p <</i> .001) and T2 (r = -0.63; <i>p <</i> .001). One metabolite (indole-3-latic acid) differentiated between low and high fatigue. Five metabolites differentiated significantly between low and high physical function (4-Hydroxybenzoic acid, m-Coumaric acid, myoinositol, tryptophan, and tyrosine). <b>Conclusions:</b>These findings substantiate prior studies showing metabolites, particularly amino acids, significantly associated with fatigue and physical function. All significant metabolites were associated with the gut microbiome. Physical function was inversely corelated with fatigue providing another potential intervention for fatigue management.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"453-463"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary Incontinence Following Transurethral Prostatectomy: Current Status and Nursing Strategies. 经尿道前列腺切除术后尿失禁:现状及护理策略。
Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-02-10 DOI: 10.1177/10998004251318909
Mingjie He, Chen Mao, Yongxia Shu, Xue Liu
{"title":"Urinary Incontinence Following Transurethral Prostatectomy: Current Status and Nursing Strategies.","authors":"Mingjie He, Chen Mao, Yongxia Shu, Xue Liu","doi":"10.1177/10998004251318909","DOIUrl":"10.1177/10998004251318909","url":null,"abstract":"<p><p><b>Background:</b> Urinary incontinence is a prevalent condition among patients who have undergone transurethral prostatectomy (TURP). The objective of this study was to assess the current status and the factors influencing the development of urinary incontinence following TURP. <b>Methods:</b> This retrospective study enrolled patients diagnosed with Benign Prostatic Hyperplasia (BPH) who underwent TURP at our hospital from November 1, 2022, to October 30, 2024. We analyzed the demographic and clinical characteristics of patients who developed postoperative urinary incontinence with those who did not. <b>Results:</b> A total of 242 patients who underwent TURP was enrolled, the incidence rate of postoperative urinary incontinence was 36.4%. There were correlations between postoperative urinary incontinence and the following factors: age (r = 0.601), diabetes (r = 0.589), and duration of surgery (r = 0.578), preoperative pelvic floor muscle training (r = -0.626). Multivariate logistic regression analysis revealed that age ≥65 years (OR = 1.941, 95% CI: 1.220∼2.403), diabetes (OR = 2.488, 95% CI: 2.192∼3.070), and surgery duration ≥60 minutes (OR = 1.995, 95% CI: 1.542∼2.426) are independent risk factors for the development of postoperative urinary incontinence in patients undergoing TURP. Preoperative pelvic floor muscle training (OR = 0.604, 95%CI: 0.319∼0.902) was a protective factor against postoperative urinary incontinence. <b>Conclusion:</b> The incidence of postoperative urinary incontinence following TURP is relatively high and is influenced by multiple factors. It is recommended that preventive and nursing measures be implemented to mitigate the occurrence of postoperative urinary incontinence. These measures should include the stringent control of blood glucose levels, optimization of surgical duration, and the standardization of preoperative pelvic floor muscle training.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"423-429"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Aerobic, Resistance, and Combined Exercise Training on Cardiorespiratory Fitness in Healthy People Aged 60 years and Over: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 有氧、阻力和联合运动训练对60岁及以上健康人心肺功能的影响:随机对照试验的系统回顾和荟萃分析
Biological research for nursing Pub Date : 2025-06-11 DOI: 10.1177/10998004251348605
Amin Azimkhani, Rasoul Kasraei, Hamidreza Sabeti, Ameer Almasoodi
{"title":"The Effect of Aerobic, Resistance, and Combined Exercise Training on Cardiorespiratory Fitness in Healthy People Aged 60 years and Over: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Amin Azimkhani, Rasoul Kasraei, Hamidreza Sabeti, Ameer Almasoodi","doi":"10.1177/10998004251348605","DOIUrl":"https://doi.org/10.1177/10998004251348605","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the effects of aerobic, resistance, and combined training on cardiorespiratory fitness in healthy older adults, with a focus on improvements in maximal/peak oxygen uptake (VO<sub>2</sub>max/peak) and the 6-min walk distance (6-MWD).<b>Methods:</b> A systematic review and meta-analysis were conducted through July 2024, searching six databases: PubMed, CINAHL, Medline, Embase, Web of Science, and Scopus. Analyses were performed using Review Manager 5.3. <b>Results:</b> Fifty-one studies involving 3152 participants met the inclusion criteria. Exercise interventions significantly improved VO<sub>2</sub>max/peak (standardized mean difference (SMD): 0.51; 95% confidence interval (CI), 0.38 to 0.65; <i>p</i> < .001) and 6-MWD (MD: 36.18 m; 95% CI, 26.52 to 45.84; <i>p</i> < .001) compared to control groups. Subgroup analyses showed consistent benefits across aerobic, resistance, and combined training modalities. Significant improvements were also observed across both medium-term (≤24 weeks) and long-term (>24 weeks) interventions, and in both male and female participants. <b>Conclusion:</b> Structured exercise interventions, regardless of type, are effective for improving cardiorespiratory fitness in older adults. The consistency of these effects across modalities, durations, and sexes underscores the adaptability and value of exercise as a central component of healthy aging strategies. Future research should aim to standardize intervention protocols and extend follow-up periods to clarify long-term outcomes and inform clinical guidelines.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251348605"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pain Resilience and Chronic Low Back Pain Outcomes: The Mediating Role of Pace of Biological Aging. 疼痛恢复力与慢性腰痛预后:生物衰老速度的中介作用。
Biological research for nursing Pub Date : 2025-06-04 DOI: 10.1177/10998004251345491
Kiari Kinnie Davis, Khalid W Freij, Fiona B A T Agbor, Asia M Wiggins, Tammie L Quinn, Demario S Overstreet, Shivraj S Grewal, Robert E Sorge, Burel R Goodin, Edwin N Aroke
{"title":"Pain Resilience and Chronic Low Back Pain Outcomes: The Mediating Role of Pace of Biological Aging.","authors":"Kiari Kinnie Davis, Khalid W Freij, Fiona B A T Agbor, Asia M Wiggins, Tammie L Quinn, Demario S Overstreet, Shivraj S Grewal, Robert E Sorge, Burel R Goodin, Edwin N Aroke","doi":"10.1177/10998004251345491","DOIUrl":"https://doi.org/10.1177/10998004251345491","url":null,"abstract":"<p><p>In this study, we aimed to investigate if the pace of biological aging serves as a critical mediator in the relationship between chronic pain resilience and chronic low back pain intensity and disability. Two hundred seven community-dwelling non-Hispanic Black (NHB) and non-Hispanic White (NHW) adults completed the Pain Resilience Scale (PRS) and Graded Chronic Pain Scale (GCPS). Blood genomic DNA was sequenced using Illumina's MethylationEPIC, and the pace of biological aging estimated using the DunedinPACE (the Dunedin Pace of Aging Calculated from the Epigenome) algorithm. In bivariate correlations, DunedinPACE significantly correlated with pain intensity (r = 0.40), and disability (r = 0.39), at <i>p <</i> .05. Pain resilience negatively correlated with pain intensity (rs = -0.22), pain disability (rs = -0.30), and DunedinPACE (r = -0.11). After controlling for chronological age, sex, race, and BMI, mediation analyses revealed a significant indirect association of pain resilience on pain intensity through the pace of biological aging (β = -0.66 (SE); Boot 95% CI [-1.06, -0.25]). Similarly, DunedinPACE partially mediated the relationship between resilience and pain disability (β = -0.82; 95% CI, [-1.20 to -0.44]). We found that higher levels of resilience correlate with a slower pace of biological aging, which in turn correlates with better pain outcomes. The pace of biological aging emerged as an important potential target for future interventions studies for pain management.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251345491"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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