Biological research for nursing最新文献

{"title":"Metabolomic Associations With Fatigue and Physical Function in Children With Cancer: A Pilot Study.","authors":"Janice S Withycombe, Jinbing Bai, Canhua Xiao, Ronald C Eldridge","doi":"10.1177/10998004251335639","DOIUrl":"https://doi.org/10.1177/10998004251335639","url":null,"abstract":"<p><p><b>Background:</b> Fatigue is a frequently reported symptom in children undergoing cancer treatment. Prior research shows an inverse relationship between fatigue and physical activity. Less is known about fatigue's relationship with physical function or the underlying biological mechanisms of fatigue. This study explored associations among fatigue, physical function, and associated metabolites. <b>Methods:</b> Children (7-18 years) provided serum samples and self-reports of fatigue and lower extremity physical function (mobility) using Pediatric Patient-Reported Outcomes Measurement Information System (PROMIS) surveys at two timepoints during cancer therapy. PROMIS scores were categorized as high/low per established cut points (high fatigue T <u>></u>47.5; high physical function T <u>></u>51.5). High-resolution liquid chromatography-mass spectrometry extracted 29 metabolites hypothesized a priori to be associated with fatigue or physical function. Descriptive statistics summarized PROMIS scores, and linear mixed effect models estimated metabolite associations adjusting for age, gender and steroid use. <b>Results:</b> Forty children participated (female, 53%; 7-12 years, 38%; 13-18 years 62%; Hodgkins Lymphoma, 33%; Acute Lymphoblastic/Lymphocytic Leukemia, 40%; Osteosarcoma, 10%; Other, 17%). Physical function and fatigue were inversely related: T1 (r = -0.64; <i>p <</i> .001) and T2 (r = -0.63; <i>p <</i> .001). One metabolite (indole-3-latic acid) differentiated between low and high fatigue. Five metabolites differentiated significantly between low and high physical function (4-Hydroxybenzoic acid, m-Coumaric acid, myoinositol, tryptophan, and tyrosine). <b>Conclusions:</b>These findings substantiate prior studies showing metabolites, particularly amino acids, significantly associated with fatigue and physical function. All significant metabolites were associated with the gut microbiome. Physical function was inversely corelated with fatigue providing another potential intervention for fatigue management.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251335639"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Microbiology of Healthcare-Associated Infections in Neurosurgery Department: A Cross-Sectional Study.","authors":"Renata Jabłońska, Paweł Sokal, Magdalena Zając, Agnieszka Królikowska, Karolina Filipska-Blejder, Irena Wrońska, Robert Ślusarz","doi":"10.1177/10998004251336748","DOIUrl":"https://doi.org/10.1177/10998004251336748","url":null,"abstract":"<p><p><b>Objective:</b> Hospital-acquired infections (HAIs) present a significant challenge in neurosurgical settings. This study aimed to assess the prevalence, risk factors, and clinical impact of HAIs in a neurosurgery department. <b>Methods:</b> A retrospective cross-sectional study was conducted on 5474 patients hospitalized in <i>a</i> neurosurgery <i>department</i> (2019-2023). HAIs were diagnosed in 93 patients (2.7%), accounting for 147 infections. The final cohort included 273 patients: 93 with HAIs and 181 matched controls (age, sex, mortality). Demographic, clinical, and microbiological data were analyzed. Nutritional status was assessed using the Nutritional Risk Screening (NRS, 2002) and consciousness was assessed using the Glasgow Coma Scale (GCS). Infections were classified according to Centers for Disease Control and Prevention (CDC) criteria. <b>Results:</b> The most frequent HAIs were pneumonia (PN, 18.3%), bloodstream infections (BSI, 16.2%), and surgical site infections (SSI, 16.3%). Malnutrition (NRS ≥3) was significantly more common in infected patients (65.6% vs. 11%, <i>p</i> < .001). Patients with GCS ≤8 had higher rates of PN (44.7%) and urinary tract infections (UTI, 32.5%) (<i>p</i> = .004), while GCS 13-15 was linked to SSI (91.7%). HAIs occurred more frequently after emergency procedures (57.8% vs. 30%, <i>p</i> < .0001). Hospital stay was significantly longer in infected patients (40 vs. 5.4 days, <i>p</i> = .001). <i>Klebsiella pneumoniae</i> (15.1%) and <i>Staphylococcus aureus</i> (11.5%) were the most common. Age and sex were not significant risk factors. <b>Conclusion:</b> HAIs in neurosurgical patients are associated with malnutrition and procedural urgency. Targeted infection control, early nutrition support, and antimicrobial stewardship are essential to improving outcomes.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251336748"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12-Year Physical Activity Trajectories and Epigenetic Age Acceleration Among Middle-Aged and Older Adults.","authors":"Tingting Liu, Yvette P Conley, Kirk I Erickson, Hongyu Miao, Colm G Connolly, Michael J Ormsbee, Changwei Li","doi":"10.1177/10998004251334415","DOIUrl":"https://doi.org/10.1177/10998004251334415","url":null,"abstract":"<p><p><b>Purpose:</b> To examine the association between trajectories of physical activity (PA) over 12 years and epigenetic age acceleration (EAA) in 3600 middle-aged and older adults of the Health and Retirement Study. <b>Methods:</b> Latent variable mixture modeling identified subgroups with similar trajectories of vigorous, moderate, and light PA from 2004 to 2016. Six EAAs, including Horvath's age acceleration, Hannum's age acceleration, GrimAge acceleration, PhenoAge acceleration, DunedinPoAm acceleration, and ZhangAA were calculated by regressing epigenetic age on chronological age in 2016. Linear regression models tested associations of PA trajectories with EAAs, controlling for age, sex, race, education, smoking, alcohol consumption, and depression. <b>Results:</b> Five trajectories were identified for each PA type. Moderate and light PA trajectories were stable or slightly changed over time. In contrast, vigorous PA trajectories were either consistently low (27.2%), slightly increased at a low level (14.9%), decreased from moderate to low levels (25.9%), increased to a high level (11.9%), or consistently high (20.1%). Moderate PA trajectories were negatively associated with EAA across six epigenetic clocks (<i>p</i> < .01). Light PA trajectories were not associated with any EAA. Vigorous PA trajectories were associated with slower GrimAge acceleration (<i>p =</i> .004) and DunedinPoAm acceleration (<i>p =</i> .03). Participants that showed consistently high or increasing vigorous PA had slower EAA compared to those with consistently low vigorous PA. <b>Conclusion:</b> Moderate and vigorous, but not light, PA trajectories were associated with slower EAAs.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251334415"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Massage and Foot Reflexology on Sleep in Newborns.","authors":"Ayşe Belpınar, Emriye Hilal Yayan, Ahmet Özdemir","doi":"10.1177/10998004251332911","DOIUrl":"https://doi.org/10.1177/10998004251332911","url":null,"abstract":"<p><p><b>Objective:</b> This study was conducted to examine the effects of massage and foot reflexology on the sleep of premature infants. <b>Materials and Methods:</b> The research was designed as a randomized controlled experimental study. The study population consisted of premature infants born at 30-37 weeks of gestation who were admitted to the Neonatal Intensive Care Unit of a hospital in the Central Anatolia Region. The sample included 108 premature infants divided into three groups: Massage group (<i>n</i> = 36), Foot reflexology group (<i>n</i> = 36), and Control group (<i>n</i> = 36). Data were collected using a neonatal follow-up form and actigraphy. Massage and foot reflexology interventions were administered to the respective groups twice daily (Morning: 07:00-09:00 and Evening: 19:00-21:00) for 15 minutes each session over two consecutive days, making up a total of four sessions. The control group received routine nursing care without any additional intervention. Pre-test (once) and post-test (once) measurements of 24-h sleep durations were assessed using actigraphy for all groups. <b>Results:</b> Sleep duration in the massage group increased compared to pre-intervention (251 minutes) and the control group (272 minutes), while the sleep duration in the foot reflexology group similarly increased compared to pre-intervention (268 minutes) and the control group (266 minutes) (<i>p <</i> .001). Sleep efficiency also showed a significant increase post-intervention, rising to 73% in the massage group and 71.8% in the foot reflexology group compared to the control group (<i>p <</i> .001). Furthermore, the number of awakenings and wakefulness duration significantly decreased in the massage and foot reflexology groups compared to the control group (<i>p <</i> .05). <b>Conclusion:</b> The findings indicate that massage and foot reflexology are effective non-pharmacological methods for improving sleep duration and sleep efficiency while reducing wakefulness duration and the number of awakenings in premature infants.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251332911"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers.","authors":"Hai Xu, Sheyuan Ding, Yu Tong, Qiong Zhang","doi":"10.1177/10998004241299375","DOIUrl":"10.1177/10998004241299375","url":null,"abstract":"<p><p><b>Background:</b> Obese patients are increasingly recognized as being at higher risk for skin diseases, particularly chronic wounds. While the exact mechanisms remain unclear, obesity is suspected to influence the development of chronic injuries via inflammatory biomarkers. Single nucleotide polymorphisms (SNPs) may further influence gene expression, protein function, and levels of inflammatory biomarkers through various mechanisms, thereby modulating inflammatory responses that contribute to wound pathogenesis. <b>Methods:</b> A two-sample two-step Mendelian Randomization (MR) was employed to explore the causal relationship between obesity and chronic wounds, focusing on the mediating role of inflammatory biomarkers. SNPs were used as instrumental variables (IVs) to infer causality. Obesity-related genetic data were sourced from the UK Biobank and GIANT consortium. Genome-wide association studies provided data on 92 inflammatory biomarkers, involving 14,824 and 575,531 individuals. Pressure injuries, lower limb venous ulcers, and diabetic foot ulcer data were obtained from FinnGen R10 and the Pan-UK Biobank. <b>Results:</b> Obesity significantly increased the risk of pressure injuries, lower limb venous ulcers, and diabetic foot ulcers. CCL19, hGDNF, IL-12B, and TNFRSF9 were identified as mediators in obesity-induced lower limb venous ulcers. <b>Conclusion:</b> This study provides genetic evidence that obesity leads to lower limb venous ulcers via inflammatory biomarkers, suggesting potential therapeutic targets for intervention.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"326-338"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Walking Exercise in Improving Physical Fitness and Depression in Patients With Schizophrenia.","authors":"Mei-Ling Huang, Miao-Chuan Chen","doi":"10.1177/10998004241290526","DOIUrl":"10.1177/10998004241290526","url":null,"abstract":"<p><p>Patients with schizophrenia often lack physical activity, which, together with physical complications, can lower their expected lifespan. Exercise strengthens their physical and mental health. The primary aim of this study was to examine the effectiveness of a walking exercise intervention in improving physical fitness, body mass index, waist-to-hip ratio, and depressive symptoms in patients with schizophrenia. A quasi-experimental study design was used. Seventy-six participants were recruited from the psychiatric daycare center at a hospital in Northern Taiwan. They were divided into two groups. The intervention group received a walking exercise intervention, while the control completed their daily courses at the psychiatric daycare center. The changes in both groups' physical fitness, BMI, waist-to-hip ratio, and depressive symptoms were monitored. Cardiorespiratory endurance significantly improved in the intervention group, attesting to the effectiveness of the walking exercise intervention. Their depression level significantly decreased across all measurement stages. The group walking exercise reduced sedentary behaviors and increased the participants' autonomous motivation, hip circumference, and cardiorespiratory fitness. Structured exercise programs may increase the patients' hippocampal neuroplasticity and reduce their depressive symptoms. The walking exercise intervention positively affected physiological traits, physical fitness, and mental health of the participants.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"229-235"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.","authors":"Jong Y Park, Cecile A Lengacher, Carmen S Rodriguez, Hongdao Meng, Kevin E Kip, Sandra Morgan, Anisha Joshi, Gizem Hueluer, Julia R Wang, Sara Tinsley, Charles Cox, John Kiluk, Kristine A Donovan, Manolete Moscoso, Elizabeth Bornstein, Jean M Lucas, Tamela Fonseca, Mahathi Krothapalli, Lynne S Padgett, Sreenidhi Nidamanur, Estella Hornback, Diya Patel, Ramya Chamkeri, Richard R Reich","doi":"10.1177/10998004241289629","DOIUrl":"10.1177/10998004241289629","url":null,"abstract":"<p><strong>Background: </strong>Genetics may influence symptoms experienced by breast cancer survivors (BCS) by moderating the effects of stress-reducing interventions, including the Mindfulness-Based Stress Reduction (MBSR(BC)) program, to reduce symptom severity. As part of a larger clinical trial, the aim of this study was to evaluate genetic variants as moderators of MBSR(BC) on improvements among BCS in cognitive functioning and symptoms.</p><p><strong>Methods: </strong>BCS (<i>n</i> = 128) were randomized to MBSR(BC) or the Breast Cancer Education Support Program. Objective neuropsychological and subjective measures of cognitive performance, and psychological and physical symptoms were collected at baseline, 6, 12, and 26 weeks. Linear mixed models were implemented to identify MBSR(BC)'s effects over time. A total of 22 single nucleotide polymorphisms (SNPs) from 20 genes known to be related to these symptoms were investigated using genomic DNA. These SNPs were tested as moderators of MBSR(BC) program effects.</p><p><strong>Results: </strong>Results showed MBSR(BC) participants experienced significantly greater benefits in cognitive functioning, however, the level of benefit varied based on one's genetic profile. Effects sizes, consistency across similar measures were investigated. Among 22 candidate SNPs, rs4680 in COMT, rs1800497 in ANKK1, and rs6277 in DRD2 demonstrated the strongest, most consistent positive effects in moderating MBSR(BC)'s impact on cognitive outcomes.</p><p><strong>Conclusions: </strong>Although the effects were small, this translational research may potentially identify BCS with genotypes that would be most influenced by the MBSR(BC) program. These results may be used to develop personalized intervention programs tailored to the genetic profile of each breast cancer survivor who received chemotherapy or chemotherapy and radiation.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, https://www.ClinicalTrials.gov Registration Number: NCT02786797.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"216-228"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Prediction Model for Dysphagia in Community-Dwelling Older Adults.","authors":"Yufeng Qiu, Wenfeng Xue, Yanxin Chen, Xiaona He, Lancai Zhao, Mengling Tang, Huafang Zhang","doi":"10.1177/10998004241290727","DOIUrl":"10.1177/10998004241290727","url":null,"abstract":"<p><p><b>Objectives.</b> Dysphagia is a geriatric syndrome, which may lead to complications such as dehydration, malnutrition, aspiration, pneumonia, and a significant reduction in quality of life. The purpose of this study was to construct and validate a prediction model for dysphagia in community-dwelling older adults and provide an assessment tool for the prevention and control of dysphagia. <b>Design.</b> Cross-sectional study. <b>Setting.</b> The community-dwelling Chinese older adults. <b>Participants.</b> 3655 participants aged 65 years and older were involved, who were randomly divided into the training set and the validation set. <b>Methods.</b> Data were collected and analyzed from June 2022 to September 2022. Univariate and multivariate logistic regression analysis were used to identify independent risk factors for dysphagia. We applied R software to develop a nomogram model to predict dysphagia in community-dwelling older adults. The predictive value of the model was assessed by the area under the ROC curve (AUC), the calibration curve was used to evaluate the reliability of the nomogram model for predicting dysphagia in community-dwelling older adults. The model's clinical utility was further evaluated using a Decision Curve Analysis (DCA). <b>Results.</b> The incidence of dysphagia was 11.8% (320/3655). Maximum tongue pressure, number of molars, pneumonia, ADL, sarcopenia, age, neurological diseases, and rheumatic immune diseases were selected as risk predictors for dysphagia. The prediction model demonstrated fair discriminative ability with the AUC was 0.709 (95%CI: 0.679-0.739) in the training set and 0.693 (95%Cl: 0.640-0.747) in the validation set, the calibration is adequate, and the Hosmer and Lemeshow test showed <i>p</i> values of 0.163 and 0.415, respectively. The DCA curve of our model shows a positive clinical net benefit. <b>Conclusions.</b> The prediction model established in this study was of a certain predictive value for the risk of dysphagia in community-dwelling older adults. By estimating the likelihood of future outcomes or the onset of certain diseases, it can assist medical personnel in formulating preventive strategies, lessening the workload of nurses, and also diminishing the financial burden on patients, thereby enhancing their overall quality of life.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"300-315"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure Symptoms Improve With More Intense Physical Activity.","authors":"Jonathan P Auld, Elaine A Thompson, Cynthia M Dougherty","doi":"10.1177/10998004241290827","DOIUrl":"10.1177/10998004241290827","url":null,"abstract":"<p><strong>Background: </strong>Little is known about how changes in physical activity (PA) over time may influence symptoms in people with heart failure (HF).</p><p><strong>Methods: </strong>A secondary analysis was conducted with data from an RCT of an exercise intervention in patients with ICDs (implantable cardioverter defibrillator) and a HF diagnosis (<i>n</i> = 96). Data were collected at baseline and 2 months of PA intervention. Physical activity (PA Steps = mean steps/day; PA Intensity = mean steps/min for most intense 30 minutes/day) were measured over 5 days at each timepoint. Physical symptoms were measured using the Patient Concerns Assessment, the SF-36 Vitality, and Bodily Pain subscales for fatigue and pain. Psychological symptoms were assessed using the Patient Health Questionnaire-9, and the State-Trait Anxiety Index. Associations between PA and physical and psychological symptoms were analyzed with multivariate regression.</p><p><strong>Results: </strong>Patients (<i>n</i> = 96) were predominately male (83%) and Caucasian (79%), aged 55.8 ± 12.3 years, BMI of 29.7 ± 5.1, with heart failure with reduced ejection fraction (HFrEF; 30.9 ± 9.9%). An <i>increase</i> in PA Steps was associated with improvement in anxiety (β = -1.178, <i>p =</i> .048). An <i>increase</i> in PA Intensity was associated with significant reductions in depression (β = -0.127, <i>p =</i> .021), anxiety (β = -0.234, <i>p =</i> .037), and fatigue (β = 0.528, <i>p =</i> .022). <i>Decreases</i> in PA Steps and PA Intensity were not associated with changes in any symptoms.</p><p><strong>Conclusion: </strong>For HF patients with an ICD, more intense PA over 2 months was associated with improved psychological symptoms and reduced fatigue. Decreases in PA (total and intensity) were not associated with changes in symptoms. Interventions promoting increasing the intensity of PA over time may be an effective approach to reduce some HF symptoms.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"236-245"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Association of Chronic Pains and Analgesics With Telomere Length: A Mendelian Randomization Study.","authors":"Jiahe Chen, Haotian Liu, Yulin Pang, Yubo Wang, Ziqi Ren, Jianli Liu, Yang Nan, Dan Liu","doi":"10.1177/10998004241303536","DOIUrl":"10.1177/10998004241303536","url":null,"abstract":"<p><p><b>Objective:</b> The aim of this study was to explore the causal relationships between chronic pains (back pain, facial pain, general pain, headaches, knee pain, hip pain, neck/shoulder pain, stomach/abdominal pain) and analgesics (codeine, diclofenac, ibuprofen, morphine, paracetamol, tramadol) with telomere length using Mendelian randomization methods. <b>Methods:</b> In the study, various statistical methods including inverse variance weighted (IVW), Mendelian Randomization-Egger, weighted median, simple mode, and weighted mode were used to investigate the relationships between chronic pains, analgesics, and telomere length. Heterogeneity and pleiotropy tests were conducted to ensure the accuracy of the results. <b>Results:</b> The results of the IVW analysis revealed positive causal relationships between hip pain (odds ratio (OR): 1.145; 95% confidence interval (CI): 1.021-1.285; <i>p</i> = .020), and stomach/abdominal pain (OR: 1.100; 95% CI: 1.008-1.200; <i>p</i> = 0.033) with telomere length. Use of tramadol (OR: 0.074; 95% CI: 0.009-0.605; <i>p</i> = 0.015) had a negative causal relationships with telomere length. <b>Conclusion:</b> This study found positive associations between hip pain and stomach/abdominal pain with telomere length, and a negative association between tramadol and telomere length. However, no significant causal relationships were found with other types of chronic pains and analgesics. This could help develop healthier chronic pain treatments, avoiding the abuse of analgesics.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"282-290"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}