Biological research for nursing最新文献_第2页

Associations of the Gap Between 2-Hour Post-Load Plasma Glucose and Fasting Blood Glucose With All-Cause or Cardiovascular Mortality in US Normoglycemic Adults. 在美国血糖正常的成年人中，负荷后2小时血糖和空腹血糖与全因死亡率或心血管死亡率之间的关系

Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-01-27 DOI: 10.1177/10998004251316688

Weiwei Liu, Zhiming Liu, Chen Ding, Jie Li, Haifeng Jiang

{"title":"Associations of the Gap Between 2-Hour Post-Load Plasma Glucose and Fasting Blood Glucose With All-Cause or Cardiovascular Mortality in US Normoglycemic Adults.","authors":"Weiwei Liu, Zhiming Liu, Chen Ding, Jie Li, Haifeng Jiang","doi":"10.1177/10998004251316688","DOIUrl":"10.1177/10998004251316688","url":null,"abstract":"BackgroundThe gap between 2-hour post-load plasma glucose (2 h PG) and fasting blood glucose (FBG) has been shown to be informative of the risk of developing prediabetes and diabetes. We aimed to examine the significance of the gap between 2 h PG and FBG in relation to all-cause or cardiovascular disease (CVD) mortality in normoglycemic adults.Methods3611 normoglycemic participants from the 2005-2016 US National Health and Nutrition Examination Survey were included and dichotomized into the low (2 h PG ≤ FBG) and high post-load (2 h PG > FBG) groups. Associations of the gap between 2 h PG and FBG with all-cause or CVD mortality were evaluated with Kaplan-Meier curves, Cox proportional hazard ratio, and subgroup analysis.ResultsThe mean age was 38.80 years, with a male prevalence of 43.59%. Finally, 1746 (50.22%) and 1865 (49.78%) participants were categorized into the low and high post-load groups, respectively. During a median follow-up of 107 months, 130 deaths (36 CVD-related) occurred. Kaplan-Meier curves showed significantly higher all-cause and CVD mortality rates in the high post-load group compared with the low post-load group. The hazard ratio and 95% confidence interval for all-cause and CVD mortality in the high post-load group were 1.816 (1.149-2.870) and 2.302 (1.052-5.038), respectively, with the low post-load group as the reference. The results were robust and consistent in the sensitivity and subgroup analyses.ConclusionThe gap between 2 h PG and FBG may be potentially useful for predicting the risk of all-cause and CVD mortality in US normoglycemic adults.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"391-399"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

12-Year Physical Activity Trajectories and Epigenetic Age Acceleration Among Middle-Aged and Older Adults. 中老年人群12年体育活动轨迹与表观遗传年龄加速

Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1177/10998004251334415

Tingting Liu, Yvette P Conley, Kirk I Erickson, Hongyu Miao, Colm G Connolly, Michael J Ormsbee, Changwei Li

{"title":"12-Year Physical Activity Trajectories and Epigenetic Age Acceleration Among Middle-Aged and Older Adults.","authors":"Tingting Liu, Yvette P Conley, Kirk I Erickson, Hongyu Miao, Colm G Connolly, Michael J Ormsbee, Changwei Li","doi":"10.1177/10998004251334415","DOIUrl":"10.1177/10998004251334415","url":null,"abstract":"Purpose: To examine the association between trajectories of physical activity (PA) over 12 years and epigenetic age acceleration (EAA) in 3600 middle-aged and older adults of the Health and Retirement Study. Methods: Latent variable mixture modeling identified subgroups with similar trajectories of vigorous, moderate, and light PA from 2004 to 2016. Six EAAs, including Horvath's age acceleration, Hannum's age acceleration, GrimAge acceleration, PhenoAge acceleration, DunedinPoAm acceleration, and ZhangAA were calculated by regressing epigenetic age on chronological age in 2016. Linear regression models tested associations of PA trajectories with EAAs, controlling for age, sex, race, education, smoking, alcohol consumption, and depression. Results: Five trajectories were identified for each PA type. Moderate and light PA trajectories were stable or slightly changed over time. In contrast, vigorous PA trajectories were either consistently low (27.2%), slightly increased at a low level (14.9%), decreased from moderate to low levels (25.9%), increased to a high level (11.9%), or consistently high (20.1%). Moderate PA trajectories were negatively associated with EAA across six epigenetic clocks (p < .01). Light PA trajectories were not associated with any EAA. Vigorous PA trajectories were associated with slower GrimAge acceleration (p = .004) and DunedinPoAm acceleration (p = .03). Participants that showed consistently high or increasing vigorous PA had slower EAA compared to those with consistently low vigorous PA. Conclusion: Moderate and vigorous, but not light, PA trajectories were associated with slower EAAs.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"442-452"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomic Associations With Fatigue and Physical Function in Children With Cancer: A Pilot Study. 代谢组学与癌症儿童疲劳和身体功能的关联：一项初步研究。

Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-04-19 DOI: 10.1177/10998004251335639

Janice S Withycombe, Jinbing Bai, Canhua Xiao, Ronald C Eldridge

{"title":"Metabolomic Associations With Fatigue and Physical Function in Children With Cancer: A Pilot Study.","authors":"Janice S Withycombe, Jinbing Bai, Canhua Xiao, Ronald C Eldridge","doi":"10.1177/10998004251335639","DOIUrl":"10.1177/10998004251335639","url":null,"abstract":"Background: Fatigue is a frequently reported symptom in children undergoing cancer treatment. Prior research shows an inverse relationship between fatigue and physical activity. Less is known about fatigue's relationship with physical function or the underlying biological mechanisms of fatigue. This study explored associations among fatigue, physical function, and associated metabolites. Methods: Children (7-18 years) provided serum samples and self-reports of fatigue and lower extremity physical function (mobility) using Pediatric Patient-Reported Outcomes Measurement Information System (PROMIS) surveys at two timepoints during cancer therapy. PROMIS scores were categorized as high/low per established cut points (high fatigue T >47.5; high physical function T >51.5). High-resolution liquid chromatography-mass spectrometry extracted 29 metabolites hypothesized a priori to be associated with fatigue or physical function. Descriptive statistics summarized PROMIS scores, and linear mixed effect models estimated metabolite associations adjusting for age, gender and steroid use. Results: Forty children participated (female, 53%; 7-12 years, 38%; 13-18 years 62%; Hodgkins Lymphoma, 33%; Acute Lymphoblastic/Lymphocytic Leukemia, 40%; Osteosarcoma, 10%; Other, 17%). Physical function and fatigue were inversely related: T1 (r = -0.64; p < .001) and T2 (r = -0.63; p < .001). One metabolite (indole-3-latic acid) differentiated between low and high fatigue. Five metabolites differentiated significantly between low and high physical function (4-Hydroxybenzoic acid, m-Coumaric acid, myoinositol, tryptophan, and tyrosine). Conclusions:These findings substantiate prior studies showing metabolites, particularly amino acids, significantly associated with fatigue and physical function. All significant metabolites were associated with the gut microbiome. Physical function was inversely corelated with fatigue providing another potential intervention for fatigue management.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"453-463"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary Incontinence Following Transurethral Prostatectomy: Current Status and Nursing Strategies. 经尿道前列腺切除术后尿失禁：现状及护理策略。

Biological research for nursing Pub Date : 2025-07-01 Epub Date: 2025-02-10 DOI: 10.1177/10998004251318909

Mingjie He, Chen Mao, Yongxia Shu, Xue Liu

{"title":"Urinary Incontinence Following Transurethral Prostatectomy: Current Status and Nursing Strategies.","authors":"Mingjie He, Chen Mao, Yongxia Shu, Xue Liu","doi":"10.1177/10998004251318909","DOIUrl":"10.1177/10998004251318909","url":null,"abstract":"Background: Urinary incontinence is a prevalent condition among patients who have undergone transurethral prostatectomy (TURP). The objective of this study was to assess the current status and the factors influencing the development of urinary incontinence following TURP. Methods: This retrospective study enrolled patients diagnosed with Benign Prostatic Hyperplasia (BPH) who underwent TURP at our hospital from November 1, 2022, to October 30, 2024. We analyzed the demographic and clinical characteristics of patients who developed postoperative urinary incontinence with those who did not. Results: A total of 242 patients who underwent TURP was enrolled, the incidence rate of postoperative urinary incontinence was 36.4%. There were correlations between postoperative urinary incontinence and the following factors: age (r = 0.601), diabetes (r = 0.589), and duration of surgery (r = 0.578), preoperative pelvic floor muscle training (r = -0.626). Multivariate logistic regression analysis revealed that age ≥65 years (OR = 1.941, 95% CI: 1.220∼2.403), diabetes (OR = 2.488, 95% CI: 2.192∼3.070), and surgery duration ≥60 minutes (OR = 1.995, 95% CI: 1.542∼2.426) are independent risk factors for the development of postoperative urinary incontinence in patients undergoing TURP. Preoperative pelvic floor muscle training (OR = 0.604, 95%CI: 0.319∼0.902) was a protective factor against postoperative urinary incontinence. Conclusion: The incidence of postoperative urinary incontinence following TURP is relatively high and is influenced by multiple factors. It is recommended that preventive and nursing measures be implemented to mitigate the occurrence of postoperative urinary incontinence. These measures should include the stringent control of blood glucose levels, optimization of surgical duration, and the standardization of preoperative pelvic floor muscle training.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"423-429"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Aerobic, Resistance, and Combined Exercise Training on Cardiorespiratory Fitness in Healthy People Aged 60 years and Over: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 有氧、阻力和联合运动训练对60岁及以上健康人心肺功能的影响：随机对照试验的系统回顾和荟萃分析

Biological research for nursing Pub Date : 2025-06-11 DOI: 10.1177/10998004251348605

Amin Azimkhani, Rasoul Kasraei, Hamidreza Sabeti, Ameer Almasoodi

{"title":"The Effect of Aerobic, Resistance, and Combined Exercise Training on Cardiorespiratory Fitness in Healthy People Aged 60 years and Over: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Amin Azimkhani, Rasoul Kasraei, Hamidreza Sabeti, Ameer Almasoodi","doi":"10.1177/10998004251348605","DOIUrl":"https://doi.org/10.1177/10998004251348605","url":null,"abstract":"Objective: To evaluate the effects of aerobic, resistance, and combined training on cardiorespiratory fitness in healthy older adults, with a focus on improvements in maximal/peak oxygen uptake (VO2max/peak) and the 6-min walk distance (6-MWD).Methods: A systematic review and meta-analysis were conducted through July 2024, searching six databases: PubMed, CINAHL, Medline, Embase, Web of Science, and Scopus. Analyses were performed using Review Manager 5.3. Results: Fifty-one studies involving 3152 participants met the inclusion criteria. Exercise interventions significantly improved VO2max/peak (standardized mean difference (SMD): 0.51; 95% confidence interval (CI), 0.38 to 0.65; p < .001) and 6-MWD (MD: 36.18 m; 95% CI, 26.52 to 45.84; p < .001) compared to control groups. Subgroup analyses showed consistent benefits across aerobic, resistance, and combined training modalities. Significant improvements were also observed across both medium-term (≤24 weeks) and long-term (>24 weeks) interventions, and in both male and female participants. Conclusion: Structured exercise interventions, regardless of type, are effective for improving cardiorespiratory fitness in older adults. The consistency of these effects across modalities, durations, and sexes underscores the adaptability and value of exercise as a central component of healthy aging strategies. Future research should aim to standardize intervention protocols and extend follow-up periods to clarify long-term outcomes and inform clinical guidelines.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251348605"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain Resilience and Chronic Low Back Pain Outcomes: The Mediating Role of Pace of Biological Aging. 疼痛恢复力与慢性腰痛预后：生物衰老速度的中介作用。

Biological research for nursing Pub Date : 2025-06-04 DOI: 10.1177/10998004251345491

Kiari Kinnie Davis, Khalid W Freij, Fiona B A T Agbor, Asia M Wiggins, Tammie L Quinn, Demario S Overstreet, Shivraj S Grewal, Robert E Sorge, Burel R Goodin, Edwin N Aroke

{"title":"Pain Resilience and Chronic Low Back Pain Outcomes: The Mediating Role of Pace of Biological Aging.","authors":"Kiari Kinnie Davis, Khalid W Freij, Fiona B A T Agbor, Asia M Wiggins, Tammie L Quinn, Demario S Overstreet, Shivraj S Grewal, Robert E Sorge, Burel R Goodin, Edwin N Aroke","doi":"10.1177/10998004251345491","DOIUrl":"https://doi.org/10.1177/10998004251345491","url":null,"abstract":"In this study, we aimed to investigate if the pace of biological aging serves as a critical mediator in the relationship between chronic pain resilience and chronic low back pain intensity and disability. Two hundred seven community-dwelling non-Hispanic Black (NHB) and non-Hispanic White (NHW) adults completed the Pain Resilience Scale (PRS) and Graded Chronic Pain Scale (GCPS). Blood genomic DNA was sequenced using Illumina's MethylationEPIC, and the pace of biological aging estimated using the DunedinPACE (the Dunedin Pace of Aging Calculated from the Epigenome) algorithm. In bivariate correlations, DunedinPACE significantly correlated with pain intensity (r = 0.40), and disability (r = 0.39), at p < .05. Pain resilience negatively correlated with pain intensity (rs = -0.22), pain disability (rs = -0.30), and DunedinPACE (r = -0.11). After controlling for chronological age, sex, race, and BMI, mediation analyses revealed a significant indirect association of pain resilience on pain intensity through the pace of biological aging (β = -0.66 (SE); Boot 95% CI [-1.06, -0.25]). Similarly, DunedinPACE partially mediated the relationship between resilience and pain disability (β = -0.82; 95% CI, [-1.20 to -0.44]). We found that higher levels of resilience correlate with a slower pace of biological aging, which in turn correlates with better pain outcomes. The pace of biological aging emerged as an important potential target for future interventions studies for pain management.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251345491"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serial Mediation: How Optimism Reduces and Pessimism Intensifies Chronic Low Back Pain Through Depression and Biological Aging. 系列中介：乐观如何通过抑郁和生物老化减少和加剧慢性腰痛。

Biological research for nursing Pub Date : 2025-06-03 DOI: 10.1177/10998004251348910

Khalid W Freij, Fiona B A T Agbor, Vinodh Srinivasasainagendra, Tammie L Quinn, Hemant K Tiwari, Robert E Sorge, Burel R Goodin, Edwin N Aroke

{"title":"Serial Mediation: How Optimism Reduces and Pessimism Intensifies Chronic Low Back Pain Through Depression and Biological Aging.","authors":"Khalid W Freij, Fiona B A T Agbor, Vinodh Srinivasasainagendra, Tammie L Quinn, Hemant K Tiwari, Robert E Sorge, Burel R Goodin, Edwin N Aroke","doi":"10.1177/10998004251348910","DOIUrl":"https://doi.org/10.1177/10998004251348910","url":null,"abstract":"There is growing evidence that psychological (e.g., optimism, pessimism, depressive symptoms) and biological factors play an essential role in the experience of chronic low back pain (CLBP). This study aimed to examine the nature of the relationship between optimism or pessimism, depressive symptoms, the pace of biological aging, CLBP severity, and interference. Using mediation analysis, we tested the hypothesis that depressive symptoms and pace of biological aging measured using the Dunedin Pace of Aging from the Epigenome (DunedinPACE) serially mediate the relationship between optimism or pessimism and CLBP severity and interference. Our sample included non-Hispanic Black and non-Hispanic White adults aged 18-82 years: 74 without pain, 56 with low-impact pain, and 77 with high-impact pain. On average, individuals with high-impact pain reported lower levels of optimism, greater pessimism, and faster DunedinPACE than those in the low-impact or no-pain group (p < .05). Mediation analyses revealed indirect associations between both optimism and pessimism with pain severity and interference serially via depressive symptoms and the pace of biological aging (p < .05). These indirect effects were not statistically significant after controlling for chronological age, sex, race, and BMI. The results suggest that psychological interventions that increase optimism and reduce pessimism may slow the biological aging process, which may improve nonspecific CLBP outcomes in non-Hispanic Black and non-Hispanic White adults.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251348910"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in DNA Methylation Associated With Psychobehavioral Interventions: A Scoping Literature Review. 与心理行为干预相关的DNA甲基化变化：范围文献综述。

Biological research for nursing Pub Date : 2025-05-31 DOI: 10.1177/10998004251346179

Karen L Saban, Linda Janusek, Paula de la Pena, Sueyeon Lee, Dina Tell, Herbert Mathews, Alexandra L Nowak, Alexandria Nyembwe, Jacquelyn Y Taylor

{"title":"Changes in DNA Methylation Associated With Psychobehavioral Interventions: A Scoping Literature Review.","authors":"Karen L Saban, Linda Janusek, Paula de la Pena, Sueyeon Lee, Dina Tell, Herbert Mathews, Alexandra L Nowak, Alexandria Nyembwe, Jacquelyn Y Taylor","doi":"10.1177/10998004251346179","DOIUrl":"https://doi.org/10.1177/10998004251346179","url":null,"abstract":"Background: DNA methylation (DNAm) is an epigenetic process of addition or reduction of methyl groups to genes that modify gene expression and can alter the physiological response to psychological stress. DNAm associated with psychological stress is malleable, making it a prime target for psychobehavioral interventions. Research is beginning to examine changes in DNAm in response to psychobehavioral interventions, such as mindfulness-based stress reduction, cognitive behavioral therapy, and yoga. A better understanding of the current evidence may provide direction for future research. Objective: The purpose of this scoping review is to summarize current studies, identify knowledge gaps, and make recommendations for further research related to examining alterations in DNAm in response to psychobehavioral interventions. Methods: A scoping review was conducted based on the methods recommended by Arksey and O'Malley (2005). Studies examining response of blood or saliva DNAm to psychobehavioral interventions in adult humans were reviewed. Results: Twenty-one studies met the inclusion criteria. Although many studies were inadequately powered, several reported differences in DNAm in response to a psychobehavioral intervention across a variety of genes, including genes related to stress and inflammation. However, the studies varied with respect to participant health status, type and duration of psychobehavioral interventions evaluated, biospecimens examined, and method of DNA analysis. Conclusions: The evaluation of DNAm in response to psychobehavioral interventions is a growing area of research. Future research is needed to address design limitations of existing investigations, evaluate the biological importance of observations, and link the DNAm response to physiological and psychological outcomes of the interventions.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251346179"},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Glycemic Variability in Patients With Intracerebral Hemorrhage and Neurological Deterioration. 脑出血患者血糖变异性与神经功能恶化的关系。

Biological research for nursing Pub Date : 2025-05-21 DOI: 10.1177/10998004251344888

Lichun Lu, Xiangyi Yin, Chen Wang, Xianlan Meng, Gongbo Li, Wenyu Zhu

{"title":"Correlation Between Glycemic Variability in Patients With Intracerebral Hemorrhage and Neurological Deterioration.","authors":"Lichun Lu, Xiangyi Yin, Chen Wang, Xianlan Meng, Gongbo Li, Wenyu Zhu","doi":"10.1177/10998004251344888","DOIUrl":"https://doi.org/10.1177/10998004251344888","url":null,"abstract":"Background: Glycemic variability and its management hold significant prognostic implications in clinical practice for patient outcomes. The aim of this study is to analyze the correlation between glycemic variability and the deterioration of neurological function in patients with intracerebral hemorrhage (ICH), to provide evidence-based support for the treatment and care of clinical ICH patients. Methods: Patients with ICH admitted to our hospital between January 2022 and August 2024 were subjected to the National Institutes of Health Stroke Scale (NIHSS) scoring upon admission and discharge. A comparative analysis of baseline characteristics and glycemic variability parameters was conducted. Results: A total of 156 patients with ICH were included. The incidence of neurological deterioration in ICH patients was 30.8%. Correlation analysis revealed significant associations between age (r = 0.602), mean glucose levels (r = 0.623), Time in Range (TIR) (r = 0.589), Mean Amplitude of Glycemic Excursions (MAGE) (r = 0.608), and Large Amplitude of Glycemic Excursions (LAGE) (r = 0.634) with the occurrence of neurological deterioration. Logistic regression analysis identified age (OR = 2.512, 95%CI: 1.924-3.006), mean glucose (OR = 2.743, 95%CI: 2.101-3.286), TIR (OR = 3.204, 95%CI: 2.985-3.607), MAGE (OR = 3.029, 95%CI: 2.601-3.748), and LAGE (OR = 2.768, 95%CI: 2.245-3.103) as significant predictors of neurological deterioration in ICH patients. Conclusion: This finding underscores the critical importance of considering both chronological age and glycemic control metrics in the prognostic evaluation of ICH patients. Integrating these factors into clinical assessments may enhance the accuracy of predicting patient outcomes and guide tailored therapeutic strategies.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251344888"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological Post-Acute Sequelae of COVID-19 in Non-Hospitalized Patients: An Integrative Review. 非住院患者COVID-19急性后神经系统后遗症：一项综合综述

Biological research for nursing Pub Date : 2025-05-05 DOI: 10.1177/10998004251335968

Jose Carlos de Andrade Vieira Junior, Murilo Rossi Lima Sander, José Airton de Oliveira Matos, André de Macêdo Medeiros, Flávio Santos da Silva, Caio Augusto Martins Aires

{"title":"Neurological Post-Acute Sequelae of COVID-19 in Non-Hospitalized Patients: An Integrative Review.","authors":"Jose Carlos de Andrade Vieira Junior, Murilo Rossi Lima Sander, José Airton de Oliveira Matos, André de Macêdo Medeiros, Flávio Santos da Silva, Caio Augusto Martins Aires","doi":"10.1177/10998004251335968","DOIUrl":"https://doi.org/10.1177/10998004251335968","url":null,"abstract":"The COVID-19 pandemic has had a significant impact on the global population. The infection, caused by SARS-CoV-2, presents with a variety of clinical manifestations, from asymptomatic cases to more severe forms, including a variety of neurological symptoms, such as fatigue, weakness, brain fog, paresthesias, dysautonomia, anosmia, and dysgeusia. Additionally, the disease is associated with the long COVID syndrome, in which there is persistence of the effects and symptoms of the acute phase. In recent years the literature has shown relevant data on long COVID, but there is still a need to deepen the knowledge about these long term manifestations. Thus, the present study aimed to describe the main neurological sequelae resulting from SARS-CoV-2 infection in non-hospitalized population during the long phase of the disease, gathering scientific evidence through an integrative review of the prevalence of symptoms, patient profile, duration and severity of sequelae, risk factors, comorbidities, and possible nervous system structural damage. The PubMed/Medline database was used with descriptors and, at the end of the screening process with predefined inclusion and exclusion criteria, 22 studies were included. A group of neurological symptoms associated with long COVID was identified: myalgia, dysgeusia, memory alterations, olfactory dysfunction, dizziness, and pain. Most patients presented multiple symptoms that lasted for more than one year with a significant impact on quality of life. The main risk factors were dyslipidemia, age, ethnicity, muscle/ joint pain, and sex. This review highlights the importance of further studies on the syndrome, its etiology, diagnosis, follow-up, and treatments.","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251335968"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0