定义遗传祖先:对护士的启示。

IF 2.1
Alexis Jimenez, Karla Lindquist, Kayla D Longoria, Benjamin M Stroebel, Bradley E Aouizerat, Elena Flowers
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引用次数: 0

摘要

简介:本文概述了测量遗传血统的方法,特别侧重于从事研究的护士的应用。我们描述了研究社区广泛实施的方法和当前工具,以介绍在测量个体遗传混合和群体遗传亚结构方面进行研究的护士。本文的预期影响是提高对遗传关联研究中测量遗传祖先对控制潜在混淆的重要性的认识和理解。最佳实践总结:遗传祖先的测量可以防止遗传关联研究中的混淆。结论:护士从整体角度看待健康,包括个人、环境和社会因素的信息。这一框架需要考虑个人遗传特征和社会身份和地位。本文作为遗传祖先相关概念的入门,包括祖先信息标记,参考人群和统计方法,从事研究的护士可以将其纳入研究设计和实施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Defining Genetic Ancestry: Implications for Nurses.

Introduction: This paper provides an overview of methods for measuring genetic ancestry, specifically focusing on applications for nurses engaged in research. We describe methods and current tools widely implemented by the research community to introduce nurses who conduct research in the landscape of measuring genetic admixture for individuals and genetic substructure for populations. The intended impact of this paper is to enhance awareness and understanding of the importance of measuring genetic ancestry to control for latent confounding in genetic association studies. Summary of best practices: Measurement of genetic ancestry can prevent confounding in genetic association studies. Conclusions: Nurses approach health from a holistic perspective that includes information about individual, environmental, and social factors. This framework necessitates consideration of individual genetic characteristics and social identity and position. This paper serves as a primer on concepts related to genetic ancestry, including ancestry informative markers, reference populations, and statistical approaches, that nurses engaged in research may incorporate into their study design and implementation.

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