Pain Resilience and Chronic Low Back Pain Outcomes: The Mediating Role of Pace of Biological Aging.

Kiari Kinnie Davis, Khalid W Freij, Fiona B A T Agbor, Asia M Wiggins, Tammie L Quinn, Demario S Overstreet, Shivraj S Grewal, Robert E Sorge, Burel R Goodin, Edwin N Aroke
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Abstract

In this study, we aimed to investigate if the pace of biological aging serves as a critical mediator in the relationship between chronic pain resilience and chronic low back pain intensity and disability. Two hundred seven community-dwelling non-Hispanic Black (NHB) and non-Hispanic White (NHW) adults completed the Pain Resilience Scale (PRS) and Graded Chronic Pain Scale (GCPS). Blood genomic DNA was sequenced using Illumina's MethylationEPIC, and the pace of biological aging estimated using the DunedinPACE (the Dunedin Pace of Aging Calculated from the Epigenome) algorithm. In bivariate correlations, DunedinPACE significantly correlated with pain intensity (r = 0.40), and disability (r = 0.39), at p < .05. Pain resilience negatively correlated with pain intensity (rs = -0.22), pain disability (rs = -0.30), and DunedinPACE (r = -0.11). After controlling for chronological age, sex, race, and BMI, mediation analyses revealed a significant indirect association of pain resilience on pain intensity through the pace of biological aging (β = -0.66 (SE); Boot 95% CI [-1.06, -0.25]). Similarly, DunedinPACE partially mediated the relationship between resilience and pain disability (β = -0.82; 95% CI, [-1.20 to -0.44]). We found that higher levels of resilience correlate with a slower pace of biological aging, which in turn correlates with better pain outcomes. The pace of biological aging emerged as an important potential target for future interventions studies for pain management.

疼痛恢复力与慢性腰痛预后:生物衰老速度的中介作用。
在这项研究中,我们旨在探讨生物衰老的速度是否在慢性疼痛恢复力、慢性腰痛强度和残疾之间的关系中起重要的中介作用。270名居住在社区的非西班牙裔黑人(NHB)和非西班牙裔白人(NHW)成年人完成了疼痛恢复量表(PRS)和分级慢性疼痛量表(GCPS)。使用Illumina的MethylationEPIC对血液基因组DNA进行测序,并使用dunedpace(从表观基因组计算的Dunedin衰老速度)算法估计生物衰老的速度。在双变量相关性中,DunedinPACE与疼痛强度(r = 0.40)和残疾(r = 0.39)显著相关,p < 0.05。疼痛恢复力与疼痛强度(rs = -0.22)、疼痛失能(rs = -0.30)和DunedinPACE (r = -0.11)呈负相关。在控制了实际年龄、性别、种族和体重指数后,中介分析显示疼痛恢复力与疼痛强度通过生物衰老的速度存在显著的间接关联(β = -0.66 (SE);启动95% CI[-1.06, -0.25])。同样,DunedinPACE部分介导了弹性和疼痛失能之间的关系(β = -0.82;95% CI,[-1.20 ~ -0.44])。我们发现,高水平的恢复力与较慢的生物衰老速度相关,这反过来又与更好的疼痛结果相关。生物衰老的速度成为未来疼痛管理干预研究的重要潜在目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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