Causal Associations of Cognitive Reserve and Hierarchical Aging-Related Outcomes: A Two-Sample Mendelian Randomization Study.

Biological research for nursing Pub Date : 2025-01-01 Epub Date: 2024-08-18 DOI:10.1177/10998004241274271

Yanyan Li, Zhenhuang Zhuang, Huaxin Si, Qinqin Liu, Jiaqi Yu, Wendie Zhou, Tao Huang, Cuili Wang

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Abstract

Purpose: Two-sample Mendelian randomization methods were used to explore the causal effects of cognitive reserve proxies, such as educational attainment, occupational attainment, and physical activity (PA), on biological (leukocyte telomere length), phenotypic (sarcopenia-related features), and functional (frailty index and cognitive performance) aging levels.

Results: Educational attainment had a potential protective effect on the telomere length (β = 0.10, 95% CI: 0.08-0.11), sarcopenia-related features (β = 0.04-0.24, 95% CI: 0.02-0.27), frailty risk (β = -0.31, 95% CI: -0.33 to -0.28), cognitive performance (β = 0.77, 95% CI: 0.75-0.80). Occupational attainment was causally related with sarcopenia-related features (β = 0.07-0.10, 95% CI: 0.05-0.14), and cognitive performance (β = 0.30, 95% CI: 0.24-0.36). Device-measured PA was potentially associated with one sarcopenia-related feature (β = 0.14, 95% CI: 0.03-0.25).

Conclusions: Our findings support the potential causality of educational attainment on biological, phenotypic, and functional aging outcomes, of occupational attainment on phenotypic and functional aging-related outcomes, and of PA on phenotypic aging-related outcomes.

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认知储备与分层衰老相关结果的因果关系：双样本孟德尔随机化研究

目的：采用双样本孟德尔随机方法探讨认知储备替代物（如教育程度、职业成就和体力活动）对生物（白细胞端粒长度）、表型（肌肉疏松症相关特征）和功能（虚弱指数和认知表现）衰老水平的因果效应：教育程度对端粒长度（β = 0.10，95% CI：0.08-0.11）、肌肉疏松症相关特征（β = 0.04-0.24，95% CI：0.02-0.27）、虚弱风险（β = -0.31，95% CI：-0.33--0.28）和认知能力（β = 0.77，95% CI：0.75-0.80）具有潜在的保护作用。职业成就与肌肉疏松症相关特征（β = 0.07-0.10，95% CI：0.05-0.14）和认知能力（β = 0.30，95% CI：0.24-0.36）有因果关系。设备测量的 PA 与一项肌肉疏松症相关特征有潜在关联（β = 0.14，95% CI：0.03-0.25）：我们的研究结果支持教育程度对生物、表型和功能性衰老结果的潜在因果关系，支持职业成就对表型和功能性衰老相关结果的潜在因果关系，以及支持性活动对表型衰老相关结果的潜在因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biological research for nursing

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