Biological research for nursing最新文献

{"title":"Effect of Infant Massage in Neonates With Hyperbilirubinemia Receiving Phototherapy: A Systematic Review and Meta-Analysis.","authors":"Zübeyde Ezgi Erçelik, Diler Aydin Yilmaz","doi":"10.1177/10998004251385121","DOIUrl":"10.1177/10998004251385121","url":null,"abstract":"<p><p>Most infants are diagnosed with hyperbilirubinemia in the first day of life. Although phototherapy is the most common treatment used in hyperbilirubinemia, different alternative therapies such as massage are also used. This systematic review and meta-analysis was designed to evaluate the effect of massage on serum bilirubin levels, defecation frequency, and length of hospital stay in neonates with hyperbilirubinemia receiving phototherapy. A review of randomized controlled trials published in English from 2008 to November 2023 was conducted using PubMed-Medline, Academic Search Ultimate-EBSCOhost, Web of Science, and Scopus databases. From 217 identified trials, six randomized controlled studies were included, with a total sample of 394 term infants. Infant massage was effective in increasing defecation frequency (MD: 0.52, 95% CI: Min: 0.29- Max: 0.76, <i>p <</i> 0.0001), reducing serum bilirubin levels on the 3rd and 4th days (MD: -1.19, 95% CI: Min: -1.50- Max: -0.89, <i>p <</i> 0.0001) (MD:-2.33, 95% CI: Min: -2.88- Max: -1.79, <i>p <</i> 0.0001), and shortening hospital stay (MD:-13.66, 95% CI: Min: -16.74- Max: -10.59, <i>p <</i> 0.0001). This systematic review and meta-analysis suggest that infant massage is a safe and effective intervention for term neonates with hyperbilirubinemia, contributing to a shorter hospital stay by lowering serum bilirubin levels and increasing defecation frequency.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"274-282"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>APOE</i> ε4 Allele and Methylation Patterns Linked to Cardiovascular Outcomes in Women With Breast Cancer.","authors":"Emily K Mewborn, Myeong-Ga Cho, Kirk I Erickson, Catherine M Bender, Yvette Conley","doi":"10.1177/10998004251385243","DOIUrl":"10.1177/10998004251385243","url":null,"abstract":"<p><p>DNA methylation affects gene expression. While the Apolipoprotein E (<i>APOE</i>) genotype impacts cardiovascular risk, <i>APOE</i> methylation impact remains unknown, particularly in women with breast cancer (BC). This study explored associations of <i>APOE</i> methylation with hypertension history and cardiovascular fitness (CVF) and whether <i>APOE</i> genotype and methylation moderate exercise effects over 6 months. This study leveraged data from a 6-month exercise randomized clinical trial in postmenopausal women with BC. Using peripheral blood, methylation M-values (Illumina Infinium Methylation EPIC Beadchip) and 13 CpG sites within and 2kb 5' and 3' to <i>APOE</i> were abstracted post data quality checks. Outcome variables: self-reported hypertension and CVF (peak oxygen consumed per kilogram per minute [VO₂max/kg/min] and peak metabolic equivalents [METs] through graded exercise testing). Participants completed 150 min/week of aerobic exercise or usual care for 6 months. Logistic and linear regression examined associations between CpG M-values and hypertension, VO₂max/kg/min and METs. Baseline M-value and <i>APOE</i> genotype were interaction terms for longitudinal analyses. This study included 102 women (Mean = 62 yrs). <i>APOE</i>ε4 carriers had increased methylation of cg06750524 (<i>p =</i> 0.04) and cg19514613 (<i>p =</i> 0.03), but lower methylation of cg21879725 (<i>p =</i> 0.04). Increased cg06750524 methylation was associated with higher hypertension odds (<i>p =</i> 0.022, OR = 2.813) and lower VO₂max/kg/min and METs (<i>p =</i> 0.005). Increased cg05501958 methylation (M = 4.539, SD = 0.17) was associated with lower hypertension odds (<i>p =</i> 0.02, OR = 0.035) and higher VO₂max/kg/min and METs (<i>p =</i> 0.022). Neither <i>APOE ε4</i> nor baseline methylation moderated exercise effects. <i>APOE</i> methylation, differentially by ε4 carriage, may impact cardiovascular outcomes and serve as a biomarker of risk in women with BC.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"177-186"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12664574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Interactions and Cell Aging Dynamics in Postpartum Women.","authors":"Nourit Houminer-Klepar, Shiran Bord, Elissa Epel, Jue Lin, Shlomi Sagi, Orna Baron-Epel","doi":"10.1177/10998004251397544","DOIUrl":"10.1177/10998004251397544","url":null,"abstract":"<p><p><b>Introduction:</b> Psychosocial stressors are linked with declined physical and psychological health, and short telomere length (TL). While positive social interactions have been linked to improved postpartum physical and mental health, little research has explored the longitudinal effects of psychosocial stressors and telomere dynamics in the sensitive postpartum period. This study aimed to examine the effect of positive and negative social interactions on TL among first-time mothers during the first year postpartum. <b>Methods:</b> A cohort of 103 first-time mothers from Northern Israel completed validated measures assessing social support, marital satisfaction, and depressive symptoms, and provided blood samples for leukocyte TL analysis. Hierarchical linear and logistic regressions, adjusting for covariates, examined the association between social interactions and change in TL. <b>Results:</b> We observed three patterns of telomere dynamics over the year: telomere shortening, moderate telomere lengthening, and relatively high telomere lengthening in the lower, medium, and upper tertiles of change in TL, respectively, used as our categorical outcome. Hierarchical logistic regressions analyses revealed that mothers with higher marital satisfaction had a 4-fold greater likelihood of substantial telomere lengthening (OR = 3.997, 95%CI [1.345, 11.876] <i>p =</i> .013), remaining significant after correction for multiple comparisons. Negative social interactions showed initial associations (OR = 0.332, 95%CI [0.114, 0.971] <i>p =</i> .044) but did not maintain significance after multiple comparison adjustment. <b>Discussion:</b> Marital satisfaction showed a robust association with telomere lengthening postpartum, representing the most consistent finding. Social relationships, particularly intimate partnership quality, may be important in the postpartum period, not just for mental health but for biological aging indices.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"205-217"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145508511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric Acid, BMI, and Neutrophil Lymphocyte Ratio Mediate the Relationship Between Soft Drink Consumption and Systolic Blood Pressure: A Nationwide Structural Equation Model Pathways Among Adolescents and Young Adults Across Indonesia.","authors":"Maria Dyah Kurniasari, Ferry Fredy Karwur, Kristiawan Prasetyo Agung Nugroho, Farida Sonya Mangma, Elisa Esa Naftali","doi":"10.1177/10998004251406291","DOIUrl":"10.1177/10998004251406291","url":null,"abstract":"<p><p><b>Background:</b> Adolescent hypertension is an emerging global issue, with metabolic and inflammatory dysregulation potentially preceding cardiovascular disease. Increasing soft drinks and fast food consumption has been associated with obesity and metabolic imbalance. However, the biological pathways connecting these dietary behaviours to blood pressure remain weakly understood in Indonesian adolescents. <b>Objectives:</b> To investigate mediating effects of body mass index, uric acid, and neutrophil-to-lymphocyte ratio on relationship between soft-drink and fast-food consumption and systolic blood pressure among Indonesian adolescents and young adults. <b>Methods:</b> A nationwide, community-based cross-sectional study was conducted among 500 adolescents aged 10-24 years, representing Indonesia's major ethnic regions. Dietary intake was assessed using semi-quantitative food frequency questionnaire. Clinical measurements included body mass index, uric acid, neutrophil-to-lymphocyte ratio, and systolic blood pressure. Bivariate and multivariate analyses followed by mediation and multi-group analyses. <b>Results:</b> The mean systolic blood pressure was 110.84mmHg; soft-drink consumption correlated with uric acid, Body Mass Index, and systolic blood pressure (<i>p <</i> 0.001). In multiple regression, Body Mass Index (β = 0.36, <i>p <</i> 0.01) and soft drink-fast food consumption interaction (β = 0.27, <i>p <</i> 0.01) independently predicted systolic blood pressure. A significant indirect effect of soft-drink consumption on systolic blood pressure mediated by Body Mass Index, Neutrophil-to- Lymphocyte Ratio, and uric acid (β = 0.02, <i>p <</i> 0.05). Multi-group analysis indicated that effects of fast-food and soft-drink intake on body mass index and neutrophil-to-lymphocyte ratio did not differ significantly across gender or uric acid. <b>Conclusions:</b> Soft-drink consumption indirectly increases systolic blood pressure through metabolic and inflammatory mechanisms. Early nursing-led interventions that promote healthy diets, metabolic screening, and school-based health education are crucial to mitigating subclinical cardiovascular risk.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"230-241"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Research Landscape of Sleep Health in Nursing: A Bibliometric and Visualization Study.","authors":"Songül Çağlar","doi":"10.1177/10998004251397656","DOIUrl":"10.1177/10998004251397656","url":null,"abstract":"<p><p>This research intends to provide a comprehensive review of existing literature on sleep within the nursing field, employing bibliometric methods. A comprehensive analysis of the available literature concerning sleep in nursing was carried out through the Web of Science Core Collection (WoSCC) on October 20, 2025. The search terms \"sleep\" and \"nursing\" played a crucial role in identifying relevant research studies. VOSviewer was applied for bibliometric analysis and visualization to identify authors, journals, countries and display the keyword co-occurrence networks. A total of 2.456 publications focused on the topic of sleep were identified from 1991 to 2025. The dataset comprised predominantly research articles (2.296, 93.5%). These publications appeared in a total of 191 distinct academic journals and collectively received 103,025 citations over the analyzed period. The number of publications increased by an average of 6.83 units per year during the observed period (R² = 0.9622; p < 0.001). In the keyword co-occurrence network, \"sleep,\" \"sleep quality,\" and \"nursing\" keywords the highest frequency. The Journal of Clinical Nursing exhibited the highest publication output with 109 articles. The United States accounted for the largest share of publications. Development and Adaptation of Sleep Instruments in Nursing was performed on 14 measurement tools. This bibliometric study revealed the research points and trends in the field of sleep in nursing research. Future research should aim to strengthen international collaboration among nurse researchers, leveraging artificial intelligence tools and wearable technologies to effectively address sleep-related issues and enhance sleep quality.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"296-308"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145544067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Supportive Therapy for Patients With Thalassemia: A Systematic Review.","authors":"Raditya Bagus Septian, Rafi Achmad Rukhama, Nisa Nur Hasanah","doi":"10.1177/10998004251406267","DOIUrl":"10.1177/10998004251406267","url":null,"abstract":"<p><p>ObjectiveTo analyze various innovative approaches in the supportive therapy of patients with thalassemia and to summarize the efficacy of different biomedical interventions from Randomized Controlled Trials (RCT).MethodsThis systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines and registered in PROSPERO (CRD420251163054). A comprehensive literature search was conducted across four major databases: Scopus, PubMed, ScienceDirect, and Sage Journals. The inclusion criteria for this review involve patients with thalassemia, focus on the supportive therapy of thalassemia, conducted in healthcare settings, and employ a RCT design. The literature quality was evaluated using the Joanna Briggs Institute (JBI) tool for RCT. The data were synthesized using a narrative synthesis approach.ResultsFrom 2,394 records, 13 articles were identified. Luspatercept and Thalidomide were found to be the most effective in reducing transfusion dependence and increasing hemoglobin levels. For iron overload, Amlodipine and Spirulina significantly improved cardiac T2*, contributing to cardioprotection. Furthermore, Curcumin supplementation was shown to improve lipid metabolism and inhibit systemic inflammation. Meanwhile, therapies using Green Tea and Vitamin E were effective in reducing markers of cellular oxidative damage, with Green Tea also demonstrating dual efficacy in reducing serum ferritin (SF) and liver iron concentration (LIC).ConclusionOverall, new and adjuvant supportive therapies significantly support the biological management of patients with thalassemia. Further studies are required to integration between pharmacological therapies and nutraceutical approaches should be further explored to optimize improvements in hematological status, oxidative stress, and patients' metabolic profiles.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"309-328"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Aquatic and Pilates Exercises Improve Pain, Mobility, Functional Disability, and Quality of Life in Women With Lumbar Disc Herniation: A Randomized Controlled Trial.","authors":"Afshin Moghadasi, Fatemeh Mousavi","doi":"10.1177/10998004251388995","DOIUrl":"10.1177/10998004251388995","url":null,"abstract":"<p><p>BackgroundLumbar disc herniation (LDH) is a common musculoskeletal condition that negatively impacts pain, mobility, functional ability, and quality of life, especially in women. While aquatic and Pilates exercises each offer benefits, limited research has explored their combined effects in LDH rehabilitation.ObjectiveTo compare the effects of aquatic exercise alone versus a combination of aquatic and Pilates exercises on pain, spinal mobility, functional disability, and quality of life in women with mild to moderate LDH.MethodsIn this randomized controlled trial, 45 women aged 30-50 years with MRI-confirmed mild to moderate LDH were assigned to one of three groups: control (n = 15), aquatic exercise (n = 15), and combined aquatic + Pilates exercise (n = 15). The intervention lasted eight weeks, with three supervised sessions per week. Outcomes were assessed using the Visual Numeric Scale (pain), Modified-Modified Schober Test (mobility), Oswestry Disability Index (disability), and SF-36 (quality of life). Data were analyzed using mixed-model ANOVA and Scheffé post hoc tests.ResultsBoth intervention groups showed significant improvements in all outcomes compared to the control group (<i>p <</i> 0.001). The combined aquatic + Pilates group showed greater improvements in spinal mobility (<i>p</i> = 0.027), functional disability (<i>p</i> = 0.042), and quality of life (<i>p</i> = 0.046) compared to the aquatic-only group.ConclusionAn eight-week program combining aquatic and Pilates exercises is more effective than aquatic exercise alone for improving pain, mobility, disability, and quality of life in women with LDH. This multi-modal, non-invasive approach may enhance clinical rehabilitation outcomes.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":"28 2","pages":"195-204"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The HALP Index as a Bridge Between Nutrition, Inflammation, and Coagulation in Predicting DVT Risk in Stroke Patients.","authors":"Siqi Zhang, Shuangyang Niu, Yonghui Wang","doi":"10.1177/10998004251404366","DOIUrl":"10.1177/10998004251404366","url":null,"abstract":"<p><p>The hemoglobin-albumin-lymphocyte-platelet (HALP) index, a composite marker reflecting nutritional, inflammatory, and immune status, has been linked to various health outcomes. However, its role in predicting deep vein thrombosis (DVT) occurrence in stroke patients and its potential influence on coagulation biomarkers, particularly D-dimer, remain poorly understood. This study aims to investigate the association between the HALP index and the occurrence of DVT in stroke patients, exploring the potential moderating role of HALP in regulating D-dimer levels and DVT formation. A retrospective study was conducted with 611 stroke patients, categorized into quartiles based on HALP scores. Multivariate logistic regression, restricted cubic spline (RCS) analysis, and subgroup analyses stratified by age, gender, body mass index (BMI), and D-dimer levels were performed to assess the relationship between HALP and DVT. Moderation analysis was used to explore the regulatory effect of HALP on D-dimer levels. HALP levels were inversely associated with DVT occurrence. Patients in higher HALP quartiles (Q3: 33.40-47.93, Q4: 47.93-152.58) exhibited significantly lower odds of DVT (<i>p <</i> .001). RCS modeling identified a threshold effect, with a sharp increase in DVT occurrence below a HALP level of 33.5. Subgroup analyses revealed that the protective association of higher HALP scores with reduced DVT incidence was consistent across all age groups and was significant in patients with both low and high D-dimer levels. This protective association was particularly strong in males (OR = 0.148) and overweight patients (OR = 0.089). The interaction between HALP and D-dimer was significant (<i>p <</i> .001), with HALP moderating the association between D-dimer and DVT occurrence. HALP is a strong, independent predictor of post-stroke DVT and moderates the prothrombotic impact of D-dimer. As a low-cost, integrative marker, HALP offers clinical value for early DVT occurrence stratification and individualized prevention strategies in stroke patients.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"218-229"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145643950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of a Blue-Blocking Filter Over One Eye on Health and Performance Outcomes and Its Implications for Night Workers.","authors":"Mariana G Figueiro, John D Bullough, Muneer Rizvydeen, Barbara Plitnick, Weixin Li, Mark S Rea","doi":"10.1177/10998004251406550","DOIUrl":"10.1177/10998004251406550","url":null,"abstract":"<p><p>The higher risk for cancer documented among night-shift nurses compared to the day-shift nurses possibly results from lower melatonin levels associated with exposure to light at night in the work environment. Research demonstrates that eliminating spectral power <530 nm to both eyes prevents light-induced nocturnal melatonin suppression, and complete occlusion of one eye reduces melatonin suppression relative to that when both eyes are open. This study investigated whether filtering short wavelengths from one eye using a blue-blocking filter, rather than occluding one eye, would maintain high melatonin levels, alertness, and visual performance. This crossover, within-subjects study ran for six nights. Subjects experienced one of six light conditions involving combinations of binocular versus monocular and filtered versus unfiltered vision per night. Normalized melatonin concentration area under the curve (AUC_n) served as the primary outcome and the numerical verification (NVT) and go/no-go (GNG) performance tasks, pupil area, and subjective sleepiness (Karolinska Sleepiness Scale [KSS]) served as secondary outcomes. Both filtered and unfiltered monocular light conditions resulted in significantly greater melatonin AUC_n than the unfiltered binocular light condition. Performance at the NVT and at the GNG was not affected by filtering one eye compared to the unfiltered binocular light condition, nor did it affect KSS ratings. Melatonin AUC_n positively correlated with pupil area for corresponding light conditions. In conclusion, filtering one eye can help preserve melatonin levels in night workers while maintaining alertness and visual performance, which could be a simple and effective solution for improving health in night-shift nurses.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"242-253"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145703236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen Stabilizes Interferon-Inducible Genes During Skeletal Muscle Regeneration.","authors":"Tara Movaghar, Juli Petereit, Barbara St Pierre Schneider","doi":"10.1177/10998004251411301","DOIUrl":"10.1177/10998004251411301","url":null,"abstract":"<p><p><b>Background:</b> Inflammation is essential for skeletal muscle repair following acute injury, and successful muscle regeneration requires a balance between pro- and anti-inflammatory signaling. Estrogen regulates inflammatory responses, suggesting a role in tissue repair. CD169+ macrophages are also associated with tissue repair. However, these cells and related interferon-inducible genes have not been investigated in regenerating muscle. <b>Objective:</b> To examine how 17β-estradiol treatment influences the expression and co-expression network of Siglec1 (encoding CD169), an interferon-inducible gene, during muscle regeneration. <b>Methods:</b> Ovariectomized mice received either 17β-estradiol or placebo before undergoing a standardized crush injury to hindlimb muscle groups and exposure to simulated flight. Mice were euthanized at 32-h, 96-h, or 192-h postinjury. Differential gene expression analysis was performed on injured muscles to assess treatment-related transcriptional changes, and additional muscles were evaluated for regeneration stage and CD169 protein expression. <b>Results:</b> At 192-h postinjury, Siglec1 was among the top upregulated genes in 17β-estradiol-treated mice relative to placebo mice, which reflected a decline in Siglec1 expression over time in the placebo group. Correlation analysis revealed that Siglec1 was strongly associated with interferon-related genes under placebo treatment, whereas the connectivity of Siglec1 under 17β-estradiol treatment was weakened. Immunohistochemistry confirmed stronger CD169 staining in regenerating muscle of 17β-estradiol-treated mice. <b>Conclusion:</b> Siglec1 expression is more stable in an estrogen state compared to an ovarian-hormone-deficient state. Understanding how estrogen deficiency alters inflammatory signaling after muscle injury may inform interventions to promote recovery in postmenopausal women, who may be at risk for impaired muscle repair.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"264-273"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}