Biological research for nursing最新文献

{"title":"A Bibliometric Analysis of Older Adult Population Research Published in <i>Biological Research for Nursing</i>.","authors":"Ibis A Moreno-Lozano, Barbara St Pierre Schneider","doi":"10.1177/10998004251414404","DOIUrl":"10.1177/10998004251414404","url":null,"abstract":"<p><p>The global increase in older adults places greater demands on understanding how body tissues change structurally and physiologically with age. Given this demographic trend and <i>Biological Research for Nursing's</i> focus on biological or biobehavioral outcomes, we analyzed the scientific production and impact, including citation count, of 87 relevant research papers published in this journal between 2002 and 2024. Using the OpenAlex database and VOSviewer, we found that the five papers published in 2018 accrued the highest citation count of 227. Among 81 articles, 12 research fronts were identified, with physical activity, frailty, sleep, and/or cognition included in several of them. A co-occurrence network of 102 authors' terms/keywords generated five clusters, where the three terms with the largest nodes were medicine, internal medicine, and physical therapy. Terms associated with more current research papers included inflammation, quality of life, economics, and grip strength. Regarding location, the United States dominated the country network but showed strong collaborative links with European and Asian nations. The author network consisted of 398 authors; however, less than 10% demonstrated strong collaborations. Therefore, <i>Biological Research for Nursing</i>, with its focus on nursing perspectives regarding aging-related biological and behavioral dimensions of health, serves as a key platform for evidence-based, holistic gerontological health care.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"346-361"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study Protocol for a Randomized Controlled Trial of Multisensory Early Oral Administration of Human Milk (M-MILK) for Very Preterm Infants: Enhancing Stress Regulation, Neurodevelopment, and Oral Feeding Skills.","authors":"Thao Griffith, Linda Janusek, Rosemary White-Traut, Stefan J Green, Amin Sachin, Cara Joyce","doi":"10.1177/10998004261418708","DOIUrl":"10.1177/10998004261418708","url":null,"abstract":"<p><p><b>Background</b>. Early life stress results in disrupted stress regulation, and less optimal neurodevelopment and oral feeding skills in very preterm infants. Despite these associations, there are few evidence-based interventions to help these fragile infants during critical stages of development. <b>Purpose</b>. This article describes an ongoing research protocol of a randomized controlled trial (RCT) to evaluate the <i>m</i>ultisensory early oral administration of human <i>milk</i> (M-MILK) as an early NICU intervention to improve stress regulation, support optimal neurodevelopment, and promote competent oral feeding skills in very preterm infants. <b>Method</b>. M-MILK is an infant-led early NICU intervention beginning on day 3 of life to provide very preterm infants with small droplets of milk orally while engaging their innate senses. Infants (N = 124) born <32 weeks gestational age are randomized to either the M-MILK or control group (standard of care). M-MILK begins on day 3 of life. We assess stress regulation, neurodevelopment, and oral feeding skills over time via salivary cortisol, buccal cell DNA methylation, NeoNatal Neurobehavioral Scale, Ages and Stages Questionnaire, Early Feeding Skills Assessment, and Neonatal Feeding Assessment Tool. Endpoints will be compared by treatment arm using linear regression and mixed-effects models for cross-sectional and longitudinal analyses, respectively. <b>Discussion</b>. Findings from this study will advance knowledge as to the efficacy of M-MILK as an epigenetically-informed intervention to enhance stress regulation, neurodevelopment, and oral feeding skills in very preterm infants during critical periods of neuroplasticity. The study has been registered at https://ClinicalTrials.gov (NCT07216664).</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"464-478"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Targeted Exercise Program on Pain, Balance, Proprioception, and Function in Adults With Knee Osteoarthritis.","authors":"Vahid Mohammadi, Saeedeh Mohebitabar, Gholam Rasul Mohammad Rahimi","doi":"10.1177/10998004261425677","DOIUrl":"10.1177/10998004261425677","url":null,"abstract":"<p><p>Knee osteoarthritis (OA) is associated with pain and reduced functional performance, increasing fall risk in older adults. While conventional physiotherapy is widely used, limited evidence exists regarding the added value of exercise programs on proprioception and balance outcomes. This study aimed to evaluate the effects of a structured four-week exercise program, in combination with conventional physiotherapy, on function, pain, proprioception, and balance in adults with knee OA. Thirty participants (aged 50-65 years) with clinically diagnosed knee OA were randomly assigned to either an experimental group (<i>n</i> = 15), which received conventional physiotherapy (including electrotherapy, manual therapy, and therapeutic modalities) combined with structured exercise, or a control group (<i>n</i> = 15), which received conventional physiotherapy alone. Outcome measures included knee function, pain, proprioception, and static balance. Data were analyzed using repeated measures ANOVA. Both groups showed significant pre-to post-test improvements across all outcomes (<i>p <</i> .05). However, the experimental group achieved markedly greater gains in proprioception (-33.85% and -36.04% at 30° and 60°, respectively), static balance (+25.13% eyes-open, +42.25% eyes-closed), and functional reach (+10.87%) compared with the control group. Pain reduction was also greater in the experimental group (-28.02% vs. -19.37%). Improvements in knee function were observed in both groups, with no significant group-by-time interaction. Integrating a targeted exercise program with physiotherapy leads to superior improvements in sensorimotor and functional outcomes in individuals with knee OA. These findings support non-pharmacological strategies to enhance mobility and reduce fall risk in this population.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"418-426"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Obstructive Sleep Apnea Among Community-Based Overweight and Obese Type 2 Diabetes Mellitus Patients: A Multisite Cross-Sectional Study.","authors":"Mei-Hsiang Lin, Ping-Ru Hsiao, Ning-Hung Chen, Chao-Chung Ho, Hsiu-Chin Hsu","doi":"10.1177/10998004261423490","DOIUrl":"10.1177/10998004261423490","url":null,"abstract":"<p><p><b>Background:</b> Although obstructive sleep apnea (OSA) frequently coexists with type 2 diabetes mellitus (T2DM), many cases remain undiagnosed, particularly among overweight or obese individuals. Objectives: This study aimed to determine the risk factors associated with OSA among overweight or obesity T2DM. <b>Methods:</b> A multicenter cross-sectional descriptive design was conducted from September 2023 to April 2024. A total of 422 T2DM participants were recruited from four Diabetes Shared Care Network clinics in Taiwan. The Pittsburgh Sleep Quality Index, Epworth Sleep Scale, and a portable sleep monitoring device were used for data collection. A hierarchical multiple regression analysis was conducted to identify the factors affecting T2DM patients with OSA, and a multinomial logistic regression analysis was used to examine the major influence factors for each OSA severity level. <b>Results:</b> 80.3% of the T2DM participants were found to have OSA; 51.8% had moderate to severe OSA. After controlling the confounding variables, age, number of comorbidities, BMI, neck circumference, snoring times, and pulse rate were significant predictors of Apnea-Hypopnea Index (AHI). Furthermore, severe OSA was significantly related to age, BMI, gender, pulse rate, and snoring times. <b>Conclusions:</b> Up to 80.3% of participants with T2DM were found to have OSA. Higher BMI, neck circumference, number of comorbidities, age, pulse rate, and snoring frequency were significantly associated with OSA. Notably, BMI and age were the most significant predictors across mild, moderate, and severe OSA. Therefore, it is strongly recommended that patients with overweight or obese T2DM undergo routine OSA screening to ensure timely diagnosis and optimize management.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"395-405"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol Analysis Using a Novel Method of Saliva Collection: Method and Application in Preterm Infants.","authors":"Marliese Dion Nist, Nicole Cistone, Claire Packer, Abigail B Shoben, Christine A Fortney, Rita H Pickler","doi":"10.1177/10998004261438483","DOIUrl":"10.1177/10998004261438483","url":null,"abstract":"<p><p>Preterm infants experience frequent stressors that activate the hypothalamic-pituitary-adrenal (HPA) axis. Cortisol can be readily quantified in saliva samples, but sufficient saliva volumes are difficult to collect from preterm infants. We report the development and validation of a novel method to collect saliva using flocked polyester swabs and the application of this method in a study of preterm infants. Saliva samples, collected from adult participants (<i>N</i> = 24), were divided and processed as \"standard\" aliquots and aliquots absorbed by and extracted from flocked polyester swabs. Cortisol levels in \"standard\" and \"swab\" aliquots were compared. We then collected saliva samples from preterm infants (<i>N</i> = 31) using flocked polyester swabs to measure HPA responses to routine, clustered nursing care. Saliva samples were collected from each infant prior to caregiving, 30-min after caregiving, and 60-min after caregiving. Aliquots from the same adult were highly correlated. Sufficient volumes of saliva were extracted from 91 of 93 infant swabs (98%). Changes in cortisol levels from baseline to 30-min and 60-min after caregiving were negatively associated with acute procedural stress, quantified using the Neonatal Infant Stressor Scale. The change in cortisol level from baseline to 60-min after caregiving was negatively associated with caregiving duration. Further research is needed to understand the relationship between caregiving stress exposure and HPA axis responses in preterm infants and to identify the myriad factors that may influence this association. Flocked polyester swabs offer a viable option for the collection of sufficient volumes of saliva to support this research.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"479-488"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of I-Shaped Kinesiotaping on Pain, Functionality, and Wound Healing After Lumbar Disc Surgery: A Randomised Controlled Trial.","authors":"Gülşah Bilgin, Emine Öncü, Melih Çekinmez","doi":"10.1177/10998004261416820","DOIUrl":"10.1177/10998004261416820","url":null,"abstract":"<p><p>Background and AimKinesiotape is commonly used as a complementary therapy, but its results can vary substantially. This study aims to evaluate the effects of I-shaped kinesiotaping on patients' pain levels, functionality, and wound healing after lumbar disc surgery.DesignPlacebo-randomized controlled trial.SettingsA public hospital.ParticipantsEighty patients undergoing lumbar discectomy, with a mean age of 49.9 ± 13.1 years, were randomized to either the kinesiotaping (kinesio) or placebo group.InterventionThe kinesio group had I-shaped kinesiotape applied 24 hours after surgery and on postoperative days 5, 10, 15, and 20, while the placebo group received placebo taping.Main MeasuresA visual analog scale for pain, analgesic medication use, the Oswestry Disability Index, the Functional Low Back Pain Scale, and wound healing were assessed on the 1st, 5th, 10th, 15th, and 30th days post-surgery.ResultsSignificant time effects were observed for both groups, with the kinesio group showing reductions in pain, analgesic medication use, and disability, along with improvements in functionality (effect size ƞ² = 0.435-0.713, <i>p</i> < 0.001). The placebo group showed similar changes (effect size ƞ² = 0.567-0.714, <i>p</i> < 0.001). No significant group or interaction effects were found.ConclusionsPost-lumbar disc surgery, kinesiotaping did not show significant advantages in pain control, analgesic use reduction, disability improvement, or wound healing. The trial protocol is available on https://ClinicalTrials.gov (NCT05476718) (https://clinicaltrials.gov/study/NCT05476718).</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"362-374"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Insights Into Maternal Antidepressant Use and the Human Infant Gut Microbiome.","authors":"Katelyn Desorcy-Scherer, Kerry McNamara, Ryan Luellwitz, Eliot Stanton, Ibrahim Zuniga-Chaves","doi":"10.1177/10998004261423546","DOIUrl":"10.1177/10998004261423546","url":null,"abstract":"<p><p>Maternal selective serotonin reuptake inhibitor (SSRI) use is common during pregnancy and lactation. Changes in serotonin signaling may affect diversity and composition of microbes in the gut. Although research suggests SSRI drives microbial change, the extent to which the infant gut microbiome is affected is unknown. The infant gut microbiome is critical in early life for support of developmental health including early training of the immune system and metabolic programming. A total of <i>N</i> = 20 (10 SSRI, 10 control) maternal/infant dyads were enrolled in a pilot study. Thirty-six infant stool samples were collected at 1-2 and 4-6 weeks of life and sequenced using 16S rRNA sequencing. Investigative models included SSRI exposure as the primary variable of interest with infant feeding pattern and mode of delivery included as covariates. Maternal antidepressant use was not associated with infant alpha (within-sample) diversity. The SSRI use may shape beta (between-sample) diversity, particularly at weeks 4-6 of life (<i>p =</i> .072). Increases in the genera <i>Gemella</i>, <i>Staphylococcus</i> and <i>Corynebacterium</i> were observed with SSRI exposure. Additionally, results reveal a SSRI-associated decrease in <i>Lactobacillus</i>. While this pilot study is not intended to provide conclusive evidence, it is an important step in informing future research directions. Results suggest a modest influence of maternal SSRI exposure on the infant gut microbiome. Future studies should seek to use techniques like metagenomics, providing functional information to assess for local or systemic health impact and ultimately, clinical relevance.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"406-417"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining mRNA-miRNA Interactions and Gene Expression in Overweight and Obesity.","authors":"Claudia Colina Prisco, Nicolaas H Fourie, Yupeng Wang, Meaghan Steck, Marcel de Jesús Vega, Letitia Y Graves-Dixon, Rosario B Jaime-Lara, Wendy A Henderson, Paule V Joseph","doi":"10.1177/10998004261433237","DOIUrl":"10.1177/10998004261433237","url":null,"abstract":"<p><p>Obesity is characterized by excess adipose tissue, metabolic imbalance, and persistent low-grade inflammation, all of which can affect brain centers and their communication with peripheral organs. The genetic basis of obesity is complex, involving genetics, metagenomics, and gene-environment interactions that impact gene expression. Micro-RNAs (miRNAs) are small, single-stranded, non-coding RNAs that post-transcriptionally regulate the translational rates of target messenger RNAs (mRNAs). Exploring miRNA-mRNA interactions in obesity offers insights into molecular processes, potential biomarkers, and therapeutic targets of this condition. The current study examined the interplay between miRNA and mRNA collected from individuals with overweight and obesity, and normal weight controls. To our knowledge, this is the first experimental attempt to construct a comprehensive dataset of miRNA-mRNA interactions in overweight and obesity. Total RNA, including miRNA, was isolated from venous blood samples collected from 95 participants. Subsequently, 100 ng of RNA from each sample was analyzed using the NanoString quantitative assay. Quantile normalization, the Bayesian-based method Combat, multi-variable linear regression, over-representation, weighted gene correlation network analyses, and functional analyses were conducted. We found an association between IQGAP1 and DAZAP2 genes and miRNA-20-a and miRNA-2113. IQGAP1 and DAZAP2 were associated with insulin signaling and energy metabolism and insulin sensitivity, respectively. We also identified a positive correlation between peripheral cortisol levels and miRNA-548 with alterations in metabolic processes and the immune system. This suggests that miRNA-mRNA interactions in overweight and obesity may impact insulin sensitivity, metabolism, and immunity, providing novel insight into miRNA-mRNA interactions in overweight and obesity. (ClinicalTrials.gov identifier #NCT00824941; https://clinicaltrials.gov/study/NCT00824941).</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"427-444"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent Breathing Training Using a Digital Device for Postoperative Lung Cancer Patients: A Randomized Controlled Trial.","authors":"Li Chen, Jialiang Liu, Haifeng Xia, Lingyan Jiang, Shiyu Shen","doi":"10.1177/10998004251411972","DOIUrl":"10.1177/10998004251411972","url":null,"abstract":"<p><p><b>Background:</b> Surgical resection is the primary curative treatment for lung cancer, but postoperative pulmonary dysfunction, reduced exercise tolerance, and impaired quality of life are common challenges. This study aimed to evaluate the effectiveness of intelligent breathing training in improving postoperative outcomes for lung cancer patients. <b>Methods:</b> A single-center randomized controlled trial was conducted among eligible lung cancer patients who underwent partial lung resection (July 2024-July 2025). Patients were randomized 1:1 to the intervention group (intelligent breathing training plus routine care) or the control group (routine care). A total of 138 patients were randomized to either the intervention group (<i>n</i> = 68) or the control group (<i>n</i> = 70). Outcomes were assessed at preoperation (T0), discharge (T1), 1 month (T2), and 3 months (T3) postoperatively. <b>Results:</b> At T1, T2, and T3 postoperatively, the intervention group demonstrated significantly superior pulmonary function compared to the control group (all <i>p <</i> 0.05), including higher forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and peak expiratory flow (PEF). Additionally, the intervention group achieved significantly longer 6-min walk distances, higher physical domain scores on the World Health Organization Quality of Life-100 (WHOQOL-100) scale, and lower scores on the Psycho-Social Adjustment to Illness Scale (PAIS-SR) at all postoperative time points (all <i>p</i> < 0.001). <b>Conclusion:</b> Intelligent breathing training effectively improves postoperative pulmonary function, exercise tolerance, and quality of life in lung cancer patients. It provides a feasible and superior alternative to traditional rehabilitation, supporting the integration of intelligent devices into clinical nursing practice.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"333-345"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychobiological Predictors of Cardiovascular Disease Risk in Veterans: Associations Among PTSD, Homocysteine, and B Vitamins.","authors":"Christina Coyle","doi":"10.1177/10998004261433527","DOIUrl":"10.1177/10998004261433527","url":null,"abstract":"<p><p>Post-traumatic stress disorder (PTSD) is associated with increased cardiovascular disease (CVD) morbidity and mortality, yet the biological mechanisms linking psychological trauma to cardiovascular risk remain incompletely understood. Disruptions in one-carbon metabolism, reflected by elevated homocysteine and altered folate and vitamin B12 levels, contribute to vascular inflammation and endothelial dysfunction and may represent a modifiable pathway linking PTSD to CVD. The purpose of this study was to examine relationships among physiological biomarkers (homocysteine, folate, vitamin B12), PTSD diagnosis, PTSD treatment participation, and CVD risk in a veteran population. A quantitative, comparative retrospective chart review was conducted among 279 U.S. veterans with documented homocysteine levels. CVD risk was categorized as high or low-to-moderate based on metabolic and vascular risk factors. Logistic regression, odds ratios, and chi-square analyses were used to examine predictors of CVD risk and elevated homocysteine. The Neuman Systems Model guided variable selection and interpretation. Elevated homocysteine was significantly associated with age, gender, race, systolic blood pressure, folate, vitamin B12, PTSD diagnosis (OR = 4.31, 95% CI [1.36-13.61]), and CVD risk (OR = 3.50, 95% CI [1.01-12.05]). Participation in PTSD treatment was significantly associated with homocysteine levels (OR = 6.43, 95% CI [2.02-20.45]). Findings support homocysteine as a clinically relevant biomarker linking PTSD and cardiovascular risk. The association between PTSD treatment and homocysteine suggests psychological interventions may influence biological pathways relevant to cardiovascular health, underscoring the value of biomarker-informed nursing assessment in trauma-exposed populations.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"445-454"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}