Biological research for nursing最新文献

{"title":"The Association of Perceived Stress, Glucocorticoids Receptors, and Corticotropin-Releasing Hormone Gene Expression During Pregnancy.","authors":"Marlene Brennen, Ruth Tappen, Vanessa Johnson","doi":"10.1177/10998004251336366","DOIUrl":"https://doi.org/10.1177/10998004251336366","url":null,"abstract":"<p><p>The preterm birth rate and the maternal mortality rate are 1.6 and 2.6 times higher for Black women than for White women, respectively, in the United States. This disproportionate difference in maternal health outcomes is a notable health inequity. The purpose of this study was to evaluate the influence of perceived stress, and glucocorticoid receptors (GR) on histone acetylation (HAT) of the corticotropin-releasing hormone (CRH) gene between non-Hispanic Black and non-Hispanic White women in their second trimester of pregnancy. This study used a cross-sectional design to analyze secondary, deidentified data including peripheral blood monocyte cells, from a prior study. The study sample consisted of 32 non-Hispanic Black women and 73 non-Hispanic White women from the parent study. A four-step hierarchical linear regression analysis was used to analyze the influence of race, perceived stress, and GR on the HAT of the CRH gene. The hierarchical linear regression analysis found that race, perceived stress, and GR significantly predicted the HAT of the CRH. GR explained 41.33% of the variation in HAT CRH of the gene, and age plus race explained an additional 3.56% of the variation in HAT CRH of the gene. The findings of this study suggest that perceived stress and GR among young Black women were associated with higher levels of HAT of the CRH gene, which may contribute to adverse pregnancy outcomes such as preeclampsia and preterm birth. These findings highlight stress-related factors contributing to maternal morbidity, and the need for a comprehensive approach to improving prenatal healthcare.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251336366"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between the Neutrophil-To-lymphocyte Ratio and Health-related Behaviors and Factors in Rural Adults With and Without Cardiometabolic Disease.","authors":"Hsiang-Ting Lu, Yu-Chih Lin, Tung-Jung Huang, Mei-Yen Chen","doi":"10.1177/10998004251336478","DOIUrl":"https://doi.org/10.1177/10998004251336478","url":null,"abstract":"<p><p>BackgroundComplete blood count (CBC) is a commonly used and cost-effective blood test in health screenings; however, its potential as a biomarker for early detection of chronic diseases remains underutilized. Previous studies have shown that the neutrophil-to-lymphocyte ratio (NLR) is associated with systemic inflammation and is correlated with cardiometabolic diseases (CMDs). Unhealthy lifestyles can trigger inflammatory responses and contribute to the progression of CMDs. This study aimed to explore the association between NLR levels, cardiometabolic risks, and health-related behaviors.MethodsA community-based, cross-sectional study was conducted in collaboration with a local hospital as part of an annual health screening for rural adults. The study outcomes included CMDs, health-related behaviors, and NLR levels. A multivariable quantile regression model, adjusted for confounding factors, was used to identify factors associated with NLR levels.ResultsA total of 11,220 participants were enrolled. CMDs prevalence was 25.8%, with hypertension and diabetes being most common. Nearly half of participants reported insufficient exercise, low water intake, and inadequate oral hygiene. Higher NLR was significantly associated with CMDs (<i>p</i> for trend <0.001). Older age (<i>p</i> < .01) and living alone (<i>p</i> < .01) were linked to higher NLR, while adequate water intake (<i>p</i> < .05) and regular exercise (<i>p</i> < .01) were associated with lower NLR levels.ConclusionsRural adults demonstrated a high prevalence of CMDs and inadequate health-related behaviors, which were associated with elevated NLR levels. Implementing NLR-guided lifestyle modifications and tailored health promotion programs may serve as innovative strategies to mitigate the progression of CMDs.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251336478"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Microbiology of Healthcare-Associated Infections in Neurosurgery Department: A Cross-Sectional Study.","authors":"Renata Jabłońska, Paweł Sokal, Magdalena Zając, Agnieszka Królikowska, Karolina Filipska-Blejder, Irena Wrońska, Robert Ślusarz","doi":"10.1177/10998004251336748","DOIUrl":"https://doi.org/10.1177/10998004251336748","url":null,"abstract":"<p><p><b>Objective:</b> Hospital-acquired infections (HAIs) present a significant challenge in neurosurgical settings. This study aimed to assess the prevalence, risk factors, and clinical impact of HAIs in a neurosurgery department. <b>Methods:</b> A retrospective cross-sectional study was conducted on 5474 patients hospitalized in <i>a</i> neurosurgery <i>department</i> (2019-2023). HAIs were diagnosed in 93 patients (2.7%), accounting for 147 infections. The final cohort included 273 patients: 93 with HAIs and 181 matched controls (age, sex, mortality). Demographic, clinical, and microbiological data were analyzed. Nutritional status was assessed using the Nutritional Risk Screening (NRS, 2002) and consciousness was assessed using the Glasgow Coma Scale (GCS). Infections were classified according to Centers for Disease Control and Prevention (CDC) criteria. <b>Results:</b> The most frequent HAIs were pneumonia (PN, 18.3%), bloodstream infections (BSI, 16.2%), and surgical site infections (SSI, 16.3%). Malnutrition (NRS ≥3) was significantly more common in infected patients (65.6% vs. 11%, <i>p</i> < .001). Patients with GCS ≤8 had higher rates of PN (44.7%) and urinary tract infections (UTI, 32.5%) (<i>p</i> = .004), while GCS 13-15 was linked to SSI (91.7%). HAIs occurred more frequently after emergency procedures (57.8% vs. 30%, <i>p</i> < .0001). Hospital stay was significantly longer in infected patients (40 vs. 5.4 days, <i>p</i> = .001). <i>Klebsiella pneumoniae</i> (15.1%) and <i>Staphylococcus aureus</i> (11.5%) were the most common. Age and sex were not significant risk factors. <b>Conclusion:</b> HAIs in neurosurgical patients are associated with malnutrition and procedural urgency. Targeted infection control, early nutrition support, and antimicrobial stewardship are essential to improving outcomes.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"10998004251336748"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers.","authors":"Hai Xu, Sheyuan Ding, Yu Tong, Qiong Zhang","doi":"10.1177/10998004241299375","DOIUrl":"10.1177/10998004241299375","url":null,"abstract":"<p><p><b>Background:</b> Obese patients are increasingly recognized as being at higher risk for skin diseases, particularly chronic wounds. While the exact mechanisms remain unclear, obesity is suspected to influence the development of chronic injuries via inflammatory biomarkers. Single nucleotide polymorphisms (SNPs) may further influence gene expression, protein function, and levels of inflammatory biomarkers through various mechanisms, thereby modulating inflammatory responses that contribute to wound pathogenesis. <b>Methods:</b> A two-sample two-step Mendelian Randomization (MR) was employed to explore the causal relationship between obesity and chronic wounds, focusing on the mediating role of inflammatory biomarkers. SNPs were used as instrumental variables (IVs) to infer causality. Obesity-related genetic data were sourced from the UK Biobank and GIANT consortium. Genome-wide association studies provided data on 92 inflammatory biomarkers, involving 14,824 and 575,531 individuals. Pressure injuries, lower limb venous ulcers, and diabetic foot ulcer data were obtained from FinnGen R10 and the Pan-UK Biobank. <b>Results:</b> Obesity significantly increased the risk of pressure injuries, lower limb venous ulcers, and diabetic foot ulcers. CCL19, hGDNF, IL-12B, and TNFRSF9 were identified as mediators in obesity-induced lower limb venous ulcers. <b>Conclusion:</b> This study provides genetic evidence that obesity leads to lower limb venous ulcers via inflammatory biomarkers, suggesting potential therapeutic targets for intervention.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"326-338"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Walking Exercise in Improving Physical Fitness and Depression in Patients With Schizophrenia.","authors":"Mei-Ling Huang, Miao-Chuan Chen","doi":"10.1177/10998004241290526","DOIUrl":"10.1177/10998004241290526","url":null,"abstract":"<p><p>Patients with schizophrenia often lack physical activity, which, together with physical complications, can lower their expected lifespan. Exercise strengthens their physical and mental health. The primary aim of this study was to examine the effectiveness of a walking exercise intervention in improving physical fitness, body mass index, waist-to-hip ratio, and depressive symptoms in patients with schizophrenia. A quasi-experimental study design was used. Seventy-six participants were recruited from the psychiatric daycare center at a hospital in Northern Taiwan. They were divided into two groups. The intervention group received a walking exercise intervention, while the control completed their daily courses at the psychiatric daycare center. The changes in both groups' physical fitness, BMI, waist-to-hip ratio, and depressive symptoms were monitored. Cardiorespiratory endurance significantly improved in the intervention group, attesting to the effectiveness of the walking exercise intervention. Their depression level significantly decreased across all measurement stages. The group walking exercise reduced sedentary behaviors and increased the participants' autonomous motivation, hip circumference, and cardiorespiratory fitness. Structured exercise programs may increase the patients' hippocampal neuroplasticity and reduce their depressive symptoms. The walking exercise intervention positively affected physiological traits, physical fitness, and mental health of the participants.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"229-235"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Prediction Model for Dysphagia in Community-Dwelling Older Adults.","authors":"Yufeng Qiu, Wenfeng Xue, Yanxin Chen, Xiaona He, Lancai Zhao, Mengling Tang, Huafang Zhang","doi":"10.1177/10998004241290727","DOIUrl":"10.1177/10998004241290727","url":null,"abstract":"<p><p><b>Objectives.</b> Dysphagia is a geriatric syndrome, which may lead to complications such as dehydration, malnutrition, aspiration, pneumonia, and a significant reduction in quality of life. The purpose of this study was to construct and validate a prediction model for dysphagia in community-dwelling older adults and provide an assessment tool for the prevention and control of dysphagia. <b>Design.</b> Cross-sectional study. <b>Setting.</b> The community-dwelling Chinese older adults. <b>Participants.</b> 3655 participants aged 65 years and older were involved, who were randomly divided into the training set and the validation set. <b>Methods.</b> Data were collected and analyzed from June 2022 to September 2022. Univariate and multivariate logistic regression analysis were used to identify independent risk factors for dysphagia. We applied R software to develop a nomogram model to predict dysphagia in community-dwelling older adults. The predictive value of the model was assessed by the area under the ROC curve (AUC), the calibration curve was used to evaluate the reliability of the nomogram model for predicting dysphagia in community-dwelling older adults. The model's clinical utility was further evaluated using a Decision Curve Analysis (DCA). <b>Results.</b> The incidence of dysphagia was 11.8% (320/3655). Maximum tongue pressure, number of molars, pneumonia, ADL, sarcopenia, age, neurological diseases, and rheumatic immune diseases were selected as risk predictors for dysphagia. The prediction model demonstrated fair discriminative ability with the AUC was 0.709 (95%CI: 0.679-0.739) in the training set and 0.693 (95%Cl: 0.640-0.747) in the validation set, the calibration is adequate, and the Hosmer and Lemeshow test showed <i>p</i> values of 0.163 and 0.415, respectively. The DCA curve of our model shows a positive clinical net benefit. <b>Conclusions.</b> The prediction model established in this study was of a certain predictive value for the risk of dysphagia in community-dwelling older adults. By estimating the likelihood of future outcomes or the onset of certain diseases, it can assist medical personnel in formulating preventive strategies, lessening the workload of nurses, and also diminishing the financial burden on patients, thereby enhancing their overall quality of life.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"300-315"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.","authors":"Jong Y Park, Cecile A Lengacher, Carmen S Rodriguez, Hongdao Meng, Kevin E Kip, Sandra Morgan, Anisha Joshi, Gizem Hueluer, Julia R Wang, Sara Tinsley, Charles Cox, John Kiluk, Kristine A Donovan, Manolete Moscoso, Elizabeth Bornstein, Jean M Lucas, Tamela Fonseca, Mahathi Krothapalli, Lynne S Padgett, Sreenidhi Nidamanur, Estella Hornback, Diya Patel, Ramya Chamkeri, Richard R Reich","doi":"10.1177/10998004241289629","DOIUrl":"10.1177/10998004241289629","url":null,"abstract":"<p><strong>Background: </strong>Genetics may influence symptoms experienced by breast cancer survivors (BCS) by moderating the effects of stress-reducing interventions, including the Mindfulness-Based Stress Reduction (MBSR(BC)) program, to reduce symptom severity. As part of a larger clinical trial, the aim of this study was to evaluate genetic variants as moderators of MBSR(BC) on improvements among BCS in cognitive functioning and symptoms.</p><p><strong>Methods: </strong>BCS (<i>n</i> = 128) were randomized to MBSR(BC) or the Breast Cancer Education Support Program. Objective neuropsychological and subjective measures of cognitive performance, and psychological and physical symptoms were collected at baseline, 6, 12, and 26 weeks. Linear mixed models were implemented to identify MBSR(BC)'s effects over time. A total of 22 single nucleotide polymorphisms (SNPs) from 20 genes known to be related to these symptoms were investigated using genomic DNA. These SNPs were tested as moderators of MBSR(BC) program effects.</p><p><strong>Results: </strong>Results showed MBSR(BC) participants experienced significantly greater benefits in cognitive functioning, however, the level of benefit varied based on one's genetic profile. Effects sizes, consistency across similar measures were investigated. Among 22 candidate SNPs, rs4680 in COMT, rs1800497 in ANKK1, and rs6277 in DRD2 demonstrated the strongest, most consistent positive effects in moderating MBSR(BC)'s impact on cognitive outcomes.</p><p><strong>Conclusions: </strong>Although the effects were small, this translational research may potentially identify BCS with genotypes that would be most influenced by the MBSR(BC) program. These results may be used to develop personalized intervention programs tailored to the genetic profile of each breast cancer survivor who received chemotherapy or chemotherapy and radiation.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, https://www.ClinicalTrials.gov Registration Number: NCT02786797.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"216-228"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure Symptoms Improve With More Intense Physical Activity.","authors":"Jonathan P Auld, Elaine A Thompson, Cynthia M Dougherty","doi":"10.1177/10998004241290827","DOIUrl":"10.1177/10998004241290827","url":null,"abstract":"<p><strong>Background: </strong>Little is known about how changes in physical activity (PA) over time may influence symptoms in people with heart failure (HF).</p><p><strong>Methods: </strong>A secondary analysis was conducted with data from an RCT of an exercise intervention in patients with ICDs (implantable cardioverter defibrillator) and a HF diagnosis (<i>n</i> = 96). Data were collected at baseline and 2 months of PA intervention. Physical activity (PA Steps = mean steps/day; PA Intensity = mean steps/min for most intense 30 minutes/day) were measured over 5 days at each timepoint. Physical symptoms were measured using the Patient Concerns Assessment, the SF-36 Vitality, and Bodily Pain subscales for fatigue and pain. Psychological symptoms were assessed using the Patient Health Questionnaire-9, and the State-Trait Anxiety Index. Associations between PA and physical and psychological symptoms were analyzed with multivariate regression.</p><p><strong>Results: </strong>Patients (<i>n</i> = 96) were predominately male (83%) and Caucasian (79%), aged 55.8 ± 12.3 years, BMI of 29.7 ± 5.1, with heart failure with reduced ejection fraction (HFrEF; 30.9 ± 9.9%). An <i>increase</i> in PA Steps was associated with improvement in anxiety (β = -1.178, <i>p =</i> .048). An <i>increase</i> in PA Intensity was associated with significant reductions in depression (β = -0.127, <i>p =</i> .021), anxiety (β = -0.234, <i>p =</i> .037), and fatigue (β = 0.528, <i>p =</i> .022). <i>Decreases</i> in PA Steps and PA Intensity were not associated with changes in any symptoms.</p><p><strong>Conclusion: </strong>For HF patients with an ICD, more intense PA over 2 months was associated with improved psychological symptoms and reduced fatigue. Decreases in PA (total and intensity) were not associated with changes in symptoms. Interventions promoting increasing the intensity of PA over time may be an effective approach to reduce some HF symptoms.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"236-245"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Association of Chronic Pains and Analgesics With Telomere Length: A Mendelian Randomization Study.","authors":"Jiahe Chen, Haotian Liu, Yulin Pang, Yubo Wang, Ziqi Ren, Jianli Liu, Yang Nan, Dan Liu","doi":"10.1177/10998004241303536","DOIUrl":"10.1177/10998004241303536","url":null,"abstract":"<p><p><b>Objective:</b> The aim of this study was to explore the causal relationships between chronic pains (back pain, facial pain, general pain, headaches, knee pain, hip pain, neck/shoulder pain, stomach/abdominal pain) and analgesics (codeine, diclofenac, ibuprofen, morphine, paracetamol, tramadol) with telomere length using Mendelian randomization methods. <b>Methods:</b> In the study, various statistical methods including inverse variance weighted (IVW), Mendelian Randomization-Egger, weighted median, simple mode, and weighted mode were used to investigate the relationships between chronic pains, analgesics, and telomere length. Heterogeneity and pleiotropy tests were conducted to ensure the accuracy of the results. <b>Results:</b> The results of the IVW analysis revealed positive causal relationships between hip pain (odds ratio (OR): 1.145; 95% confidence interval (CI): 1.021-1.285; <i>p</i> = .020), and stomach/abdominal pain (OR: 1.100; 95% CI: 1.008-1.200; <i>p</i> = 0.033) with telomere length. Use of tramadol (OR: 0.074; 95% CI: 0.009-0.605; <i>p</i> = 0.015) had a negative causal relationships with telomere length. <b>Conclusion:</b> This study found positive associations between hip pain and stomach/abdominal pain with telomere length, and a negative association between tramadol and telomere length. However, no significant causal relationships were found with other types of chronic pains and analgesics. This could help develop healthier chronic pain treatments, avoiding the abuse of analgesics.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"282-290"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Impact of Serum Calcium Levels on Acute Coronary Syndrome Risk: A 19-Year Cohort Study in Korea.","authors":"Eujene Jung, Dong Ki Kim, Seok Jin Ryu, Hyun Ho Ryu","doi":"10.1177/10998004241295360","DOIUrl":"10.1177/10998004241295360","url":null,"abstract":"<p><p><b>Background:</b> This study aims to investigate the association between serum calcium levels and acute coronary syndrome (ACS) risk, examining whether this relationship differs by sex, given the known differences in calcium metabolism and hormonal influences between males and females. <b>Methods:</b> Utilizing the Korean Genome Epidemiology Study (KoGES) prospective cohort data, our primary exposure variables were serum calcium level and sex. The incidence of ACS served as the main outcome of interest. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression analysis. An interaction analysis was conducted to assess the interaction effect of calcium level and sex on ACS incidence. <b>Results:</b> After adjusting for confounding variables, high calcium intake did not significantly increase ACS incidence, with a hazard ratio (HR) of 1.07 (95% CI: 0.90-1.26). There was also no significant difference in ACS risk between females and males (HR: 0.81, 95% CI: 0.61-1.04). However, interaction effect analysis revealed that higher calcium levels were associated with an increased risk of ACS only in females (HR: 1.24, 95% CI: 1.07-1.58), whereas the association in males was not statistically significant (HR: 0.90, 95% CI: 0.71-1.15). <b>Conclusion:</b> Our study results indicate that elevated serum calcium levels alone did not independently increase the risk of ACS; however, high serum calcium levels were associated with an increased risk of ACS in females but not in males, underscoring the importance of sex-specific factors in assessing and managing ACS risk and highlighting the necessity for personalized medical approaches to improve cardiovascular health outcomes for women.</p>","PeriodicalId":93901,"journal":{"name":"Biological research for nursing","volume":" ","pages":"246-254"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}