Biochimie最新文献_第4页

Hypothyroidism impacts mammary tumor-associated adipose tissue and breast cancer epithelial cell dialogue. 甲状腺功能减退影响乳腺肿瘤相关脂肪组织和乳腺癌上皮细胞对话。

IF 3

Biochimie Pub Date : 2025-08-09 DOI: 10.1016/j.biochi.2025.08.012

Leila E Zyla, Flavia A Bruna, Flavia E Santiano, Silvina E Gómez, Rocío Cano, Mariángeles Ávila Maniero, Elisa O Pietrobon, Paula M Ginevro, Fernando D Cuello-Carrión, Virginia Pistone-Creydt, Rubén W Carón, Constanza M López Fontana

{"title":"Hypothyroidism impacts mammary tumor-associated adipose tissue and breast cancer epithelial cell dialogue.","authors":"Leila E Zyla, Flavia A Bruna, Flavia E Santiano, Silvina E Gómez, Rocío Cano, Mariángeles Ávila Maniero, Elisa O Pietrobon, Paula M Ginevro, Fernando D Cuello-Carrión, Virginia Pistone-Creydt, Rubén W Carón, Constanza M López Fontana","doi":"10.1016/j.biochi.2025.08.012","DOIUrl":"10.1016/j.biochi.2025.08.012","url":null,"abstract":"Thyroid hormones play a key role in adipose tissue development and function. Hypothyroidism (HypoT) can delay mammary tumor development in rats, possibly by altering mammary adipose tissue (MAT) and its interaction with epithelial cells. To explore this hypothesis, we evaluated the effects of conditioned media derived from mammary adipose tissue (MAT-CMs) of hypothyroid (HypoT) and euthyroid (EUT) rats, with and without mammary tumors, on the behavior of mammary epithelial cells. Specifically, we assessed cell viability, proliferation, apoptosis, adhesion, and migration in tumorigenic (MCF-7, MDA-MB-231) and non-tumorigenic (MCF-10A) human mammary epithelial cell lines exposed to the MAT-CMs. Mammary tumors were induced in female Sprague-Dawley rats using 7,12-dimethylbenz[a]anthracene (15 mg/rat), and animals were randomly assigned to HypoT (0.01 % 6-N-propyl-2-thiouracil in drinking water; n = 30) or EUT (tap water; n = 30) groups. MAT fragments were incubated in M199 medium for 24 h, and the resulting CMs were collected and applied to cell cultures. In vivo, HypoT rats exhibited larger mammary fat pads, reduced tumor incidence, volume, and growth rate, and extended tumor-free survival. In vitro, non-tumor MAT-CMs from HypoT rats promoted apoptosis in MCF-10A cells, reduced viability and adhesion of MCF-7 cells, and increased proliferation while decreasing adhesion in MDA-MB-231 cells. Tumor MAT-CMs from HypoT rats stimulated proliferation in tumorigenic cells and inhibited apoptosis in MCF-10A cells. In conclusion, these findings indicate that HypoT modifies the secretory profile of MAT, with tumor MAT-CMs from HypoT potentially enhancing tumorigenic behaviors in mammary tumor cells.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring therapeutic targets with the HMM-SA structural alphabet: Methods, tools, and application to HIV-2 protease. 用HMM-SA结构字母表探索治疗靶点：方法、工具和对HIV-2蛋白酶的应用。

IF 3

Biochimie Pub Date : 2025-08-08 DOI: 10.1016/j.biochi.2025.08.001

Anne-Claude Camproux, Marine Baillif, Léa Dufay, Leslie Regad

{"title":"Exploring therapeutic targets with the HMM-SA structural alphabet: Methods, tools, and application to HIV-2 protease.","authors":"Anne-Claude Camproux, Marine Baillif, Léa Dufay, Leslie Regad","doi":"10.1016/j.biochi.2025.08.001","DOIUrl":"10.1016/j.biochi.2025.08.001","url":null,"abstract":"The rapid expansion of available three-dimensional protein structures-derived from both experimental techniques and bioinformatic predictions-offers unprecedented opportunities for drug discovery, particularly for targets that have historically been difficult to characterize. However, the effective analysis of these increasingly complex and voluminous structural datasets remains a major challenge. Efficient representations of protein conformations are essential to facilitate large-scale comparison, structural classification, and functional interpretation in therapeutic contexts. The concept of structural alphabets, introduced by Pr S. Hazout in 1999, provides a robust and scalable framework to represent local protein backbone conformations using a limited set of recurring structural motifs. This representation enables a one-dimensional encoding of three-dimensional protein structures that retains essential geometric features beyond secondary structure, while allowing systematic and interpretable analyses. In this review, we focus on HMM-SA, a structural alphabet constructed using a hidden Markov model. HMM-SA defines 27 structural motifs, including 18 regions specifically dedicated to loops, and captures the statistical dependencies between them. We present a detailed overview of the HMM-SA framework, and of the computational tools derived from this structural alphabet, developed to explore protein function, conformational variability, and the structural determinants of molecular recognition. The utility of HMM-SA is illustrated through a case study on HIV-2 protease (PR2), a critical enzyme in antiretroviral drug development. By analyzing PR2 structural asymmetry, ligand-induced conformational changes, and mutation-driven alterations, we highlight the ability of HMM-SA-based methods to identify key structural features involved in ligand specificity and resistance mechanisms, thereby advancing therapeutic target analysis.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In memoriam of professor Serge Hazout (1950-2005) - a bioinformatics pioneer in France. 纪念法国生物信息学先驱塞尔日·哈佐特教授（1950 - 2005）。

IF 3

Biochimie Pub Date : 2025-08-08 DOI: 10.1016/j.biochi.2025.08.005

Alexandre G de Brevern

引用次数: 0

A clot to uncover: SARS-CoV-2 nucleocapsid can outcompete the FOXP3 forkhead domain for DNA binding in vitro. 一个有待发现的凝块：SARS-CoV-2核衣壳可以在体外与FOXP3叉头结构域竞争DNA结合。

IF 3

Biochimie Pub Date : 2025-08-07 DOI: 10.1016/j.biochi.2025.08.006

Keiran McInnes, Sylvia Fanucchi

{"title":"A clot to uncover: SARS-CoV-2 nucleocapsid can outcompete the FOXP3 forkhead domain for DNA binding in vitro.","authors":"Keiran McInnes, Sylvia Fanucchi","doi":"10.1016/j.biochi.2025.08.006","DOIUrl":"10.1016/j.biochi.2025.08.006","url":null,"abstract":"During COVID-19, systemic coagulopathy can lead to strokes and embolisms and may also contribute to long COVID. This coagulopathy is the result of overactivated platelets in circulation that lead to inappropriate clot formation. FOXP3 is a transcription factor involved in platelet development. Loss of FOXP3 function leads to abnormal platelets resembling those seen during COVID-19. Thus, FOXP3 may be dysregulated in COVID-19. The SARS-CoV-2 nucleocapsid (NC) is a multifunctional protein typically associated with viral genome packaging and virion assembly. However, it is also capable of binding DNA and may alter host gene expression. Here, potential interactions between the DNA-binding forkhead domain (FHD) of FOXP3 and the SARS-CoV-2 NC were investigated. Identification of a novel interaction between FOXP3 and SARS-CoV-2 NC may provide new clues to the pathophysiology of COVID-19. To address this aim, both proteins were overexpressed in T7 E. coli, purified via immobilised metal affinity chromatography, and monitored for interactions in the absence and presence of DNA using pull-down assays, electrophoretic mobility shift assays, and fluorescence anisotropy. A direct interaction was identified between the two proteins in the absence of DNA in vitro. Additionally, both proteins were found to bind DNA simultaneously under limiting conditions, but competed for binding under saturating conditions, where excess NC led to dissociation of FHD from the FHD-NC-DNA complex. This result implicates NC in FOXP3 dysfunction, potentially contributing to the coagulopathy and other symptoms observed during COVID-19. This work may inform future therapeutic strategies for severe COVID-19.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic acids inhibit local and systemic effects induced by Bothrops brazili venom. 酚酸抑制巴西红腹虫毒液引起的局部和全身效应。

IF 3

Biochimie Pub Date : 2025-08-06 DOI: 10.1016/j.biochi.2025.08.003

Sarah de Sousa Ferreira, Diana Pontes da Silva, Manoela Torres-Rêgo, Allanny Alves Furtado, Eduardo Augusto da Silva Diniz, Karla Patrícia de Oliveira Luna, Arnóbio Antônio da Silva-Júnior, Renata Mendonça Araújo, Marcela Abbott Galvão Ururahy, Davi Serradella Vieira, Matheus de Freitas Fernandes-Pedrosa

{"title":"Phenolic acids inhibit local and systemic effects induced by Bothrops brazili venom.","authors":"Sarah de Sousa Ferreira, Diana Pontes da Silva, Manoela Torres-Rêgo, Allanny Alves Furtado, Eduardo Augusto da Silva Diniz, Karla Patrícia de Oliveira Luna, Arnóbio Antônio da Silva-Júnior, Renata Mendonça Araújo, Marcela Abbott Galvão Ururahy, Davi Serradella Vieira, Matheus de Freitas Fernandes-Pedrosa","doi":"10.1016/j.biochi.2025.08.003","DOIUrl":"10.1016/j.biochi.2025.08.003","url":null,"abstract":"Bothropic envenomation induces local damage, such as edema, necrosis, and hemorrhage, as well as systemic effects, including cardiovascular, renal and coagulation disturbances. While serum therapy remains, the primary treatment used for snakebites and efficiently neutralizes systemic damage, it inadequately addresses local tissue injury. Aiming to understand the pathophysiological mechanism of Bothrops brazili envenomation and explore novel complementary treatments, this study evaluated the local and systemic injuries caused by B. brazili venom and their mitigation by chlorogenic and rosmarinic acids. The venom exhibited high proteolytic and phospholipase activities, caused inflammation with edema formation, increased myeloperoxidase and cytokine dosage (IL-1β and IL-6). These effects were attenuated by phenolic acids. Molecular docking analysis assessed the interaction of these acids with B. brazili venom toxins, specifically catalytic PLA2 (BbTX-III) and non-catalytic Lys49-PLA2 (MTX-II). Chlorogenic and rosmarinic acids showed superior binding energies with MTX-II (-135.5683 ± 45.8415 kcal/mol and -166.8876 ± 17.7874 kcal/mol, respectively) compared to BbTX-III (-120.0387 ± 7.4546 kcal/mol and -114.3389 ± 15.4885 kcal/mol, respectively). Furthermore, these acids reduced myotoxicity, hemorrhage, hemostatic disturbances, and kidney and liver injuries, as well as leukogram and platelet alterations induced by B. brazili venom. The chlorogenic and rosmarinic acids demonstrated antiophidic potential by inhibiting both the local and systemic effects of envenomation. These findings suggest that their potential use as complementary therapies against envenomation caused by B. brazili.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent clinical, inflammatory, and histopathological responses induced by Amazonian Tityus venoms: insights and limitations of current antivenom therapy. 亚马逊Tityus毒液诱导的不同临床，炎症和组织病理学反应：当前抗蛇毒血清治疗的见解和局限性。

IF 3

Biochimie Pub Date : 2025-08-06 DOI: 10.1016/j.biochi.2025.08.004

Karina Furlani Zoccal, Karla de Castro Figueiredo Bordon, Mouzarllem Barros Reis, Paloma Beatriz Rosa Nunes de Souza Chini, Jonas Gama Martins, Beatriz Acquaroni Zuanazzi, Gisele Adriano Wiezel, Ana Carolina Campos Dos Santos, Rudi Emerson de Lima Procópio, Eliane Candiani Arantes

{"title":"Divergent clinical, inflammatory, and histopathological responses induced by Amazonian Tityus venoms: insights and limitations of current antivenom therapy.","authors":"Karina Furlani Zoccal, Karla de Castro Figueiredo Bordon, Mouzarllem Barros Reis, Paloma Beatriz Rosa Nunes de Souza Chini, Jonas Gama Martins, Beatriz Acquaroni Zuanazzi, Gisele Adriano Wiezel, Ana Carolina Campos Dos Santos, Rudi Emerson de Lima Procópio, Eliane Candiani Arantes","doi":"10.1016/j.biochi.2025.08.004","DOIUrl":"10.1016/j.biochi.2025.08.004","url":null,"abstract":"Scorpion stings are considered a neglected condition and represent a serious health problem in many tropical countries, especially for children and the elderly. In Brazil, the yellow scorpion (Tityus serrulatus) is widely found and responsible for the majority of severe envenoming cases; however, other medically relevant species endemic to the Brazilian Amazon region, such as Tityus silvestris, Tityus metuendus and Tityus obscurus, remain underexplored. In the present study, we characterized the clinical, inflammatory and histopathological responses induced by venoms from these Amazonian species in a murine model (Balb/c mice), using T. serrulatus as a reference. Envenomation with T. silvestris resulted in pronounced systemic manifestations, including elevated clinical scores, hyperglycemia, leukocytosis, cytokine release (IL-6, IL-1β, IL-10), and tissue injury in the lungs and kidneys, comparable to the pathophysiological manifestations from T. serrulatus venom. In contrast, T. metuendus and T. obscurus induced milder inflammatory profiles. It is noteworthy that cross-reactivity assays revealed limited immunoreactivity and reduced in vivo neutralization of T. metuendus and T. obscurus venoms by the commercially available T. serrulatus-based antivenom. These findings reveal critical limitations in relying on a single-species antivenom for treating scorpion envenomation across diverse regions and underscore the need for region-specific therapeutic strategies tailored to the distinct venom profiles and pathogenicity of Amazonian Tityus species.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TSPO, reactive oxygen species and oxidative stress in physiological and pathological situations: a complex relationship. TSPO、活性氧和氧化应激在生理和病理情况下的复杂关系。

IF 3

Biochimie Pub Date : 2025-08-05 DOI: 10.1016/j.biochi.2025.08.002

Didier Morin, Jean-Jacques Lacapère

引用次数: 0

Codon usage and antibiotic resistance: A hidden evolutionary mechanism. 密码子使用与抗生素耐药性：一个隐藏的进化机制。

IF 3

Biochimie Pub Date : 2025-07-31 DOI: 10.1016/j.biochi.2025.07.027

Ujwal Dahal, Anu Bansal

{"title":"Codon usage and antibiotic resistance: A hidden evolutionary mechanism.","authors":"Ujwal Dahal, Anu Bansal","doi":"10.1016/j.biochi.2025.07.027","DOIUrl":"10.1016/j.biochi.2025.07.027","url":null,"abstract":"Antibiotic resistance represents a global health crisis, and emerging evidence suggests that codon usage, traditionally considered a silent aspect of genetic coding, plays a pivotal role in the evolution of resistance. Traditional resistance mechanisms, such as efflux pumps, enzymatic inactivation, and target modification, have been extensively studied. Still, recent findings highlight the role of codon optimization in enhancing the synthesis of resistance determinants in pathogens, including Acinetobacter baumannii, Neisseria gonorrhoeae, and Klebsiella pneumoniae. Comparative genomic analyses employing metrics such as Codon Adaptation Index (CAI), Effective Number of Codons (ENC), and Relative Synonymous Codon Usage (RSCU), alongside advanced bioinformatic and machine learning approaches, have identified subtle yet significant shifts in codon usage patterns between resistant and susceptible strains. Additionally, experimental studies using in vitro assays, in vivo models, and synthetic biology approaches prove that translational control through codon modulation contributes to adaptive responses under antibiotic pressure. Understanding these associations offers potential avenues for developing novel diagnostic biomarkers and therapeutic strategies. Therefore, this review underscores the necessity of an interdisciplinary approach to decipher the complex interplay between codon usage and antibiotic resistance, ultimately informing future efforts to mitigate the impact of multidrug-resistant pathogens.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-silico prioritization of pathogenic Interleukin-37b variants and a fusion platform for high-yield soluble production. 致病性白介素-37b变异体的芯片优先排序和高效可溶性生产的融合平台。

IF 3

Biochimie Pub Date : 2025-07-30 DOI: 10.1016/j.biochi.2025.07.026

Sana Tahir, Jannat Rahim, Saima Sadaf

{"title":"In-silico prioritization of pathogenic Interleukin-37b variants and a fusion platform for high-yield soluble production.","authors":"Sana Tahir, Jannat Rahim, Saima Sadaf","doi":"10.1016/j.biochi.2025.07.026","DOIUrl":"10.1016/j.biochi.2025.07.026","url":null,"abstract":"Human interleukin-37 isoform 1 (IL-37b) is a key anti-inflammatory cytokine with significant therapeutic potential for inflammatory and immune-mediated disorders. However, its clinical translation is limited by poor understanding of disease-associated genetic variants and lack of an expression system for soluble production. While addressing both challenges, this study presents (a) a prioritized catalog of high-confidence, pathogenic IL-37b variants, and (b) a fusion-based expression platform for its soluble production, providing essential resources for future functional validations. Screening of over 3000 IL-37b variants using various computational tools and multi-algorithm consensus approach identified 25 potentially pathogenic non-synonymous single nucleotide variants (nsSNVs). Amongst these, 16 variants (e.g., D64 V/N, L72R, L111Q, V113F, C122R, F154S, I155 N, Y157C, E168G, G174A, I111T) were predicted to significantly destabilize IL-37b's structure and impair its interaction with the IL-18 receptor. Further, guided by complementary in-silico predictions, an aspartate-rich lunasin peptide yielded the highest soluble expression, constituting ∼40 % of total E. coli cellular proteins. The fusion expression system achieved ∼80 % solubility (compared to <10 % for wild-type IL-37b) and a yield of 167 mg/L following Ni2+-affinity purification under optimized conditions (25 °C, lactose autoinduction). The findings underscore the significance of complementary computational workflows in establishing an end-to-end pipeline for variant-to-solution analysis of IL-37b - a dual foundation linking in silico discovery to therapeutic development.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Venomics and insect prey specificity of the Central American scorpion Centruroides limbatus (Pocock, 1898) and its comparison with close species Centruroides bicolor (Pocock, 1898). 中美洲蝎子Centruroides limbatus （Pocock, 1898）的毒液组学和昆虫猎物特异性及其与近缘种Centruroides bicolor的比较（Pocock, 1898）。

IF 3

Biochimie Pub Date : 2025-07-24 DOI: 10.1016/j.biochi.2025.07.025

Cecilia Díaz, Jennifer Rivera, Arturo Chang-Castillo, Fabián Bonilla, Natalia Ortiz, Adriana Alfaro-Chinchilla, Mahmood Sasa

{"title":"Venomics and insect prey specificity of the Central American scorpion Centruroides limbatus (Pocock, 1898) and its comparison with close species Centruroides bicolor (Pocock, 1898).","authors":"Cecilia Díaz, Jennifer Rivera, Arturo Chang-Castillo, Fabián Bonilla, Natalia Ortiz, Adriana Alfaro-Chinchilla, Mahmood Sasa","doi":"10.1016/j.biochi.2025.07.025","DOIUrl":"10.1016/j.biochi.2025.07.025","url":null,"abstract":"Centruroides limbatus and Centruroides bicolor are phylogenetically related species with different geographical distributions. The scarce envenomation cases in Costa Rica suggest they are probably 'mammal harmless', but their venom's effect on other animals has been poorly characterized. We aimed to describe the protein venom composition of C. limbatus and C. bicolor, in the context of their trophic habits and prey specificity. We applied a proteomics shotgun approach to analyze the composition of venom peptides of C. limbatus and compare them with those expressed by C. bicolor. We also tested the venom's lethal effect on insects and their ability to induce paralysis. Among the recovered NaTxs, there were C. bicolor Cbi1, C. suffusus CssIX, C. noxius Cn11, C. gracilis Cg2, and C. vittatus β-toxins. Regarding KTxs, we identified ergtoxins, limbatotoxins, and hongotoxins, all peptides commonly found in Centruroides venoms, as well as C. noxius cobatoxin-1 and C. margaritatus Cm39. Regarding lethality, as demonstrated with other buthid venoms, crickets were very sensitive, whereas mealworms were the most resistant. The current study shows that these scorpion species display similar venom compositions, including previously identified peptides from other Centruroides with and without medical importance, and as expected, they show only minor specificity differences.","PeriodicalId":93898,"journal":{"name":"Biochimie","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0