Asian journal of andrology最新文献_第6页

Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases. 生理时钟基因调控睾酮合成及其在男性疾病中的研究进展。

Asian journal of andrology Pub Date : 2025-03-18 DOI: 10.4103/aja20258

Gang Ning, Bo-Nan Li, Hui Wu, Ruo-Bing Shi, A-Jian Peng, Hao-Yu Wang, Xing Zhou

引用次数: 0

Re: Commentary on "Testis tissue cryopreservation may be considered in boys with cryptorchidism". 回复：关于“睾丸组织冷冻保存可用于隐睾男孩”的评论。

Asian journal of andrology Pub Date : 2025-03-18 DOI: 10.4103/aja20255

Linn Salto Mamsen, Simone Hildorf, Elissavet Ntemou, Danyang Wang, Dina Cortes, Jens Fedder, Jørgen Thorup, Claus Yding Andersen

引用次数: 0

Impact of physical activity on semen quality: a review of current evidence. 体育活动对精液质量的影响：对现有证据的回顾。

Asian journal of andrology Pub Date : 2025-03-14 DOI: 10.4103/aja20252

Jing Chen, Jin-Ming Guo, Bang-Jian Jiang, Fan-Yuan Sun, Yong-Cun Qu

引用次数: 0

Exploration of evaluation criteria based on the biological variation in the external quality assessment for basic semen analysis in China. 中国精液基础分析外部质量评价中基于生物学变异的评价标准探讨。

Asian journal of andrology Pub Date : 2025-03-11 DOI: 10.4103/aja2024118

Xi-Yan Wu, Jin-Chun Lu, Xin-Hua Peng, Jing-Liang He, Dao Wang, Cong-Ling Dai, Wen-Bing Zhu, Gang Liu, Wei-Na Li

{"title":"Exploration of evaluation criteria based on the biological variation in the external quality assessment for basic semen analysis in China.","authors":"Xi-Yan Wu, Jin-Chun Lu, Xin-Hua Peng, Jing-Liang He, Dao Wang, Cong-Ling Dai, Wen-Bing Zhu, Gang Liu, Wei-Na Li","doi":"10.4103/aja2024118","DOIUrl":"https://doi.org/10.4103/aja2024118","url":null,"abstract":"Abstract: This study explores whether the current external quality assessment (EQA) level and acceptable bias for basic semen analysis in China are clinically useful. We collected data of semen EQA from Andrology laboratories in the Hunan Province (China) in 2022 and searched for data in the published literature from January 2000 to December 2023 in China. On the basis of these data, we analyzed the coefficients of variation and acceptable biases of different quality control materials for basic semen analysis through robust statistics. We compared these findings with quality specifications based on biological variation from optimal, desirable, and minimum levels of bias to seek a unified and more suitable semen EQA bias evaluation standard for China's national conditions. Different sources of semen quality control material exhibited considerable variation in acceptable biases among laboratories, ranging from 8.2% to 56.9%. A total of 50.0% of the laboratories met the minimum quality specifications for progressive motility (PR), whereas 100.0% and 75.0% of laboratories met only the minimum quality specifications for sperm concentration and total motility (nonprogressive [NP] + PR), respectively. The Z value for sperm concentration and PR+NP was equivalent to the desirable performance specification, whereas the Z value for PR was equivalent only to the minimum performance specification. This study highlights the feasibility of operating external quality assessment schemes for basic semen analysis using quality specifications based on biological variation. These specifications should be unified among external quality control (EQC) centers based on biological variation.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystic fibrosis-causing variants in Chinese patients with congenital absence of the vas deferens: a cohort and meta-analysis. 中国先天性输精管缺失患者的囊性纤维化变异：一项队列和荟萃分析

Asian journal of andrology Pub Date : 2025-03-11 DOI: 10.4103/aja2024124

Yi Lu, Jing Wang, Zhong-Lin Cai, Teng-Yan Li, Hong-Jun Li, Bin-Bin Wang

{"title":"Cystic fibrosis-causing variants in Chinese patients with congenital absence of the vas deferens: a cohort and meta-analysis.","authors":"Yi Lu, Jing Wang, Zhong-Lin Cai, Teng-Yan Li, Hong-Jun Li, Bin-Bin Wang","doi":"10.4103/aja2024124","DOIUrl":"https://doi.org/10.4103/aja2024124","url":null,"abstract":"Abstract: Individuals with congenital absence of the vas deferens (CAVD) may transmit cystic fibrosis (CF)-causing variants of the cystic fibrosis transmembrane conductance regulator (CFTR) gene to their offspring through assisted reproductive technology (ART). We aimed to delineate the spectrum and estimate the prevalence of CF-causing variants in Chinese individuals with CAVD through a cohort analysis and meta-analysis. CFTR was sequenced in 145 Chinese individuals with CAVD. CFTR variants were classified as CF-causing or non-CF-causing variants regarding clinical significance. A comprehensive genotype analysis was performed in Chinese individuals with CAVD, incorporating previous studies and our study cohort. The prevalence of CF-causing variants was estimated through meta-analysis. In our cohort, 56 different CFTR variants were identified in 108 (74.5%) patients. Twenty variants were categorized as CF-causing and were detected in 28 (19.3%) patients. A comprehensive genotype analysis of 867 patients identified 174 different CFTR variants. Sixty-four were classified as CF-causing variants, 56.3% of which had not been previously reported in Chinese patients with CF. Meta-analysis showed that 14.8% (95% confidence interval [CI]: 11.0%-18.9%) CAVD cases harbored one CF-causing variant, and 68.6% (95% CI: 65.1%-72.0%) CAVD cases carried at least one CFTR variant. Our study underscores the urgent need for extensive CFTR screening, including sequencing of whole exons and flanking regions and detection of large rearrangements and deep intronic CF-causing variants, in Chinese individuals with CAVD before undergoing ART. The established CF-causing variants spectrum may aid in the development of genetic counseling strategies and preimplantation diagnosis to prevent the birth of a child with CF.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 10-year longitudinal analysis of the impact of demographic, lifestyle, and medical factors on semen qualities in men in a city in the midwestern region of the United States of America. 美国中西部地区某城市人口、生活方式和医学因素对男性精液质量影响的10年纵向分析。

Asian journal of andrology Pub Date : 2025-03-07 DOI: 10.4103/aja2024108

Malik Scott, Anaelena Rodriguez, Orry Marciano, Rachel Nordgren, Scott D Lundy, Omer A Raheem

{"title":"A 10-year longitudinal analysis of the impact of demographic, lifestyle, and medical factors on semen qualities in men in a city in the midwestern region of the United States of America.","authors":"Malik Scott, Anaelena Rodriguez, Orry Marciano, Rachel Nordgren, Scott D Lundy, Omer A Raheem","doi":"10.4103/aja2024108","DOIUrl":"https://doi.org/10.4103/aja2024108","url":null,"abstract":"Abstract: This study was to survey the relationship between semen values and demographics, comorbidities, and recreational substance use in a large cohort of adult men at the University of Chicago Medical Center Department of Urology (Chicago, IL, USA). We performed an analysis from January 2013 to December 2023 of semen samples obtained from adult patients at our institution and collected their demographics, comorbid medical conditions, and recreational substance use information. Patients were divided into categories of normozoospermia, oligozoospermia, and azoospermia on the basis of the 5th version of the World Health Organization (WHO) guidelines. Data were analyzed by univariate linear and logistic regression models, after which statistically significant variables were placed into multivariable models. Azoospermia and oligozoospermia were both associated with Caucasian or Black, Indigenous, and People of Color (BIPOC) race (both P < 0.001), increasing age (P = 0.005 and P < 0.001, respectively), anemia (P < 0.001 and P = 0.02, respectively), lifetime tobacco use (both P < 0.001), lifetime alcohol use (P = 0.02 and P < 0.001, respectively), and lifetime use of at least two recreational substances (P < 0.001 and P = 0.003, respectively) in multivariable models. Oligospermia was additionally associated with benign prostatic hyperplasia (BPH; P = 0.003) in multivariable models. This study suggests that at-risk populations may benefit from additional early screening and workup for infertility.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of isolated male epispadias: concealed versus nonconcealed cases in a Chinese tertiary hospital. 某三级医院孤立性男性隐蔽性和非隐蔽性上膈肌的比较分析。

Asian journal of andrology Pub Date : 2025-03-04 DOI: 10.4103/aja2024114

Jia-Yi Li, Bo Yu, Meng-Cheng Yang, Zong-Han Li, Hong-Cheng Song, Wei-Ping Zhang

{"title":"Comparative analysis of isolated male epispadias: concealed versus nonconcealed cases in a Chinese tertiary hospital.","authors":"Jia-Yi Li, Bo Yu, Meng-Cheng Yang, Zong-Han Li, Hong-Cheng Song, Wei-Ping Zhang","doi":"10.4103/aja2024114","DOIUrl":"https://doi.org/10.4103/aja2024114","url":null,"abstract":"Abstract: Isolated male epispadias typically presents with preputial defects and dorsal urethral dehiscence. A less common subtype, known as concealed epispadias, is distinguished by an intact prepuce. Despite its clinical relevance, there is limited literature on this variant. In this study, we retrospectively analyzed the clinical data of 86 pediatric patients with isolated male epispadias treated in Beijing Children's Hospital (Beijing, China) from May 2004 to July 2023, including 19 cases of concealed epispadias and 67 of nonconcealed epispadias. We compared clinical characteristics, preoperative diagnostics, surgical techniques, postoperative outcomes, and sexual function during follow-up between the concealed and nonconcealed groups. No significant differences were observed between the two groups regarding surgical methods, postoperative complications, or rates of urinary incontinence. However, notable distinctions were found in the age at initial diagnosis, timing of surgery, frequency of incontinence, location of the urethral meatus, and postoperative urinary incontinence scores (all P < 0.05). Given the absence of penopubic epispadias in concealed cases, we categorized glans and penile epispadias within nonconcealed epispadias as distal epispadias (n = 40) and subsequently compared them with concealed epispadias cases. The postoperative urinary incontinence scores did not differ significantly between the concealed and distal epispadias groups. These findings suggest that concealed epispadias represents a relatively milder form of the condition, characterized by the absence of penopubic involvement, lower rates of urinary incontinence, and favorable surgical outcomes. However, the intact prepuce in concealed cases underscores the need for careful identification and early diagnosis.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel homozygous splicing mutation in AK7 associated with multiple morphological abnormalities of the sperm flagella. 与精子鞭毛多种形态异常有关的 AK7 基因新型同源剪接突变。

Asian journal of andrology Pub Date : 2025-03-01 Epub Date: 2024-09-17 DOI: 10.4103/aja202479

Thomas Greither, Holger Herlyn

引用次数: 0

High sperm DNA fragmentation - finding a needle in the haystack: tips on selecting the best sperm for ICSI and ART. 精子 DNA 碎片率高--大海捞针：为 ICSI 和 ART 挑选最佳精子的技巧。

Asian journal of andrology Pub Date : 2025-03-01 Epub Date: 2024-09-03 DOI: 10.4103/aja202451

Elisabetta Baldi, Giovanni M Colpi, Zhong-Wei Huang, Balasingam Balagobi, Florence Boitrelle, Rupin Shah, Ashok Agarwal

引用次数: 0

Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development. 探索新型 SRD5A2 变异对 46,XY 性发育障碍的临床影响。

Asian journal of andrology Pub Date : 2025-03-01 Epub Date: 2024-09-24 DOI: 10.4103/aja202469

Yu Mao, Jian-Mei Huang, Yu-Wei Chen-Zhang, He Lin, Yu-Huan Zhang, Ji-Yang Jiang, Xue-Mei Wu, Ling Liao, Yun-Man Tang, Ji-Yun Yang

{"title":"Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development.","authors":"Yu Mao, Jian-Mei Huang, Yu-Wei Chen-Zhang, He Lin, Yu-Huan Zhang, Ji-Yang Jiang, Xue-Mei Wu, Ling Liao, Yun-Man Tang, Ji-Yun Yang","doi":"10.4103/aja202469","DOIUrl":"10.4103/aja202469","url":null,"abstract":"Abstract: This study was conducted retrospectively on a cohort of 68 patients with steroid 5 α-reductase 2 (SRD5A2) deficiency and 46,XY disorders of sex development (DSD). Whole-exon sequencing revealed 28 variants of SRD5A2 , and further analysis identified seven novel mutants. The preponderance of variants was observed in exon 1 and exon 4, specifically within the nicotinamide adenine dinucleotide phosphate (NADPH)-binding region. Among the entire cohort, 53 patients underwent initial surgery at Sichuan Provincial People's Hospital (Chengdu, China). The external genitalia scores (EGS) of these participants varied from 2.0 to 11.0, with a mean of 6.8 (standard deviation [s.d.]: 2.5). Thirty patients consented to hormone testing. Their average testosterone-to-dihydrotestosterone (T/DHT) ratio was 49.3 (s.d.: 23.4). Genetic testing identified four patients with EGS scores between 6 and 9 as having this syndrome; and their T/DHT ratios were below the diagnostic threshold. Furthermore, assessments conducted using the crystal structure of human SRD5A2 have provided insights into the potential pathogenic mechanisms of these novel variants. These mechanisms include interference with NADPH binding (c.356G>C, c.365A>G, c.492C>G, and c.662T>G) and destabilization of the protein structure (c.727C>T). The c.446-1G>T and c.380delG variants were verified to result in large alterations in the transcripts. Seven novel variations were identified, and the variant database for the SRD5A2 gene was expanded. These findings contribute to the progress of diagnostic and therapeutic approaches for individuals with SRD5A2 deficiency.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"211-218"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0