Asian journal of andrology最新文献_第6页

Combined effects of urine exposure and cryopreservation on sperm quality: an in vitro study of retrograde ejaculation. 尿液暴露和低温保存对精子质量的联合影响：逆行射精的体外研究。

IF 2.7

Asian journal of andrology Pub Date : 2026-09-01 Epub Date: 2026-05-22 DOI: 10.4103/aja20265

Ming-Jie Liang, Qian-Yi Li, Tao Pang, Huang Liu, Qi-Ling Wang, Ying-Yi Zhou, Jia-Ming Zhuang, Ying Zhang

{"title":"Combined effects of urine exposure and cryopreservation on sperm quality: an in vitro study of retrograde ejaculation.","authors":"Ming-Jie Liang, Qian-Yi Li, Tao Pang, Huang Liu, Qi-Ling Wang, Ying-Yi Zhou, Jia-Ming Zhuang, Ying Zhang","doi":"10.4103/aja20265","DOIUrl":"10.4103/aja20265","url":null,"abstract":"Sperm quality influences fertility and offspring health through both genomic inheritance and epigenetic inheritance. Thus, for use in clinical-assisted reproductive technology (ART), spermatozoa must have optimal genomic and epigenetic structures. In patients with retrograde ejaculation, spermatozoa are usually recovered from urine and then cryopreserved for ART. However, the effects of urine exposure and subsequent freeze-thaw cycles on sperm quality remain unclear. This is particularly true for epigenetic changes and their underlying mechanisms. In this study, we examined how different durations of urine exposure (10 min and 40 min) followed by freeze-thaw cycles affected sperm motility, DNA integrity, and methylation levels of imprinting genes (H19-imprinted maternally expressed transcript [ H19 ], mesoderm-specific transcript [ MEST ], and the transposable element Alu [ Alu ]). As the duration of urine exposure increased, sperm motility (median [interquartile range]) decreased from 48.0% (39.0%-52.5%) to 1.0% (1.0%-5.0%), the DNA fragmentation index (DFI; median [interquartile range]) increased from 12.0% (9.3%-19.9%) to 23.5% (13.9%-33.9%), the MEST methylation level (mean ± standard deviation [s.d.]) increased from 3.8% ± 1.5% to 11.5 ± 1.2%, and the H19 methylation level (mean ± s.d.) decreased from 86.9% ± 0.9% to 82.1% ± 0.5%. The freeze-thaw process further reduced sperm motility, while the DFI and methylation levels of MEST and H19 did not significantly change. The Alu methylation level remained stable. These findings demonstrate that urine exposure affects sperm motility, DNA integrity, and methylation levels of some imprinting genes. These effects intensify over time. In contrast, the freeze-thaw process impacts only sperm motility. In clinical practice, minimizing exposure to urine might improve sperm quality.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"628-633"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of exercise on sperm epigenetic modification and intergenerational inheritance. 运动对精子表观遗传修饰和代际遗传的影响。

IF 2.7

Asian journal of andrology Pub Date : 2026-08-21 DOI: 10.4103/aja202631

Jin-Ming Guo, Hai-He Zhou, Yong-Cun Qu

{"title":"The impact of exercise on sperm epigenetic modification and intergenerational inheritance.","authors":"Jin-Ming Guo, Hai-He Zhou, Yong-Cun Qu","doi":"10.4103/aja202631","DOIUrl":"https://doi.org/10.4103/aja202631","url":null,"abstract":"Paternal environmental factors can influence offspring health intergenerationally through alterations in sperm epigenetics. Exercise, as a key modifiable lifestyle factor, may similarly affect epigenetic inheritance. Emerging evidence from animal and human studies indicates that exercise modulates sperm DNA methylation and noncoding RNA expression. In animal models, paternal exercise has also been linked to changes in offspring phenotypes. However, inconsistencies exist across studies because of variations in exercise modalities and the specific epigenetic markers analyzed. More importantly, the mechanisms underlying the relationship between sperm epigenetic alterations and offspring phenotypes remain unclear. This review integrates evidence from January 2010 to December 2025 to summarize exercise-induced changes in sperm epigenetics and their associations with offspring metabolic and behavioral outcomes. It critically discusses major inconsistencies in the current literature and highlights underexplored areas, including exercise-induced changes in histone modifications and chromatin architecture in sperm, as well as a striking lack of human data on offspring health. We propose that future rigorous exercise standardization, multidimensional epigenetic profiling, well-designed human studies, and functional validation are essential to establish causality and translate findings into effective interventional strategies.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148803036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of common heavy metals and trace elements on semen quality: a meta-analysis and bibliometrics. 常见重金属和微量元素对精液质量的影响：荟萃分析和文献计量学。

IF 2.7

Asian journal of andrology Pub Date : 2026-07-31 DOI: 10.4103/aja20261

Nai-Yun Li, Lu Zhang, Yong-Han Li, Chu-Chu Li, Wan-Qi Ren, Qi Zhong, Fang-Biao Tao, Qun-Shan Shen, Pu-Yu Su, Geng-Fu Wang

{"title":"Impact of common heavy metals and trace elements on semen quality: a meta-analysis and bibliometrics.","authors":"Nai-Yun Li, Lu Zhang, Yong-Han Li, Chu-Chu Li, Wan-Qi Ren, Qi Zhong, Fang-Biao Tao, Qun-Shan Shen, Pu-Yu Su, Geng-Fu Wang","doi":"10.4103/aja20261","DOIUrl":"https://doi.org/10.4103/aja20261","url":null,"abstract":"Emerging evidence highlights a link between heavy metal exposure and semen quality, but discrepancies persist regarding the effects of metals like lead and cadmium across different biological matrices. This systematic review and meta-analysis aimed to explore the association between heavy metal exposure in blood, urine, and seminal plasma and male semen quality. A comprehensive search was conducted across four databases (PubMed, Embase, Scopus, and Cochrane Library), and a bibliometric analysis was performed using the Web of Science Core Collection. Based on this analysis, a systematic literature review and meta-analyses were conducted. Database searches were updated until November 2024. A total of 10 qualitative and 14 quantitative studies were included. Exposure to lead and cadmium in seminal plasma was significantly correlated with progressive sperm motility, with odds ratio (OR) of 2.27 (95% confidence interval [CI]: 1.18 to 4.34) for lead and of 2.55 (95% CI: 1.29 to 5.03) for cadmium. Arsenic exposure was significantly linked to total sperm motility (OR = 2.88, 95% CI: 1.35 to 6.17), while zinc deficiency in seminal plasma was associated with reduced total sperm motility (OR = 1.77, 95% CI: 1.17 to 2.66). Given the widespread exposure to heavy metals, assessing their impact on male reproductive health should be prioritized as a public health concern. This study highlights the reprotoxicity of heavy metals in seminal plasma, blood, and urine, with seminal plasma emerging as the most sensitive biomarker for reproductive risk.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erectile dysfunction in aging men: evidence and insights related to antihypertensive and antidiabetic medications. 老年男性勃起功能障碍：与降压和降糖药物相关的证据和见解。

IF 2.7

Asian journal of andrology Pub Date : 2026-07-31 DOI: 10.4103/aja202621

Zhan-Peng Liu, Guiting Lin, Xiang-Hu Meng

{"title":"Erectile dysfunction in aging men: evidence and insights related to antihypertensive and antidiabetic medications.","authors":"Zhan-Peng Liu, Guiting Lin, Xiang-Hu Meng","doi":"10.4103/aja202621","DOIUrl":"https://doi.org/10.4103/aja202621","url":null,"abstract":"With global population aging, erectile dysfunction is becoming increasingly prevalent among middle-aged and older men, who frequently present with cardiometabolic comorbidities, such as hypertension and diabetes mellitus. Although these conditions are well-established risk factors for erectile dysfunction, their long-term pharmacological management may exert heterogeneous and adverse effects on erectile function, complicating clinical decision-making. This review synthesizes current evidence on the shared pathophysiological mechanisms linking erectile dysfunction with hypertension and diabetes mellitus, including endothelial dysfunction, oxidative stress, vascular remodeling, metabolic dysregulation, and neurovascular impairment. This review also critically evaluates the effects of commonly prescribed antihypertensive and antidiabetic drug classes on erectile function, highlighting both their beneficial and detrimental profiles. By integrating mechanistic insights with clinical evidence, this review highlights medication-associated sexual dysfunction in aging men. It emphasizes its recognition and management in clinical practice. The goal is to guide individualized treatment strategies that control cardiometabolic disease while preserving sexual health and quality of life.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A high-glucose diet aggravates experimental autoimmune prostatitis via DHVD3/VDR/ERK axis-mediated Th17 differentiation. 高糖饮食通过DHVD3/VDR/ERK轴介导的Th17分化加重实验性自身免疫性前列腺炎。

IF 2.7

Asian journal of andrology Pub Date : 2026-07-31 DOI: 10.4103/aja202587

Di Niu, Shao-Yu Yue, Xu Wang, Sheng-Ao Wei, Wei-Yi Li, Li Zhang, He-Xi Du, Chao-Zhao Liang

{"title":"A high-glucose diet aggravates experimental autoimmune prostatitis via DHVD3/VDR/ERK axis-mediated Th17 differentiation.","authors":"Di Niu, Shao-Yu Yue, Xu Wang, Sheng-Ao Wei, Wei-Yi Li, Li Zhang, He-Xi Du, Chao-Zhao Liang","doi":"10.4103/aja202587","DOIUrl":"https://doi.org/10.4103/aja202587","url":null,"abstract":"Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent genitourinary disease that has gradually become recognized as a potential autoimmune disease. Our previous research revealed that a high-glucose diet exacerbated experimental autoimmune prostatitis (EAP), a widely used animal model of CP/CPPS. However, its effects on the metabolism of EAP mice remain unknown. Here, we applied non-targeted metabolomics analysis of feces and enzyme-linked immunosorbent assays to identify differential metabolites in EAP mice with and without high-glucose feeding. Metabolomics analysis demonstrated significant enrichment of the vitamin digestion and absorption pathway. Glucose-fed EAP mice exhibited increased fecal excretion and reduced absorption of 1,25-dihydroxyvitamin D3 (DHVD3) into the bloodstream, accompanied by decreased expression of the vitamin D receptor (VDR) in prostate tissue. In vitro experiments, proteomic sequencing, western blot, and flow cytometry analyses demonstrated that DHVD3 suppressed T helper 17 (Th17) cell differentiation by activating the VDR/extracellular signal-regulated kinase (ERK) pathway. DHVD3 supplementation ameliorated Th17 responses and EAP severity in glucose-fed mice, whereas the administration of the VDR antagonist MeTC7 reversed these effects. We concluded that high-glucose feeding aggravates EAP through DHVD3/VDR/ERK axis-mediated Th17 differentiation. VD3 supplementation may benefit CP/CPPS patients consuming a high-sugar diet.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of sperm DNA fragmentation index levels on embryo development potential and clinical outcomes in infertile couples undergoing IVF/ICSI treatment. 精子DNA断裂指数水平对接受IVF/ICSI治疗的不育夫妇胚胎发育潜力和临床结果的影响

IF 2.7

Asian journal of andrology Pub Date : 2026-07-28 DOI: 10.4103/aja202619

Yu-Chao Zhang, Jing-Yan Wang, Chun-Yan Shen, Yang-Qing Liu, Yan-Li Liu, Xian-Feng Yang, Yi-Chun Guan, Wen-Juan Zhang

{"title":"The impact of sperm DNA fragmentation index levels on embryo development potential and clinical outcomes in infertile couples undergoing IVF/ICSI treatment.","authors":"Yu-Chao Zhang, Jing-Yan Wang, Chun-Yan Shen, Yang-Qing Liu, Yan-Li Liu, Xian-Feng Yang, Yi-Chun Guan, Wen-Juan Zhang","doi":"10.4103/aja202619","DOIUrl":"10.4103/aja202619","url":null,"abstract":"The sperm DNA fragmentation (SDF) impact on embryo development, particularly regarding the fertilization methods and female age, remains incompletely defined. This study evaluated the effect of the sperm DNA fragmentation index (DFI) on embryo quality and development and examined whether this effect was modified by insemination method or maternal age. This retrospective cohort study included 3567 infertility treatment cycles at The Third Affiliated Hospital of Zhengzhou University (Zhengzhou, China) between January 2019 and April 2025. The DFI was measured using the Sperm Chromatin Structure Assay (SCSA), and patients were stratified into low, moderate, and high DFI groups. The embryo quality was assessed morphokinetically on day 3 and days 5-7. Generalized estimating equations (GEEs) were employed to account for multiple embryos per patient, with adjustments for female age, body mass index (BMI), infertility cause, and insemination method. A high DFI was significantly associated with reduced good-quality blastocysts rate ( P < 0.001). Stratified analyses revealed that the adverse effects of a high DFI were most pronounced in ICSI cycles and among women aged ≥35 years, where it correlated with markedly lower usable and good blastocyst rates (adjusted Exp[β] = 0.99 and 0.98, respectively; P = 0.002 and 0.008, respectively). In conclusion, an elevated DFI is negatively associated with embryo developmental potential in a dose-dependent manner, particularly in cycles involving ICSI and among couples with advanced maternal age. However, when the analysis was restricted to fresh embryo transfer, high DFI levels did not result in worse reproductive outcomes.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotype-based management of fertilization and cleavage failure: case-series evidence from DNAH10, DNAH12, CFAP47 , and PLCZ1. 基于基因型的受精和卵裂失败管理：来自DNAH10、DNAH12、CFAP47和PLCZ1的病例系列证据。

IF 2.7

Asian journal of andrology Pub Date : 2026-07-28 DOI: 10.4103/aja202629

Ke-Er Gan, Hui-Ling Zhong, Yu Li, Wen-Yi Liu, Song-Bang Ou, Zhong-Kun Liang, Jin Li, Ling Zhou, Tuerxunayi Yalikun, Tuan Li, Hui Chen, Wen-Jun Wang, Zu-Yong He, Ping Yuan

{"title":"Genotype-based management of fertilization and cleavage failure: case-series evidence from DNAH10, DNAH12, CFAP47 , and PLCZ1.","authors":"Ke-Er Gan, Hui-Ling Zhong, Yu Li, Wen-Yi Liu, Song-Bang Ou, Zhong-Kun Liang, Jin Li, Ling Zhou, Tuerxunayi Yalikun, Tuan Li, Hui Chen, Wen-Jun Wang, Zu-Yong He, Ping Yuan","doi":"10.4103/aja202629","DOIUrl":"10.4103/aja202629","url":null,"abstract":"Fertilization and early-cleavage failure are the major causes of assisted reproductive technology failure, but genotype-guided care is underused. We conducted whole-exome sequencing with Sanger confirmation in 20 men from couples with unexplained fertilization and cleavage failure after in vitro fertilization or intracytoplasmic sperm injection (ICSI). Then, further sperm transmission electron microscopy, immunofluorescence, and, where appropriate, embryo quantitative parental contamination test (qPCT) and kinship analysis were integrated in selected cases. Six novel variants were found in four families: two each in dynein axonemal heavy chain 10 ( DNAH10 ) and dynein axonemal heavy chain 12 ( DNAH12 ) and one in cilia and flagella associated protein 47 ( CFAP47 ) and phospholipase C zeta 1 ( PLCZ1 ), respectively. DNAH10/DNAH12 variants segregated with multiple morphological abnormalities of the sperm flagella and showed \"9+2\" axonemal disruption and reduced dynein signals. Hemizygous CFAP47 c.8006C>T is associated with cleavage failure and altered PLCZ1 localization. Homozygous PLCZ1 c.589C>T in a consanguineous pedigree coincided with multinuclear (≥3 pronuclei) zygotes, and qPCT/kinship indicated excess paternal contribution, consistent with suspected polyspermy in multinuclear zygotes. Management-matched genotype: ICSI restored fertilization in DNAH10/DNAH12 deficiency, whereas ICSI plus assisted oocyte activation (AOA) improved cleavage and yielded ongoing pregnancies in CFAP47/PLCZ1 deficiency. These findings outline potentially actionable clinical strategies-ICSI for axonemal dynein defects and ICSI plus AOA for activation pathway defects-and support targeted genetic testing plus embryo qPCT/kinship in selected cases.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracavernosal injection of autologous platelet concentrates for managing erectile dysfunction: a meta-analysis of randomized placebo-controlled trials on platelet-rich plasma and platelet-rich fibrin matrix. 海绵体内注射自体浓缩血小板治疗勃起功能障碍：富血小板血浆和富血小板纤维蛋白基质随机安慰剂对照试验的荟萃分析

IF 2.7

Asian journal of andrology Pub Date : 2026-07-28 DOI: 10.4103/aja202588

Missy Savira, Ponco Birowo, Nur Rasyid, Eric Chung, Widi Atmoko

{"title":"Intracavernosal injection of autologous platelet concentrates for managing erectile dysfunction: a meta-analysis of randomized placebo-controlled trials on platelet-rich plasma and platelet-rich fibrin matrix.","authors":"Missy Savira, Ponco Birowo, Nur Rasyid, Eric Chung, Widi Atmoko","doi":"10.4103/aja202588","DOIUrl":"10.4103/aja202588","url":null,"abstract":"Platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM) have gained interest in the last few years as a regenerative therapy for erectile dysfunction (ED). The present study aimed to systematically investigate the efficacy and safety of PRP/PRFM compared to a placebo for the management of ED. Adhering to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, we systematically searched PubMed and Scopus from the database inception to February 2025. Randomized controlled trials (RCTs) investigating the International Index of Erectile Function (IIEF) score, sexual and overall satisfaction, peak systolic velocity (PSV) and end-diastolic velocity (EDV), and the complication rate of PRP/PRFM compared to placebo for men with ED were included. We included six RCTs, comprising 179 patients in the PRP/PRFM group and 180 in the placebo group. There was a notable variability in PRP/PRFM injection protocols. The analysis found that PRP/PRFM is associated with higher IIEF scores at ≥6 months of follow-up compared to placebo. Significant differences were also observed in the percentage of subjects attaining minimal clinically important differences of IIEF-Erectile Function from the first-month follow-up and in the Visual Analog Scale (VAS) scores post-injection, favoring the PRP/PRFM group. In contrast, sexual and overall satisfaction, PSV, and EDV were comparable. In the subgroup analysis, significant differences in IIEF scores compared to the placebo at the end of follow-up were noted only in the PRP group but not in the PRFM group. In conclusion, PRP and PRFM are well-tolerated, but PRP may yield superior results over PRFM compared to placebo, particularly after 6 months post-treatment. However, the results should be interpreted with caution due to small sample size, heterogeneity in protocols, and indirect comparison between PRP and PRFM. Further well-designed clinical trials are warranted.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic changes of serum albumin-to-globulin ratio predict major adverse cardiovascular events in prostate cancer patients undergoing androgen deprivation therapy. 血清白蛋白-球蛋白比的动态变化预测雄激素剥夺治疗前列腺癌患者的主要不良心血管事件。

IF 2.7

Asian journal of andrology Pub Date : 2026-07-28 DOI: 10.4103/aja202614

Yi-Hong Zhou, Yan Hiu Athena Lee, Yu-Xin Tang, Ying-Bo Dai, Peter Kf Chiu, Jeremy Yc Teoh, Chi Fai Ng

{"title":"Dynamic changes of serum albumin-to-globulin ratio predict major adverse cardiovascular events in prostate cancer patients undergoing androgen deprivation therapy.","authors":"Yi-Hong Zhou, Yan Hiu Athena Lee, Yu-Xin Tang, Ying-Bo Dai, Peter Kf Chiu, Jeremy Yc Teoh, Chi Fai Ng","doi":"10.4103/aja202614","DOIUrl":"10.4103/aja202614","url":null,"abstract":"There are rising concerns regarding the cardiovascular diseases associated with androgen deprivation therapy (ADT) for prostate cancer (PCa). This study aims to investigate the relationship between the dynamic changes (from baseline to 3 months after ADT) of serum albumin-to-globulin ratio (AGR) and major adverse cardiovascular events (MACE) in PCa patients undergoing ADT. Male patients aged >60 years diagnosed with PCa undergoing ADT in Hong Kong (China) between December 01, 1999, and March 31, 2021, were included. AGR values at baseline and after 3 months of ADT initiation were recorded. The incidence of new-onset 4-point MACE (4P-MACE) and composite of adverse cardiovascular events (CACE) were designated as the primary outcomes. The individual components of CACE were designated as the secondary outcomes. A total of 970 patients were analyzed, with age (mean ± standard deviation) of 75.1 ± 7.8 years. The number of patients with increased AGR and decreased AGR were 515 (53.1%) and 455 (46.9%), respectively. Patients with a decreased AGR had significantly higher risks of 4P-MACE, CACE, heart failure (HF), myocardial infarction (MI), and stroke than patients with an increased AGR. No significant difference in the risk of all-cause mortality between the two groups was observed (hazard ratio: 1.049, 95% confidence interval: 0.879-1.253, P = 0.594). Moreover, the change in AGR outperformed the baseline AGR in predicting 4P-MACE, CACE, HF, MI, and stroke. In PCa patients undergoing ADT, dynamic changes of AGR are associated with risks for 4P-MACE, CACE, HF, MI, and stroke.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel mutations in ZMYND15 expand the phenotypic spectrum to acephalic spermatozoa: abnormal sperm head-tail connection mediated by SUN5. ZMYND15的新突变将表型谱扩展到头型精子：由SUN5介导的异常精子头尾连接。

IF 2.7

Asian journal of andrology Pub Date : 2026-07-28 DOI: 10.4103/aja2025109

Qian-Jun Zhang, Hao Lin, Rui-Long Hao, Yun-Fei Zhang, Yu-Ping Lin, Si-Cong Zeng, Huan Zhang, Wei-Na Li

{"title":"Novel mutations in ZMYND15 expand the phenotypic spectrum to acephalic spermatozoa: abnormal sperm head-tail connection mediated by SUN5.","authors":"Qian-Jun Zhang, Hao Lin, Rui-Long Hao, Yun-Fei Zhang, Yu-Ping Lin, Si-Cong Zeng, Huan Zhang, Wei-Na Li","doi":"10.4103/aja2025109","DOIUrl":"10.4103/aja2025109","url":null,"abstract":"Acephalic spermatozoa syndrome (ASS) is a rare cause of male infertility characterized by sperm tails lacking heads. Although zinc finger MYND-type containing 15 ( ZMYND15 ) mutations are linked to male infertility, their role in ASS is unknown. In this study, whole-exome sequencing identified novel homozygous truncating mutations, c.292C>T (p.Arg98Ter) and c.337G>T (p.Glu113Ter), in ZMYND15 from two infertile patients. These mutations caused protein truncation and impaired function, leading to extremely low sperm counts, poor motility, and numerous acephalic spermatozoa. Electron microscopy and sperm immunofluorescence revealed abnormal sperm neck structures, missing mitochondrial sheaths, failure of acrosome formation, and a lack of central microtubules. Experiments showed reduced mutant protein expression and high rates of degradation. Coimmunoprecipitation experiments indicated a direct interaction between ZMYND15 and Sad1 and UNC84 domain containing 5 (SUN5), crucial for forming the sperm head-tail connection. One patient achieved a live birth via intracytoplasmic sperm injection (ICSI), whereas the other had an early miscarriage. This study links ZMYND15 mutations directly to ASS, highlighting its role in spermatogenesis and offering insights for clinical diagnosis and treatment.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0