Asian journal of andrology最新文献_第5页

A 10-year longitudinal analysis of the impact of demographic, lifestyle, and medical factors on semen qualities in men in a city in the midwestern region of the United States of America. 美国中西部地区某城市人口、生活方式和医学因素对男性精液质量影响的10年纵向分析。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-03-07 DOI: 10.4103/aja2024108

Malik Scott, Anaelena Rodriguez, Orry Marciano, Rachel Nordgren, Scott D Lundy, Omer A Raheem

{"title":"A 10-year longitudinal analysis of the impact of demographic, lifestyle, and medical factors on semen qualities in men in a city in the midwestern region of the United States of America.","authors":"Malik Scott, Anaelena Rodriguez, Orry Marciano, Rachel Nordgren, Scott D Lundy, Omer A Raheem","doi":"10.4103/aja2024108","DOIUrl":"10.4103/aja2024108","url":null,"abstract":"Abstract: This study was to survey the relationship between semen values and demographics, comorbidities, and recreational substance use in a large cohort of adult men at the University of Chicago Medical Center Department of Urology (Chicago, IL, USA). We performed an analysis from January 2013 to December 2023 of semen samples obtained from adult patients at our institution and collected their demographics, comorbid medical conditions, and recreational substance use information. Patients were divided into categories of normozoospermia, oligozoospermia, and azoospermia on the basis of the 5 th version of the World Health Organization (WHO) guidelines. Data were analyzed by univariate linear and logistic regression models, after which statistically significant variables were placed into multivariable models. Azoospermia and oligozoospermia were both associated with Caucasian or Black, Indigenous, and People of Color (BIPOC) race (both P < 0.001), increasing age ( P = 0.005 and P < 0.001, respectively), anemia ( P < 0.001 and P = 0.02, respectively), lifetime tobacco use (both P < 0.001), lifetime alcohol use ( P = 0.02 and P < 0.001, respectively), and lifetime use of at least two recreational substances ( P < 0.001 and P = 0.003, respectively) in multivariable models. Oligospermia was additionally associated with benign prostatic hyperplasia (BPH; P = 0.003) in multivariable models. This study suggests that at-risk populations may benefit from additional early screening and workup for infertility.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"464-469"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel bi-allelic variants in DNAH10 lead to multiple morphological abnormalities of sperm flagella and male infertility. DNAH10的新型双等位变异导致精子鞭毛的多种形态异常和男性不育。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-02-25 DOI: 10.4103/aja2024116

Muhammad Shoaib, Muhammad Zubair, Wasim Shah, Meftah Uddin, Ansar Hussain, Ghulam Mustafa, Fazal Rahim, Huan Zhang, Imtiaz Ali, Tanveer Abbas, Yousaf Raza, Sui-Xing Fan, Qing-Hua Shi

{"title":"Novel bi-allelic variants in DNAH10 lead to multiple morphological abnormalities of sperm flagella and male infertility.","authors":"Muhammad Shoaib, Muhammad Zubair, Wasim Shah, Meftah Uddin, Ansar Hussain, Ghulam Mustafa, Fazal Rahim, Huan Zhang, Imtiaz Ali, Tanveer Abbas, Yousaf Raza, Sui-Xing Fan, Qing-Hua Shi","doi":"10.4103/aja2024116","DOIUrl":"10.4103/aja2024116","url":null,"abstract":"Abstract: Multiple morphological abnormalities of sperm flagella (MMAF) is a severe form of asthenoteratozoospermia, characterized by morphological abnormalities and reduced motility of sperm, causing male infertility. Although approximately 60% of MMAF cases can be explained genetically, the etiology of the remaining cases is unclear. Here, we identified two novel compound heterozygous variants in the gene, dynein axonemal heavy chain 10 ( DNAH10 ), in three patients from two unrelated Pakistani families using whole-exome sequencing (WES), including one compound heterozygous mutation ( DNAH10 : c.9409C>A [p.P3137T]; c.12946G>C [p.D4316H]) in family 1 and another compound heterozygous mutation ( DNAH10 : c.8849G>A [p.G2950D]; c.11509C>T [p.R3687W]) in family 2. All the identified variants are absent or rare in public genome databases and are predicted to have deleterious effects according to multiple bioinformatic tools. Sanger sequencing revealed that these variants follow an autosomal recessive mode of inheritance. Hematoxylin and eosin (H&E) staining revealed MMAF, including sperm head abnormalities, in the patients. In addition, immunofluorescence staining revealed loss of DNAH10 protein signals along sperm flagella. These findings broaden the spectrum of DNAH10 variants and expand understanding of the genetic basis of male infertility associated with the MMAF phenotype.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"516-523"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of human umbilical cord-derived mesenchymal stem cell therapy for cavernous nerve injury-induced erectile dysfunction in the rat model. 人脐带间充质干细胞治疗海绵状神经损伤性勃起功能障碍大鼠模型的作用。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-02-28 DOI: 10.4103/aja2024115

Wei Wang, Ying Liu, Zi-Hao Zhou, Kun Pang, Jing-Kai Wang, Peng-Fei Huan, Jing-Ru Lu, Tao Zhu, Zuo-Bin Zhu, Cong-Hui Han

{"title":"Effects of human umbilical cord-derived mesenchymal stem cell therapy for cavernous nerve injury-induced erectile dysfunction in the rat model.","authors":"Wei Wang, Ying Liu, Zi-Hao Zhou, Kun Pang, Jing-Kai Wang, Peng-Fei Huan, Jing-Ru Lu, Tao Zhu, Zuo-Bin Zhu, Cong-Hui Han","doi":"10.4103/aja2024115","DOIUrl":"10.4103/aja2024115","url":null,"abstract":"Abstract: Stem cell treatment may enhance erectile dysfunction (ED) in individuals with cavernous nerve injury (CNI). Nevertheless, no investigations have directly ascertained the implications of varying amounts of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) on ED. We compare the efficacy of three various doses of HUC-MSCs as a therapeutic strategy for ED. Sprague-Dawley rats (total = 175) were randomly allocated into five groups. A total of 35 rats underwent sham surgery and 140 rats endured bilateral CNI and were treated with vehicles or doses of HUC-MSCs (1 × 10 6 cells, 5 × 10 6 cells, and 1 × 10 7 cells in 0.1 ml, respectively). Penile tissues were harvested for histological analysis on 1 day, 3 days, 7 days, 14 days, 28 days, 60 days, and 90 days postsurgery. It was found that varying dosages of HUC-MSCs enhanced the erectile function of rats with bilateral CNI and ED. Moreover, there was no significant disparity in the effectiveness of various dosages of HUC-MSCs. However, the expression of endothelial markers (rat endothelial cell antigen-1 [RECA-1] and endothelial nitric oxide synthase [eNOS]), smooth muscle markers (alpha smooth muscle actin [α-SMA] and desmin), and neural markers (neurofilament [RECA-1] and neurogenic nitric oxide synthase [nNOS]) increased significantly with prolonged treatment time. Masson's staining demonstrated an increased in the smooth muscle cell (SMC)/collagen ratio. Significant changes were detected in the microstructures of various types of cells. In vivo imaging system (IVIS) analysis showed that at the 1 st day, the HUC-MSCs implanted moved to the site of damage. Additionally, the oxidative stress levels were dramatically reduced in the penises of rats administered with HUC-MSCs.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"508-515"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body fat distribution and semen quality in 4304 Chinese sperm donors. 4304名中国捐精者体脂分布与精液质量。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-02-14 DOI: 10.4103/aja2024119

Si-Han Liang, Qi-Ling Wang, Dan Li, Gui-Fang Ye, Ying-Xin Li, Wei Zhou, Rui-Jun Xu, Xin-Yi Deng, Lu Luo, Si-Rong Wang, Xin-Zong Zhang, Yue-Wei Liu

{"title":"Body fat distribution and semen quality in 4304 Chinese sperm donors.","authors":"Si-Han Liang, Qi-Ling Wang, Dan Li, Gui-Fang Ye, Ying-Xin Li, Wei Zhou, Rui-Jun Xu, Xin-Yi Deng, Lu Luo, Si-Rong Wang, Xin-Zong Zhang, Yue-Wei Liu","doi":"10.4103/aja2024119","DOIUrl":"10.4103/aja2024119","url":null,"abstract":"Abstract: Extensive studies have identified potential adverse effects on semen quality of obesity, based on body mass index, but the association between body fat distribution, a more relevant indicator for obesity, and semen quality remains less clear. We conducted a longitudinal study of 4304 sperm donors from the Guangdong Provincial Human Sperm Bank (Guangzhou, China) during 2017-2021. A body composition analyzer was used to measure total and local body fat percentage for each participant. Generalized estimating equations were employed to assess the association between body fat percentage and sperm count, motility, and morphology. We estimated that each 10% increase in total body fat percentage (estimated change [95% confidence interval, 95% CI]) was significantly associated with a 0.18 × 10 6 (0.09 × 10 6 -0.27 × 10 6 ) ml and 12.21 × 10 6 (4.52 × 10 6 -19.91 × 10 6 ) reduction in semen volume and total sperm count, respectively. Categorical analyses and exposure-response curves showed that the association of body fat distribution with semen volume and total sperm count was stronger at higher body fat percentages. In addition, the association still held among normal weight and overweight participants. We observed similar associations for upper limb, trunk, and lower limb body fact distributions. In conclusion, we found that a higher body fat distribution was significantly associated with lower semen quality (especially semen volume) even in men with a normal weight. These findings provide useful clues in exploring body fat as a risk factor for semen quality decline and add to evidence for improving semen quality for those who are expected to conceive.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"524-530"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From non-clinically significant to clinically significant prostate cancer: identifying predictors of discrepancy from biopsy to radical prostatectomy. 从无临床意义的前列腺癌到临床意义的前列腺癌：确定活检与根治性前列腺切除术差异的预测因素。

Asian journal of andrology Pub Date : 2025-07-01 DOI: 10.4103/aja202547

Yong-Qing Zhang, Zheng Liu, Bi-Ran Ye, Shi-Wei Liu, Fang-Ning Wan, Zhe Hong, Hua Xu, Bo Dai

{"title":"From non-clinically significant to clinically significant prostate cancer: identifying predictors of discrepancy from biopsy to radical prostatectomy.","authors":"Yong-Qing Zhang, Zheng Liu, Bi-Ran Ye, Shi-Wei Liu, Fang-Ning Wan, Zhe Hong, Hua Xu, Bo Dai","doi":"10.4103/aja202547","DOIUrl":"https://doi.org/10.4103/aja202547","url":null,"abstract":"Accurate classification between non-clinically significant prostate cancer (non-csPCa) and clinically significant prostate cancer (csPCa) is essential for effective risk stratification and optimal management of prostate cancer. This study aimed to evaluate the consistency between preoperative and postoperative assessments of non-csPCa, and identify preoperative variables that can effectively predict the risk of csPCa. We analyzed data from 277 patients initially classified as non-csPCa after biopsy who underwent radical prostatectomy (RP) between August 2015 and January 2024. Univariate and multivariate logistic regression analyses were performed to identify predictors of csPCa. Receiver operating characteristic curves, calibration curves, and decision curve analyses were used to evaluate the performance of the nomogram model. Differences in biochemical recurrence rates between the non-csPCa group and csPCa group were analyzed using the log-rank test. Overall, 183 (66.1%) patients were reclassified as csPCa on the basis of postoperative pathology, with this group showing a higher incidence of biochemical recurrence versus non-csPCa (14 cases vs 0; P = 0.004). The following factors were independent predictors of csPCa: age, free prostate-specific antigen (fPSA)/total prostate-specific antigen (tPSA) ratio, cumulative cancer length, clinical tumor stage, and PSA density. In addition, a nomogram was developed with good predictive accuracy (area under the curve: 0.782). The substantial inconsistency between biopsy and RP pathology findings in the classification of non-csPCa highlights the limitations of biopsy-only management. The developed nomogram predicting the risk of csPCa provides urologists with a valuable tool for improved risk stratification and PCa management.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-01-07 DOI: 10.4103/aja2024101

Guo-Rong Yang, Chao Lv, Kai-Kai Lv, Yang-Yang Wu, Xiao-Wei Hao, Qing Yuan, Tao Song

{"title":"Age-related changes in the impact of metabolic syndrome on prostate volume: a cross-sectional study.","authors":"Guo-Rong Yang, Chao Lv, Kai-Kai Lv, Yang-Yang Wu, Xiao-Wei Hao, Qing Yuan, Tao Song","doi":"10.4103/aja2024101","DOIUrl":"10.4103/aja2024101","url":null,"abstract":"Abstract: This study investigated the impact of metabolic syndrome (MetS) and its components on prostate volume (PV) in the general Chinese population. In total, 43 455 participants in The First Medical Center of the Chinese PLA General Hospital (Beijing, China) from January 1, 2012, to December 31, 2022, undergoing health examinations were included in the study. Participants were categorized into four groups according to PV quartiles: Q1 (PV ≤24.94 ml), Q2 (PV >24.94 ml and ≤28.78 ml), Q3 (PV >28.78 ml and ≤34.07 ml), and Q4 (PV >34.07 ml), with Q1 serving as the reference group. Logistic regression analyses were used to examine the association between MetS and PV, with subgroup analyses conducted by age. Among the participants, 18 787 (43.2%) were diagnosed with MetS. In the multivariate analysis model, a significant correlation between MetS and PV was observed, with odds ratios (ORs) increasing as PV increased (Q2, OR = 1.203, 95% confidence interval [CI]: 1.139-1.271; Q3, OR = 1.300, 95% CI: 1.230-1.373; and Q4, OR = 1.556, 95% CI: 1.469-1.648). Analysis of MetS components revealed that all components were positively associated with PV, with abdominal obesity showing the most significant effect. The number of MetS components was identified as a dose-dependent risk factor for elevated PV. The impact of MetS, its components, and component count on PV exhibited a decreasing trend with advancing age. Overall, the influence of MetS, its components, and component count on PV was predominantly observed in the age groups of 40-49 years and 50-59 years. Early intervention targeting MetS can significantly alleviate the increase in PV, particularly benefiting individuals aged 40-59 years who have abdominal obesity.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"475-481"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observation on the therapeutic effect of a modified Devine procedure with subcutaneous sliding fixation method for concealed penis. 改良Devine手术加皮下滑动固定治疗隐匿性阴茎的疗效观察。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-03-25 DOI: 10.4103/aja20251

Mohammed Abdulkarem Al-Qaisi, Hai-Fu Tian, Jia-Jin Feng, Ke-Ming Chen, Jin Zhang, Yun-Shang Tuo, Xue-Hao Wang, Bin-Cheng Huang, Muhammad Arslan Ul Hassan, Rui He, Guang-Yong Li

{"title":"Observation on the therapeutic effect of a modified Devine procedure with subcutaneous sliding fixation method for concealed penis.","authors":"Mohammed Abdulkarem Al-Qaisi, Hai-Fu Tian, Jia-Jin Feng, Ke-Ming Chen, Jin Zhang, Yun-Shang Tuo, Xue-Hao Wang, Bin-Cheng Huang, Muhammad Arslan Ul Hassan, Rui He, Guang-Yong Li","doi":"10.4103/aja20251","DOIUrl":"10.4103/aja20251","url":null,"abstract":"Abstract: To evaluate the therapeutic effect of a modified Devine procedure with a subcutaneous sliding fixation method for the treatment of congenital concealed penis, we retrospectively selected 45 patients with congenital concealed penises who were admitted to General Hospital of Ningxia Medical University (Yinchuan, China) between September 2020 and November 2023. In all cases, the penis was observed to be short, and retracting the skin at the base revealed a normal penile body, which immediately returned to its original position upon release. All patients underwent the modified Devine procedure with subcutaneous sliding fixation and completed a 12-week postoperative follow-up. A statistically significant increase in penile length was observed postoperatively, with the median length increasing from 4.0 (interquartile range [IQR]: 3.5-4.8; 95% confidence interval [CI]: 3.9-4.4) cm to 8.0 (IQR: 7.8-8.0; 95% CI: 7.7-7.9) cm, with P < 0.001. The parents were satisfied with the outcomes, including increased penile length, improved hygiene, and enhanced esthetics. Except for mild foreskin edema in all cases, no complications (such as infections, skin necrosis, or penile retraction) were observed. The edema was resolved within 4 weeks after the operation. This study demonstrates that the modified Devine procedure utilizing the subcutaneous sliding fixation method yields excellent outcomes with minimal postoperative complications, reduced penile retraction, and high satisfaction rates among patients and their families.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"470-474"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strategy to reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml -1 and PI-RADS 1-3. 一种减少tPSA患者不必要的前列腺活检的策略，tPSA为10 ng ml-1， PI-RADS为1-3。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-01-28 DOI: 10.4103/aja202499

Qi-Fei Dong, Yi-Xun Liu, Yu-Han Chen, Yi-Fan Ma, Tao Zhou, Xue-Feng Fan, Xiang Yu, Chang-Ming Wang, Jun Xiao

{"title":"A strategy to reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml -1 and PI-RADS 1-3.","authors":"Qi-Fei Dong, Yi-Xun Liu, Yu-Han Chen, Yi-Fan Ma, Tao Zhou, Xue-Feng Fan, Xiang Yu, Chang-Ming Wang, Jun Xiao","doi":"10.4103/aja202499","DOIUrl":"10.4103/aja202499","url":null,"abstract":"Abstract: We propose a strategy to reduce unnecessary prostate biopsies in Chinese patients with total prostate-specific antigen (tPSA) >10 ng ml -1 and Prostate Imaging Reporting and Data System (PI-RADS) scores between 1 and 3. Clinical data derived from 517 patients of The First Affiliated Hospital of USTC (Hefei, China) from January 2020 to December 2023 who met the screening criteria for the study were retrospectively collected. Independent predictors were identified via univariate and multivariate logistic regression analysis. The diagnostic capacity of clinical variables was evaluated using the receiver operating characteristic (ROC) curves and area under the curve (AUC). A prostate biopsy strategy was developed via risk stratification. Of the 517 patients, 17/348 (4.9%) with PI-RADS 1-2 were diagnosed with clinically significant prostate cancer (csPCa), and 27/169 (16.0%) patients with PI-RADS 3 were diagnosed with csPCa. The appropriate prostate-specific antigen density (PSAD) cut-off values were 0.45 ng ml -2 for PI-RADS 1-2 patients and 0.3 ng ml -2 for PI-RADS 3 patients. The appropriate prostate volume (PV) cut-off values were 40 ml for PI-RADS 1-2 patients and 50 ml for PI-RADS 3 patients. The prostate biopsy strategy based on PSAD and PV developed in this study can reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml -1 and PI-RADS 1-3. In the study, 66.5% (344/517) patients did not need to undergo prostate biopsy, at the expense of missing only 1.7% (6/344) patients with csPCa.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"531-536"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re: Commentary on "Testis tissue cryopreservation may be considered in boys with cryptorchidism". 回复：关于“睾丸组织冷冻保存可用于隐睾男孩”的评论。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-03-18 DOI: 10.4103/aja20255

Linn Salto Mamsen, Simone Hildorf, Elissavet Ntemou, Danyang Wang, Dina Cortes, Jens Fedder, Jørgen Thorup, Claus Yding Andersen

引用次数: 0

The dark side of transurethral access for LUTS/BPH surgery: a narrative review. 经尿道LUTS/BPH手术的阴暗面：叙述回顾。

Asian journal of andrology Pub Date : 2025-06-20 DOI: 10.4103/aja202523

Bruno Bucca, Christian Gozzi, Luca Matteo Gobbi, Eugenio Bologna, Leslie Claire Licari, Vincenzo Asero, Orietta Dalpiaz, Thomas Alber, Alessandro Calarco, Marco Martini, Fabrizio Presicce

{"title":"The dark side of transurethral access for LUTS/BPH surgery: a narrative review.","authors":"Bruno Bucca, Christian Gozzi, Luca Matteo Gobbi, Eugenio Bologna, Leslie Claire Licari, Vincenzo Asero, Orietta Dalpiaz, Thomas Alber, Alessandro Calarco, Marco Martini, Fabrizio Presicce","doi":"10.4103/aja202523","DOIUrl":"10.4103/aja202523","url":null,"abstract":"The transurethral route is the access of choice for benign prostatic hyperplasia (BPH) surgical treatment. Transurethral resection of the prostate (TURP) has been the gold standard in surgical intervention for BPH; however, the advent of novel surgical techniques and the exploration of new energy sources in recent decades have seen this primacy contested. Nevertheless, the transurethral route harbors numerous challenges and pitfalls that can pose significant risks even for the most experienced endoscopic urologists. Complications associated with transurethral access are well documented yet often underestimated by endoscopic surgeons, primarily because the pathological conditions arising from transurethral surgery typically fall within the realm of those specializing in genitourinary reconstructive surgery. This narrative review describes and critically discusses the specific pitfalls associated with transurethral surgery for BPH. Urethral strictures, transient or permanent postoperative incontinence, reintervention, and de novo/persistent lower urinary tract symptoms (LUTS) represent the main complications of transurethral treatments for BPH. These problems still stand as the foremost challenge for all endoscopists despite recent technological advancements. The use of increasingly miniaturized instruments, more mindful energy application, sphincter-sparing enucleation techniques, and the advent of so-called minimally invasive surgical techniques (MISTs) all contribute to a more conscious and anatomically respectful transurethral approach. An endoscopic transvesical suprapubic access may be another alternative strategy to minimize the complications of transurethral route in the future.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0