{"title":"Tomographic biomarkers in OCT: From description to automated quantification in clinical practice","authors":"R. Abreu-González, P. Udaondo, J. Donate-López","doi":"10.1016/j.oftale.2026.502531","DOIUrl":"10.1016/j.oftale.2026.502531","url":null,"abstract":"","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"101 10","pages":"Article 502531"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. de-Juan-Hernández, M.E. García-Lagarto, V.M. Asensio-Sánchez
{"title":"Amyloidosis of the eyelid and conjunctiva","authors":"L. de-Juan-Hernández, M.E. García-Lagarto, V.M. Asensio-Sánchez","doi":"10.1016/j.oftale.2026.502492","DOIUrl":"10.1016/j.oftale.2026.502492","url":null,"abstract":"<div><div>Amyloidosis is characterized by the extracellular deposition of abnormal amyloid protein fibrils in tissues. Amyloidosis of the eyelid and conjunctiva (AEC) is a rare clinical finding. We present the case of a 48-year-old female patient with pinkish-yellow infiltration in the upper and lower bulbar conjunctiva, along with a firm, well-circumscribed nodular lesion on the lower eyelid of the right eye. Biopsies of the eyelid and conjunctiva were performed, and histological examination confirmed amyloid deposition with Congo red staining. AEC is a rare entity that is often underdiagnosed. Although it most frequently manifests as a localized process, systemic involvement must always be ruled out.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"101 10","pages":"Article 502492"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Hamdy Ghoraba, M.A. Abdelhafez Elsayed, A.H. Hamdi Ghoraba, M. Leila
{"title":"Unusual closure of a large traumatic macular hole after an unorthodox pars plana vitrectomy","authors":"H. Hamdy Ghoraba, M.A. Abdelhafez Elsayed, A.H. Hamdi Ghoraba, M. Leila","doi":"10.1016/j.oftale.2026.502564","DOIUrl":"10.1016/j.oftale.2026.502564","url":null,"abstract":"<div><div>This retrospective case report describes the closure of a large traumatic macular hole following PPV, posterior hyaloid detachment, and air tamponade despite the inability to perform ILM surgery. An 11-year-old male presented with a full-thickness macular hole following blunt trauma and a BCVA of counting fingers. Serial OCT examination precluded spontaneous closure. The surgery consisted of PPV and induction of posterior hyaloid detachment. All attempts to perform a modified ILM flap technique failed. Air tamponade was used at the end of the surgery. The post-operative OCT images showed U-type closure of the hole. The BCVA improved to 6/60. We recommend a modified ILM flap technique in large full-thickness traumatic macular holes to improve the functional and anatomical outcomes. Despite the inability of ILM surgery, the hole closure described in this report is an unusual finding.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"101 10","pages":"Article 502564"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blue light and melatonin: A critical review of scientific evidence and biohacker myths in ophthalmology","authors":"C. Campo-Beamud, G. Roig-Ferreruela","doi":"10.1016/j.oftale.2026.502590","DOIUrl":"10.1016/j.oftale.2026.502590","url":null,"abstract":"<div><div>Blue light is a physiological component of visible light, essential for daytime vision and circadian synchronization. There is no evidence supporting the routine use of blue-blocking glasses for preventive or therapeutic purposes. The most effective strategies are based on light hygiene, reduction of nocturnal exposure, and patient education. Strengthening scientific communication is necessary to counter misinformation and maintain an evidence-based ophthalmological discourse.</div><div>Blue light has been associated with potential effects on visual function, sleep, and circadian physiology, although clinical evidence remains heterogeneous. In recent years, dissemination of claims unsupported by clinical evidence regarding spectral filters for preventive purposes has increased. The aim of this review was to critically analyze the available scientific evidence on the visual, circadian, and systemic effects of blue light and contrast it with messages disseminated through media and social networks.</div><div>A narrative review of the literature published between 2009 and 2025 was conducted using PubMed, Scopus, and the Cochrane Library, prioritizing human studies and institutional position statements relevant to ophthalmological practice.</div><div>Available systematic reviews and controlled trials indicate that blue-filtering lenses do not provide clinically meaningful improvements in visual acuity or symptoms of digital eye strain, and show small and inconsistent effects on sleep-related outcomes. Under typical viewing conditions, screen light exposure remains well below levels associated with photochemical retinal damage in experimental models. Therefore, current evidence does not support the routine preventive or therapeutic use of blue-blocking glasses. The most effective strategies rely on light hygiene, reduction of nocturnal light exposure, and patient education.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"101 10","pages":"Article 502590"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delayed inflammatory chorioretinopathy with VKH-like features and bilateral choroidal neovascularization after nivolumab-ipilimumab dual checkpoint blockade for metastatic melanoma.","authors":"T Stalmashka, Á Martínez Sobrino, S Pastor-Idoate","doi":"10.1016/j.oftale.2026.502667","DOIUrl":"10.1016/j.oftale.2026.502667","url":null,"abstract":"<p><p>This case describes a delayed bilateral posterior pole inflammation with secondary choroidal neovascularization (CNV) occurring after discontinuation of dual immune checkpoint inhibition (ICI) for metastatic cutaneous melanoma. A 53-year-old man presented with sudden visual loss five months after his last ICI infusion. Although symptoms were initially unilateral, fundus examination and multimodal imaging revealed bilateral posterior pole involvement, with an active CNV and retinal pigment epithelium (RPE) disturbances in both eyes. Intravitreal anti-vascular endothelial growth factor (anti-VEGF) monotherapy in one eye and corticosteroid monotherapy in the other provided limited benefit. Combined therapy achieved partial anatomical improvement but limited functional visual recovery, particularly in the initially symptomatic eye. In conclusion, this case highlights that ICI-associated inflammatory chorioretinopathy with VKH-like features may present late and progress despite treatment discontinuation, underscoring the role of multimodal imaging in guiding targeted management.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":"502667"},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Conjunctival bee sting successfully managed with complete stinger removal: a case report.","authors":"J Coín-Ruiz, C Alba-Linero, C Gómez-Cabrera","doi":"10.1016/j.oftale.2026.502669","DOIUrl":"10.1016/j.oftale.2026.502669","url":null,"abstract":"<p><p>Ocular bee stings are uncommon injuries that may cause a wide spectrum of clinical manifestations depending on the affected structure. We report a case of conjunctival bee sting with successful complete removal of the stinger, followed by a favorable clinical outcome. Clinical images illustrating the stinger in situ and after removal are presented. Current literature suggests that although immediate removal is recommended, retained stingers may occasionally be well tolerated.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":"502669"},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guillain-Barré syndrome associated with optic neuritis following Mycoplasma pneumoniae infection.","authors":"C Francisco, L Francisco, A Lemos","doi":"10.1016/j.oftale.2026.502670","DOIUrl":"10.1016/j.oftale.2026.502670","url":null,"abstract":"<p><p>The involvement of both the central and peripheral nervous systems in Mycoplasma pneumoniae infection is rare. We report a patient who developed bilateral optic neuritis and Guillain-Barré syndrome (GBS) following a Mycoplasma pneumoniae infection. A 32-year-old man presented with progressive weakness, ataxia, and dysphagia after a recent respiratory infection. Clinical, cerebrospinal fluid, and neurophysiological findings were consistent with GBS, and treatment with intravenous immunoglobulin was initiated. Two days later, the patient developed visual loss, and post-infectious autoimmune optic neuritis was diagnosed. Treatment with methylprednisolone and plasmapheresis led to significant neurological and visual recovery. At one-year follow-up, the patient had full neurological recovery and maintained 20/20 visual acuity in both eyes. This case illustrates the rare coexistence of GBS and optic neuritis and highlights that, despite severe presentation, timely diagnosis and immunotherapy can result in excellent long-term outcomes.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":"502670"},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149019032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Lorente, A Urcelay, A Sachkouskaya, I Sánchez Rodríguez-Acosta, B Lorente
{"title":"Endophthalmitis prevention in Refractive Lens Exchange.","authors":"R Lorente, A Urcelay, A Sachkouskaya, I Sánchez Rodríguez-Acosta, B Lorente","doi":"10.1016/j.oftale.2026.502646","DOIUrl":"10.1016/j.oftale.2026.502646","url":null,"abstract":"<p><p>The aim of this study was to evaluate the safety and efficacy of the intracameral antibiotics vancomycin, cefuroxime, and moxifloxacin, as well as the need for topical antibiotics preoperatively, postoperatively, or both. A systematic review and meta-analysis were conducted using PubMed to compare their efficacy in cataract surgery performed by phacoemulsification. We also assessed the additional benefit of topical antibiotics in preventing endophthalmitis when intracameral antibiotics and povidone-iodine were used. All included studies supported the use of intracameral antibiotics at the end of surgery. The results were more favourable for moxifloxacin and vancomycin than for cefuroxime, although no statistically significant differences were found. In addition, the secondary analysis showed no additional benefit from the perioperative use of topical antibiotics. Intracameral antibiotic injection is a safe and effective measure for the prevention of endophthalmitis following phacoemulsification. The use of vancomycin remains controversial. Furthermore, postoperative topical antibiotics do not appear to provide any additional benefit when intracameral antibiotics are administered.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":"502646"},"PeriodicalIF":0.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The paradigm shift in diabetic retinopathy: From microvascular alteration to neurovascular pathology.","authors":"I Pinilla, M Sopeña-Pinilla, M I López-Galvez","doi":"10.1016/j.oftale.2026.502645","DOIUrl":"10.1016/j.oftale.2026.502645","url":null,"abstract":"","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":"502645"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B López Pérez, A Marco Campmany, I Benítez Hurtado
{"title":"Ocular dirofilariasis after the Valencia floods \"DANA\" 2024. A case report: From eyelid to conjunctiva.","authors":"B López Pérez, A Marco Campmany, I Benítez Hurtado","doi":"10.1016/j.oftale.2026.502650","DOIUrl":"10.1016/j.oftale.2026.502650","url":null,"abstract":"<p><p>Human Dirofilaria infection is increasingly reported in Europe, driven by rising temperatures and the expansion of ecological niches suitable for its mosquito vectors. We report the case of a 20-year-old woman with ocular involvement after volunteering during the clean-up following the October 2024 DANA (Isolated High-Level Depression) floods in Valencia, Spain. The nematode was initially observed in the upper eyelid, later migrating to the subconjunctival space and ultimately forming an infrapalpebral subcutaneous nodule. We highlight the diagnostic challenge posed by the parasite's continuous migration, which hindered its visualization during examinations and therefore delayed its isolation and definitive identification.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":"502650"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}