Archivos de la Sociedad Espanola de Oftalmologia最新文献

{"title":"Progressive visual dysfunction and retinal neurodegeneration in patients with fibromyalgia","authors":"E. Garcia-Martin ,&nbsp;M.J. Vicente Altabas ,&nbsp;E. Vilades Palomar ,&nbsp;E. Orduna Hospital ,&nbsp;B. Cordon Ciordia ,&nbsp;J. Garcia-Campayo ,&nbsp;M. Puebla-Guedea ,&nbsp;M. Satue Palacian","doi":"10.1016/j.oftale.2025.06.008","DOIUrl":"10.1016/j.oftale.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Pathophysiology of fibromyalgia is still not well known. There are certain theories than point out a possible neurodegeneration component.</div></div><div><h3>Objectives</h3><div>To evaluate variations in visual function parameters and in the macular ganglion cell layer (CGR) of patients with fibromyalgia (FM) over a period of 5 years, and compare these results with controls.</div></div><div><h3>Methods</h3><div>85 patients with FM and 41 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity (VA) with ETDRS, contrast sensitivity vision (CSV) with Pelli Robson, color vision with Farnsworth and Lanthony D15 tests and retinal evaluation using Cirrus HD-OCT 3000 (Carl Zeiss, California). All subjects were re-evaluated after 5 years. It was also analyzed the association between progressive structural, functional and disease severity changes. Furthermore, patients were classified into three groups (1, atypical; 2, depressive; 3, biologic).</div></div><div><h3>Results</h3><div>Progressive changes were detected in visual function parameters and CGR thickness in FM patients after 5 years. Patients with FM presented worse low contrast VA (p = 0.022), color discrimination (Lanthony’s C index, p = 0.006) and decreased CGR thickness (nasal inferior, p &lt; 0.001) over the follow up time, compared with controls. Changes in color vision were associated with CGR thinning, but no correlations with disease severity were observed.</div></div><div><h3>Conclusions</h3><div>It has been noticed progressive visual dysfunction and CGR loss in patients suffering from FM. The analysis of visual function parameters and CGR thickness using Cirrus OCT could be of value to control FM disease.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 601-609"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute esotropia concurrent with adenoviral keratoconjunctivitis","authors":"J. Moya-Roca ,&nbsp;M. Lledó-Riquelme ,&nbsp;E. Campos-Mollo ,&nbsp;J. Hernández-Jiménez ,&nbsp;C. Porcar-Plana ,&nbsp;M. Lledó-Carreres ,&nbsp;E. Navarro-Hernández","doi":"10.1016/j.oftale.2025.07.007","DOIUrl":"10.1016/j.oftale.2025.07.007","url":null,"abstract":"<div><div>Acute acquired comitant esotropia is a rare manifestation of strabismus that has been used to describe an acute late-onset of esotropia with diplopia in a previously orthotropic individual. It often occurs in older children and adults and has been associated with multiple etiologies. Despite the multiple reports conducted its cause is still controversial. We describe a young patient with epidemic keratoconjunctivitis with an acute comitant esotropia. He had no underlying diseases and regained stereo acuity after surgical alignment of both eyes.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 640-643"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autosomal dominant retinitis pigmentosa: An extended family report of the Asp-190-Tyr variant","authors":"P. Moreira Martins,&nbsp;C. Ferreira,&nbsp;E. Saraiva,&nbsp;P. Sepúlveda,&nbsp;L. Silva,&nbsp;F. Sousa-Neves","doi":"10.1016/j.oftale.2025.07.009","DOIUrl":"10.1016/j.oftale.2025.07.009","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Retinitis pigmentosa (RP) represents a spectrum of rod-cone inherited disorders with characteristic symptoms, and functional changes. The Asp-190-Tyr pathogenic variant of the RHO gene impairs rodopsin transport through the endoplasmic reticulum, leading to accumulation within photoreceptors, inducing cytotoxicity. This report presents the ophthalmologic phenotype of this rare variant.</div></div><div><h3>Materials and methods</h3><div>Retrospective study including patients from one extended family presenting with RP, with an autosomal dominant (AD) variant of the RHO gene (Asp-190-tyr). Baseline demographic/ophthalmologic data and ancillary testing was collected.</div></div><div><h3>Results</h3><div>Twelve individuals were included; eight had generalized RP. The mean age was 64 years - four were female. Genetic testing in 5/8 patients with RP revealed an AD variant in the RHO gene, with replacement of an aspartic acid with tyrosine at codon 190. Visual acuity ranged from no light perception to 6/10. Fundoscopy and fundus autofluorescence showed bilateral generalized RP pattern: optic disc pallor, bone spicules, and arterial narrowing. Perimetry in four patients showed tunnel vision. Electrophysiology revealed marked wave reduction in both pattern and flash ERG. Severe atrophy of the outer retinal layers with cystoid macular oedema was observed in 4/8 patients.</div></div><div><h3>Conclusions</h3><div>This study highlights the phenotype of the Asp-190-Tyr variant. Previously, it was described in a family with a regional pattern of RP and relatively preserved visual function. Our study changes this paradigm, with patients presenting with a generalized RP phenotype and significant visual impairment. The provided data may help offer accurate prognostic information to patients with this variant.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 585-591"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular ischaemia after inadvertent perforation of the eyeball and intravitreal injection of anesthetic agents during retrobulbar anaesthesia","authors":"J.L. Sánchez-Vicente,&nbsp;M. Portillo-Martínez,&nbsp;J.V. Guijarro-Ambel,&nbsp;E.M. Gámez-Jiménez,&nbsp;E. Cosano-Palma,&nbsp;F. López-Herrero","doi":"10.1016/j.oftale.2025.07.014","DOIUrl":"10.1016/j.oftale.2025.07.014","url":null,"abstract":"<div><div>Perforation of the eyeball during retrobulbar anesthesia is rarely reported. A case of inadvertent ocular perforation during retrobulbar anesthesia in cataract surgery is presented. Retinal complications and follow up after six months are described.</div><div>A 58-year-old man presented with vision loss following cataract surgery on his right eye by phacoemulsification and intraocular lens implantation under retrobulbar anaesthesia performed one week earlier. Visual acuity was 0.05. Fundus examination revealed a vitreous haemorrhage in the lower area. A rounded haemorrhage was present next to the lower temporal arcade with a possible entry orifice. Optical coherence tomography, tomographic angiography and fluorescein angiography showed retinal ischaemia in the juxtapapillary macular area.</div><div>The patient was followed for 6 months. Visual acuity improved to 0.5. Optical coherence tomography and tomographic angiography showed a reduction of the edema in the retinal layers, with a persistent loss of the inner nuclear and outer plexiform layer.</div><div>Accidental intravitreal injection of bupivacaine and lidocaine during retrobulbar anaesthesia can result in permanent visual impairment. Extreme attention should be paid to the injection technique to avoid this complication.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 630-635"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of conjunctival colonization by cefuroxime-resistant bacteria in cataract surgery patients younger than 75 years and aged 75 or older","authors":"J.L. Urcelay-Segura ,&nbsp;J.M. Bellón-Cano ,&nbsp;T. Cuesta-Rodríguez ,&nbsp;M.E. Fernández-Rubio","doi":"10.1016/j.oftale.2025.08.006","DOIUrl":"10.1016/j.oftale.2025.08.006","url":null,"abstract":"<div><h3>Background and objective</h3><div>Bacteria isolated in postoperative endophthalmitis (PE) were reduced to cefuroxime-resistant bacteria in cataract surgery with intracameral cefuroxime as prophylaxis; age &gt; 84 years was at risk for PEs caused by Gram-negative-bacteria and Staphylococci; no risks were identified for Enterococci, the most abundant isolations. The prevalence of Enterococci in the preoperative conjunctiva was associated with age &gt; 74 years, diabetes, obesity, and dacryocystorhinostomy-history (DCR-history). The aim of the study is to differentiate the risk of age from that of other patient characteristics, establishing 2 different age groups.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective cross-sectional study in a tertiary referral center. In 7,085 patients &lt; 75 years old and 7,798 ≥ 75 years, the incidence rate ratio (IRR) of Enterococci, Enterobacteriaceae, Non-fermentative-Gram-negative-bacilli (NFGNB) and Coagulase-negative-Staphylococci (CNS) was calculated for the following factors: diabetes, obesity, DCR-history, sex-male, smoking-habit, and climate, using multivariate Poisson regression, IBM SPSS Statistic for Windows, version 25.0. Armonk, NY: IBM Corp.</div></div><div><h3>Results</h3><div>Diabetes, obesity, male-sex and smoking-habit were more prevalent in patients &lt; 75 years old. The IRRs of Enterococci, Enterobacteriaceae and NFGNB were higher in this age group: [Enterococci IRRs: diabetes, 1.54 vs 1.42; obesity, 2.95 vs 1.50; DCR-history, 3.78 vs 1.08]; [Enterobacteriaceae IRRs: diabetes, 1.47 vs 1.13; obesity, 2.27 vs 1.99; male-sex, 1.76 vs 1.65]; [NFGNB IRRs: diabetes, 1.79 vs 1.16; autumn-weather, 2.05 vs 1.56]. Diabetes-obesity simultaneously: Enterobacteriaceae IRR, 3.30 vs 2.28; Enterococci IRR, 3.28 vs 1.62.</div></div><div><h3>Conclusions</h3><div>Diabetes, obesity and DCR-history increase the IRR of Enterococci, Enterobacteriaceae and NFGNB in patients &lt; 75 years more than they actually do in patients ≥ 75.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 10","pages":"Pages 592-600"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible syphilitic ellipsoiditis.","authors":"F Garcia Ibor, N Ruiz Del Rio, A Caro Ortega","doi":"10.1016/j.oftale.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.oftale.2025.09.013","url":null,"abstract":"","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus necrotizing retinitis in an immunocompetent patient: A case report.","authors":"A Lo Cascio, A Bures Jelstrup","doi":"10.1016/j.oftale.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.oftale.2025.09.012","url":null,"abstract":"<p><p>Thi is the case of a necrotizing retinitis associated with occlusive retinal vasculitis due to cytomegalovirus (CMV) in an immunocompetent patient with complex diagnosis and management, but with resolution after the start of appropriate antiviral therapy, with subsequent control of intraocular inflammation and visual recovery. CMV was confirmed as the pathogen using the polymerase chain reaction (PCR) assay of aqueous humor samples.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the accuracy of a digital color vision test.","authors":"M Gobira, V Freire, C Tinoco, G S Avelino, P Carricondo, A Dias, M A Negreiros","doi":"10.1016/j.oftale.2025.09.008","DOIUrl":"10.1016/j.oftale.2025.09.008","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>The aim of this study was to assess the precision of a web-based tool in measuring color vision in ophthalmic patients, comparing it to the traditional in-clinic evaluation using the Ishihara test, the most used test in clinical context.</p><p><strong>Materials and methods: </strong>We conducted a prospective validation comparing the Eyecare Colour Vision Test® to the standard Ishihara test, with patients undergoing both tests sequentially. Patients wore their standard spectacles as needed for both tests. Inclusion criteria involved individuals above 18 years with visual acuity equal to or better than + 1 logMAR (20/200) in each eye. Visual acuity measurements were converted from Snellen to LogMAR, and statistical analyses included Bland-Altman and descriptive statistics.</p><p><strong>Results: </strong>The study, encompassing 330 patients, compared Eyecare Color Vision Test® to conventional Ishihara test, the score for correct responses by the Eyecare Color Vision Test® was 4073 as compared to 4081 by Ishihara standard test- a concordance rate of 87,88%. Sensitivity of 96.43% (CI 95%, 81.65% to 99.91%), and specificity of 99.34% (CI 95%, 97.63% to 99.92%) for the diagnosis of color vision deficiency.</p><p><strong>Conclusion: </strong>The Eyecare Color Vision Test® demonstrates accuracy and reliability, with the potential to facilitate remote CVD diagnosis.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30-Gauge Needle Descemet Membrane Endothelial Keratoplasty Graft Obtention: A novel, safer and cheap technique.","authors":"P Pérez-García, J A Gegúndez-Fernández, M Arino-Gutiérrez, M Molero-Senosiaín, B Burgos-Blasco, D Díaz-Valle","doi":"10.1016/j.oftale.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.oftale.2025.09.011","url":null,"abstract":"<p><p>This work aims to present a novel technique for obtaining grafts for Descemet Membrane Endothelial Keratoplasty (DMEK) safely and efficiently, thanks to its fast learning curve and reduced risk of graft tears. The technique involves the peripheral dissection of the endothelium starting with a superficial incision made using a 30-Gauge needle, 1 mm inside Schwalbe's line across 360º of the corneal periphery. Trypan Blue is then applied to visualize the dissection boundary, and a DMEK Sinskey hook is used to lift 1 mm of the peripheral graft along the entire circumference. The technique continues with the separation of Descemet's membrane from the stroma, as is commonly performed. This technique reduces costs by employing a standard needle and achieves low failure rates compared to other techniques.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveitis associated with immunotherapy and its response to monotherapy with difluprednate: A case report.","authors":"C M Ortega, A T Pérez Bello, B F Graizman Kohan, M D Eraso Quintero, J Stuart Pennington, F M Preto","doi":"10.1016/j.oftale.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.oftale.2025.09.010","url":null,"abstract":"<p><p>Nivolumab and ipilimumab are immune checkpoint inhibitors widely used for the treatment of metastatic melanoma. They can cause various adverse effects in a significant percentage of treated patients, including uveitis. Symptoms include decreased visual acuity, pain, redness, and photophobia, which typically resolve with appropriate anti-inflammatory therapy. The aim of this work is to report a case of uveitis in a patient on ipilimumab and nivolumab for the treatment of metastatic melanoma, as well as the response to therapy with difluprednate.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}