J Noguera Campos, S Pose Bazarra, N Castro Casal, A Urbano Bueno, M D Álvarez Díaz
{"title":"Topical permethrin 5% as a treatment for pediatric patients with phthiriasis palpebrarum: A case report.","authors":"J Noguera Campos, S Pose Bazarra, N Castro Casal, A Urbano Bueno, M D Álvarez Díaz","doi":"10.1016/j.oftale.2025.05.008","DOIUrl":"10.1016/j.oftale.2025.05.008","url":null,"abstract":"<p><p>Phthiriasis palpebrarum is defined as the involvement of the eyelids by the Phthirus pubis parasite. It is a pathology considered as a sexually transmitted disease, whose treatment can be challenging in some situations. We present the case of a 4-year-old patient with eyelashes severely affected by this parasite, who cooperated poorly for mechanical removal. Given this situation, we decided to prescribe a single dose of topical permethrin 5% and several applications of vaseline, repeating this treatment a week later, which led to the complete resolution of the condition. This case introduces topical permethrin 5% as an effective, safe and widely available option for the treatment of this pathology, especially for pediatric patients or those who do not cooperate adequately for mechanical removal of the parasites.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P B Blasco Palacio, A Aramburu-Gonzalez, I Rodríguez García
{"title":"New OCT sign in X-linked retinoschisis without macular schisis: \"Inverted roof fovea\".","authors":"P B Blasco Palacio, A Aramburu-Gonzalez, I Rodríguez García","doi":"10.1016/j.oftale.2025.05.003","DOIUrl":"10.1016/j.oftale.2025.05.003","url":null,"abstract":"<p><p>We present the case of a 52-year-old man with a stable ophthalmological follow-up for the last 10 years. Clinically asymptomatic, except for floaters in both eyes. In the fundus, bilateral peripheral retinoschisis was observed without associated macular schisis. The electroretinogram (ERG) is electronegative and shows a genetic confirmation of the pathogenic variant c.461A > G; p.(Gln154Arg) of the RS1 gene compatible with the diagnosis of juvenile X-linked retinoschisis (RSLX). The foveal architecture in Optical Coherence Tomography (OCT) presents \"inverted roof fovea\" not previously described, having found two similar cases in the literature. In males in whom we find the sign of \"inverted roof fovea\", we should check the fundus, and if we find peripheral retinoschisis, we recommend insisting on the family history, and increase its study with an ERG and molecular genetic analysis, ruling out RSLX.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Camargo-Parra, F J Bonilla-Escobar, E Lozano-Cruz, O Salamanca, A Martínez-Blanco, A F Plaza-Hernández
{"title":"Validation and Update of the Glaucoma Quality of Life (GQL)-15 Questionnaire for Spanish-Speaking Individuals.","authors":"K Camargo-Parra, F J Bonilla-Escobar, E Lozano-Cruz, O Salamanca, A Martínez-Blanco, A F Plaza-Hernández","doi":"10.1016/j.oftale.2025.05.004","DOIUrl":"10.1016/j.oftale.2025.05.004","url":null,"abstract":"<p><strong>Background and objective: </strong>Glaucoma, a leading cause of preventable blindness, significantly impacts patients' quality of life (QoL). The GQL-15 (1999) assesses functional disability due to glaucoma through 15 items across 4 domains. However, it has not been validated in Spanish. This study aimed to validate and update the GQL-15 for Spanish-speaking individuals.</p><p><strong>Methods: </strong>We conducted a cross-sectional study with individuals diagnosed with glaucoma at 2 ophthalmological referral centers in Cali-Colombia. Researchers translated the GQL-15 into Spanish and modified it by replacing the 'reading newspaper' item with 'reading on a cellphone/mobile/smartphone' to modernize the questionnaire (GQL-15 m). The GQL-15 m was tested for validity and reliability using Cronbach's alpha (α) coefficient, exploratory factor analysis, and criterion validity. Reproducibility was assessed through a 2-week test-retest analysis.</p><p><strong>Results: </strong>A total of 157 out of 468 eligible patients with glaucoma participated in the survey (33% response rate). The mean age was 67 ± 12 years (64%, women). The GQL-15 m showed a mean total score of 29.3 ± 7.31, suggesting good QoL. Internal consistency was high for both the GQL-15 (α = 0.97) and GQL-15 m (α = 0.96). Criterion validity was supported by significant correlations between the GQL-15 m scores and the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ 25), World Health Organization Quality of Life-BREF (WHOQoL-BREF), Glaucoma Symptom Scale (GSS), Glaucoma Utility Index (GUI), and visual acuity. Reproducibility was high, with an intraclass correlation coefficient (ICC) of 0.89.</p><p><strong>Conclusions: </strong>The GQL-15 m is a reliable and valid instrument for assessing QoL in Spanish-speaking individuals with glaucoma and has potential for broader application across various cultural contexts.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C E Monera Lucas, C Mora Caballero, J Escolano Serrano, A Machan, G Castilla Martínez, D Romero Valero, J Campello Lluch
{"title":"Analysis of ChatGPT-4's performance on ophthalmology questions from the MIR exam.","authors":"C E Monera Lucas, C Mora Caballero, J Escolano Serrano, A Machan, G Castilla Martínez, D Romero Valero, J Campello Lluch","doi":"10.1016/j.oftale.2025.05.002","DOIUrl":"10.1016/j.oftale.2025.05.002","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the performance of ChatGPT in solving clinical scenarios in ophthalmology, specifically questions from the specialty exams for Resident Medical Interns (MIR).</p><p><strong>Design: </strong>Cross-sectional design for evaluating a diagnostic tool.</p><p><strong>Method: </strong>Ophthalmology questions from the MIR exams from the 2010-2023 sessions were collected. The performance of ChatGPT in successfully answering the questions was calculated. The results were also compared with those obtained by ophthalmology professionals. Additionally, sensitivity, specificity, and positive and negative probability coefficients were calculated.</p><p><strong>Results: </strong>A total of 54 questions were collected, with those from the subspecialty \"Retina\" being the most frequent. ChatGPT's overall score was 90.2%, with a sensitivity of 92.59% and a specificity of 96.8%. The average concordance with the evaluators' answers was 86.41%. The agreement between the evaluators was 79.62%.</p><p><strong>Conclusions: </strong>ChatGPT-4 is a useful tool for solving clinical scenarios and theoretical questions in ophthalmology. Proper use of the tool, supervised by professionals, can help optimize the care processes for ophthalmology patients.</p>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Garcia-Martin, J Pérez-Velilla, B Cordon, E Vilades, M J Rodrigo, L E Pablo
{"title":"Update on the usefulness of optical coherence tomography-mediated angiography in neurodegenerative diseases.","authors":"E Garcia-Martin, J Pérez-Velilla, B Cordon, E Vilades, M J Rodrigo, L E Pablo","doi":"10.1016/j.oftale.2025.05.001","DOIUrl":"10.1016/j.oftale.2025.05.001","url":null,"abstract":"","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Labay-Tejado , J. Laguna , M.J. Navarro-Angulo , L. Muñoz , M. Jodar , E. Milla
{"title":"XEN 63 in a case of refractory glaucoma secondary to microphthalmia and aphakia","authors":"S. Labay-Tejado , J. Laguna , M.J. Navarro-Angulo , L. Muñoz , M. Jodar , E. Milla","doi":"10.1016/j.oftale.2025.03.010","DOIUrl":"10.1016/j.oftale.2025.03.010","url":null,"abstract":"<div><div>Microphthalmia (MO) predisposes to glaucoma and congenital cataracts (CC). Cataract removal in MO is characterized by several complications such as aphakic glaucoma (AG).</div><div>We report the case of a 33-year-old male with MO, aphakia, and refractory glaucoma who underwent inferonasal ab-interno XEN 63 implantation, after posterior vitrectomy. Whole Exome Sequencing (WES) analysis was performed identifying the likely pathogenic variant c.197G>A (p.Cys66Tyr) in heterozygosity in the <em>PAX6</em> gene related to Peters anomaly (PA) and the variant of unclear significance c.353T>C (p.Leu118Pro) in heterozygosity in the <em>CRYBB3</em> gene, potentially related to CC. Until the 12-month follow-up, the patient maintained intraocular pressure (IOP) between 16 and 18 mmHg without medication or complications.</div><div>XEN 63, when combined with posterior vitrectomy may be an option in select cases, owing to its versatility. However, further investigation is required. Genetic analysis provides a pre-symptomatic diagnosis and may lead to a more personalised medicine.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 5","pages":"Pages 289-294"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L.A. Oseguera Chávez, L.E. Salas Medina, C. Palacio Pastrana, W. Cedillo Suárez
{"title":"Endothelial changes in patients with and without diabetes after manual small-incision cataract surgery","authors":"L.A. Oseguera Chávez, L.E. Salas Medina, C. Palacio Pastrana, W. Cedillo Suárez","doi":"10.1016/j.oftale.2025.03.016","DOIUrl":"10.1016/j.oftale.2025.03.016","url":null,"abstract":"<div><h3>Background and objective</h3><div>In Mexico there is a high prevalence of diabetes, which is one of the most frequent etiologies of cataract. The impact of diabetes on postoperative corneal decompensation associated with MSICS has not been studied in our country. The objective of the study was to determine the difference in corneal endothelial changes between diabetic and non-diabetic patients by preoperative specular microscopy and at one month and 3 months after MSICS.</div></div><div><h3>Patients and methods</h3><div>Prospective, longitudinal, paired, non-randomized study with two groups; Group 1: diabetic patients and Group 2: non-diabetic patients. All patients had a complete ophthalmologic evaluation and preoperative and postoperative specular microscopy at one month and 3 months.</div></div><div><h3>Results</h3><div>119 eyes were included. The percentage of CD loss at 1 month was 11.1% in diabetic patients and 6.3% in non-diabetic patients. At 3 months the percentage of loss was 9.9% in diabetic patients and 5.4% in non-diabetic patients. The CV was higher in patients with diabetes and was significant at 1 month; however, at 3 months the values were comparable. The percentage of HEX decreased significantly in the first month in patients with diabetes.</div></div><div><h3>Conclusions</h3><div>There was a significant difference with greater CD loss, greater CV and less HEX in patients with diabetes vs. without diabetes at 1 month after the M-SICS procedure, however, it was not statistically significant at 3 months. This suggests greater endothelial stress, longer recovery time and remodeling of the corneal endothelium in patients with diabetes.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 5","pages":"Pages 246-253"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the Enigma: Gigantic primary de novo poorly-differentiated ductal adenocarcinoma of the lacrimal gland with aggressive features. A case report and literature review","authors":"S. Malik, C. Ahluwalia, A. Aziz Khan","doi":"10.1016/j.oftale.2025.03.018","DOIUrl":"10.1016/j.oftale.2025.03.018","url":null,"abstract":"<div><div>Primary ductal adenocarcinoma (PDA) of the lacrimal gland is a rare and aggressive malignancy originating from ductal epithelial cells. Its rarity and diverse clinical presentations pose significant diagnostic challenges, emphasizing the need for accurate diagnosis and appropriate management strategies. The study presents an intriguing case of a 50-year-old man with a large de novo primary ductal adenocarcinoma of the lacrimal gland, initially misdiagnosed as a meningeal solitary fibrous tumor due to its atypical clinical presentation of “down and out” proptosis. The case underscores the importance of histopathology to achieve a correct diagnosis and guide management decisions. Despite aggressive treatment approaches, the prognosis of primary ductal adenocarcinoma patients remains grim due to its aggressive behavior and tendency for recurrence and metastasis. The present case study emphasizes that a differential of primary ductal adenocarcinoma should be considered despite the presence of anomalous clinical and radiological presentation.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 5","pages":"Pages 295-301"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serious incidents involving ocular medical devices reported to the AEMPS","authors":"L.C. Ramón-Carreira , E.M. Sobas , J.C. Pastor","doi":"10.1016/j.oftale.2025.03.008","DOIUrl":"10.1016/j.oftale.2025.03.008","url":null,"abstract":"<div><div>The implementation of the Medical Device Regulation and Royal Decree 192/2023 not only requires manufacturers to enhance safety measures in the production of medical devices but is also complemented by additional regulations impacting hospitals, clinics, and healthcare personnel. Among these is the requirement to identify and report serious incidents to the Spanish Agency of Medicines and Medical Devices (AEMPS). To establish a baseline and evaluate the dissemination efforts of these concepts at the level of scientific societies and other organizations, serious incidents involving ophthalmic medical devices reported to AEMPS since 2018 and subject to health alerts have been identified. Although the percentage remains minimal, it is notable that issues with software or equipment such as surgical microscopes and Optical Coherence Tomography (OCT) are now being reported.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 5","pages":"Pages 274-277"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Yılmaz , G. Demirci , S. Karaman , M. Sargolzaeimoghaddam , E.S. Uluçam , A. Sarg
{"title":"Williams-Beuren syndrome case series with thinner fovea centralis and central corneal thicknesses","authors":"G. Yılmaz , G. Demirci , S. Karaman , M. Sargolzaeimoghaddam , E.S. Uluçam , A. Sarg","doi":"10.1016/j.oftale.2025.01.012","DOIUrl":"10.1016/j.oftale.2025.01.012","url":null,"abstract":"<div><h3>Background/aims</h3><div>To characterize the ocular signs of Williams-Beuren syndrome (WBS) in 3 cases examined at XXX University Ophthalmology Clinic.</div></div><div><h3>Methods</h3><div>Three patients with a diagnosis of WBS underwent comprehensive ophthalmic evaluation at the XXX University Ophthalmology, including best-corrected visual acuity, slitlamp biomicroscopy, dilated fundus examination, optical coherence tomography, corneal topography and colour fundus imaging.</div></div><div><h3>Results</h3><div>All 3 cases had decreased best corrected visual acuity, decreased ILM-RNFL thicknesses with a persistence of inner retinal layers on the SD-OCT examinations, decreased central corneal thickness yet normal epithelial thickness measurements and retinal arteriolar tortuosity in fundus examination.</div></div><div><h3>Conclusion</h3><div>WBS is a complex multisystem genetic disorder. The ocular findings observed in these cases which are decreased corneal thickness with normal epithelial thickness, decreased ILM-RPE thicknesses, and retinal arteriolar tortuosity may provide future insight into systemic vascular findings affected by a microdeletion of chromosome 7q11.23 which also contains elastin gene in WBS.</div></div>","PeriodicalId":93886,"journal":{"name":"Archivos de la Sociedad Espanola de Oftalmologia","volume":"100 5","pages":"Pages 238-245"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}