Annals of the American Thoracic Society最新文献

{"title":"Challenging the Definition of Positive Airway Pressure Adherence in Pediatric Populations.","authors":"Chun T Au, Shania Sheth, Lena Xiao, Rianna Sabajna, Adele Baker, Maida L Chen, Indra Narang","doi":"10.1093/annalsats/aaoag261","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag261","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not Always Black and White: Unresolving Pneumonia in a Woman With Cirrhosis.","authors":"Ralph L Sabang, Areen Pitaktong, Kuldeep Ghosh, Fouzia Shakil, Oleg Epelbaum","doi":"10.1093/annalsats/aaoag262","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag262","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Framing: From Personal to Organizational Health Literacy.","authors":"Deepshikha C Ashana","doi":"10.1093/annalsats/aaoag273","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag273","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood Disadvantage Association with Sleep Apnea and Longitudinal Cardiovascular Events and Mortality.","authors":"Cinthya Pena-Orbea, David Bruckman, Jarrod E Dalton, J Daryl Thornton, Jay L Alberts, Catherine M Heinzinger, Nancy Foldvary-Schaefer, Reena Mehra","doi":"10.1093/annalsats/aaoag259","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag259","url":null,"abstract":"<p><strong>Rationale: </strong>Neighborhood socioeconomic disadvantage is associated with adverse cardiovascular outcomes, but its relationship with obstructive sleep apnea (OSA) severity and sleep-related hypoxemia is not well defined.</p><p><strong>Objective: </strong>To assess the association of Area Deprivation Index (ADI) with OSA and major adverse cardiovascular events (MACE).</p><p><strong>Methods: </strong>We conducted an observational cohort study of adults in a large institutional sleep registry who underwent polysomnography (PSG) or type III sleep testing. Neighborhood disadvantage was quantified using Area Deprivation Index (ADI) quintiles (ADI-Q1 least disadvantaged; ADI-Q5 most disadvantaged). Associations between ADI, OSA severity (apnea-hypopnea index [AHI]), sleep hypoxemia (percentage of sleep time with oxygen saturation<90%, T90), and incident MACE (heart failure, stroke, atrial fibrillation, coronary artery disease, or death) were assessed using multivariable models adjusted for demographics, comorbidities, smoking, and cardiovascular medications.</p><p><strong>Measurements and main results: </strong>Among 72,443 adults (52,874 PSG;19,569 type III testing), greater neighborhood deprivation was associated with more severe sleep-related hypoxia (higher T90 and lower oxygen saturation nadir; p < 0.0001) but not with AHI. Over median follow-up of 5.6 years (PSG) and 2.8 years (type III), residence in the most disadvantaged neighborhoods was associated with increased risk of MACE or death (PSG ADI-Q5 vs Q1:HR1.22,95%CI1.13-1.33; type III ADI-Q4 vs Q1:HR1.41,95%CI1.12-1.78). In the type III cohort, hypoxia modified the association between ADI and outcomes (interaction p = 0.025).</p><p><strong>Conclusions: </strong>Neighborhood disadvantage is associated with greater sleep-related hypoxia and worse cardiovascular outcomes among patients evaluated for OSA, independent of apnea frequency. Incorporating measures of sleep-related hypoxia and neighborhood disadvantage into cardiovascular risk stratification may play a role in the identification of high-risk populations.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Stop 'em if you've got 'em!\" - Determinants and Consequences of CF Treatment Availability in Discontinuation Research.","authors":"Alex H Gifford","doi":"10.1093/annalsats/aaoag272","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag272","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charting One More Unknown Territory on the Bronchiectasis Map: A Canadian Perspective.","authors":"Hayoung Choi","doi":"10.1093/annalsats/aaoag274","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag274","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Dyspnea Phenotypes After COVID-19: The Missing Autonomic Dimension and the Need for a Critical Illness Comparator.","authors":"Zuhair Ali Naqvi, Muhammad Saad Mahmood, Huzaifa Imdad Bhatti, Muhammad Meer Akbar","doi":"10.1093/annalsats/aaoag267","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag267","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fall-related injuries in long-term oxygen therapy: Incidence and predictive factors.","authors":"Filip Björklund, Andreas Palm, Josefin Sundh, Magnus Ekström","doi":"10.1093/annalsats/aaoag264","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag264","url":null,"abstract":"<p><strong>Introduction: </strong>Fall-related injuries are a common cause of morbidity and impaired quality of life among patients with severe respiratory disease. Use of long-term oxygen therapy (LTOT) may be associated with a further increased risk.</p><p><strong>Methods: </strong>This was a longitudinal study of patients starting LTOT between 2006 and 2023 in the Swedish DISCOVERY cohort. Rates of healthcare contact due to three types of fall-related injuries (distal radius fracture, hip fracture, and skull trauma) were compared to those of age- and sex-matched population controls using nationwide registries. For patients on LTOT, pre-identified potentially predictive factors were analyzed against a composite outcome of any fall-related injury using Cox and Fine-Gray regression, independently, adjusting for age, sex and Charlson Comorbidity Index (CCI), and in a joint model adjusting for all predictive factors.</p><p><strong>Results: </strong>A total 16,915 patients with LTOT (mean age 76±9 years, 57% female, 63% underlying COPD) and an equal number of matched controls were included. Compared with controls, LTOT patients had increased overall rates of both hospitalizations (15.5 vs 7.3 per 100 patient-years) and outpatient (16.9 vs 13.6 per 100 patient-years) healthcare contacts due to fall-related injuries, driven by hip fractures and skull trauma, whereas distal radius fractures were more common among patients without LTOT. The strongest independent predictive factors for fall-related injury during LTOT were history of previous fall-related injury (HR1.8; 95% confidence interval 1.7-2.0) and increased CCI. The overall predictive capability of the model was poor (C-statistic 0.65).</p><p><strong>Conclusion: </strong>Patients on LTOT have a high rate of health care contacts due to hip fractures and skull trauma, but whether this increase is caused by use of oxygen equipment or underlying frailty remains unknown. While individual falls were difficult to predict, indicators such as previous fall injury and comorbidities, may inform optimized follow-up and interventions aimed at mitigating risk.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effectiveness in Systemic Sclerosis-Associated Interstitial Lung Disease: Interpreting Signals Amid Heterogeneity.","authors":"Michelle A Ghebranious, Shervin Assassi","doi":"10.1093/annalsats/aaoag269","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag269","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Naqvi et al.: Persistent Dyspnea Phenotypes After COVID-19: The Missing Autonomic Dimension and the Need for a Critical Illness Comparator.","authors":"Pauliane Vieira Santana, Pedro Caruso, Carlos Roberto Ribeiro de Carvalho","doi":"10.1093/annalsats/aaoag268","DOIUrl":"https://doi.org/10.1093/annalsats/aaoag268","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}