Annales de biologie clinique最新文献_第3页

[Summary of the 33nd national meeting of the Collège National de Biochimie des Hôpitaux]. [美国国立生物化学学院第33届全国会议综述Hôpitaux]。

Annales de biologie clinique Pub Date : 2025-06-12 DOI: 10.1684/abc.2025.1979

Magali Annette-Reisch, Bertrand Beaune, Aurore Catteau, Ma'atem Caillierez, Rosa-Maria Guéant-Rodriguez, Véronique Raverot, Benoit Soudan

引用次数: 0

Prevalence of hemophilia in women and girls in Burkina Faso. 布基纳法索妇女和女童血友病患病率。

Annales de biologie clinique Pub Date : 2025-06-12 DOI: 10.1684/abc.2025.1969

Koumpingnin Nebie, Ghislaine Yameogo/Sawadogo, Salam Sawadogo, Jerome Koulidiati, Catherine Traore, Myriam W Nikiema/Minoungou, Donatien Kima, Nestor F Yougbare, Yasmina M Traore, Salifo Sawadogo, Brigitte Tardy, Awa Oumar Toure, Catherine Lambert, Eleonore Kafando

{"title":"Prevalence of hemophilia in women and girls in Burkina Faso.","authors":"Koumpingnin Nebie, Ghislaine Yameogo/Sawadogo, Salam Sawadogo, Jerome Koulidiati, Catherine Traore, Myriam W Nikiema/Minoungou, Donatien Kima, Nestor F Yougbare, Yasmina M Traore, Salifo Sawadogo, Brigitte Tardy, Awa Oumar Toure, Catherine Lambert, Eleonore Kafando","doi":"10.1684/abc.2025.1969","DOIUrl":"10.1684/abc.2025.1969","url":null,"abstract":"Despite being primarily affecting males, hemophilia, a X-linked bleeding disorder, can also concern women and girls (WG) who are hemophilia carriers (HC), as they can display FVIII or FIX levels < 40% and, or, bleeding manifestations even with normal levels of FVIII or IX. We sought to investigate the prevalence of hemophilia in women and girl relatives of persons with hemophilia in Burkina Faso. A descriptive cross-sectional survey was conducted from September 2021 to September 2023. Female relatives of male persons with hemophilia (PwH) currently followed-up at hospitals were included after providing a written consent and completing the ISTH bleeding assessment questionnaire. Blood samples were collected for hemostasis (Prothrombin time, activated partial thromboplastin time, Factor VIII or IX level) and other (Complete Blood Count, C-reactive protein; ABO/Rh blood typing) tests. Overall, 94 WG relatives of PwH participated. Their mean age being 34.2 ± 11.4 years. Seven out of 92 tested (7.6%) exhibited FVIII or FIX levels between 6% and 39% and then had been identified as WGH. Common bleeding symptoms were bleeding from the oral cavity and menorrhagia. We highlighted the high value of FVIII/IX testing for female relatives to PwH.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 3","pages":"269-279"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of severe hypernatremia in a cachectic patient hospitalized for pneumococcal pneumonia]. 肺炎球菌性肺炎住院的病毒症患者发生严重高钠血症1例。

Annales de biologie clinique Pub Date : 2025-06-09 DOI: 10.1684/abc.2025.1980

Anne Giraudeau, Maxime Pawlowski, Dylan Belhassen, Claude Bendavid, Caroline Moreau

引用次数: 0

[Immunological illustrations of the main B and T lymphomas (flow cytometry immunological profiles obtained from lymph node and splenic suspensions associated with characteristic morphological images)]. [主要B型和T型淋巴瘤的免疫学图示（从淋巴结和脾脏悬浮液中获得的流式细胞术免疫图谱与特征形态学图像相关）]。

Annales de biologie clinique Pub Date : 2025-06-01 DOI: 10.1684/abc.2025.1971

Radu Chiriac, Marie Donzel, Alexandra Traverse-Glehen, Lucile Baseggio

{"title":"[Immunological illustrations of the main B and T lymphomas (flow cytometry immunological profiles obtained from lymph node and splenic suspensions associated with characteristic morphological images)].","authors":"Radu Chiriac, Marie Donzel, Alexandra Traverse-Glehen, Lucile Baseggio","doi":"10.1684/abc.2025.1971","DOIUrl":"10.1684/abc.2025.1971","url":null,"abstract":"The diagnosis of B- and T-cell lymphomas relies on a multidisciplinary approach that combines morphological, immunological (via flow cytometry - FCM), and genetic analyses. The integration of cytological evaluation from tissue biopsy imprints with FCM enables rapid diagnostic orientation, which is valuable for guiding further complementary investigations. This atlas illustrates the main types of B- and T-cell lymphomas using cytology images, FCM data, and histological analyses derived from lymph node and splenic samples. The FCM profiles were established using routinely employed antibody panels. While results may show slight variations depending on the cytometer settings and fluorochromes used, they remain generally comparable across different instruments. An orientation panel consisting of 16 antibodies is used for the initial classification of lymphomas, with specific markers allowing for subsequent assessment of antigen expression according to cell type and pathological context. The combined study of cytological and histological features provides an integrated perspective of lymphoid pathology.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 3","pages":"237-268"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Therapeutic effectiveness and safety of artemether lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children aged 5 to 15 years in three epidemiological strata of malaria in Niger]. [蒿甲醚氟苯曲明治疗尼日尔3个疟疾流行病学分层5 ~ 15岁儿童无并发症恶性疟原虫疟疾的疗效和安全性]。

Annales de biologie clinique Pub Date : 2025-06-01 DOI: 10.1684/abc.2025.1973

Idrissa Yacouba, Ibrahima Issa, Maman Kabirou Sanoussi, Mamane Jika, Boureima Seidou Hamani, Oumarou Diallo, Seyni Issoufou, Aboubacar Mahamadou, Yahaya Abou, Daniel Koko, Lamine Mahaman Moustapha, Maman Laminou Ibrahim

{"title":"[Therapeutic effectiveness and safety of artemether lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children aged 5 to 15 years in three epidemiological strata of malaria in Niger].","authors":"Idrissa Yacouba, Ibrahima Issa, Maman Kabirou Sanoussi, Mamane Jika, Boureima Seidou Hamani, Oumarou Diallo, Seyni Issoufou, Aboubacar Mahamadou, Yahaya Abou, Daniel Koko, Lamine Mahaman Moustapha, Maman Laminou Ibrahim","doi":"10.1684/abc.2025.1973","DOIUrl":"https://doi.org/10.1684/abc.2025.1973","url":null,"abstract":"Malaria is a major public health issue in Niger. This study aims to provide information on the therapeutic efficacy of antimalarials, specifically focusing on artemether-lumefantrin (AL) in children aged 5 to 15 years in Aderbissinat, Aguié, and Baban Tabki. To evaluate the therapeutic efficacy of AL in children in the specified regions. The study was conducted from August 26 to October 25, 2022, using the standard WHO/2015 28-day follow-up method. Biological confirmation was done using rapid diagnostic tests (RDT) and microscopy, while PCR was used to distinguish between reinfections and recrudescences. Out of 352 suspected malaria patients, 263 were included in the study. There were 5 lost to follow-up, 1 voluntary withdrawal, and 3 protocol violations. The malaria prevalence was 92%, with an average parasite density of 42,606 P/μL and a sex-ratio of 1.02. The overall adequate clinical and parasitological response (ACPR) after PCR correction was 97.25%, with 100% in Aderbissinat and Aguié, and 90% in Baban Tabki. No major adverse events were recorded. The results support the use of AL for the treatment of uncomplicated malaria as per the National Malaria Control Program (NMCP).","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 3","pages":"280-292"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Inclusions basophiles cristallines dans un cas de gammapathie monoclonale IgA de signification indéterminée]. [意义不明的单克隆IgA伽马病中嗜碱性晶体的夹杂物]。

Annales de biologie clinique Pub Date : 2025-06-01 DOI: 10.1684/abc.2025.1974

Radu Chiriac

引用次数: 0

[French laboratories turn-around-time (TAT) for troponin measurement for Emergency Departments: the EN-TRO-PRISE survey]. [法国急诊科肌钙蛋白检测的实验室周转时间（TAT）： EN-TRO-PRISE调查]。

Annales de biologie clinique Pub Date : 2025-06-01 DOI: 10.1684/abc.2025.1975

Camille Gobeaux, Guillaume Lefevre, Bruno Lehodey, Mathieu Kuentz, Valery Bourbonneux, Matthieu Pecquet, Pierre Hausfater, Marie-Christine Beauvieux, Cédric Gil-Jardine, Christophe Choquet, Valérie Machie, Valéry Brunel, Jérémy Guenezan, Sandrine Charpentier, Yann-Erick Claessens

{"title":"[French laboratories turn-around-time (TAT) for troponin measurement for Emergency Departments: the EN-TRO-PRISE survey].","authors":"Camille Gobeaux, Guillaume Lefevre, Bruno Lehodey, Mathieu Kuentz, Valery Bourbonneux, Matthieu Pecquet, Pierre Hausfater, Marie-Christine Beauvieux, Cédric Gil-Jardine, Christophe Choquet, Valérie Machie, Valéry Brunel, Jérémy Guenezan, Sandrine Charpentier, Yann-Erick Claessens","doi":"10.1684/abc.2025.1975","DOIUrl":"10.1684/abc.2025.1975","url":null,"abstract":"The latest international recommendations advocate for the measurement of cardiac troponin (cTn) in the context of acute coronary syndrome (ACS) with a result turnaround time of less than 1 or 2 hours. To establish a national overview of organizational practices and turnaround times for these measurements. Two surveys targeting emergency physicians and biologists described the qualitative and quantitative organizational data of cTn measurement. 27 hospitals with an annual number of visits totaling 35,000 [28,700-55,500], with 8.5% of patients presenting with chest pain and 0.9% with ACS. The satisfaction rate of emergency physicians regarding the turnaround time is 27%, and 50% wish to see it reduced. Quantitatively, 74,112 troponin requests were analyzed, 33% of which were performed during on-call periods. Cardiac cTnT represents 70% of the measurements, and 98 % of the methods are highly sensitive. The median pre-registration time is 19 minutes [10-35], laboratory-processing time is 55 minutes [42-82], and overall turnaround time is 81 minutes [60-121]. The turnaround time is shorter when there is a connected prescription or an expert system for biological validation (p < 0.0001). The turnaround times for troponin results are on average >1 hour. For most laboratories (83 %), the turnaround time is in line with European recommendations allowing the application of an H0-H2 algorithm.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 3","pages":"293-302"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Studying daratumumab's interference in serum protein electrophoresis: two case reports]. 【研究达拉单抗对血清蛋白电泳的干扰：两例报告】。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1963

Alexandre Leonard, Benjamin Bonnet, Carolyne Croizier, Bertrand Evrard, Vincent Sapin, Anne Fogli, Damien Bouvier

引用次数: 0

Evaluation of the prognostic value of coagulation function and cerebral hemodynamic changes in acute ischemic stroke patients with rheumatoid arthritis. 急性缺血性脑卒中合并类风湿患者凝血功能及脑血流动力学变化的预后价值评价。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1965

Ying Yang, Linxin Zhang, Xing Zhao, Juan Li, Qingping Chen, Yaya Gao, Jun Yan

{"title":"Evaluation of the prognostic value of coagulation function and cerebral hemodynamic changes in acute ischemic stroke patients with rheumatoid arthritis.","authors":"Ying Yang, Linxin Zhang, Xing Zhao, Juan Li, Qingping Chen, Yaya Gao, Jun Yan","doi":"10.1684/abc.2025.1965","DOIUrl":"10.1684/abc.2025.1965","url":null,"abstract":"To explore the relationship between early coagulation changes, cerebral hemodynamics, and neurological prognosis in acute ischemic stroke (AIS) patients with rheumatoid arthritis (RA). Seventy-two AIS patients with RA were included. Coagulation markers (PT, APTT, FIB) and transcranial Doppler ultrasound (TCD) assessments of middle cerebral artery (MCA) mean velocity (Vm) and pulsatility index (PI) were measured at baseline and after 14 days of treatment. Prognosis was evaluated using the modified Rankin Scale (mRS) at 3 months, dividing patients into good (mRS ≤ 2) and poor prognosis (mRS > 3) groups. Multivariate logistic regression and ROC analysis assessed the predictive value of coagulation and hemodynamic changes for adverse outcomes. After 14 days, APTT and MCA (PI) increased, while FIB decreased in both groups (P < 0.05). The good prognosis group had higher MCA Vm and lower FIB at baseline (P < 0.05). Independent risk factors for poor prognosis included diabetes, NIHSS score ≥ 8, FIB, and MCA (Vm, PI) (P < 0.05). ROC analysis showed combined FIB, Vm, and PI had better predictive value for poor outcomes. Early hypercoagulable state and suboptimal cerebral hemodynamics are associated with poor neurological outcomes in AIS with RA.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 2","pages":"185-94"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Usefulness of the thrombin generation test in hypercoagulability states]. [凝血酶生成试验在高凝状态下的有效性]。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1955

Paul Billoir, Sébastien Miranda, Hervé Lévesque, Ygal Benhamou, Véronique Le Cam Duchez

{"title":"[Usefulness of the thrombin generation test in hypercoagulability states].","authors":"Paul Billoir, Sébastien Miranda, Hervé Lévesque, Ygal Benhamou, Véronique Le Cam Duchez","doi":"10.1684/abc.2025.1955","DOIUrl":"10.1684/abc.2025.1955","url":null,"abstract":"Thrombin is one of the key components of the hemostatic system. The thrombin generation assay (TGA) assesses the activation, propagation and inhibition of coagulation. This global coagulation test is of interest for assessing the risk of bleeding and thrombosis. Numerous studies have been performed in the \"thrombophilia\". We performed a systematic review of studies on thrombinography in thrombophilia. The included studies, published in English, were original investigations using TGT during venous thromboembolic disease, arterial occlusive pathology, pregnancy, anti-phospholipid syndrome, constitutional thrombophilias, or oncology. Eighty studies were selected between January 2003 and June 2022. Most had fewer than 100 patients. The only two studies that included more than 1000 patients showed an increased risk of thrombotic recurrence or increased mortality from cardiovascular disease associated with increased thrombin generation. All \"thrombophilia\" have been studied, but lack of standardization between conditions has limited the development of clinical research with this assessment technique. Harmonization of practices may provide more relevant systems for predicting the occurrence of arterial or venous thrombotic events.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 2","pages":"121-46"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0