Annales de biologie clinique最新文献_第2页

[Diagnosis of significant hepatic fibrosis in patients with chronic hepatitis B: another simple, effective and inexpensive method]. 【诊断慢性乙型肝炎患者显著肝纤维化：另一种简单、有效、廉价的方法】。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1964

Boni Guy-Martial Kouame, Bi Foua Jonas Vanie, Amena Guy Germaine Niamke, Kouzahon Colombe Jeannine Lohore, Aké Chibrou Bénédicte Yapo-Kee, Youzan Ferdinand Djohan

引用次数: 0

[Overview of practices among French clinical pathologists specialized in haemostasis]. [法国临床病理学家在止血方面的实践综述]。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1959

Andréas Perrier-Cornet, Nicolas Gendron, Céline Desconclois, Virginie Planche, Caroline Vayne, Fabienne Nedelec Gac, Cécile Lavenu-Bombled, Dominique Lasne, Claire Flaujac, Myriam Hormi

{"title":"[Overview of practices among French clinical pathologists specialized in haemostasis].","authors":"Andréas Perrier-Cornet, Nicolas Gendron, Céline Desconclois, Virginie Planche, Caroline Vayne, Fabienne Nedelec Gac, Cécile Lavenu-Bombled, Dominique Lasne, Claire Flaujac, Myriam Hormi","doi":"10.1684/abc.2025.1959","DOIUrl":"10.1684/abc.2025.1959","url":null,"abstract":"Medical biology is a medical specialty shared by medical doctor (MD) and pharmacists (PharmD), and Hemostasis is one of its disciplines. Since 2007, physicians have lost interest in medical biology. In haemostasis, the regulatory heterogeneity of status between medical biologists/MDs and medical biologists/PharmDs in a strained health system raises two major issues: (i) with demographic change, optimal patient care may no longer be guaranteed, (ii) medical biologists/PharmDs are sometimes forced to go beyond the scope of their regulatory field of practice. We conducted a survey in 2022 to examine hemostasis advice and consultation practices: 152 professionals responded, including 99 pharmacist-biologists (65.1%), 42 physician-biologists (27.6%) and 11 clinicians (7.2%). Of the practitioners questioned, 91.9% gave diagnostic advice and 75.0% therapeutic advice. 41% of respondents carried out haemostasis consultations, including 24.2% of pharmacists. Our survey reveals a little-known role for medical biologists specialized in haemostasis, particularly pharmacists, and calls for a global reflection on a possible regulated and supervised evolution of their field of practice, to enable them to pursue their mission in complete safety.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 2","pages":"147-60"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic value of small dense low-density lipoprotein and trace elements in coronary artery disease. 小密低密度脂蛋白及微量元素对冠状动脉疾病的诊断价值。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1960

Na Zhang, Yue Xu, Hao Liang, Qingsong Wang, Yu An, Haichao Gao, Jiangman Zhao, Hong Wang

{"title":"Diagnostic value of small dense low-density lipoprotein and trace elements in coronary artery disease.","authors":"Na Zhang, Yue Xu, Hao Liang, Qingsong Wang, Yu An, Haichao Gao, Jiangman Zhao, Hong Wang","doi":"10.1684/abc.2025.1960","DOIUrl":"10.1684/abc.2025.1960","url":null,"abstract":"Coronary artery disease (CAD) is a worldwide leading cause of death. Considering that 20%-40% of patients with CAD have a long asymptomatic period of atherosclerosis, it has become urgent to explore the feasibility of diagnosing CAD at an early stage. This is an observational, case-control study, a total of 489 consecutive CAD patients and 75 non-CAD controls were recruited. The levels of low-density lipoprotein subfractions (LDLC1-7) in serum were measured by the Quantimetrix Lipoprint LDL system. The levels of 18 trace elements (vanadium, chromium, manganese, cobalt, nickel, copper, zinc, gallium, arsenic, selenium, strontium, cadmium, tin, antimony, barium, mercury, thallium, and lead) were tested using inductively coupled plasma mass spectrometry. Six machine learning algorithms (Logistic Regression, K Neighbors, GaussianNB, Random Forest, Decision Tree and XGBoost) were used to construct CAD diagnostic models. The levels of LDLC-3, LDLC-4, LDLC-5, and lead were significantly higher in CAD patients, while the levels of LDLC-1, chromium, manganese, cobalt, and strontium were lower (p < 0.05 for all). Univariate logistic regression analysis indicates that LDLC-3, LDLC-4, and lead were the risk factors for CAD development (odds ratio >1 and p < 0.05 for all), while LDLC-1, chromium, manganese, cobalt, and strontium were the protective factors for CAD (odds ratio < 1 and p < 0.05 for all). XGBoost had the best overall diagnostic performance among the six algorithms. There are significant differences in the levels of several LDL subfractions and trace elements between non-CAD controls and CAD patients. These biomarkers may help the diagnostic of CAD while applying machine learning algorithms.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 2","pages":"161-75"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical biology in France through the eyes of young medical biologists]. [年轻医学生物学家眼中的法国临床生物学]。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1958

Emeline Gernez, Yasmine Nezzar, Mouhamed Ouni, Charles R Lefèvre, Jessica Sanda, Laura Plasse, Farouk Bouraima, Jules Al Samara, Guillaume Feugray, Aleksei Tikhonov, Anne Giraudeau, Ibrahima Ba, Vincent Guillet

引用次数: 0

Comparison of automated methods for the determination of antimüllerian hormone in women. 妇女抗<s:1>勒氏杆菌激素自动测定方法的比较。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1967

Andreea Ion, Julie Brossaud, Jean-Benoît Corcuff, Cindy Lauro, Agnès Georges

{"title":"Comparison of automated methods for the determination of antimüllerian hormone in women.","authors":"Andreea Ion, Julie Brossaud, Jean-Benoît Corcuff, Cindy Lauro, Agnès Georges","doi":"10.1684/abc.2025.1967","DOIUrl":"10.1684/abc.2025.1967","url":null,"abstract":"Antimüllerian hormone (AMH), a protein secreted by granulosa cells, is a quantitative marker of the ovarian reserve. Due to its clinical value, the anti-müllerian hormone is a test highly prescribed by doctors, especially in the medically assisted procreation (MAP) department. The antral follicle count (AFC) and the result of the AMH test, are systematically evaluated during a fertility preservation consultation and also as part of the monitoring of ovarian function. Different methods for the measurement of AMH level exist, but none of them is currently available in our hormonology laboratory at Bordeaux University Hospital. The introduction of one of these technical assays in our laboratory could shorten the delay of reaching the result. According to our objectives, our study made it possible to observe the performance and analytical limits of the Biomerieux and Fujirebio technology, by comparing it with Roche technology, known as the reference, by analysing 50 AMH samples, on each of them and evaluating the results. In our study, despite a good agreement between the three assay methods, the importance of an international standard from a diagnostic point of view was once again noted. National medical commissions do strongly insist on the need of setting up an international standard in order to facilitate the development of reference values, decrease inter-laboratory variability and the cost due to repeated assays, as well as to improve patient safety by avoiding poor estimation of values.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 2","pages":"227-30"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Voluntary self-poisoning with metformin and antiretroviral therapy drugs]. [二甲双胍和抗逆转录病毒治疗药物自愿自我中毒]。

Annales de biologie clinique Pub Date : 2025-05-22 DOI: 10.1684/abc.2025.1966

Noémie Perez Munoz, Philippe Vest, Michael Peres, Pauline Ponsin, Carine Hejl

{"title":"[Voluntary self-poisoning with metformin and antiretroviral therapy drugs].","authors":"Noémie Perez Munoz, Philippe Vest, Michael Peres, Pauline Ponsin, Carine Hejl","doi":"10.1684/abc.2025.1966","DOIUrl":"10.1684/abc.2025.1966","url":null,"abstract":"Metformin is the first-line oral drug prescribed in type 2 diabetes. The main severe side effect of this drug is metformin associated lactic acidosis (MALA), which generally occurs accidentally and rarely in patients with renal failure. We present here a case of voluntary self-poisoning with metformin and antiretroviral therapy drugs. On admission, the patient showed lactic acidosis with a pH of 7.19 (normal ranges: 7.38-7.42) and lactates at 9.40 mmol/L (normal ranges: 0.50-2.20 mmol/L). Metformin and antiretroviral therapy intoxication was confirmed by detecting these drugs with high performance liquid chromatography coupled with diode array detector (HPLC-PDA) and a another HPLC with mass spectrometry (HPLC-MS) then by a metformin dosage at 814 mg/L (therapeutic ranges: 1-2 mg/L). During hospitalization, liver dysfunctionned, contributing to an altered lactate elimination. Therefore, lactic acidosis increased as the patient's state worsened. Therapeutics were inefficient, leading to patient's death 30 hours after presentation. This observation illustrates a rare case of voluntary intoxication with a high dose of metformin and its unusual association with antiretroviral therapy drugs, that could increase lactic acidosis and cause liver failure.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"83 2","pages":"211-9"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strongyloides stercoralis hyperinfection syndrome: case report of therapeutic failure with ivermectin. 粪圆线虫过度感染综合征：伊维菌素治疗失败1例报告。

Annales de biologie clinique Pub Date : 2025-05-12 DOI: 10.1684/abc.2025.1968

Yazid El Alaoui Boufares, Grégoire Pasquier, Laurence Lachaud

引用次数: 0

[Glucose-6-phosphate dehydrogenase variants: new WHO classification (2024)]. [葡萄糖-6-磷酸脱氢酶变异：新的WHO分类（2024）]。

Annales de biologie clinique Pub Date : 2025-05-12 DOI: 10.1684/abc.2025.1970

Alexandre Raynor, Claire Berquet, Stéphane Moutereau

引用次数: 0

[Increased troponin T in a patient with myositis]. 肌炎患者肌钙蛋白T增高。

Annales de biologie clinique Pub Date : 2025-03-03 DOI: 10.1684/abc.2025.1954

Sarah Diabate, Céline Bouchet-Seraphin, Sandrine Vuillaumier-Barrot, Guillaume Lefevre, Katell Peoc'h