Anales de pediatria最新文献

{"title":"Epididymitis associated with an intravesical foreign body","authors":"Sara Cabello Gómez , Óscar Manuel López Moreira , Gustavo Delgado Duatis , Madai Curbelo Rodríguez","doi":"10.1016/j.anpede.2026.504135","DOIUrl":"10.1016/j.anpede.2026.504135","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504135"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation and exposure time in videofluoroscopic swallow studies: A 7-year analysis","authors":"Andrés Domingo Belanche ,&nbsp;María José Romea Montañés ,&nbsp;Ignacio Ros Arnal ,&nbsp;Gerardo Rodríguez Martínez ,&nbsp;Cristina Gutierrez Alonso ,&nbsp;Beatriz Izquierdo Alonso ,&nbsp;Ruth García Romero","doi":"10.1016/j.anpede.2026.504160","DOIUrl":"10.1016/j.anpede.2026.504160","url":null,"abstract":"<div><h3>Introduction</h3><div>Videofluoroscopic swallow studies (VFSSs) are considered the gold standard for evaluating dysphagia. Since the technique involves ionizing radiation, reducing the radiation dose received by pediatric patients must be a priority. This requires the establishment of appropriate diagnostic reference levels.</div></div><div><h3>Objectives</h3><div>To evaluate and analyze the radiation dose and exposure time during VFSS in pediatric patients managed in a tertiary care center. Additionally, to determine the relationship between clinical variables and radiation exposure, and to compare the results with the European diagnostic reference levels.</div></div><div><h3>Material and methods</h3><div>We conducted a retrospective and descriptive study between 2015 and 2022. The dose-area product and fluoroscopy time were analyzed, along with clinical and epidemiological variables and their association with VFSS findings. We also compared the results to the European pediatric imaging diagnostic reference levels (PiDRL) for VFSS.</div></div><div><h3>Results</h3><div>A total of 322 VFSS were analyzed. Dysphagia was present in 68.6% of cases, and was most commonly oropharyngeal (65%), with combined impairment of swallowing efficiency and safety (61.1%). Dysphagia was more frequent and severe in patients with neurological disorders. Aspiration and/or penetration events were observed in two-thirds of the patients, with approximately 80% being silent (i.e., without cough). The median dose-area product was 9.2 cGy/cm² (IQR, 5.1−15) and the median exposure time was 123 s (IQR, 85−167.3), both values below the thresholds recommended by the 2018 European guidelines and similar studies. We found a direct correlation of both radiation dose and exposure time to age, the degree of disability, the presence of dysphagia, the Bolus Residue Scale (BRS) score, and impairment of swallowing efficiency and safety.</div></div><div><h3>Conclusions</h3><div>The radiation dose and fluoroscopy time were lower than those reported in previous studies, probably due to technical improvements in the procedure. Establishing updated diagnostic reference levels for pediatric VFSS should be a priority in order to optimize radiation exposure in a population with greater radiosensitivity. This study also aims to contribute to the development of a standardized radiation protocol for pediatric VFSS to allow for more consistent and comparable data across centers.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504160"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting international pediatric and neonatal cardiopulmonary resuscitation guidelines for use in Spain: an inescapable need","authors":"Roberto Martín-Asenjo ,&nbsp;María Teresa Moral-Pumarega","doi":"10.1016/j.anpede.2026.504175","DOIUrl":"10.1016/j.anpede.2026.504175","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504175"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of gene therapy in pediatric patients with Fanconi anemia: a systematic review","authors":"Sandra Elena Cano Reyes ,&nbsp;Carolina Rincón Fuerte ,&nbsp;Sara Catalina Pantano Jiménez ,&nbsp;Nicolas Sáenz de San Pelayo Ovalle ,&nbsp;Víctor Hugo Rincón Contreras ,&nbsp;María Alejandra Delgado Carreño","doi":"10.1016/j.anpede.2026.504176","DOIUrl":"10.1016/j.anpede.2026.504176","url":null,"abstract":"<div><h3>Introduction</h3><div>Fanconi anemia is a genetic disorder characterized by high risk of hematological and oncological disease. The aim of this review was to summarize the evidence on the safety and efficacy of gene therapy in pediatric patients with Fanconi anemia.</div></div><div><h3>Methods</h3><div>Systematic review (PROSPERO registration record CRD420251152704). We searched PubMed/MEDLINE, Scopus, Web of Science, ClinicalTrials.gov, ICTRP, and CENTRAL. The study outcomes included safety, engraftment and persistence, and hematologic outcomes. The risk of bias was assessed with the RoB 2 tool.</div></div><div><h3>Results</h3><div>The review included seven studies, all conducted in patients with <em>FANCA</em> variants, that evaluated autologous hematopoietic stem cell-based gene therapy from mobilization and collection to lentiviral transduction and reinfusion without conditioning. Safety profile: favorable, with no serious adverse events attributable to the vector/cells and no evidence of lentiviral replication, clonal dominance, or genotoxicity in follow-up periods of up to 7 years. Engraftment/persistence: detectable vector copy numbers and stable polyclonal patterns, more durable engraftment with higher cell doses. Hematological outcomes: stabilization/improvement of cytopenia; transfusion independence in some patients and deferral of bone marrow transplantation. The efficacy of gene therapy was greater in younger patients and in those without advanced bone marrow failure. The overall risk of bias was high.</div></div><div><h3>Conclusions</h3><div>Gene therapy showed a favorable safety profile, with no serious adverse events or evidence of genotoxicity. Efficacy was greater in younger children, in those without advanced marrow failure, and with higher doses of corrected CD34+ cells. However, as the included studies were phase I/II trials, the results should be interpreted cautiously; nevertheless, gene therapy appears to be a promising and safe treatment option in the early stages of the disease.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504176"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to «New pathogenic variant c.3855 + 4A >G in the NIPBL gene associated with Cornelia de Lange syndrome type 1 (OMIM#122470)» [An Pediatr (Barc). 2025;102:503771]","authors":"Sandra Maeso-Méndez ,&nbsp;Saioa Jiménez Echevarría ,&nbsp;Zuriñe García Casales ,&nbsp;Ignacio Díez López","doi":"10.1016/j.anpede.2026.504193","DOIUrl":"10.1016/j.anpede.2026.504193","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504193"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147750044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrotendinous xanthomatosis in the pediatric age group: Early diagnosis based on two case reports","authors":"José Luis Aparicio Sánchez,&nbsp;Manuel Antonio Rodríguez Lanza,&nbsp;Omar Guillé Díaz,&nbsp;María Teresa Navarro Navarro,&nbsp;Mariam Amira Bouteldja Fernández","doi":"10.1016/j.anpede.2026.504171","DOIUrl":"10.1016/j.anpede.2026.504171","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504171"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147494841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish 2026 guidelines for neonatal stabilization and resuscitation: analysis, adaptation, and position statement of the neonatal resuscitation Group of the Spanish Society of Neonatology","authors":"Alejandro Avila-Alvarez ,&nbsp;Gonzalo Zeballos-Sarrato ,&nbsp;Montserrat Izquierdo Renau ,&nbsp;César Ruiz Campillo ,&nbsp;Celia Gómez Robles ,&nbsp;Eva González Colmenero ,&nbsp;María de la Asunción Pino Vázquez ,&nbsp;Miguel Sánchez Mateos ,&nbsp;Elena García Victori ,&nbsp;Raquel Escrig Fernández ,&nbsp;Nelia Navarro Patiño ,&nbsp;Sara Ansó Oliván ,&nbsp;Martín Iriondo Sanz","doi":"10.1016/j.anpede.2026.504143","DOIUrl":"10.1016/j.anpede.2026.504143","url":null,"abstract":"<div><div>The recommendations of the International Liaison Committee on Resuscitation (ILCOR) published at the end of 2025 provide the current scientific framework for neonatal resuscitation and support in the transition to extrauterine life. As in previous updates, the Neonatal Resuscitation Group of the Spanish Society of Neonatology (GRN-SENeo) presents a review and position document analyzing the changes introduced with respect to the previous guideline and adapting the current evidence to the specific circumstances and health care context of Spain. The aim of this document is to disseminate the position of the group on the implementation of these recommendations at the national level, reached by consensus and addressing the most controversial aspects through the nominal group technique. The management algorithms are reviewed and updated, incorporating new aspects in pre-delivery neonatal management planning and briefing, umbilical cord management, initial stabilization, ventilation and oxygen supplementation strategies, as well as the use of new devices and vascular access routes. Through this guideline, the GRN-SENeo establishes a sustained institutional reference framework aimed at ensuring homogeneity, safety and quality in the management of the newborn in the delivery room, while fulfilling its commitment to continuous updating as scientific knowledge evolves.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504143"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemolacria in acute hemorrhagic edema of infancy","authors":"Beatriz de Sousa,&nbsp;Joana Baptista,&nbsp;Andreia Lopes,&nbsp;Liliana Macedo","doi":"10.1016/j.anpede.2025.504108","DOIUrl":"10.1016/j.anpede.2025.504108","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504108"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-epileptic paroxismal episodes in pediatrics: experience in a pediatric emergency department","authors":"Sonia Clavero Sánchez ,&nbsp;Juan Manuel Guijarro Núñez ,&nbsp;Caridad Jun García García ,&nbsp;Anna Duat Rodríguez ,&nbsp;Jose Antonio Alonso-Cadenas","doi":"10.1016/j.anpede.2026.504168","DOIUrl":"10.1016/j.anpede.2026.504168","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504168"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axenfeld loop: Differential diagnosis of intraocular foreign body","authors":"Inés Loreto Gallán Farina ,&nbsp;Carmen Villanueva Rodríguez ,&nbsp;Pilar Roy Montesinos ,&nbsp;María Vázquez-Sánchez","doi":"10.1016/j.anpede.2026.504132","DOIUrl":"10.1016/j.anpede.2026.504132","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"104 4","pages":"Article 504132"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147460910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}