Anales de pediatria最新文献

{"title":"Evolution of antibiotic prescription in Primary Health Care according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN).","authors":"Carlos Marcilla Vázquez, Juan Ríos Laorden, Ángeles Lloret Callejo, Francisco Tejada Cifuentes, María José Tirado Peláez, Ignacio Párraga-Martínez","doi":"10.1016/j.anpede.2025.503840","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503840","url":null,"abstract":"<p><strong>Introduction: </strong>Spain is the fourth European country with the highest antibiotic consumption at the community level, being children aged 0-4 years one of the age groups with the highest amount of consumption. The aim of this study was to analyze the evolution of antibiotic prescription of the pediatric population in a Primary Health Care area according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN) in a period of ten years (2014-2023), as well as to evaluate the impact of the COVID-19 pandemic by the comparison between 2020-2021 years and a previous (2014-2019) and a later periods of time (2022-2023).</p><p><strong>Material and methods: </strong>Retrospective observational study of the prescription of antibiotics for systemic use (J01 group of the Anatomical Therapeutic Chemical Classification) in pediatric patients (0-14 years) belonging to the Primary Health Care area of the Gerencia de Atención Integrada (GAI) de Albacete between 2014 and 2023.</p><p><strong>Results: </strong>Mean antibiotic prescription was 16.90 defined daily doses per 1000 inhabitants per day (DID) and 12.10 DOT (days of therapy). Pre-pandemic data (2014-2019) was 19.32 DID and 13.92 DOT, being reduced during the two years of the pandemic (2020-2021) to 8.30 DID and 6.05 DOT and subsequently increased to 18.05 DID and 12.40 DOT in post-pandemic years (2022-2023). An improvement in the adequacy of antibiotic prescription was observed after the COVID-19 pandemic, with a reduction of the consumption of amoxicillin-clavulanate and a greater consumption of penicillin and amoxicillin during pre-pandemic and pandemic years (p < 0.05).</p><p><strong>Conclusions: </strong>Thoughout the period of years analysed, an improvement in the consumption indicators proposed by the PRAN, with a higher use of beta-lactamase sensitive penicillins and amoxicillin and a reduced consumption of amoxicillin-clavulanate.</p>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503840"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyorchidism: A rare ultrasound finding.","authors":"Maria Font Roset, Isabel Sánchez Bueno, Anton Foguet Vidal, Stephan Otto Schneider","doi":"10.1016/j.anpede.2025.503769","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503769","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503769"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phleboliths as a radiological marker of venous malformation.","authors":"Israel Pérez-López, Marta Cebolla-Verdugo, Ricardo Ruiz-Villaverde","doi":"10.1016/j.anpede.2025.503748","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503748","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503748"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for the management of functional dyspepsia from the SEGHNP working group on motility and functional gastrointestinal disorders.","authors":"Miguel Ángel Carro Rodríguez, Inmaculada Hidalgo Montes, Carmen Jovani Casano, Aránzazu Recio Linares, Etna Masip Simó, Gloria Rodrigo Garcia, Andrés Bodas Pinedo","doi":"10.1016/j.anpede.2025.503860","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503860","url":null,"abstract":"<p><strong>Introduction: </strong>Functional dyspepsia (FD) is a functional gastrointestinal disorder that affects a significant number of patients, especially adolescents. Diagnosis is often challenging on account of both the differential diagnosis with organic diseases and the overlap with other disorders involving the gut-brain axis. Furthermore, there is a lack of scientific evidence on the effectiveness of the different treatments. As a result, there is evidence of substantial heterogeneity in the management of these patients due, in part, to the absence of clinical practice guidelines on this disease.</p><p><strong>Material and methods: </strong>A group was formed that consisted of 19 members of the working group on motility and functional gastrointestinal disorders (FGIDS) of the SEGHNP. The group defined 27 clinical questions regarding the management of FD. After a review of the literature and two rounds of anonymous voting, the group elaborated a document summarizing the current evidence and offering recommendations.</p><p><strong>Results: </strong>The group produced a summary of the evidence and developed 27 recommendations on FD.</p><p><strong>Conclusion: </strong>We developed an algorithm with the aim of standardizing the management of patients with FD.</p>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503860"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the treatment of cystic fibrosis: CFTR modulators.","authors":"Maria Dolores Pastor-Vivero, Jordi Costa I Colomer, Carlos Martín de Vicente, Saioa Vicente-Santamaria, Ruth Garcia Romero, David González Jiménez, Carmen Luna Paredes","doi":"10.1016/j.anpede.2025.503857","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503857","url":null,"abstract":"<p><p>Cystic fibrosis is a severe genetic disease caused by variants in the CFTR gene. Although it is a multisystem disease, respiratory involvement is the main cause of morbidity and mortality. Cystic fibrosis transmembrane conductance regulator modulator (CFTRm) therapies have advanced the treatment of this disease by improving function of this protein. Ivacaftor, the first CFTRm, has been found to significantly improve lung function and quality of life in patients with certain gating variants. However, only a small percentage of patients in Spain are eligible for this treatment. Combinations of correctors and potentiators, such as lumacaftor-ivacaftor or tezacaftor-ivacaftor, have been developed for treatment of patients with the most frequent variant (F508del), although with limited benefits. Triple therapy with elexacaftor-tezacaftor-ivacaftor has been found to significantly improve respiratory, gastrointestinal and nutritional outcomes as well as quality of life, thus changing the management of CF in eligible patients. The impact of triple therapy is also reflected in an increase in life expectancy and a decrease in mortality and lung transplantation. As regards hepatic and pancreatic involvement, while CFTR modulators have exhibited promising effects, further research is required. The use of CFTR modulators has also shifted nutritional status trends in patients with CF, reducing the risk of undernutrition but increasing the risk of obesity. The use of these drugs for treatment of less frequent variants and for potential antenatal treatment is currently being investigated. Despite these advances, there is still a subset of patients who are ineligible for treatment with modulators or highly effective therapy.</p>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503857"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The paradox of MBD, we know how to treat it but we don't know how to diagnose it.","authors":"Clara Chover Martínez, María Portolés Morales, Pilar Sáenz González, Álvaro Solaz García","doi":"10.1016/j.anpede.2025.503801","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503801","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503801"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital lung malformations: Do preoperative symptoms have an impact in surgical outcomes?","authors":"María López-Díaz, Ester Fernández Díez, Indalecio Cano Novillo, Elena Bergón, Rocío Morante Valverde, Alberto Galindo Izquierdo, Juan L Antón-Pacheco","doi":"10.1016/j.anpede.2025.503835","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503835","url":null,"abstract":"<p><strong>Introduction: </strong>The management of congenital lung malformations (CLMs) is controversial because most of them are asymptomatic. The aim of our study was to analyze the association of preoperative symptoms with surgical outcomes in patients with CLMs treated by means of minimally invasive surgery (MIS).</p><p><strong>Patients and methods: </strong>Retrospective study of patients with CLM treated with MIS in our hospital between 2003 and 2023. We recorded data on the following variables: demographic characteristics, size, type and location of the lesion, mediastinal shift, clinical symptoms, surgical time, conversion to open surgery, duration of chest drainage (days), length of stay and postoperative complications.</p><p><strong>Results: </strong>The sample included 116 patients, 98 (84.4%) asymptomatic and 18 (15.5%) with clinically significant symptom: infectious in 10 (55.5%) and respiratory distress in eight. The most frequent histopathological type was congenital pulmonary airway malformation (35.5%), followed by intralobar sequestration (27.3%), and the lower lobes were most commonly involved (78.4%). Larger lesion size on the CT scan was significantly associated with the development of symptoms (P = .027) and with an increased frequency of conversion to open surgery. However, the incidence of postoperative complications was not greater in the symptomatic group.</p><p><strong>Conclusions: </strong>Postoperative complications were not significantly more frequent in the symptomatic group of patients. Larger lesion size on imaging was associated with a significantly increased probability of developing symptoms, so these patients may benefit from early surgical resection.</p>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503835"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procedural pain in pediatric care: Nitrous oxide and the greenhouse effect.","authors":"Itziar Marsinyach Ros, Marta Pérez Alba","doi":"10.1016/j.anpede.2025.503839","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503839","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503839"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National multicenter registry on lung ultrasound in infants born before 26 weeks' gestational age (MINI-LUS).","authors":"Almudena Alonso-Ojembarrena, Rebeca Gregorio-Hernández, Manuel Sánchez-Luna","doi":"10.1016/j.anpede.2025.503837","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503837","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503837"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes-zoster en un paciente vacunado recientemente de varicela.","authors":"Omar Al-Wattar-Ceballos, Marina Montero-García, Mónica Gómez-Manzanares, Carlos Mendoza-Chaparro","doi":"10.1016/j.anpede.2025.503723","DOIUrl":"https://doi.org/10.1016/j.anpede.2025.503723","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":" ","pages":"503723"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}