Cancer Cell International最新文献

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Predicting survival of persons with newly-diagnosed multiple myeloma. 预测新诊断多发性骨髓瘤患者的生存。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-09 DOI: 10.1186/s12935-025-03916-6
Limei Zhang, Yun Wang, Robert Peter Gale, Yang Liang
{"title":"Predicting survival of persons with newly-diagnosed multiple myeloma.","authors":"Limei Zhang, Yun Wang, Robert Peter Gale, Yang Liang","doi":"10.1186/s12935-025-03916-6","DOIUrl":"10.1186/s12935-025-03916-6","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"301"},"PeriodicalIF":6.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-omics profiling of metastatic colorectal cancer reveals the transcriptional network of focal adhesion and immune suppression and the role of p-RPS6. 转移性结直肠癌的多组学分析揭示了局灶黏附和免疫抑制的转录网络以及p-RPS6的作用。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-07 DOI: 10.1186/s12935-025-03924-6
Yimei Jiang, Zhe Li, Fang Zheng, Wenqing Jia, Zichao Guo, Zhuoqing Xu, Chenhao Huang, Zhiliang Li, Changgang Wang, Kun Liu, Haoran Feng, Ren Zhao, Xi Cheng
{"title":"Multi-omics profiling of metastatic colorectal cancer reveals the transcriptional network of focal adhesion and immune suppression and the role of p-RPS6.","authors":"Yimei Jiang, Zhe Li, Fang Zheng, Wenqing Jia, Zichao Guo, Zhuoqing Xu, Chenhao Huang, Zhiliang Li, Changgang Wang, Kun Liu, Haoran Feng, Ren Zhao, Xi Cheng","doi":"10.1186/s12935-025-03924-6","DOIUrl":"10.1186/s12935-025-03924-6","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is one of the deadliest malignancies worldwide characterized by rapid progression, high metastasis propensity. Our study aimed to identify the driving biological factors of metastatic CRC.</p><p><strong>Methods: </strong>We obtained frozen tumor tissues of 8 metastatic CRC (mCRC) patients and 10 non-metastatic CRC (nmCRC) patients from Ruijin Hospital for proteome analysis. FFPE tumor and adjacent normal tissues of another 8 metastatic CRC patients and 8 non-metastatic CRC patients were collected for transcriptome and whole exome sequencing. Mutational burden and signatures were revealed and differentially expressed genes and proteins were analyzed. Molecular Complex Detection was used to build the core network. KEGG and GO pathway enrichment analysis were performed. IHC staining against p-RPS6 and subsequent quantification were performed on human samples.</p><p><strong>Results: </strong>We identified 53,917 SNPs by WES with a median of 1154 variants per sample and 23.08 mutations per megabase (Mb). We observed the mutation burdens were similar between mCRC tumor and nmCRC tumor tissues (p = 0.57), as well as the mutation frequencies of HRR and MMR related genes. All mCRC samples were affected by RTK-RAS, NOTCH and WNT pathway mutations. We constructed a 16-hub-gene network in mCRC which was characterized by dis-modulation of cell adhesion (SELE, SELL and SELP) and immune exhaustion (CXCR2, CCR7, CXCR1, CXCL13, CCL7, CCL19, CXCL11 and CD19) in mCRC tumor microenvironment. We detected 22 differentially expressed proteins, 54 phosphorylated proteins and 6 tyrosine-phosphorylated proteins between mCRC and nmCRC tumors. Phosphorylated RPS6 (p-RPS6) was the most differentially expressed protein between mCRC and nmCRC tumor tissues, which was found to be positively correlated with EMT proteins and poor prognosis in CRC. The IHC staining against p-RPS6 on human samples supported the strong expression in mCRC tumor samples.</p><p><strong>Conclusions: </strong>We identified the key transcriptome network in mCRC and confirmed the important role for RPS6 phosphorylation in mCRC. Our study suggested that the features of mCRC tumors were not driven by gene mutations. We revealed the EMT feature and immune exhaustion of the mCRC tumor microenvironment.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"300"},"PeriodicalIF":6.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the secret of glioblastoma multiforme: the role of lactylation in tumor progression, drug resistance and immune microenvironment. 揭开多形性胶质母细胞瘤的秘密:乳酸化在肿瘤进展、耐药和免疫微环境中的作用。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-07 DOI: 10.1186/s12935-025-03933-5
Yifei Xiao, Ruipeng Zheng, Fengjun Lv, Guang Yang, Haitao Ge, Mingchun Yang, Kan Wang, Yu Cheng
{"title":"Unlocking the secret of glioblastoma multiforme: the role of lactylation in tumor progression, drug resistance and immune microenvironment.","authors":"Yifei Xiao, Ruipeng Zheng, Fengjun Lv, Guang Yang, Haitao Ge, Mingchun Yang, Kan Wang, Yu Cheng","doi":"10.1186/s12935-025-03933-5","DOIUrl":"10.1186/s12935-025-03933-5","url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma multiforme (GBM), the most prevalent and lethal type of brain cancer, is characterized by a poor prognosis despite advancements in comprehensive treatments, including surgery, chemotherapy, and radiotherapy. Lactylation, an emerging epigenetic modification, has been shown to influence the biological behavior of tumor cells; however, its role in GBM remains to be further elucidated.</p><p><strong>Methods: </strong>In this study, we analyzed the relationship between lactylation-related genes (LRGs) and malignant biological behavior, temozolomide resistance, and the immune microenvironment of GBM using scRNA-seq data from public databases. Subsequently, we identified temozolomide-resistant lactylation-related genes (TMZR-LRGs) through differential gene expression analysis. Based on these genes, we proceeded to classify GBM subtypes and establish a risk prediction model to assess patient prognosis and treatment response. Finally, we validated the impact of lactylation on TMZ resistance and malignant biological behavior of GBM both in vivo and in vitro by knocking out UBE2E1 to increase cellular lactylation levels.</p><p><strong>Result: </strong>ScRNA-seq analysis and in vivo and in vitro experiments both demonstrated that lactylation was significantly up-regulated in GBM cells. In the GBM subtype, MES-like cells have the highest lactylation level. Furthermore, an increase in lactylation levels enhanced the malignant proliferation and temozolomide resistance of GBM cells. The risk model based on TMZR-LRGs effectively predicted the prognosis and immune characteristics of GBM patients and had the potential to accurately identify targeted therapeutic drugs for GBM.</p><p><strong>Conclusion: </strong>Lactylation is critical for malignant progression, temozolomide resistance and the establishment of an immunosuppressive microenvironment of GBM. The risk model based on lactylation-related genes is an effective tool for assessing the prognosis and treatment response of GBM patients. LRGs have potential as therapeutic targets for GBM, providing a new direction for improving patient outcomes.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"299"},"PeriodicalIF":6.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction Note: LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146. 注:LncRNA HAND2-AS1作为microRNA-146的海绵,通过修复RARB对膀胱癌发挥抑癌作用。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-07 DOI: 10.1186/s12935-025-03936-2
Liping Shan, Wei Liu, Yunhong Zhan
{"title":"Retraction Note: LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146.","authors":"Liping Shan, Wei Liu, Yunhong Zhan","doi":"10.1186/s12935-025-03936-2","DOIUrl":"10.1186/s12935-025-03936-2","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"298"},"PeriodicalIF":6.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the potential role of miR-451a as a tumor suppressor in immunogenic cell death induction and dendritic cell maturation in colorectal cancer cell lines. 研究miR-451a作为肿瘤抑制因子在结直肠癌细胞系免疫原性细胞死亡诱导和树突状细胞成熟中的潜在作用。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-07 DOI: 10.1186/s12935-025-03919-3
Mahdieh Azizi, Alireza Andalib, Marzieh Rezaei
{"title":"Investigating the potential role of miR-451a as a tumor suppressor in immunogenic cell death induction and dendritic cell maturation in colorectal cancer cell lines.","authors":"Mahdieh Azizi, Alireza Andalib, Marzieh Rezaei","doi":"10.1186/s12935-025-03919-3","DOIUrl":"10.1186/s12935-025-03919-3","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, as conventional therapies are frequently hampered by treatment resistance and the presence of an immunosuppressive tumor microenvironment (TME). Immunotherapy, particularly strategies based on immunogenic cell death (ICD) induction can activate the TME by enhancing tumor immunogenicity and promoting T cell infiltration, potentially improving the efficacy of cancer immunotherapies in CRC. This study investigates the potential of miR-451a as a tumor suppressor in the release of ICD associated damage-associated molecular patterns in CRC cell lines and maturation of dendritic cells (DCs).</p><p><strong>Methods: </strong>Human CRC cell lines (SW48, SW1116, SW480, and Caco-2) were treated with oxaliplatin alone or transfected with the hsa-miR-451a mimic, scrambled miRNA, or a combination of the hsa-miR-451a mimic and oxaliplatin for 48 h. Cell viability was measured using MTT assays, and apoptosis was assessed through annexin V and PI staining. Flow cytometry was employed to evaluate calreticulin (CRT) levels on the cell surface and to analyze the percentages of CD11c + CD86 + CD80 + mature DCs. Additionally, ATP levels were quantified using a luminescence assay, and HMGB1 levels were measured by ELISA.</p><p><strong>Results: </strong>Our results demonstrated that the overexpression of miR-451a significantly increased apoptosis and CRT surface exposure in all four CRC cell lines, like the effects observed with oxaliplatin, when compared to both the control and scrambled miRNA groups (P < 0.05, P < 0.01, P < 0.001, and P < 0.0001). However, the combination of miR-451a with oxaliplatin did not yield synergistic effects across all cell lines. Additionally, the ability of miR-451a to increase extracellular ATP and HMGB1 levels, as well as its effect on DC maturation, varied among cell lines.</p><p><strong>Conclusions: </strong>The findings of this study presents novel insights into the potential role of miR-451a as a tumor-suppressive agent in CRC. By examining its effect on ICD across four different CRC cell lines, we provide a comprehensive analysis of its impact on both tumor cells and the immune system. Our results suggest that miR-451a induce certain characteristics of the ICD response, which vary depending on the cellular context.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"297"},"PeriodicalIF":6.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of m6A RNA methylation regulators in pancreatic cancer: interactions and potential implications. m6A RNA甲基化调节因子在胰腺癌中的作用:相互作用和潜在意义。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-04 DOI: 10.1186/s12935-025-03922-8
Li Liao, Xiaoqiang Xu, Yu Cao, Kezhong Tang, Qiaoping Xu
{"title":"Role of m6A RNA methylation regulators in pancreatic cancer: interactions and potential implications.","authors":"Li Liao, Xiaoqiang Xu, Yu Cao, Kezhong Tang, Qiaoping Xu","doi":"10.1186/s12935-025-03922-8","DOIUrl":"10.1186/s12935-025-03922-8","url":null,"abstract":"<p><p>Pancreatic cancer (PC) is a highly invasive malignant tumor associated with significant mortality rates, primarily due to challenges in early diagnosis, high invasiveness, and pronounced drug resistance. In recent years, N6-methyladenosine (m6A), one of the most abundant RNA modifications in eukaryotic cells, has been shown to play a critical role in various RNA processes, including alternative splicing, maturation, stability, translation and degradation. m6A is dynamically and reversibly regulated by its methyltransferases, demethylases and m6A-binding proteins, which have been reported to significantly influence the development and progression of various cancers, including PC. We review the latest advancements in m6A regulators and their roles in PC, and introduce the mechanism and signaling pathways of m6A factors affecting PC occurrence and development. Furthermore, we summarize the potential applications of m6A regulators in improving drug resistance and immunotherapy efficacy, as well as the therapeutic promise of small-molecule inhibitors targeting m6A-related proteins, to provide innovative methods and strategies for the diagnosis and treatment of pancreatic cancer.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"292"},"PeriodicalIF":6.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Very long-chain fatty acids accumulate in breast cancer tissue and serum. 长链脂肪酸在乳腺癌组织和血清中积累。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-04 DOI: 10.1186/s12935-025-03928-2
Alicja Pakiet, Michalina Ciosek, Oliwia Lange, Katarzyna Duzowska, Agata Janczy, Małgorzata Kapusta, Yelyzaveta Razghonova, Marcin Ekman, Anna Abacajew-Chmyłko, Paweł Kabata, Adriana Mika
{"title":"Very long-chain fatty acids accumulate in breast cancer tissue and serum.","authors":"Alicja Pakiet, Michalina Ciosek, Oliwia Lange, Katarzyna Duzowska, Agata Janczy, Małgorzata Kapusta, Yelyzaveta Razghonova, Marcin Ekman, Anna Abacajew-Chmyłko, Paweł Kabata, Adriana Mika","doi":"10.1186/s12935-025-03928-2","DOIUrl":"10.1186/s12935-025-03928-2","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) remains one of the most common cancers with relatively high mortality and is associated with alterations in fatty acid (FA) metabolism. While typical FAs have been extensively studied, there is increasing evidence for a potential role of very long chain fatty acids (VLCFAs) in cancer growth and progression.</p><p><strong>Methods: </strong>This study involved 54 BC patients from whom samples of malignant tumor, normal fibroglandular tissue, and breast adipose tissue were collected. Their FA content was analyzed by gas chromatography-mass spectrometry. The expression of fatty acid elongases (ELOVLs) and FA-transporting proteins was analyzed in the tissues by RT-PCR and immunofluorescence.</p><p><strong>Results: </strong>Higher levels of saturated and monounsaturated VLCFAs were found in BC tissues compared to normal tissues (p < 0.001) and in patients' blood compared to healthy controls blood (p < 0.001). However, the level of VLCFAs was lower in BC adipose tissue compared to healthy control adipose tissue (p < 0.001). Interestingly, there were no obvious differences in ELOVL1 mRNA or protein levels between normal and cancer tissues.</p><p><strong>Conclusions: </strong>Elevated levels of VLCFAs in BC tissue are the result of lipid uptake from outside the tumor rather than in situ synthesis.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"296"},"PeriodicalIF":6.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages. B7-H3通过ccr5高表达的肿瘤相关巨噬细胞促进乳腺癌的侵袭转移
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-04 DOI: 10.1186/s12935-025-03932-6
Tiantian Dai, Zhihua Xu, Yadi Li, Mengni Wu, Yue Qiu, ZhuJun Chao, Renhai Jiang, Yan Chen, Linlin Lu
{"title":"Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages.","authors":"Tiantian Dai, Zhihua Xu, Yadi Li, Mengni Wu, Yue Qiu, ZhuJun Chao, Renhai Jiang, Yan Chen, Linlin Lu","doi":"10.1186/s12935-025-03932-6","DOIUrl":"10.1186/s12935-025-03932-6","url":null,"abstract":"<p><p>Breast cancer (BC) ranks first in morbidity and second in mortality in all female cancers, and previous studies support the contribution of tumor-associated macrophages (TAMs) to cancer progression. B7-H3 is aberrantly expressed in a variety of solid cancers, and may also promote cancer progression, but its function is still yet to be known. In this study, the importance of B7-H3 in BC pathogenesis was investigated through TAM. The expression of B7-H3 and CCR5 on macrophages/monocytes was first detected in 135 human BC tissues and peripheral blood by flow cytometry. In the tumor microenvironment, the expression of B7-H3 on TAM was positively correlated with CCR5 levels on TAM. Clinical analysis indicated that CCR5<sup>high</sup> TAM was significantly correlated with the size of tumors (T) (P = 0 .011) and E-cadherin (P < 0.0001). In vitro, knockdown of B7-H3 reduced the expression of CCL3/4 on a cell line of monocytes THP-1. Further studies showed that B7-H3 could recruit TAMs through the CCL3/4-CCR5 axis, and that CCR5<sup>high</sup>TAM recruited in the tumor microenvironment could enhance BC migration and invasion. In addition, B7-H3 and CCR5 can facilitate the EMT process through the MAPK/ERK and NF-ΚB pathways. In conclusion, it is speculated that B7-H3 may regulate CCR5<sup>high</sup> TAMs through the CCL3/4-CCR5 axis, thereby promoting BC migration and invasion.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"293"},"PeriodicalIF":6.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mendelian randomization study of type 2 diabetes and cancer risk in East Asians. 东亚2型糖尿病和癌症风险的孟德尔随机研究。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-04 DOI: 10.1186/s12935-025-03929-1
Ling Li, Fangxuan Li, Zhanyu Pan
{"title":"A Mendelian randomization study of type 2 diabetes and cancer risk in East Asians.","authors":"Ling Li, Fangxuan Li, Zhanyu Pan","doi":"10.1186/s12935-025-03929-1","DOIUrl":"10.1186/s12935-025-03929-1","url":null,"abstract":"<p><p>Our research aims to explore genetic correlation between T2D predisposition and risks of several cancers, which have been predominantly focused on populations of European ancestry. In an East Asian population, we leverage two-sample Mendelian Randomization to investigate the complex association between Type 2 Diabetes (T2D) and cancer susceptibility. This investigation utilizes genetic data summarized from three reputable sources: the Japanese ENcyclopedia of GEnetic associations by Riken (JENGER), the Asian Genetic Epidemiology Network (AGEN), and the Meta Analyses of Glucose and Insulin-related traits (MAGIC). We explored the associations between exposure datasets, which included T2D, glycated hemoglobin (HbA1c) and fasting glucose (FG) levels, and the risk of several prevalent cancers for the outcome datasets. By analyzing 174 SNPs associated with T2D, 15 SNPs related to FG, and 74 SNPs linked to HbA1c, we discovered a significant inverse relationship between T2D and the majority of cancers, including gastric (OR = 0.875, 95%CI: 0.825-0.928), breast (OR = 0.907, 95%CI: 0.850-0.967), esophageal (OR = 0.761, 95%CI:0.681-0.851), colorectal (OR = 0.877, 95%CI:0.834-0.923), hematological malignancy (OR = 0.837, 95%CI:0.752-0.933), lung (OR = 0.916, 95%CI:0.858-0.977), hepatocellular (OR = 0.865, 95%CI:0.787-0.951), prostate (OR = 0.862, 95%CI:0.812-0.914), and endometrial cancer (OR = 0.841). The power of gastric cancer, breast cancer, esophageal cancer, colorectal cancer and prostate cancer reached the desired 80%. Conversely, we did not observe a reverse correlation between T2D and specific cancers in the East Asian population. There is limited evidence that genetically predicted FG and HbA1c levels are associated with specific cancer. Moreover, conducting multivariable MR analysis did not alter the correlation between T2D and specific tumors. These findings explain the causal associations of genetic liability to T2D with various types of cancers in East Asian ancestry, and this association is not affected by glycemic biomarkers.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"295"},"PeriodicalIF":6.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2. Periplocin通过诱导Nrf2的降解加速非小细胞肺癌的铁致细胞死亡。
IF 6 2区 医学
Cancer Cell International Pub Date : 2025-08-04 DOI: 10.1186/s12935-025-03925-5
Jinhao Wang, Yue Zhu, Jialiang Song, Fengping Yang, Peng Wang, Ziyi Zhang, Yuxuan Li, Minghe Dai, Yinuo Wang, Waleed Yousuf, Jiayu Li, Dian Yang, Shaoxuan Cheng, Shuyan Liu, Zhaoxia Dai, Xun Qiu, Yingqiu Zhang, Zengchun Hu
{"title":"Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2.","authors":"Jinhao Wang, Yue Zhu, Jialiang Song, Fengping Yang, Peng Wang, Ziyi Zhang, Yuxuan Li, Minghe Dai, Yinuo Wang, Waleed Yousuf, Jiayu Li, Dian Yang, Shaoxuan Cheng, Shuyan Liu, Zhaoxia Dai, Xun Qiu, Yingqiu Zhang, Zengchun Hu","doi":"10.1186/s12935-025-03925-5","DOIUrl":"10.1186/s12935-025-03925-5","url":null,"abstract":"<p><strong>Background: </strong>Non-small cell lung cancer represents the main histological subtype of lung cancer. Periplocin is a major cardiac glycoside found in the traditional Chinese medicine Cortex periplocae administered in cardiovascular and autoimmune diseases. Inspired by recent findings reporting the anticancer activities of periplocin, this study investigates its potential effects against lung cancer.</p><p><strong>Methods: </strong>The influence of periplocin on non-small cell lung cancer cells was examined by CCK-8, colony formation, and EdU staining assays, followed by transcriptomic profiling with RNA sequencing. Gene set enrichment analysis was conducted to identify pathways affected by periplocin. Nrf2 expression was assessed by Western blotting and turnover was investigated by cycloheximide chase assays. Cellular ferroptosis was induced by the GPX4 inhibitor with or without periplocin treatment. The in vivo effects of periplocin were assessed using lung cancer xenograft mouse models.</p><p><strong>Results: </strong>Periplocin inhibited lung cancer cell growth in vitro. Transcriptomic analysis showed significant downregulation of Nrf2 downstream targets. Biochemical characterization revealed that periplocin increased Nrf2 turnover by promoting proteasomal degradation, leading to decreased levels of downstream transcripts. Functionally, Nrf2 reduction imposed by periplocin treatment rendered lung cancer cells increased susceptibility to ferroptosis induction. Finally, periplocin treatment demonstrated similar inhibition to restrict lung cancer xenograft growth as compared to the ferroptosis inducer imidazole ketone erastin, with both compounds leading to elevated expression of the ferroptosis marker COX2 in xenograft tumor tissues.</p><p><strong>Conclusion: </strong>Our investigation suggests periplocin as a potential agent in the development of ferroptosis-inducing therapies against non-small cell lung cancer.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"294"},"PeriodicalIF":6.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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