Role of m6A RNA methylation regulators in pancreatic cancer: interactions and potential implications.

IF 6 2区医学 Q1 ONCOLOGY

Cancer Cell International Pub Date : 2025-08-04 DOI:10.1186/s12935-025-03922-8

Li Liao, Xiaoqiang Xu, Yu Cao, Kezhong Tang, Qiaoping Xu

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Abstract

Pancreatic cancer (PC) is a highly invasive malignant tumor associated with significant mortality rates, primarily due to challenges in early diagnosis, high invasiveness, and pronounced drug resistance. In recent years, N6-methyladenosine (m6A), one of the most abundant RNA modifications in eukaryotic cells, has been shown to play a critical role in various RNA processes, including alternative splicing, maturation, stability, translation and degradation. m6A is dynamically and reversibly regulated by its methyltransferases, demethylases and m6A-binding proteins, which have been reported to significantly influence the development and progression of various cancers, including PC. We review the latest advancements in m6A regulators and their roles in PC, and introduce the mechanism and signaling pathways of m6A factors affecting PC occurrence and development. Furthermore, we summarize the potential applications of m6A regulators in improving drug resistance and immunotherapy efficacy, as well as the therapeutic promise of small-molecule inhibitors targeting m6A-related proteins, to provide innovative methods and strategies for the diagnosis and treatment of pancreatic cancer.

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m6A RNA甲基化调节因子在胰腺癌中的作用：相互作用和潜在意义。

胰腺癌（PC）是一种高侵袭性恶性肿瘤，死亡率高，主要是由于早期诊断困难，高侵袭性和明显的耐药性。n6 -甲基腺苷（N6-methyladenosine, m6A）是真核细胞中最丰富的RNA修饰之一，近年来已被证明在多种RNA过程中发挥关键作用，包括选择性剪接、成熟、稳定、翻译和降解。m6A受其甲基转移酶、去甲基化酶和m6A结合蛋白的动态可逆调控，据报道，m6A结合蛋白显著影响包括PC在内的各种癌症的发生和进展。本文综述了m6A调控因子及其在PC中的作用的最新进展，并介绍了m6A调控因子影响PC发生发展的机制和信号通路。此外，我们总结了m6A调节因子在改善耐药和免疫治疗疗效方面的潜在应用，以及靶向m6A相关蛋白的小分子抑制剂的治疗前景，为胰腺癌的诊断和治疗提供创新的方法和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.