Cancer Cell International最新文献

{"title":"Correlation between the use of dried Toad skin-radix clematidis and the development of intestinal dysbiosis and colorectal cancer.","authors":"Xue-Yan Wang, Li-Jun Pan, Bing Yang, Yang Liu, Dong-Xin Tang","doi":"10.1186/s12935-025-03861-4","DOIUrl":"https://doi.org/10.1186/s12935-025-03861-4","url":null,"abstract":"<p><strong>Objective: </strong>To examine the impact of different intestinal microbiota conditions on the absorption of couplet medicines (dried toad skin and radix clematidis) into the bloodstream, and to evaluate the therapeutic effects of drug-containing plasma, produced under different intestinal microbiota conditions, on colorectal cancer HT-29 cells.</p><p><strong>Methods: </strong>In Experiment I, after the pseudo-sterile rat model was established, intragastric administration was performed. Explore the influence of different states of intestinal bacteria on rat organ coefficients, intestine bacteria, plasma metabolites, and so on. In Experiment II, the HT-29 cells of colon cancer were given to each group of drug-containing plasma for intervention to explore the intervention effect of HT-29-cell plasma produced under the influence of different states of intestinal bacteria.</p><p><strong>Results: </strong>Pseudo-sterile conditions can affect the body weight, organ coefficients, and immune cell ratios of rats, leading to dysbiosis in various segments of their intestinal microbiota. After administering traditional Chinese medicine under pseudo-sterile conditions, the immune cell ratios in rats returned to normal, and the dysbiosis in the intestinal microbiota improved. There were 271 differential metabolites in the plasma between the groups. Cellular experiments indicate that plasma containing drugs obtained under normal gut microbiota conditions can significantly inhibit the proliferation and migration of HT-29 cells (p < 0.01), while the inhibitory effect of plasma containing drugs obtained under dysbiotic gut microbiota conditions is reduced (p < 0.05).</p><p><strong>Conclusion: </strong>There is a bidirectional regulatory effect between the gut microbiota and the core medicinal pair. On one hand, dysbiosis weakens the efficacy of the medication. Dysbiosis can affect the blood components of the core medicinal pair. Compared to the drug-containing plasma produced under normal gut microbiota conditions, the drug-containing plasma produced under dysbiosis conditions has a reduced inhibitory effect on the proliferation of HT-29 cells. On the other hand, the drug repairs certain functions of the microbiota. After the drug enters the intestine, it exerts a positive regulatory effect on the dysbiosis of the intestinal microbiota in rats, partially improving the dysbiosis caused by antibiotics, restoring the balance of CD3+, CD4+, and CD8 + ratios in rats, and partially restoring the anticancer activity of drug-containing plasma.</p><p><strong>Clinical trial number: </strong>not applicable.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"228"},"PeriodicalIF":5.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of physical activity and epigenetic changes in colorectal cancer prevention.","authors":"Yu Sun, Ooi Boon Keat, Sogand Rajabi","doi":"10.1186/s12935-025-03872-1","DOIUrl":"https://doi.org/10.1186/s12935-025-03872-1","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"227"},"PeriodicalIF":5.3,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC00601 promotes the progression of glioma via the p-STAT3 signaling pathway.","authors":"Chao Ma, Linqi Wang, Renwu Zhang, Tong Li, Peng Li, Yuxiang Ding, Dejun Wu, Yinyan Wang","doi":"10.1186/s12935-025-03735-9","DOIUrl":"10.1186/s12935-025-03735-9","url":null,"abstract":"<p><strong>Background: </strong>Gliomas, the most common malignant tumors of the central nervous system, primarily originate from glial cells, which support nerve cells. Due to their high malignancy and aggressiveness, gliomas frequently result in poor prognoses. Increasing evidence suggests that long non-coding RNAs (lncRNAs) have diverse roles in cancer; however, their specific functions in gliomas remain poorly understood. This study elucidates the roles and potential mechanisms of the lncRNA LINC00601 in glioma.</p><p><strong>Methods: </strong>Bioinformatics analysis was utilized to identify the expression of LINC00601 and to perform related survival analysis. Glioma cells were transfected with a control vector small interfering RNA (si-NC) or small interfering RNA LINC00601 (si-LINC00601). Cell proliferation was evaluated using the CCK-8 assay and plate colony formation assay. Cell migration and invasion were assessed using the Transwell assay. Protein expression was detected by Western blot analysis, and lncRNA levels were measured using quantitative real-time PCR (qRT-PCR).</p><p><strong>Results: </strong>Bioinformatics analysis revealed that LINC00601 is associated with the pathological grade and prognosis of glioma, as evidenced by data from the TCGA and CGGA databases. In vivo experiments showed that LINC00601 knockdown inhibits the proliferation, migration, and invasion of U251 and U87 cells. Based on sequencing and Western blot results, this effect is thought to be linked to changes in Phosphorylated Signal Transducer and Activator of Transcription 3 (p-STAT3) expression. Additionally, in vitro knockdown of LINC00601 has been shown to inhibit glioma growth.</p><p><strong>Conclusions: </strong>LINC00601, which facilitates glioma progression by modulating the p-STAT3 signaling pathway, could serve as a potential molecular target for glioma therapy.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"220"},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on NcRNAs in HBV/cccDNA-driven HCC progression.","authors":"Yang-Hsiang Lin, Ming-Wei Lai, Chau-Ting Yeh, Wey-Ran Lin","doi":"10.1186/s12935-025-03849-0","DOIUrl":"10.1186/s12935-025-03849-0","url":null,"abstract":"<p><p>Hepatitis B virus (HBV) integration, the HBx protein (and its mutants), and covalently closed circular DNA (cccDNA) are critical for HBV replication, packaging, and transmission to new host cells. Although nucleos(t)ide analogs (NAs) are a class of antiviral drugs that effectively suppress HBV replication, they do not eliminate cccDNA. This persistent cccDNA, often referred to as an \"invisible bullet\", plays a pivotal role not only in the horizontal transmission of HBV but also within the context of hepatocellular carcinoma (HCC). Growing evidence reveals that noncoding RNAs (ncRNAs) are deeply involved in cancer progression, as well as the HBV life cycle and related pathogenesis, including liver inflammation, fibrosis, and HCC. This involvement occurs through various mechanisms, as ncRNAs regulate gene transcription, act as miRNA sponges, modulate signaling pathways, and influence downstream effects. These functions depend on the proper formation of RNA structures, which are critical for maintaining the biological activity of ncRNAs. The structure of RNAs appears to play a pivotal role in their functional capacity. Moreover, both ncRNAs and viral nucleotides contribute to G-quadruplex structure formation, which is essential for the HBV life cycle and cancer progression. In this review, we provide an updated overview of the mechanisms by which key ncRNAs mediate HBV/cccDNA actions in HCC progression and focus on their roles in gene expression and structural formation/modification.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"224"},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and therapeutic potential of disulfidptosis-related genes in colon adenocarcinoma: a comprehensive multi-omics study.","authors":"Ye Song, Haoran Zhu, Junyang Wei, Shanxue Yin","doi":"10.1186/s12935-025-03855-2","DOIUrl":"10.1186/s12935-025-03855-2","url":null,"abstract":"<p><strong>Background: </strong>Disulfidptosis-related genes (DRGs) have emerged as key players in the prognosis of colon cancer(CC) and hold promise as potential therapeutic targets. This study systematically evaluates their prognostic significance and explores their potential for therapeutic intervention in colon adenocarcinoma.</p><p><strong>Methods: </strong>Colon adenocarcinoma(COAD) samples were categorized based on DRG expression to analyze differences in the immune landscape across molecular subtypes. Variations between high-risk (HRG) and low-risk (LRG) groups and changes in cell population dynamics across different stages were examined. The expression patterns of Diaphanous-Related Formin 1 (DIAPH1) and NADH: Ubiquinone Oxidoreductase Subunit B10 (NDUFB10), key components of the prognostic model, were assessed during T cell development. The model was validated using external datasets, and single-cell analysis was performed to investigate spatial distribution differences in tumor-infiltrating cell populations.</p><p><strong>Results: </strong>DRGs were critical in modulating T cell differentiation in COAD. DIAPH1 and NDUFB10 showed significant fluctuations during T cell development, indicating their involvement in immune regulation. Single-cell analysis revealed distinct spatial distribution patterns between T cells and epithelial cells. The ProjecTILs algorithm identified a higher proportion of Th1 cells, while Graph Convolutional Network (GCN) analysis showed no significant differences in T cell subtype proportions across different phenotypes. In vitro experiments further demonstrated that the knockdown of DIAPH1 and NDUFB10 in T cells effectively inhibited tumor proliferation.</p><p><strong>Conclusion: </strong>The DRG-based prognostic model demonstrated strong predictive power in COAD, highlighting the potential of DRGs as therapeutic targets. These findings provide a solid foundation for developing novel treatment strategies targeting disulfide ptosis pathways in CC.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"226"},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of single-cell and bulk RNA sequencing data unveils antigen-presenting and processing fibroblasts and establishes a predictive model in gastric cancer.","authors":"Chenggang Zhang, Fangqi Chen, Jie Li, Yixuan He, Juan Sun, Zicheng Zheng, Guanmo Liu, Yihua Wang, Weiming Kang, Xin Ye","doi":"10.1186/s12935-025-03878-9","DOIUrl":"10.1186/s12935-025-03878-9","url":null,"abstract":"<p><strong>Background: </strong>Antigen-presenting and processing fibroblasts (APPFs) have emerged as pivotal regulators of antitumor immunity. However, the predictive value of APPF-related genes (APPFRGs) in the prognosis and tumor immune status of gastric cancer (GC) remains largely unexplored.</p><p><strong>Methods: </strong>Bioinformatics analysis was conducted using single-cell and bulk RNA sequencing datasets of GC retrieved from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. The APPFs were identified using AUCell algorithm based on APP-associated genes obtained from the InnateDB database. CellChat algorithm was utilized to evaluate interactions between cells. The non-negative matrix factorization (NMF) clustering analysis was performed to identify APPF-related subgroups based on TCGA‑stomach adenocarcinoma cohort. LASSO and multivariate Cox regression analysis were conducted to establish the predictive model. Immunohistochemistry of GC tissue microarrays was performed to validate the model.</p><p><strong>Results: </strong>Compared to non-APPFs, APPFs exhibited more interactions with myeloid cells, endothelial cells, and lymphocytes via MHC-II signaling network. The two APPF-related subgroups clustered by NMF demonstrated significant differences in prognosis and immune cell infiltration. Five APPFRGs (CPVL, ZNF331, TPP1, LGALS9, TNFAIP2) were identified to establish the predictive model and stratify GC patients based on risk score. The prognosis was significantly different between the two risk groups and was validated using GEO datasets. A nomogram that efficiently predicted the overall survival of GC patients was established by integrating the risk score with age, T stage, N stage, and M stage. Furthermore, the high-risk group exhibited reduced infiltration of activated CD4⁺ T cell and increased infiltration of Treg cells, higher resistance to chemotherapy and immunotherapy, and lower tumor mutation burden. Finally, the immunohistochemical results of GC tissue microarrays revealed higher expression of CPVL, ZNF331, and TPP1, and lower expression of LGALS9 and TNFAIP2 in GC compared to adjacent normal tissues. Additionally, higher risk score in GC samples was relevant with poor differentiation, positive nerve invasion, advanced T and TNM stages, and higher expression of FOXP3.</p><p><strong>Conclusions: </strong>APPFs may play an important role in the regulation of tumor immune microenvironment in GC and warrant further exploration. The predictive model based on APPFRGs effectively predicts the prognosis and tumor immune status of GC.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"225"},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MitCOM-based prognostic model identifies GLUD1 as a key suppressor of glioblastoma growth and invasion through regulation of mitochondrial structure and metabolism.","authors":"Yang Li, Chaoying Qin, Liangqi Jiang, Jun Su, Zhen Li, Qing Liu, Yuanbing Yao","doi":"10.1186/s12935-025-03875-y","DOIUrl":"10.1186/s12935-025-03875-y","url":null,"abstract":"","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"222"},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HBx mutant-regulated RPL13AP25 mediates suboptimal virological response to entecavir and HCC progression.","authors":"Yang-Hsiang Lin, Ming-Wei Lai, Yu-De Chu, Kwang-Huei Lin, Chao-Wei Hsu, Rong-Nan Chien, Po-Heng Chuang, Chih-Lang Lin, Chau-Ting Yeh","doi":"10.1186/s12935-025-03873-0","DOIUrl":"10.1186/s12935-025-03873-0","url":null,"abstract":"<p><strong>Background: </strong>A number of effective antiviral agents for chronic hepatitis B are available worldwide, and these agents have exhibited satisfactory virologic suppression, but suboptimal responses still occur in some patients. We aimed to explore the contribution of long non-coding RNAs (lncRNAs) in mediating suboptimal responses in chronic hepatitis B patients, which remains to be fully elucidated.</p><p><strong>Methods: </strong>Cox regression models were used to analyze associations between suboptimal response and clinical factors. Hepatitis B virus X (HBx) gene was sequenced from entecavir-treated patients who developed hepatocellular carcinoma (HCC). Functional assays were conducted using Transwell assays, MTT assays, and xenograft model.</p><p><strong>Results: </strong>Suboptimal response was found to be a significant independent predictor of HCC development. Five of the six patients who developed HCC in the suboptimal response period were found to have HBx mutations (HBx-L100 insertion, HBx-G32R/K130M, HBx-Q87G/k130M/C143R, HBx-L123S, and HBx-H94Y/K130M). Overexpression of the HBx-H94Y/K130M mutation in HepG2.2.15 cells showed significantly increased cccDNA accumulation and enhanced cell migration compared to controls and other HBx mutants. RNA-seq analysis identified RPL13AP25 as a direct target of HBx-H94Y/K130M. RPL13AP25 was highly expressed in HCC tissues, and its elevated expression was associated with poor overall survival and enhanced cell motility and cccDNA accumulation both in vitro and in vivo. Mechanistically, both HBx-H94Y/K130M and RPL13AP25 enhanced the hyperphosphorylation of eIF4EBP1, leading to its dissociation from eIF4E, which subsequently enhances protein synthesis and ultimately contributes to HCC.</p><p><strong>Conclusions: </strong>The HBx-H94Y/K130M mutant, selected during the period of suboptimal virological response, appears to promote cccDNA accumulation, likely through the upregulation of RPL13AP25, which contributed to HCC progression.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"223"},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino acid-based risk stratification model improves prognostic precision in diffuse large B-cell lymphoma.","authors":"Chaowei Zhang, Mingyue Cai, Weiyi Yao, Qing Hong, Yuxuan Han, Na Chen","doi":"10.1186/s12935-025-03879-8","DOIUrl":"10.1186/s12935-025-03879-8","url":null,"abstract":"<p><p>Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. We hope to provide a new conceptual basis for evaluating patient prognosis and guiding diagnosis and treatment. Twenty patients newly diagnosed with DLBCL were selected as the experimental group, and 10 healthy volunteers composed the control group. The expression of amino acids in the plasma of patients and healthy controls was detected via liquid chromatography-tandem mass spectrometry (LC‒MS/MS). The sparse partial least squares discriminant analysis (sPLS-DA) model was established. Pathway enrichment analysis was performed on the selected differential amino acids. Tryptophan and glutamine, are significantly correlated with prognosis, which can be used as potential DLBCL biomarkers. MATLAB was used to create a partial least squares regression (PLSR) prognostic model and a support vector regression (SVR) machine learning prognostic model. The R²of the PLSR model is 0.33, and the RMSE is 14.22. A paired - sample T - test was conducted on the predicted values and the actual values, with P = 0.999. The R² of the SVR model is 0.89, the MAE is 1.95, and the MBE is 0.77. After training, the PLSR prognostic model and SVR machine can predict the prognosis of DLBCL and provide convenient guidance for the treatment of DLBCL.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"221"},"PeriodicalIF":5.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of ARF6 for a potential prognostic biomarker of acute myeloid leukemia.","authors":"Chike Zhang, Yang Liu, Xiaoshuang Yuan, Xu Yang, Bo Yang, Yi Huang, Feiqing Wang, Zhixu He, Yanju Li","doi":"10.1186/s12935-025-03847-2","DOIUrl":"10.1186/s12935-025-03847-2","url":null,"abstract":"<p><strong>Background: </strong>The small GTPase ADP-ribosylation factor 6 (ARF6) is key in cell membrane transport and cytoskeleton remodeling. It has been proven to drive the occurrence and development of a variety of tumors. The subject of this study is to investigate the expression characteristics, prognostic value, and mechanism of action of ARF6 in acute myeloid leukemia (AML).</p><p><strong>Methods: </strong>We investigated ARF6 expression and prognostic significance using data from databases such as Genotype-Tissue Expression, The Cancer Genome Atlas Program, Gene Expression Omnibus database, and Cancer Cell Line Encyclopedia. Then we validated ARF6 expression in AML using clinical samples and cell lines. Subsequently, functional enrichment analysis of ARF6-related differential genes was carried out to explore the potential mechanism of ARF6 in the occurrence and development of AML. The expression level of ARF6 and its function and mechanism on AML cells were investigated by in vitro cell experiments.</p><p><strong>Results: </strong>Our findings revealed that ARF6 was upregulated in most tumors compared with matched samples from healthy individuals, and its overexpression was significantly relevant to poor survival outcomes. In AML, ARF6 expression showed correlations with age, white blood cell count, French-American-British classification, and treatment outcomes. High ARF6 expression emerged as an independent prognostic factor in Cox regression analysis. Pathway enrichment analysis denoted that ARF6 mainly contributed to cell proliferation, cell adhesion, and immune regulation, and its expression level correlated with immune cell infiltration in AML. In addition, protein-protein interaction network analysis showed that ARF6 was associated with TLR4, ITGAX, ITGAM, FCGR3A, CD86, and CD4. Experimental validation demonstrated elevated ARF6 expression in AML patient samples, and the utilization of ARF6 inhibitors in AML cells resulted in the inhibition of cell proliferation, arrest of the cell cycle, and increase of apoptosis through the PI3K/AKT/NF-κB pathway.</p><p><strong>Discussion: </strong>To sum up, our results suggest that high expression of ARF6 may serve as a potential marker for poor prognosis in AML by the PI3K/AKT/NF-κB pathway. This study provides novel insights into potential targeted therapies for AML, aiming to improve the prognosis of patients with this aggressive malignancy.</p>","PeriodicalId":9385,"journal":{"name":"Cancer Cell International","volume":"25 1","pages":"218"},"PeriodicalIF":5.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}