Juan Maza-Solano, Ainhoa García-Lliberós, Xenia Mota-Rojas, Andrea Barrios, Christian Calvo-Henríquez, Isam Alobid, Serafín Sánchez-Gómez, Leigh J Sowerby
{"title":"Cross-cultural adaptation of the CRS-PRO questionnaire into Spanish.","authors":"Juan Maza-Solano, Ainhoa García-Lliberós, Xenia Mota-Rojas, Andrea Barrios, Christian Calvo-Henríquez, Isam Alobid, Serafín Sánchez-Gómez, Leigh J Sowerby","doi":"10.1016/j.otoeng.2025.512219","DOIUrl":"10.1016/j.otoeng.2025.512219","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis (CRS) is a prevalent disease responsible for significant morbidity. Diagnostic criteria are well established but response to clinical and surgical treatment need greater consistency. The objective of this paper was to perform a cross-cultural adaptation of the CRS-PRO to the Spanish language for its use as a routine questionnaire in the evaluation of CRS.</p><p><strong>Methods: </strong>The CRS-PRO questionnaire was translated using a three-step procedure in 50 patients, following the recommendations of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Native speakers of both European and South American Spanish participated in the translation.</p><p><strong>Results: </strong>Of the initial 12 items, 4 were discordant among the three translators before a consensus was reached (Step 1). The item \"breathe through the nose\" (1/12) did not match between the back translation and the initial version of the CRS-PRO (Step 2). Step 3 generated a final revised Spanish version of the CRS-PRO. Fifty patients (average age 51.1, 48% male) completed the questionnaire. Significant gender differences were found in responses to \"My face hurt\" (P = .043). Significant differences in \"My face hurt\" also appeared for those completing the questionnaire in less than 80 s (P = .047). Differences in \"problems with smell\" (P = .039) were noted between chronic rhinosinusitis with and without polyposis.</p><p><strong>Conclusion: </strong>This study presents the validated and Spanish-adapted version of the CRS-PRO questionnaire to evaluate CRS symptoms in the Spanish-speaking population.</p>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512219"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gonçalo Caetano, Filipa Morgado, Joana Póvoa, Francisco Branquinho
{"title":"Improving voice quality in laryngectomy patients with botulinum toxin A.","authors":"Gonçalo Caetano, Filipa Morgado, Joana Póvoa, Francisco Branquinho","doi":"10.1016/j.otoeng.2025.512222","DOIUrl":"10.1016/j.otoeng.2025.512222","url":null,"abstract":"<p><strong>Introduction: </strong>Tracheoesophageal (TEP) speech is the main voice rehabilitation method following laryngectomy. Pharyngoesophageal hypertonicity is one of the main causes for failure to achieve tracheoesophageal speech after laryngectomy. Botulinum toxin A (BTA) has been used to chemically denervate the pharyngeal musculature, and is an alternative to invasive surgical procedures. The aim of this work is to study the effectiveness and safety of this procedure.</p><p><strong>Material & methods: </strong>A retrospective cohort study from 2019 to 2023 was performed of 20 patients with failure to achieve a functional tracheoesophageal voice following laryngectomy. These patients undergone local pharyngoesophageal segment BTA injection. A total of 100 units of BTA were injected at 6 different sites, 3 in each side. Perceptual ratings of voice quality were performed before and 72 h after BTA injection by a speech therapist using a 7-point equal-appearing interval scale.</p><p><strong>Results: </strong>Speech quality mean rating (μ) improved from 2.05 before to 4.55 after BTA injection (P = .004), 17 (85%) patients had an improvement in postinjection perceptual TEP speech quality ratings, with scores in the good-to-excellent range (5-6 in the 7-point equal-appearing interval scale) in 12 patients (60%). Three patients (15%) didn't improve their voice quality, two of them with no discernible TEP speech. No adverse effects were reported.</p><p><strong>Conclusions: </strong>The majority of the patients enrolled in this study (85%) showed an improvement in TEP speech following BTA injection. This is a safe and effective method to improve TEP speech following laryngectomy.</p>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512222"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of interleukin-33 expression on prognosis in patients with nasopharyngeal carcinoma","authors":"İbrahim Arslan , Hatice Yılmazçoban , Hülya Eyigör , Canan Sadullahoğlu , Derya Salim Kıvrak , Gözde Akgün , Ömer Tarık Selçuk","doi":"10.1016/j.otoeng.2024.01.011","DOIUrl":"10.1016/j.otoeng.2024.01.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Interleukin-33 (IL-33) is a newly defined inflammatory cytokine that is a member of the interleukin-1 (IL-1) gene family. This cytokine is expressed in structural cells, such as the vascular endothelium, bronchial epithelial cells, keratinocytes, epithelial cells of the stomach, and fibroblastic reticular cells of lymphoid tissues. Several studies suggest that IL-33 plays a role in head-and-neck cancer. The aim of this study was to retrospectively examine IL-33 expression in nasopharyngeal carcinoma (NPC) and to evaluate its relationship between clinicopathological characteristics and prognosis.</div></div><div><h3>Methods</h3><div>In this monocentric, retrospective analysis, the data of 43 cases diagnosed with primary NPC and 20 cases with normal nasopharyngeal tissue (diagnosed between 2014 and 2020) were evaluated regarding the relationship between the immunohistochemically analyzed IL-33 expression status and corresponding clinicopathological parameters.</div></div><div><h3>Results</h3><div>The mean age was 56.9 years. The majority (67.4%) of the patients had an early tumor stage (T1–T2). IL-33 expression was positive in 56% of the cases. The five-year overall survival rate was 77% for all patients, 90% for the patients with positive IL-33 expression, and 55% for those without IL-33 expression (<em>p</em> = 0.008, univariate analysis). In multivariate analysis, IL-33 expression was shown to be the only independent prognostic marker for nasopharyngeal carcinoma (<em>p</em> = 0.014).</div></div><div><h3>Conclusion</h3><div>This retrospective study showed that IL-33 expression could be considered an independent factor affecting positively prognosis in NPC.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 2","pages":"Pages 76-82"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Victoria Mallo-Miranda , Carmelo Morales-Angulo
{"title":"Otorhinolaryngological manifestations of autoinflammatory diseases. Systematic review","authors":"María Victoria Mallo-Miranda , Carmelo Morales-Angulo","doi":"10.1016/j.otoeng.2024.09.005","DOIUrl":"10.1016/j.otoeng.2024.09.005","url":null,"abstract":"<div><h3>Objectives</h3><div>To detail the main otorhinolaryngological manifestations of autoinflammatory diseases, aiming to contribute to early diagnosis and treatment.</div></div><div><h3>Data sources</h3><div>Searches were conducted in PubMed, LILACS, Cochrane Library.</div></div><div><h3>Review methods</h3><div>A systematic review of the medical literature on autoinflammatory diseases was conducted to identify characteristic head and neck manifestations, using PRISMA criteria. Observational studies or systematic reviews with a minimum of 10 cases per disease were included. Qualitative synthesis and a risk assessment were carried out.</div></div><div><h3>Results</h3><div>Our review included 29 articles that met the inclusion criteria, with 10 to 486 patients per study. Autoinflammatory diseases with characteristic head and neck manifestations included VEXAS syndrome (auricular, nasal, or laryngotracheal chondritis), NPRL3-AID (hearing loss), NPRL12-AID (cervical lymphadenopathies, hearing loss and oral ulcers), HIDSs syndrome (painful cervical nodes and oral ulcers), haploinsufficiency A20 (oral ulcers), TRAPS (pharyngitis, aphthous stomatitis, periorbital edema, and cervical lymphadenopathies), Behcet’s disease (oral and pharyngeal ulcers), PFAPA syndrome (recurrent tonsillitis, oral ulcers, and painful cervical adenopathies), Kawasaki disease (cervical nodes, pharyngitis and changes in oral mucosa) and undefined periodic fever (pharyngitis, oral ulcers, and painful cervical nodes).</div></div><div><h3>Conclusion</h3><div>Given their complex diagnosis and unique head and neck manifestations, otolaryngologists must be well-versed in these diseases for early detection and treatment. ENT specialists should consider the possibility of an autoinflammatory disease when encountering symptoms such as auricular, nasal, or laryngeal chondritis, recurrent oral ulcers, painful inflammatory lymphadenopathies, periorbital edema, recurrent pharyngitis, or hearing loss within the context of compatible systemic conditions.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 2","pages":"Pages 116-129"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Sumarroca , Carmen Vega , Susana López , Andreas Leidinger , Gabriel Pedemonte , Xavier León , José Miguel Costa-González
{"title":"Lower lip reconstruction with the Karapandzic flap or the Colmenero flap: Description of results","authors":"Anna Sumarroca , Carmen Vega , Susana López , Andreas Leidinger , Gabriel Pedemonte , Xavier León , José Miguel Costa-González","doi":"10.1016/j.otoeng.2024.10.001","DOIUrl":"10.1016/j.otoeng.2024.10.001","url":null,"abstract":"<div><h3>Background and objective</h3><div>Reconstruction of medium and large oncological defects of the lower lip must preserve the functionality and aesthetics of the area and is usually solved with local pedicled flaps, rarely compared between them. The aim of this study is to analyse our case series of lower lip reconstruction using the Karapandzic flap or the Colmenero flap, and to describe their techniques and results.</div></div><div><h3>Materials and methods</h3><div>We performed a retrospective review of patients who underwent lower lip resection and reconstruction with the Colmenero flap or Karapandzic flap during the period 2015–2022 with a minimum follow-up time of more than one year. The defect size, treatment, complications, reinterventions and final outcome were analysed.</div></div><div><h3>Results</h3><div>A total of 22 patients underwent surgery: 13 of them were reconstructed with Karapandzic flaps, all bilateral (26 flaps) and with a mean defect size of 4.05 cm (2.9–6.5 cm). 9 patients were reconstructed with Colmenero flaps, of which 4 bilaterally (13 flaps), with a mean defect size of 4.16 cm (3–7.5 cm). All flaps were viable and all complications (5 among Karapandzic flaps and 4 among Colmenero flaps), mostly minor, were resolved. There were no statistically significant differences between the sizes of the reconstructed defects or between the complications of the two flaps. All patients had a total oral intake of food, no speech defects and a good final aesthetic result.</div></div><div><h3>Conclusions</h3><div>The surgical techniques of lower lip reconstruction with the Karapandzic flap or the Colmenero flap are very reliable, simple in design, with similar and very satisfactory functional and aesthetic results.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 2","pages":"Pages 83-90"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bell's palsy and COVID-19: A cohort study with historical rate comparison: Comment","authors":"Hinpetch Daungsupawong , Viroj Wiwanitkit","doi":"10.1016/j.otoeng.2024.11.001","DOIUrl":"10.1016/j.otoeng.2024.11.001","url":null,"abstract":"","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 2","pages":"Pages 134-135"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Lassaletta , Miryam Calvino , Isabel Sánchez-Cuadrado , Giovanni Danesi , Ilaria Patelli , Michela Zana , Íñigo Ruiz de Erenchun-Lasa , Manuela del Carmen Zapata , Eva María Muñoz Yuste , Daniel Schaudel , Cherisse Mark , Gionata Conni , Pedro Luis Sarría Echegaray , Guillermo til-Pérez , Isaac David Gutiérrez Pérez , Elena Muñoz Pascual
{"title":"Evaluation of remote programming of cochlear implants under challenging conditions","authors":"Luis Lassaletta , Miryam Calvino , Isabel Sánchez-Cuadrado , Giovanni Danesi , Ilaria Patelli , Michela Zana , Íñigo Ruiz de Erenchun-Lasa , Manuela del Carmen Zapata , Eva María Muñoz Yuste , Daniel Schaudel , Cherisse Mark , Gionata Conni , Pedro Luis Sarría Echegaray , Guillermo til-Pérez , Isaac David Gutiérrez Pérez , Elena Muñoz Pascual","doi":"10.1016/j.otoeng.2025.02.002","DOIUrl":"10.1016/j.otoeng.2025.02.002","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>During the strained period of the COVID-19 pandemic, an international multi-centric clinical pilot study of remote cochlear implant fitting (remote programming) took place with the primary aim of evaluating the satisfaction of patients and practitioners with this procedure.</div></div><div><h3>Materials and methods</h3><div>Cochlear implant users and clinical practitioners from clinics in Spain and Italy completed a questionnaire to evaluate their experience regarding their satisfaction with the procedure and with its efficacy.</div></div><div><h3>Results</h3><div>54 responses were collected from 48 users and 42 responses were collected from 9 clinical practitioners. Practitioners were able to perform both remote fitting and remote telemetry. They rated their satisfaction with the procedure highly, with a median value of 9.5/10. Over 90% were satisfied with the results of the procedure, and all who responded would be willing to use remote programming again. Practitioners also rated the technical performance highly. Users rated their satisfaction with the procedure with a median value of 8/10. The great majority of users would be willing to undergo remote programming again (81.3%), and most would recommend the procedure to other users (74%).</div></div><div><h3>Conclusions</h3><div>Remote programming is a well-received procedure among both clinical practitioners and cochlear implant users, and offers a useful alternative when in-person visits are not practical or not possible, as was the case during the pandemic.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 2","pages":"Pages 91-98"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survival of patients with malignant head and neck tumors diagnosed during the COVID-19 pandemic","authors":"Xavier León , Cristina Valero , Anna Holgado , Cristina Vázquez-López , Rosselin Vásquez , Arnau Parellada , Miquel Quer , Albert Pujol","doi":"10.1016/j.otoeng.2025.02.001","DOIUrl":"10.1016/j.otoeng.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>The COVID-19 pandemic significantly affected healthcare access worldwide. Few studies have analysed whether the pandemic negatively impacted patients with head and neck malignant tumours diagnosed during this period. This study aims to determine if there were differences in oncological outcomes between patients diagnosed during the pandemic and those diagnosed previously.</div></div><div><h3>Material and methods</h3><div>A retrospective study was conducted on patients with malignant head and neck tumours diagnosed during the pandemic and the previous five years at a tertiary center.</div></div><div><h3>Results</h3><div>The study cohort included 872 patients diagnosed between March 2018 and February 2022. The quarter with the fewest diagnoses was the COVID-4 period (March-2020 to June-2020), coinciding with the strictest lockdown phases. There were no significant changes in patient characteristics or treatment types due to the pandemic. No significant differences in 3-year disease-specific survival were observed between patients diagnosed and treated during the COVID period (March-2020 to February-2021, disease-specific survival 73.0%) and those treated during the previous five years (March-2015 to February-2020, disease-specific survival 70.6%, <em>P</em> = 0.377).</div></div><div><h3>Conclusions</h3><div>The COVID-19 pandemic led to a decrease in the number of diagnoses of malignant head and neck tumours during the strictest lockdown phases in our country. However, no statistically significant differences in oncological outcomes were observed as a consequence of the pandemic.</div></div>","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"76 2","pages":"Pages 106-115"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}