Acta otorrinolaringologica espanola最新文献

Bamboo nodules on the vocal cords: a rare clinical challenge. 声带上的竹结节：一个罕见的临床挑战。

Acta otorrinolaringologica espanola Pub Date : 2025-07-10 DOI: 10.1016/j.otoeng.2025.512266

María San Millán-González, Michael Bauer, Ana Fernández-Rodríguez, José Antonio Cámara-Arnaz

引用次数: 0

Exploring DIAPH1 Gene Mutations in Patients with Sensorineural Hearing Loss of Unknown Etiology in Northern Spain. 西班牙北部不明病因感音神经性听力损失患者中膜片基因突变的研究

Acta otorrinolaringologica espanola Pub Date : 2025-07-10 DOI: 10.1016/j.otoeng.2025.512269

Rocío González-Aguado, Aida Veiga-Alonso, Esther Onecha, Carmelo Morales-Angulo

{"title":"Exploring DIAPH1 Gene Mutations in Patients with Sensorineural Hearing Loss of Unknown Etiology in Northern Spain.","authors":"Rocío González-Aguado, Aida Veiga-Alonso, Esther Onecha, Carmelo Morales-Angulo","doi":"10.1016/j.otoeng.2025.512269","DOIUrl":"https://doi.org/10.1016/j.otoeng.2025.512269","url":null,"abstract":"Objective: To determine the prevalence of variants in the DIAPH1 gene among patients with bilateral sensorineural hearing loss of unknown etiology in northern Spain and to characterize the associated phenotype. As a secondary objective, this study aims to improve genetic counseling by linking genotype to phenotype through clinical characterization of variant carriers.Patients and methods: A six-year observational descriptive study was conducted at a tertiary referral center. Patients with bilateral sensorineural hearing loss of unknown origin were evaluated using DNA sequencing through next-generation sequencing. A gene panel was utilized to identify pathogenic or likely pathogenic variants in the DIAPH1 gene.Results: Among 385 patients with SNHL, four (1%) harbored DIAPH1 variants. Two patients (0.5%) had pathogenic or likely pathogenic variants associated with macrothrombocytopenia and neutropenia (c.3586dupA, c.3575-3C > G), exhibiting early-onset, progressive bilateral SNHL, and vestibular abnormalities. One received a cochlear implant with good outcomes.Conclusions: Pathogenic variants in the DIAPH1 gene are rare among patients with bilateral sensorineural hearing loss of unknown etiology in northern Spain. These variants lead to bilateral SNHL with autosomal dominant inheritance. In our study, we identified two novel pathogenic DIAPH1 variants associated with macrothrombocytopenia, and also presenting neutropenia and vestibular involvement.","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512269"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retropharyngeal adenopathy in carcinoma arising in Zenker's diverticulum. 癌发源于Zenker憩室的咽后腺病。

Acta otorrinolaringologica espanola Pub Date : 2025-07-10 DOI: 10.1016/j.otoeng.2025.512267

Beatriz Pallarés Martí, Juan José Díaz Argüello, Yolanda Escamilla Carpintero

引用次数: 0

Aberrant intratympanic internal carotid artery. 腔内颈内动脉异常。

Acta otorrinolaringologica espanola Pub Date : 2025-07-10 DOI: 10.1016/j.otoeng.2025.512268

Saúl Astray Gómez, Celia Montón-Gómez, Carlos De Paula-Vernetta

引用次数: 0

Patient reported voice outcomes following multi-disciplinary approach to botulism toxin for spasmodic dysphonia. 多学科肉毒杆菌毒素治疗痉挛性发声障碍后患者报告的声音结果。

Acta otorrinolaringologica espanola Pub Date : 2025-06-19 DOI: 10.1016/j.otoeng.2025.512261

Sahil Kakar, Keshav Kumar Gupta, Emma Richards, Colin Shirley, Paige Bradley, Anita Sonsale

{"title":"Patient reported voice outcomes following multi-disciplinary approach to botulism toxin for spasmodic dysphonia.","authors":"Sahil Kakar, Keshav Kumar Gupta, Emma Richards, Colin Shirley, Paige Bradley, Anita Sonsale","doi":"10.1016/j.otoeng.2025.512261","DOIUrl":"10.1016/j.otoeng.2025.512261","url":null,"abstract":"Purpose: Spasmodic dysphonia (SD) is a debilitating disorder primarily affecting voice production. Current treatment includes repeat botulinum toxin (botox) injections for symptomatic management. The aim of this study is to review the impact of botox injections on patient reported outcome measures (PROM), using a novel and unique quality of life, proforma, and side effects in patients treated at our centre.Methods: This retrospective case series evaluated all patients who were treated in our specialised voice clinic, at a single tertiary referral centre between May 2019 and April 2024 with botox for SD. The primary outcome measure was PROM of voice quality weekly post-injection as per a unique proforma. Variables extracted included patient demographics, treatment specifics and complications.Results: Fifty-two patients were included representing 21 (40.4%) males. Forty-two (80.8%) suffered from adductor spasmodic dysphonia with 8 (15.4%) having abductor dysphonia and 1 (1.92%) with mixed dysphonia. Patients with abductor dysphonia had a statistical improvement in voice following dose 2, (1.8-3.0, p = 0.03) and dose 3 (1.4-3.2, p = <0.001). Patients with adductor dysphonia had significant improvements in voice following all doses (2.1-2.9, p = 0.01), (1.9-3.0, p = <0.01) and (2.1-3.0, p = <0.01). The most common complication was a 'breathy voice', ranging from 31.4% to 51.0% but all patients reported this as transient.Conclusion: Patient reported quality of voice is improved following botox injections for spasmodic dysphonia, and most patients do not suffer from long-term complications.","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512261"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skull base surgery via extended endoscopic endonasal approach: Predictors of ear-nose-throat complications. 经扩展内窥镜鼻内入路颅底手术：耳鼻喉并发症的预测因素。

Acta otorrinolaringologica espanola Pub Date : 2025-06-19 DOI: 10.1016/j.otoeng.2025.512264

Anna Penella, Alejandro Portillo, Ricardo Bartel, Jose María Caballero, Enric Cisa, Francesc Cruellas, Mireia Golet, Jose L Sanmillan, Alberto Torres, Xavier González-Compta

{"title":"Skull base surgery via extended endoscopic endonasal approach: Predictors of ear-nose-throat complications.","authors":"Anna Penella, Alejandro Portillo, Ricardo Bartel, Jose María Caballero, Enric Cisa, Francesc Cruellas, Mireia Golet, Jose L Sanmillan, Alberto Torres, Xavier González-Compta","doi":"10.1016/j.otoeng.2025.512264","DOIUrl":"10.1016/j.otoeng.2025.512264","url":null,"abstract":"Objective: To identify predictive factors for ear-nose-throat (ENT) complications in patients undergoing skull base surgery via extended endoscopic endonasal approaches (EEEA).Methods: Single-center retrospective observational study of a cohort of patients who underwent EEEA for skull base surgery between January 2015 and December 2021. Patients were stratified according to ENT complications.Results: Sixty-one patients were included in the study: 37 women (60.66%) and 24 men (39.34%). Craniopharyngioma was the most frequently observed pathology (36%). 40 patients (65,57%) presented with ENT complications, being olfactory disturbance the most common complication (40,98%), followed by nasal obstruction (24,59%) and synechiae formation (18,03%). Logistic regression analysis revealed that younger age (P = .026) and excision of middle turbinates during EEEA surgery (P = .034) were independent factors with a significant association with ENT complications. Anterior septal deviation was an independent factor significantly associated with synechiae formation (P = .023).Conclusion: Surgeons performing skull base surgery using EEEA should be aware that excision of middle turbinate, younger age and anterior septal deviation may be risk factors for ENT postoperative complications.","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512264"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Speech discrimination and binaural processing in bilateral symmetric vs. asymmetric sensorineural hearing loss. 双侧对称型与非对称型感音神经性听力损失的言语辨别与双耳加工。

Acta otorrinolaringologica espanola Pub Date : 2025-06-19 DOI: 10.1016/j.otoeng.2025.512265

Mai Mohamed El Ghazaly, Esraa Mahmoud Mohamed Meckawy, Hesham Saad Kozou, Doaa Mohamed Elmoazen

{"title":"Speech discrimination and binaural processing in bilateral symmetric vs. asymmetric sensorineural hearing loss.","authors":"Mai Mohamed El Ghazaly, Esraa Mahmoud Mohamed Meckawy, Hesham Saad Kozou, Doaa Mohamed Elmoazen","doi":"10.1016/j.otoeng.2025.512265","DOIUrl":"10.1016/j.otoeng.2025.512265","url":null,"abstract":"Purpose: To investigate the effects of symmetric and asymmetric sensorineural hearing loss (SSNHL and ASNHL) on speech discrimination abilities and binaural processing, including integration and interaction.Materials and methods: This cross-sectional study included 36 adult patients with bilateral sensorineural hearing loss, divided into two groups based on the symmetry of their hearing loss: ASNHL and SSNHL. Speech discrimination abilities were evaluated using the maximum speech discrimination score (SDSmax) with Arabic monosyllabic words. Binaural integration was assessed using the free-recall double dichotic digit test (DDT), while binaural interaction was evaluated through the binaural fusion test (BFT).Results: The SDSmax of the worse-hearing ear in ASNHL patients (48.89 ± 10.13%) was significantly lower than in SSNHL patients (69.33 ± 7.97%) with comparable degrees of hearing loss. ASNHL patients exhibited a greater disparity between the better and worse-hearing ears in DDT scores (53.15 ± 13.98%) compared to SSNHL patients (22.96 ± 5.93%). Additionally, the BFT scores in ASNHL patients (55.14 ± 13.30%) were significantly lower than in SSNHL patients (72.92 ± 12.55%).Conclusions: ASNHL patients experience greater impairments in speech discrimination, binaural integration, and interaction compared to SSNHL patients. These differences likely stem from auditory deprivation and asymmetry-induced deficits. Developing tailored hearing rehabilitation strategies is critical to addressing the unique challenges posed by asymmetric hearing loss.","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512265"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of orbital complications of acute rhinosinusitis: A 13-year experience. 急性鼻窦炎眼眶并发症的处理：13年的经验。

Acta otorrinolaringologica espanola Pub Date : 2025-06-19 DOI: 10.1016/j.otoeng.2025.512262

Mónica Rueda Vega, M Montserrat Asensi Diaz, María C Scola Torres, Carolina López Granados, Mónica Hernando, Juan Antonio Pasamontes

{"title":"Management of orbital complications of acute rhinosinusitis: A 13-year experience.","authors":"Mónica Rueda Vega, M Montserrat Asensi Diaz, María C Scola Torres, Carolina López Granados, Mónica Hernando, Juan Antonio Pasamontes","doi":"10.1016/j.otoeng.2025.512262","DOIUrl":"10.1016/j.otoeng.2025.512262","url":null,"abstract":"Introduction: After the development of antibiotics and early diagnostic methods, the complications of acute rhinosinusitis (ARS) have reduced in recent years. However, in clinical practice, we still observe both orbital and intracranial complications. The aim of this study is to describe a series of patients with complications of ARS and to define what clinical and radiological characteristics may indicate the need of surgical treatment.Materials: Retrospective observational study of patients diagnosed with orbital complications secondary to ARS who were hospitalized at a tertiary hospital between 2010 and 2023. Demographic, clinical, radiological, microbiological data, therapeutic strategy and hospitalization time were studied.Results: Fifty-six patients were included (59% male), with a mean age of 11.5 years (37 under 18 years old). The most frequent symptoms were eyelid edema (98%) and erythema (89%), proptosis (46%) and fever (50%). According to Chandler's classification, the most frequent complications were subperiosteal abscesses (46%) and orbital cellulitis (23%). There were six cases of orbital abscesses and one cavernous sinus thrombosis. The most frequently used antibiotic was amoxicillin + clavulanic acid (54%). Surgical intervention was necessary in 26 patients (46%).Conclusion: Orbital complications of ARS are rare, but they can have potentially vision-threatening and life-threatening complications. Therefore, it is essential to consider them in the differential diagnosis, and in case of suspicion, initiate antibiotic treatment as soon as possible, with or without surgical drainage. Endoscopic surgery is the preferred approach, but it may be necessary to combine it with external drainage, especially in lateral locations or on the orbital roof.","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512262"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Otorhinolaryngological manifestations in patients with eosinophilic granulomatosis with polyangiitis in a single university center. 单一大学中心嗜酸性肉芽肿病合并多血管炎患者的耳鼻喉科表现。

Acta otorrinolaringologica espanola Pub Date : 2025-06-19 DOI: 10.1016/j.otoeng.2025.512263

Julia Fernández-Enseñat, Fabricio Benavides-Villanueva, Andrea Martínez-Camerano, Vanesa Calvo-Rio, Ricardo Blanco, Carmelo Morales-Angulo

{"title":"Otorhinolaryngological manifestations in patients with eosinophilic granulomatosis with polyangiitis in a single university center.","authors":"Julia Fernández-Enseñat, Fabricio Benavides-Villanueva, Andrea Martínez-Camerano, Vanesa Calvo-Rio, Ricardo Blanco, Carmelo Morales-Angulo","doi":"10.1016/j.otoeng.2025.512263","DOIUrl":"10.1016/j.otoeng.2025.512263","url":null,"abstract":"Objectives: Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis affecting multiple systems, with common ear, nose and throat (ENT) manifestations. This study aimed to evaluate the most frequent ENT manifestations in EGPA patients and the relationship between nasal polyps and other clinical findings such as ANCA tests and eosinophilia.Materials and methods: A retrospective observational study was conducted on EGPA patients diagnosed between 2000 and 2024 at a tertiary hospital using the 2022 ACR/EULAR criteria. Head and neck examinations, including audiometry, and their imaging and histopathological studies were reviewed. Patients were classified based on the presence or absence of nasal polyps, and the relationship between ANCA positivity and eosinophilia was assessed.Results: Of 173 patients with ANCA vasculitis, 22 met EGPA criteria, with a prevalence of 3.6 per 100,000 in Cantabria. Head and neck manifestations were observed in 90.5% of patients (19/21). Sinonasal involvement was the most frequent (82%), with otological manifestations in 31.8% (7/21). Nasal polyps were the most common manifestation (7/21). Head and neck biopsies were performed in 7 cases (32%), which showed no evidence of vasculitis. There was no statistically significant association between nasal polyps, ANCA positivity, and eosinophilia.Conclusions: Sinonasal involvement is prevalent in EGPA, often presenting as chronic rhinitis or rhinosinusitis with or without polyps. Otological issues, such as eustachian tube dysfunction and sensorineural hearing loss, are also common. No laryngeal, oral, or salivary gland lesions were observed. There was no significant correlation between the presence of polyps and ANCA positivity or eosinophilia.","PeriodicalId":93855,"journal":{"name":"Acta otorrinolaringologica espanola","volume":" ","pages":"512263"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on the article: Recurrent peritonsillar abscess in adults: Incidence and risk factors in a prospective longitudinal cohort 评论文章：成人复发性腹膜周围脓肿：前瞻性纵向队列的发病率和危险因素。

Acta otorrinolaringologica espanola Pub Date : 2025-05-01 DOI: 10.1016/j.otoeng.2025.512233

Francisco Javier García-Callejo, Miguel Juantegui Azpilicueta

引用次数: 0