ACS ES&T waterPub Date : 2025-02-17DOI: 10.1021/acsestwater.4c0115310.1021/acsestwater.4c01153
Bin Wang, Henglin Xiao, Guanghui Tao, Wenbin Guo, Lu Li, Hongyu Wang*, Junfeng Su, Zihan Zheng, Dao Zhou, Ling Chen* and Wangye Lu,
{"title":"In Situ Lanthanum Growth in Magnetic Chitosan Microgel for Accelerated Phosphate Separation from Water: Metal Efficiency, Specific Hydrogel Swelling, and Mechanistic Insights","authors":"Bin Wang, Henglin Xiao, Guanghui Tao, Wenbin Guo, Lu Li, Hongyu Wang*, Junfeng Su, Zihan Zheng, Dao Zhou, Ling Chen* and Wangye Lu, ","doi":"10.1021/acsestwater.4c0115310.1021/acsestwater.4c01153","DOIUrl":"https://doi.org/10.1021/acsestwater.4c01153https://doi.org/10.1021/acsestwater.4c01153","url":null,"abstract":"<p >In this work, lanthanum was in situ incubated in magnetic chitosan microgel (LCS) for phosphate separation from surface water. Compared to commercial La(OH)<sub>3</sub> and its direct encapsulation into CS, in situ La incubation in CS structure could render an La efficiency (Γ<sub>La</sub>) 3.3 times higher than that of commercial La(OH)<sub>3</sub>, harvesting the highest P capacity (95.25 mg P/g) at the lowest La content. LCS microgel can be easily extracted by magnetic separation, regenerated by NaOH, and thus reused for cyclic phosphate removal. Compared to monovalent anions, divalent SO<sub>4</sub><sup>2–</sup> could largely accelerate P capture on LCS microgel within the first several hours. The effect of SO<sub>4</sub><sup>2–</sup> was comparatively analyzed in batch modes and then verified by stirred-flow reactors using practical lake water as the feed. Under continuous operation, the presence of SO<sub>4</sub><sup>2–</sup> could increase the dynamic P capacity and help suppress effluent P to a low concentration level, with the system breakthrough time nearly doubled. Further characterization analysis clarified the specific swelling behavior of LCS hydrogel network in the presence of SO<sub>4</sub><sup>2–</sup>, which could increase the specific surface area and pore size for phosphate diffusion and uptake. Overall, our work highlighted a promising option for the fabrication of inorganic/polymer composites and provided useful insights for water treatment.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1426–1436 1426–1436"},"PeriodicalIF":4.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS ES&T waterPub Date : 2025-02-17DOI: 10.1021/acsestwater.4c0085810.1021/acsestwater.4c00858
Biwei Yang, Dong Ren, Peng Zhang, Yifan Guo, Gan Zhang, Alex Tat-Shing Chow, Zongwei Cai, Penghui Du* and Junjian Wang*,
{"title":"Heating Temperature and Oxygen Availability Alter the Role of Pyrogenic Dissolved Organic Matter in Sulfamethoxazole Photodegradation","authors":"Biwei Yang, Dong Ren, Peng Zhang, Yifan Guo, Gan Zhang, Alex Tat-Shing Chow, Zongwei Cai, Penghui Du* and Junjian Wang*, ","doi":"10.1021/acsestwater.4c0085810.1021/acsestwater.4c00858","DOIUrl":"https://doi.org/10.1021/acsestwater.4c00858https://doi.org/10.1021/acsestwater.4c00858","url":null,"abstract":"<p >Increasingly frequent wildfires tend to raise the levels of pyrogenic dissolved organic matter (DOM) and affect the photodegradation of organic pollutants in waterbodies within fire-prone watersheds. However, it remains unclear whether heating temperature and oxygen availability modify the DOM impact on the photodegradation of pollutants, such as sulfamethoxazole, a frequently detected antibiotic of significant concern. Here, we investigated the effects of DOM from nonheated soil and hypoxically and aerobically heated soils (250 or 400 °C) on sulfamethoxazole photodegradation and quantified the influence percentages of multiple pathways, including light screening, photosensitization, and reverse-back reduction. All DOMs inhibited sulfamethoxazole photodegradation, with lower inhibition seen for hypoxically heated soil DOMs than others. Additionally, 400 °C-heated soil DOMs exhibited more pronounced photosensitizing and reverse-back reduction pathways than 250 °C-heated soil DOMs. The relative abundances of condensed aromatics and oxygen-rich aromatics, which were higher in DOM from aerobically heated soil than from soil heated hypoxically, were significantly correlated with the influence percentages of photosensitization and the reverse-back reduction pathways. Our findings underscore the importance of wildfire prevention in mitigating the impact of pyrogenic DOM (particularly from aerobic heating) on pollutant retention by inhibiting photodegradation.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1125–1136 1125–1136"},"PeriodicalIF":4.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS ES&T waterPub Date : 2025-02-14DOI: 10.1021/acsestwater.5c0008810.1021/acsestwater.5c00088
Jörg E. Drewes*, Alexander Bassen, Markus Fischer, Anna-Katharina Hornidge, Karen Pittel, Hans-Otto Pörtner, Sabine Schlacke, Claudia Traidl-Hoffmann, Anke Weidenkaff, Mareike Blum, Kerstin Burghaus, Jonas Geschke, Tallulah Gundelach, Matti Gurreck, Rüdiger Haum, Sarah Löpelt, Katharina Michael, Alexander Mitranescu, Katharina Molitor, Jürgen Orasche, Benno Pilardeaux, Jan Siegmeier, Marion Schulte zu Berge, Dominique Schüpfer, Astrid Schulz and Finn Wendland,
{"title":"Water in a Heated World","authors":"Jörg E. Drewes*, Alexander Bassen, Markus Fischer, Anna-Katharina Hornidge, Karen Pittel, Hans-Otto Pörtner, Sabine Schlacke, Claudia Traidl-Hoffmann, Anke Weidenkaff, Mareike Blum, Kerstin Burghaus, Jonas Geschke, Tallulah Gundelach, Matti Gurreck, Rüdiger Haum, Sarah Löpelt, Katharina Michael, Alexander Mitranescu, Katharina Molitor, Jürgen Orasche, Benno Pilardeaux, Jan Siegmeier, Marion Schulte zu Berge, Dominique Schüpfer, Astrid Schulz and Finn Wendland, ","doi":"10.1021/acsestwater.5c0008810.1021/acsestwater.5c00088","DOIUrl":"https://doi.org/10.1021/acsestwater.5c00088https://doi.org/10.1021/acsestwater.5c00088","url":null,"abstract":"","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1071–1074 1071–1074"},"PeriodicalIF":4.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsestwater.5c00088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS ES&T waterPub Date : 2025-02-13DOI: 10.1021/acsestwater.4c0114710.1021/acsestwater.4c01147
Xinyue Zhang, Zhichao Yang*, Hongchao Li* and Bingcai Pan,
{"title":"Identifying the Nonradical Mechanism in Mn Oxide-Mediated Peracetic Acid Activation Processes: Reactive Metal Species vs Electron Transfer Process","authors":"Xinyue Zhang, Zhichao Yang*, Hongchao Li* and Bingcai Pan, ","doi":"10.1021/acsestwater.4c0114710.1021/acsestwater.4c01147","DOIUrl":"https://doi.org/10.1021/acsestwater.4c01147https://doi.org/10.1021/acsestwater.4c01147","url":null,"abstract":"<p >Transition-metal oxide-mediated peroxide activation systems have been demonstrated to initiate selective degradation of pollutants, while the underlying mechanism remains unclear and sometimes controversial. In this study, we systematically explored the reactive species/pathways for pollutant degradation in the Mn oxide octahedron molecular sieve (OMS-2)-triggered peracetic acid (PAA) activation system. By separating PAA activation and pollutant oxidation processes using a sequential activation/oxidation system or galvanic oxidation system, we confirm that the OMS-2/PAA system follows the reactive metal species mechanism, where surface reactive Mn(IV) species, rather than Mn–PAA complexes, are primarily responsible for the nonradical oxidation of bisphenol A. OMS-2 shows varied peroxide-activating activities (i.e., catalase-like and peroxidase-like activities) toward different peroxides (i.e., H<sub>2</sub>O<sub>2</sub>, PAA, and persulfates), depending on the reactivity of surface reactive Mn(IV) species with those peroxides. In addition, the long-lived surface reactive Mn(IV) species exhibit excellent resistance to fluctuations in solution pH and interference from coexisting anions and natural organic matter. This study offers novel insights into the nonradical mechanism involved in Mn oxide-mediated peroxide activation processes.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1406–1415 1406–1415"},"PeriodicalIF":4.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS ES&T waterPub Date : 2025-02-13DOI: 10.1021/acsestwater.4c0104610.1021/acsestwater.4c01046
Chao Wang, Shuo Zhao and Sen Qiao*,
{"title":"Achieving High-Level Nitrogen Removal Performance for Unstable Partial Nitrification Effluent through Endogenous Dissimilatory Nitrate Reduction to Ammonium Function of Anammox Bacteria","authors":"Chao Wang, Shuo Zhao and Sen Qiao*, ","doi":"10.1021/acsestwater.4c0104610.1021/acsestwater.4c01046","DOIUrl":"https://doi.org/10.1021/acsestwater.4c01046https://doi.org/10.1021/acsestwater.4c01046","url":null,"abstract":"<p >The combination of partial nitrification (PN) and anammox (PN-anammox) was the mainstream technology for carbon-deficient and ammonium-rich wastewater treatment. Nevertheless, the stable operation of the PN-anammox process has always faced significant challenges including unstable nitrite (NO<sub>2</sub><sup>–</sup>) accumulation and nitrate (NO<sub>3</sub><sup>–</sup>) generation. In this paper, it was first presented that NO<sub>3</sub><sup>–</sup> and ammonium (NH<sub>4</sub><sup>+</sup>) could simultaneously be degraded by anammox bacteria via an endogenous dissimilatory nitrate reduction to ammonium (DNRA) pathway followed by a traditional anammox reaction. The transmission electron microscopy images and the inhibition experiments results of penicillin G and iodoacetic acid suggested that the intracellular carbon (glycogen) inside anammox bacteria supplied electrons for this endogenous DNRA conversion of NO<sub>3</sub><sup>–</sup>. The isotope experiments further demonstrated that the full endogenous DNRA transformation of NO<sub>3</sub><sup>–</sup> was synchronized even in the presence of external NH<sub>4</sub><sup>+</sup>. Based on this method, a PN-anammox system was established, and a high total nitrogen removal performance (95.50%∼100.00%) was achieved even with an unstable PN process. Our work further displayed the complex nitrogen metabolic mechanism of anammox bacteria, the obstacles in the PN-anammox process could be solved by relying on the endogenous DNRA function in anammox bacteria.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1270–1280 1270–1280"},"PeriodicalIF":4.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Feasibility of In Situ Bioelectrocatalytic Computation to Implement Simultaneous Nitrogen Removal of Anaerobic Digestate and Biogas Upgrading","authors":"Xueqin Lu, Yisheng Liu, Yijing Gao, Zhaobin Liu, Yibo Sun, Jiabang Li, Youcai Zhao, Guihua Zhuo and Guangyin Zhen*, ","doi":"10.1021/acsestwater.4c0109110.1021/acsestwater.4c01091","DOIUrl":"https://doi.org/10.1021/acsestwater.4c01091https://doi.org/10.1021/acsestwater.4c01091","url":null,"abstract":"<p >A two-chamber bioelectrochemical system was constructed to investigate the feasibility of bioelectrocatalysis regulation to enhance simultaneous nitrogen removal from anaerobic digestate and biogas upgrading. The key mechanisms of the bioelectrocatalytic process in inducing the cathode/anode biofilm development and the multiroutes of carbon/nitrogen metabolisms were elucidated. The results showed that increasing the cathode potential led to a higher CH<sub>4</sub> production rate. In particular, when the cathode potential was adjusted to −0.8 V vs Ag/AgCl, the CH<sub>4</sub> production rate increased rapidly to 14.5 ± 2.9 mL/L/day. Under these conditions, the NH<sub>4</sub><sup>+</sup>-N removal in the anode chamber reached 90%, and the total nitrogen removal was 79.5 ± 1.8%. These findings confirmed the effective simultaneous achievement of CO<sub>2</sub> electromethanogenesis and anode denitrogenation. Moreover, <i>Methanobacterium</i> was continuously enriched in the cathode biofilm, with an abundance of 13.9%. Similarly, the abundance of <i>Candidatus_Brocadia</i> (anaerobic ammonia oxidation bacteria genus) in the anode biofilm was increased from 2.9 to 10.9%. Applying bioelectrocatalysis can target functional microorganism enrichment, stabilize the system operation, and realize efficient nitrogen removal and CO<sub>2</sub> electromethanogenesis. This study provides a beneficial supplement to the conventional anaerobic digestion technology for further enhancing simultaneous nitrogen removal of anaerobic digestate and biogas upgrading.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1331–1343 1331–1343"},"PeriodicalIF":4.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS ES&T waterPub Date : 2025-02-12DOI: 10.1021/acsestwater.4c0109810.1021/acsestwater.4c01098
Mei Wang, Chen Wang*, Siyi Lin, Guomao Zheng, Zhiyou Fu, Yingchen Bai, Chenglian Feng, Wen Sun, Yueyue Liu and Fengchang Wu*,
{"title":"Developing Aquatic Life Criteria for Benzalkonium Chlorides Based on QSAR-ICE-SSD Prediction and Ecological Risk Assessment","authors":"Mei Wang, Chen Wang*, Siyi Lin, Guomao Zheng, Zhiyou Fu, Yingchen Bai, Chenglian Feng, Wen Sun, Yueyue Liu and Fengchang Wu*, ","doi":"10.1021/acsestwater.4c0109810.1021/acsestwater.4c01098","DOIUrl":"https://doi.org/10.1021/acsestwater.4c01098https://doi.org/10.1021/acsestwater.4c01098","url":null,"abstract":"<p >Benzalkonium chlorides (BACs) are emerging prevalent antimicrobial chemicals in aquatic ecosystems, but there is limited research on their aquatic toxicity and the development of aquatic life criteria (ALC), hindering ecological risk assessments and regulatory policies. To address this knowledge gap, we studied three predominant BAC homologues: BAC-C12, BAC-C14, and BAC-C16. These compounds are widely used in industrial applications and are frequently detected in surface waters, making them a priority for aquatic toxicity assessment and ALC development. A novel approach integrating quantitative structure–activity relationship (QSAR) and interspecies correlation estimation (ICE) models was developed to predict aquatic toxicity, validated with an experimental test. The expanded toxicity data set, including predicted and measured values, was used to develop species sensitivity distribution (SSD) models for deriving ALC. The criterion maximum concentrations (CMC) were determined to be 7.04, 6.66, and 5.72 μg/L for BAC-C12, BAC-C14, and BAC-C16, respectively, while criterion continuous concentrations (CCC) were 1.18, 1.11, and 0.95 μg/L for BAC-C12, BAC-C14, and BAC-C16, respectively. Ecological risk assessment based on data from previous literature revealed that BAC-C12 and BAC-C14 pose a non-negligible risk to aquatic ecosystems in the investigated countries, underlining the need for further monitoring and regulatory action.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1353–1363 1353–1363"},"PeriodicalIF":4.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS ES&T waterPub Date : 2025-02-11DOI: 10.1021/acsestwater.5c0010910.1021/acsestwater.5c00109
Joon Chuah*,
{"title":"Bridging the Human–Water Divide: Advancing Socio-Hydrology for Sustainable Water Management and Governance","authors":"Joon Chuah*, ","doi":"10.1021/acsestwater.5c0010910.1021/acsestwater.5c00109","DOIUrl":"https://doi.org/10.1021/acsestwater.5c00109https://doi.org/10.1021/acsestwater.5c00109","url":null,"abstract":"","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 4","pages":"1510 1510"},"PeriodicalIF":4.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Activation of Peroxymonosulfate by CuO-Supported Attapulgite/Activated Carbon for Organic Contaminant Removal","authors":"Rui Huang, Jingjing Xia, Yiding Wang, Zixuan Gao, Zeng Xue, Jinfeng Zhu, Ming Ming, Hongmin Zhao, Songxue Wang*, Wenxiang Xia and Baoxiu Zhao*, ","doi":"10.1021/acsestwater.4c0114810.1021/acsestwater.4c01148","DOIUrl":"https://doi.org/10.1021/acsestwater.4c01148https://doi.org/10.1021/acsestwater.4c01148","url":null,"abstract":"<p >In this study, the CuO@ATT/AC catalyst was designed and synthesized by a simple process of immersion–doping–calcination to boost the catalytic performance toward peroxymonosulfate (PMS) and remove sulfadiazine (SDZ). The results of optimized preparation experiments indicated that the doping of the materials with AC markedly enhanced the activation of PMS, demonstrating not only superior catalytic performance but also a reduction in the leaching of Cu. The CuO@ATT/AC/PMS system achieved 96.5% SDZ removal within 60 min with only 0.03 mg/L of Cu leaching. In addition, the removal efficiency of SDZ reached above 90% across a wide pH range of 5–9 and operating temperature (25–35 °C). CuO@ATT/AC demonstrated exceptional stability and reusability, achieving a 95% removal rate for SDZ after five cycles. Furthermore, both radical and nonradical species were implicated in the degradation of SDZ. <sup>•</sup>OH, SO<sub>4</sub><sup>•–</sup>, and <sup>1</sup>O<sub>2</sub> were identified as the primary reactive species involved in the system. This study presents an environmentally friendly and cost-effective composite catalyst for the degradation and elimination of organic contaminants in water.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1416–1425 1416–1425"},"PeriodicalIF":4.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS ES&T waterPub Date : 2025-02-11DOI: 10.1021/acsestwater.4c0117510.1021/acsestwater.4c01175
Yanan Liu, Feifan Wu, Chong Huang, Qiang Li and Jianying Hu*,
{"title":"Organophosphorus Flame-Retardant 2-Isopropylphenyl Diphenyl Phosphate Antagonizes Estrogen, Retinoic Acid, and Retinoic X Receptors and Leads to Adverse Reproductive Outcomes in Japanese Medaka (Oryzias latipes)","authors":"Yanan Liu, Feifan Wu, Chong Huang, Qiang Li and Jianying Hu*, ","doi":"10.1021/acsestwater.4c0117510.1021/acsestwater.4c01175","DOIUrl":"https://doi.org/10.1021/acsestwater.4c01175https://doi.org/10.1021/acsestwater.4c01175","url":null,"abstract":"<p >2-Isopropylphenyl diphenyl phosphate (2IPPDPP) is the main component of the widely used flame-retardant mixture Firemaster 550 (FM550) and is increasingly detected in the environment; however, few studies focused on its toxicity. Here, we identified its antagonistic activities against medaka estrogen receptor (mER), retinoic acid receptor (mRAR), and retinoid X receptor (mRXR) with 50% inhibitory concentrations of 29.0, 14.6, and 39.4 μM, respectively. After sexually mature female medaka were exposed to 2IPPDPP at 136.2, 838.1, and 1433.7 ng/L for 35 days, its concentrations in the ovary (327.7−2746.1 ng/g lipid weight (lw)) and muscle (109.3−2797.1 ng/g lw) were higher than those in the liver (89.7−1164.8 ng/g lw) and brain (64.4−1152.6 ng/g lw), showing high exposure for eggs. The antiestrogenic activity may contribute to the downregulation of <i>vtg</i> gene expressions in the liver, therefore leading to ovarian retardation, which may reduce egg production by 32.4% at 838.1 ng/L and 37.3% at 1433.7 ng/L. 2IPPDPP exposure impacted embryonic development at 1 h postfertilization, causing abnormal mitosis, uneven cell division, and ultimately early embryonic mortality (42.7% at 838.1 ng/L and 51.7% at 1433.7 ng/L) by inhibiting <i>pdk1</i> expression. Such toxicity may also occur in higher vertebrates, raising concerns about its risks.</p>","PeriodicalId":93847,"journal":{"name":"ACS ES&T water","volume":"5 3","pages":"1446–1452 1446–1452"},"PeriodicalIF":4.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}