[Rinsho ketsueki] The Japanese journal of clinical hematology最新文献_第6页

[Skin toxicities following auto PBSCT with thiotepa-based conditioning in adult patients: a single-center retrospective analysis]. 成人患者自体PBSCT加硫替帕后的皮肤毒性：单中心回顾性分析。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.413

Tomomi Oka, Momoko Nishikori, Hiroyuki Irie, Mitsumasa Watanabe, Toshiyuki Kitano, Chisaki Mizumoto, Junya Kanda, Kohei Yamashita, Takashi Nomura, Akifumi Takaori-Kondo

{"title":"[Skin toxicities following auto PBSCT with thiotepa-based conditioning in adult patients: a single-center retrospective analysis].","authors":"Tomomi Oka, Momoko Nishikori, Hiroyuki Irie, Mitsumasa Watanabe, Toshiyuki Kitano, Chisaki Mizumoto, Junya Kanda, Kohei Yamashita, Takashi Nomura, Akifumi Takaori-Kondo","doi":"10.11406/rinketsu.66.413","DOIUrl":"https://doi.org/10.11406/rinketsu.66.413","url":null,"abstract":"Autologous stem cell transplantation (ASCT) with thiotepa-based conditioning is known to be frequently associated with skin complications in children, but there are no comprehensive reports on skin reactions in adults. We retrospectively analyzed skin problems in 44 patients who underwent ASCT with thiotepa-based conditioning at our institution between January 2017 and April 2023. Skin problems were observed in 19 patients (43.1%), and included blisters or erythema of grade 2 or higher in 8 patients (18.1%). Edema was observed in 8 patients (42%), blisters in 8 patients (42%), and blisters and erythema in 3 patients (16%). These skin changes showed a late onset pattern, ranging from days 22 to 101 (median day 53) post ASCT. In all cases, these skin problems gradually improved with symptomatic treatment. No factors significantly associated with skin problems were identified. A better understanding of the mechanisms involved in the development of these skin problems in thiotepa-conditioned adult patients should lead to better prevention and treatment.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 6","pages":"413-419"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Management of pregnancy and delivery in patients with inherited thrombophilia]. 遗传性血栓患者妊娠和分娩的管理。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.495

Eriko Morishita

引用次数: 0

[Molecularly targeted therapy strategies for adult T-cell leukemia/lymphoma]. [成人t细胞白血病/淋巴瘤的分子靶向治疗策略]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.449

Koji Ando

引用次数: 0

[Novel therapeutic approaches for multiple myeloma]. 多发性骨髓瘤的新治疗方法。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.440

Kyoko Yoshihara

引用次数: 0

[Intramuscular abscess and multiple lymphadenitis due to Nocardia asiatica infection requiring differential diagnosis from smoldering adult T-cell leukemia/lymphoma]. [由亚洲诺卡菌感染引起的肌肉内脓肿和多发性淋巴结炎需要与阴烧成人t细胞白血病/淋巴瘤鉴别诊断]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.121

Mahito Yamashiro, Tomo Nakajima, Yuka Irei, Riko Miyagi, Sakiko Kitamura, Keita Tamaki, Yukiko Nishi, Kazuho Morichika, Sawako Nakachi, Hiroki Maehara, Takuya Fukushima, Hiroaki Masuzaki

{"title":"[Intramuscular abscess and multiple lymphadenitis due to Nocardia asiatica infection requiring differential diagnosis from smoldering adult T-cell leukemia/lymphoma].","authors":"Mahito Yamashiro, Tomo Nakajima, Yuka Irei, Riko Miyagi, Sakiko Kitamura, Keita Tamaki, Yukiko Nishi, Kazuho Morichika, Sawako Nakachi, Hiroki Maehara, Takuya Fukushima, Hiroaki Masuzaki","doi":"10.11406/rinketsu.66.121","DOIUrl":"10.11406/rinketsu.66.121","url":null,"abstract":"A 72-year-old male engaged in horticulture developed a progressively enlarging painful mass in the left upper arm. The first biopsy revealed no malignancy or pathogenic bacteria. He completed an adequate course of antibiotics for infectious lymphadenitis, but showed no apparent improvement. Computed tomography demonstrated systemic lymphadenopathy, suggesting malignant lymphoma. Monoclonal integration of the HTLV-1 proviral genome in peripheral blood cells was confirmed by Southern blot analysis, but repeated lymph node biopsies identified no malignant cells. Based on these findings, a diagnosis of smoldering adult T-cell leukemia/lymphoma was made. After prolonged culture of the specimen, Nocardia sp. were detected and 16S rRNA sequencing confirmed infection by Nocardia asiatica. Combination therapy with sulfamethoxazole-trimethoprim and minocycline was started, and the systemic lymphadenopathy improved within 3 months. Although Nocardia asiatica infection manifesting as systemic lymphadenitis is extremely rare, it should be considered as a possibility in immunocompromised patients to ensure an accurate diagnosis.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 2","pages":"121-126"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Chronic graft-versus-host disease manifesting as isolated myositis]. 慢性移植物抗宿主病，表现为孤立性肌炎。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.318

Ayako Yamamura, Takashi Hanada, Taichi Hirano, Kazuhito Tanaka, Nao Nishimura, Shinya Endo, Kenji Tokunaga, Yoshiki Mikami, Jun-Ichirou Yasunaga

{"title":"[Chronic graft-versus-host disease manifesting as isolated myositis].","authors":"Ayako Yamamura, Takashi Hanada, Taichi Hirano, Kazuhito Tanaka, Nao Nishimura, Shinya Endo, Kenji Tokunaga, Yoshiki Mikami, Jun-Ichirou Yasunaga","doi":"10.11406/rinketsu.66.318","DOIUrl":"https://doi.org/10.11406/rinketsu.66.318","url":null,"abstract":"A 26-year-old man underwent HLA-matched sibling allogeneic peripheral blood stem cell transplantation for acute myeloid leukemia with KMT2A rearrangement and maintained complete remission. On day338 post-transplant, he developed fever, myalgia, and markedly elevated creatinine kinase. We initially suspected drug-induced rhabdomyolysis and stopped the offending drugs, but his symptoms did not improve. Immunohistological findings with PD-1 staining in a muscle biopsy led to the diagnosis of graft versus host disease (GVHD)-associated myositis. The myositis resolved with prednisolone treatment based on the conventional chronic GVHD treatment protocol. Chronic GVHD with myositis alone is rare, and GVHD-associated myositis has been difficult to differentiate from other forms of myositis due to its lack of specific pathological features. Recently, PD-1 and HLA-DR expression have been reported as characteristic features of chronic GVHD-associated myositis. The pathological finding of PD-1-positive cell infiltration was useful in diagnosis and treatment in our case.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 5","pages":"318-323"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.369

引用次数: 0

[CAR T-cell therapy and bispecific antibodies for relapsed/refractory large B-cell lymphoma]. CAR - t细胞疗法和双特异性抗体治疗复发/难治性大b细胞淋巴瘤。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.432

Hideki Goto

引用次数: 0

[Successful treatment with EPOCH followed by mogamulizumab for angioimmunoblastic T-cell lymphoma with myelofibrosis and pure red cell aplasia]. [EPOCH治疗血管免疫母细胞t细胞淋巴瘤伴骨髓纤维化和纯红细胞发育不全的成功治疗]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.24

Ayako Yamamura, Kisato Nosaka, Hiro Tatetsu, Jun-Ichirou Yasunaga

{"title":"[Successful treatment with EPOCH followed by mogamulizumab for angioimmunoblastic T-cell lymphoma with myelofibrosis and pure red cell aplasia].","authors":"Ayako Yamamura, Kisato Nosaka, Hiro Tatetsu, Jun-Ichirou Yasunaga","doi":"10.11406/rinketsu.66.24","DOIUrl":"10.11406/rinketsu.66.24","url":null,"abstract":"The patient was a 70-year-old woman. She visited a doctor for sore throat, facial edema, and lymphadenopathy. Lymph node biopsy was performed, and led to a diagnosis of AITL. When the patient was admitted to our department for treatment, she had severe anemia with Hb 4.2 g/dl, and bone marrow aspiration resulted in a dry tap. Bone marrow biopsy revealed infiltration of tumor cells, a severe decrease in erythroblastic cells, and bone marrow fibrosis. Although lymph node size was reduced by THP-COP, bone marrow biopsy showed residual infiltration of tumor cells. In addition, since low reticulocyte counts and anemia persisted, weekly red blood cell transfusions were required. Therefore, the treatment regimen was changed to EPOCH. After two cycles of EPOCH, anemia improved, and red cell transfusions were no longer required. Bone marrow examination after four cycles showed disappearance of lymphoma cells and no evidence of bone marrow fibrosis or erythroblasts. However, due to residual bone marrow infiltration of lymphoma cells, treatment with mogamulizumab was started. Complete remission was maintained for five years. This indicates that EPOCH and mogamulizumab are treatment options for AITL patients with bone marrow involvement, PRCA, and myelofibrosis.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.18

Kodai Kunisada, Mizuki Ogura, Yuki Oda, Moe Yogo, Tomomi Takei, Kota Sato, Taku Kikuchi, Yu Abe, Nobuhiro Tsukada, Tadao Ishida

{"title":"[Therapy-related myeloid neoplasms with inv (16)(p13.1q22);CBFB::MYH11 during treatment for AL amyloidosis].","authors":"Kodai Kunisada, Mizuki Ogura, Yuki Oda, Moe Yogo, Tomomi Takei, Kota Sato, Taku Kikuchi, Yu Abe, Nobuhiro Tsukada, Tadao Ishida","doi":"10.11406/rinketsu.66.18","DOIUrl":"10.11406/rinketsu.66.18","url":null,"abstract":"[Patient] A 65-year-old man. [History of present illness] An abnormal chest shadow was noted in March of 2011, and hoarseness was observed in November of 2017. Both times, AL amyloidosis was diagnosed by biopsy. The patient was admitted to our department for treatment in March 2018, and received 6 cycles of melphalan plus dexamethasone for systemic AL amyloidosis in May. His condition was good, but a blood test in August 2019 showed white blood cells 50,000/µl and 44.9% blasts in the peripheral blood, leading to a diagnosis of treatment-related acute leukemia (AML with inv (16)(p13.1q22);CBFB::MYH11). He achieved complete remission with standard treatment, but relapsed in May 2020, CNS relapsed in September 2020, CNS relapsed again in July 2021, and CNS relapsed a third time in May 2022. He underwent intensive chemotherapy, whole brain radiation therapy, 13 rounds of intrathecal injection, and five cycles of venetoclax plus azacitidine, but his general condition gradually worsened. He was transferred to best supportive care in November and died in June 2023. [Discussion] Although advances in treatment have extended survival in systemic AL amyloidosis, long-term follow-up for secondary cancer is important for patients with long-term exposure, as in this case.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0