[Skin toxicities following auto PBSCT with thiotepa-based conditioning in adult patients: a single-center retrospective analysis].

Abstract

Autologous stem cell transplantation (ASCT) with thiotepa-based conditioning is known to be frequently associated with skin complications in children, but there are no comprehensive reports on skin reactions in adults. We retrospectively analyzed skin problems in 44 patients who underwent ASCT with thiotepa-based conditioning at our institution between January 2017 and April 2023. Skin problems were observed in 19 patients (43.1%), and included blisters or erythema of grade 2 or higher in 8 patients (18.1%). Edema was observed in 8 patients (42%), blisters in 8 patients (42%), and blisters and erythema in 3 patients (16%). These skin changes showed a late onset pattern, ranging from days 22 to 101 (median day 53) post ASCT. In all cases, these skin problems gradually improved with symptomatic treatment. No factors significantly associated with skin problems were identified. A better understanding of the mechanisms involved in the development of these skin problems in thiotepa-conditioned adult patients should lead to better prevention and treatment.