[Rinsho ketsueki] The Japanese journal of clinical hematology最新文献_第7页

[Complete response of musculoskeletal chronic GVHD achieved with extracorporeal photopheresis therapy]. [体外光疗治疗肌肉骨骼慢性GVHD的完全缓解]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.228

Toru Ashimoto, Hitoshi Minamiguchi, Masami Kanasaki, Ryo Fukunaga, Kazuki Abe, Mina Kumode, Shiho Nagai, Ai Asai, Masaki Iwasa, Aya Fujishiro, Rie Nishimura, Makoto Murata

{"title":"[Complete response of musculoskeletal chronic GVHD achieved with extracorporeal photopheresis therapy].","authors":"Toru Ashimoto, Hitoshi Minamiguchi, Masami Kanasaki, Ryo Fukunaga, Kazuki Abe, Mina Kumode, Shiho Nagai, Ai Asai, Masaki Iwasa, Aya Fujishiro, Rie Nishimura, Makoto Murata","doi":"10.11406/rinketsu.66.228","DOIUrl":"https://doi.org/10.11406/rinketsu.66.228","url":null,"abstract":"A 48-year-old man with acute myeloid leukemia underwent HLA-matched related donor peripheral blood stem cell transplantation. He developed chronic graft-versus-host disease (cGVHD) of the liver on day 359, which became dependent on cyclosporine and prednisolone. Long-term administration of cyclosporine led to progressive renal dysfunction. Ibrutinib was started, but was stopped due to acute cardiac failure. Mycophenolate mofetil was then started and liver cGVHD improved. The patient developed bacterial pneumonia and COVID-19 during this period. He began to experience limited range of motion in the shoulder joints beyond 2 years after transplantation, and suffered from progressive symptoms. To prevent additional infections due to myelosuppression, drug-induced liver dysfunction, and progression of renal dysfunction, extracorporeal photopheresis (ECP) was chosen to treat musculoskeletal cGVHD. ECP was started on day 1202 and completed 6 months later following the recommended schedule, without severe adverse events. Shoulder joint symptoms completely resolved with ECP, and the cGVHD score in joints decreased from 2 to 0. ECP is considered a promising treatment option for cGVHD patients who are at risk of infection and liver or renal dysfunction.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 4","pages":"228-232"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.190

引用次数: 0

[Refractory acute monocytic leukemia with cutaneous infiltration complicated by sterile pustules after CPX-351 administration]. [CPX-351给药后伴有皮肤浸润的难治性急性单核细胞白血病并发无菌脓疱]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.165

Takahiro Nishiyama, Takuya Maki, Tomohiro Yamada, Kohei Usui, Yusuke Yamaga, Shoichiro Okazaki

{"title":"[Refractory acute monocytic leukemia with cutaneous infiltration complicated by sterile pustules after CPX-351 administration].","authors":"Takahiro Nishiyama, Takuya Maki, Tomohiro Yamada, Kohei Usui, Yusuke Yamaga, Shoichiro Okazaki","doi":"10.11406/rinketsu.66.165","DOIUrl":"10.11406/rinketsu.66.165","url":null,"abstract":"CPX-351 (Vyxeos®), a liposomal formulation used in the treatment of acute myeloid leukemia, has been associated with cutaneous adverse events, particularly purpura, in previous clinical trials. We present the case of a 73-year-old woman with refractory acute monocytic leukemia and leukemia cutis, who was treated with CPX-351 as salvage induction therapy. Following treatment, the extramedullary lesions resolved; however, some skin lesions developed into pustular eruptions. These pustules appeared during the neutropenic phase, and cultures ruled out infection, leading to the diagnosis of sterile pustulosis. Supportive care, including skin care measures and application of antibiotic ointment, allowed for continued treatment, and the pustules resolved after crusting. To our knowledge, this is the first reported case of sterile pustulosis associated with CPX-351 treatment, highlighting the importance of early detection and appropriate management of skin complications for the successful continuation of therapy.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 3","pages":"165-169"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Preface]. (前言)。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.420

Yoichi Imai

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.1

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[Breast implant-associated anaplastic large cell lymphoma that developed 20 years after breast reconstruction and was successfully treated with chemotherapy]. [乳房植入物相关的间变性大细胞淋巴瘤，在乳房重建后20年发生，并通过化疗成功治疗]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.244

Kazuya Manabe, Hiroshi Takahashi, Yasuhiro Uchida, Kengo Suzuki, Naomi Kamei, Mamiko Endo, Masahiko Fukatsu, Takahiro Sano, Kiyohito Hayashi, Motoki Takano, Daisuke Koyama, Satoshi Kimura, Rei Sekine, Hiroyo Meguro, Yasuyuki Kobayashi, Yuko Hashimoto, Takayuki Ikezoe

{"title":"[Breast implant-associated anaplastic large cell lymphoma that developed 20 years after breast reconstruction and was successfully treated with chemotherapy].","authors":"Kazuya Manabe, Hiroshi Takahashi, Yasuhiro Uchida, Kengo Suzuki, Naomi Kamei, Mamiko Endo, Masahiko Fukatsu, Takahiro Sano, Kiyohito Hayashi, Motoki Takano, Daisuke Koyama, Satoshi Kimura, Rei Sekine, Hiroyo Meguro, Yasuyuki Kobayashi, Yuko Hashimoto, Takayuki Ikezoe","doi":"10.11406/rinketsu.66.244","DOIUrl":"https://doi.org/10.11406/rinketsu.66.244","url":null,"abstract":"Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a type of anaplastic large cell lymphoma, that was first described in the revised 4th edition of the WHO Classification of Tumors released in 2017. The textured implants are thought to form bacterial biofilm and cause chronic inflammation, which may be associated with tumorigenesis. We present a 50-year-old woman who had a past medical history of breast reconstruction with the implant 20 years ago. She presented with abdominal distension caused by intraperitoneal lymphadenopathy. She was diagnosed with suspicion of idiopathic multicentric Castleman disease and received pulse therapy with corticosteroid and eight courses of tocilizumab, which resulted in progression of the disease. Positron emission tomography-computed tomography showed new masses in liver and an effusion around the breast implant, and BIA-ALCL was suspected. Pathological examination of the liver tumor and cell blocks made from fluid collected around the implant confirmed the diagnosis of ALCL. Six cycles of brentuximab vedotin in combination with cyclophosphamide, doxorubicin and prednisolone (BV-CHP) led to complete remission. Her implant was subsequently removed. It is important to keep in mind the possibility of BIA-ALCL when lymphadenopathy is observed in patients with a history of breast reconstruction with textured implants.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 4","pages":"244-249"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Erythrocytosis induced by SGLT2 inhibitors]. [SGLT2抑制剂诱导的红细胞增多]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.220

Yoko Edahiro

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.267

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[Progressive multifocal leukoencephalopathy developed 3 years after related HLA-haploidentical peripheral blood stem cell transplantation]. [相关hla -单倍体外周血干细胞移植3年后发生进行性多灶性白质脑病]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.36

Kumiko Ando, Kazuo Nakamichi, Kiyoharu Hirose, Yuichi Taneyama, Harumi Kakuda, Hidemasa Ochiai

{"title":"[Progressive multifocal leukoencephalopathy developed 3 years after related HLA-haploidentical peripheral blood stem cell transplantation].","authors":"Kumiko Ando, Kazuo Nakamichi, Kiyoharu Hirose, Yuichi Taneyama, Harumi Kakuda, Hidemasa Ochiai","doi":"10.11406/rinketsu.66.36","DOIUrl":"10.11406/rinketsu.66.36","url":null,"abstract":"The patient was a 22-year-old man. 8 years ago, he developed T-cell lymphoblastic lymphoma and relapsed during treatment. He underwent HLA-haploidentical peripheral blood stem cell transplantation (PBSCT) from a related donor and achieved remission. After transplantation, he developed severe chronic graft-versus-host disease (GVHD) with systemic involvement, requiring long-term administration of several immunosuppressive drugs. About 3 years and 9 months after the transplant, he was experiencing depression, anorexia, and weight loss. Brain MRI showed hyperintense lesions in T2-weighted imaging extending from the right cerebellar hemisphere to the middle cerebellar peduncle with slight enhancement, and lymphoma recurrence was also suspected. Finally, a quantitative real-time PCR test was positive for JC virus (JCV) in the cerebrospinal fluid (CSF) at 61 copies/ml, leading to a diagnosis of progressive multifocal leukoencephalopathy (PML). We considered the patient to have prolonged secondary immunodeficiency after transplantation, and gradually reduced his immunosuppressive drugs. After that, the JCV in CSF became less sensitive to detection. This case highlights the importance of monitoring for PML as a potential late complication after hematopoietic stem cell transplantation, and provides the valuable insight that improvement was achieved only through dose reduction and discontinuation of immunosuppressive drugs.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Combination therapy with efgartigimod, fostamatinib, eltrombopag and prednisolone for a patient with refractory immune thrombocytopenia]. [依加替莫、福司他替尼、依曲巴格和强的松龙联合治疗难治性免疫性血小板减少症1例]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.117

Toru Kida, Takayuki Ozawa, Tomoya Takahashi, Ayano Esaki, Hiroaki Masaie, Seiji Tadokoro, Satoru Kosugi

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