[Dermatopathic lymphadenopathy in chronic skin graft-versus-host disease].

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI:10.11406/rinketsu.66.127

Kana Kato, Takeshi Kobayashi, Tsunekazu Hishima, Kaori Kondo, Yasutaka Sadaga, Chika Kato, Satoshi Sakai, Yasuhiro Kambara, Hiroki Fujiwara, Kou Teshima, Kazuya Asano, Yoshimi Nabe, Kazuya Kurihara, Atsushi Jinguji, Masashi Shimabukuro, Fumihiko Ouchi, Kazuki Inai, Naoki Shingai, Takashi Toya, Hiroaki Shimizu, Yuho Najima, Yoshiki Okuyama, Noriko Doki

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Abstract

A 46-year-old woman developed chronic skin graft-versus-host disease (GVHD) with bilateral axillary lymph node (LN) swelling 7 months after cord blood transplantation for acute myeloid leukemia. Histological examination of the LNs revealed dermatopathic lymphadenopathy (DL). After treatment with topical steroids, GVHD improved and lymphadenopathy subsided.DL typically occurs associated with chronic dermatologic disorders, and its pathology is characterized by paracortical LN hyperplasia by Langerhans cells and interdigitating cell infiltration. LN swelling rarely occurs with GVHD, and the clinical course in this patient suggests that her DL was caused by chronic skin GVHD. Interestingly, chimerism analysis of the Langerhans cells indicated donor origin.

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[Rinsho ketsueki] The Japanese journal of clinical hematology

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