[Rinsho ketsueki] The Japanese journal of clinical hematology最新文献_第10页

[Future prospects for the development of novel agents for acute myeloid leukemia]. [开发治疗急性髓性白血病新型药物的未来前景]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.353

Naoko Hosono

引用次数: 0

[Current status and challenges of AML treatment with FLT3 inhibitors]. [FLT3抑制剂治疗急性髓细胞白血病的现状与挑战]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.684

Yuichi Ishikawa

{"title":"[Current status and challenges of AML treatment with FLT3 inhibitors].","authors":"Yuichi Ishikawa","doi":"10.11406/rinketsu.65.684","DOIUrl":"https://doi.org/10.11406/rinketsu.65.684","url":null,"abstract":"FLT3 mutation is one of the most frequent genetic mutations in AML, identified in approximately 30% of patients, and FLT3-ITD mutation is considered a poor prognostic factor. Based on these molecular and clinical backgrounds, FLT3 mutations are considered promising therapeutic targets in AML, and intensive development of targeted therapeutics has been ongoing for more than two decades. Recently, combination of FLT3 inhibitors with intensive chemotherapy for untreated AML patients with FLT3 mutations and FLT3 inhibitor monotherapy for relapsed/refractory patients have been approved. In Japan, the combination of quizartinib and intensive chemotherapy for untreated FLT3-ITD-positive AML was approved in 2023. Clinical use of FLT3 inhibitors shows strong promise for improving the clinical outcomes of these AML patients with an extremely poor prognosis. Meanwhile, various resistance mechanisms to FLT3 inhibitors have been identified, including the emergence of resistance-associated mutations, and attenuated inhibitory effects of FLT3 inhibitors involving the bone marrow microenvironment surrounding AML cells. Thus, future efforts should aim to optimize combination therapy based on the characteristics of each FLT3 inhibitor, develop biomarkers that could inform treatment selection, and to better understand these resistance mechanisms and develop methods for overcoming them.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"65 7","pages":"684-692"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Veno-venous extracorporeal membrane oxygenation for capillary leak syndrome during induction chemotherapy in acute myeloid leukemia]. [静脉-静脉体外膜氧合治疗急性髓性白血病诱导化疗期间的毛细血管渗漏综合征]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.169

Tadashi Okamura, Shogo Murata, Kyohei Miyamoto, Misato Tane, Yuka Okabe, Satomi Takeda, Shotaro Tabata, Hideki Kosako, Yoshikazu Hori, Yusuke Yamashita, Toshiki Mushino, Hiroki Hosoi, Takashi Sonoki

{"title":"[Veno-venous extracorporeal membrane oxygenation for capillary leak syndrome during induction chemotherapy in acute myeloid leukemia].","authors":"Tadashi Okamura, Shogo Murata, Kyohei Miyamoto, Misato Tane, Yuka Okabe, Satomi Takeda, Shotaro Tabata, Hideki Kosako, Yoshikazu Hori, Yusuke Yamashita, Toshiki Mushino, Hiroki Hosoi, Takashi Sonoki","doi":"10.11406/rinketsu.65.169","DOIUrl":"https://doi.org/10.11406/rinketsu.65.169","url":null,"abstract":"A 44-year-old woman was diagnosed with acute myeloid leukemia (RUNX1::RUNX1T1 translocation) and received induction chemotherapy with idarubicin hydrochloride and cytosine arabinoside. The pneumonia that had been present since admission worsened, and a drug-induced skin rash appeared. On day 17, she presented with respiratory failure and shock, complicated by hemoconcentration and hypoalbuminemia. This was considered capillary leak syndrome due to pneumonia and drug allergy, so she was started on pulse steroid therapy and IVIG, and was intubated on the same day. On day 18, venovenous-extracorporeal membrane oxygenation (VV-ECMO) was started due to worsening blood gas parameters despite ventilatory management. Bronchoalveolar lavage fluid was serous, and both blood and sputum cultures yielded negative. The patient was weaned from VV-ECMO on day 26 as the pneumonia improved with recovery of hematopoiesis. She was disoriented, and a CT scan on day 28 revealed cerebral hemorrhage. Her strength recovered with rehabilitation. After induction chemotherapy, RUNX1::RUNX1T1 mRNA was not detected in bone marrow. The patient received consolidation chemotherapy, and has maintained complete remission. Severe respiratory failure during induction chemotherapy for acute leukemia can be fatal, but VV-ECMO may be lifesaving.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"65 3","pages":"169-174"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Histiocytic sarcoma derived from the same origin as splenic marginal zone lymphoma revealed by exome analysis]. [通过外显子组分析发现与脾边缘区淋巴瘤同源的组织细胞肉瘤]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.737

Daiki Komata, Mutsumi Takahata, Yoshinori Makino, Takashi Ishio, Hiroshi Iwasaki, Shin Ichihara, Masumi Tsuda, Shinya Tanaka, Makoto Ibata

{"title":"[Histiocytic sarcoma derived from the same origin as splenic marginal zone lymphoma revealed by exome analysis].","authors":"Daiki Komata, Mutsumi Takahata, Yoshinori Makino, Takashi Ishio, Hiroshi Iwasaki, Shin Ichihara, Masumi Tsuda, Shinya Tanaka, Makoto Ibata","doi":"10.11406/rinketsu.65.737","DOIUrl":"10.11406/rinketsu.65.737","url":null,"abstract":"Histiocytic sarcoma (HS) is a rare aggressive hematological malignancy reported to occur secondary to B cell lymphoma. We report a case of HS secondary to splenic marginal zone lymphoma (SMZL) complicated by autoimmune hemolytic anemia (AIHA) in a 64-year-old man. He was referred to our department with anemia and was diagnosed as having AIHA. After starting treatment with prednisolone, atypical lymphocytes appeared in his blood tests, and a bone marrow biopsy revealed invasion by B cell lymphoma. A CT scan showed splenomegaly and a pancreatic mass, which confirmed the diagnosis of SMZL. The patient received bendamustine and rituximab as chemotherapy, which rapidly improved the anemia and splenomegaly and reduced atypical lymphocytes. However, left lumbar back pain appeared along with an increase in the pancreatic mass, and he died suddenly of acute renal failure. An autopsy revealed that the tumor had invaded several organs including the pancreas, and immunohistochemistry was positive for CD163, leading to the diagnosis of HS. Furthermore, the specimens of SMZL and HS were positive for IgH gene reconstitution, and exome analysis showed genetic abnormalities in 226 genes including CARD11, suggesting that the SMZL and HS had the same origin.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"65 8","pages":"737-741"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clostridioides difficile infection diagnosed by nucleic acid amplification test in a patient with Epstein-Barr Virus-related T-cell lymphoproliferative disorder]. [通过核酸扩增检验诊断出一名与爱泼斯坦-巴氏病毒相关的 T 细胞淋巴增生性疾病患者感染了艰难梭菌]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.732

Hideshige Seki, Megumi Yasunaga, Ken Morita, Mineo Kurokawa

{"title":"[Clostridioides difficile infection diagnosed by nucleic acid amplification test in a patient with Epstein-Barr Virus-related T-cell lymphoproliferative disorder].","authors":"Hideshige Seki, Megumi Yasunaga, Ken Morita, Mineo Kurokawa","doi":"10.11406/rinketsu.65.732","DOIUrl":"10.11406/rinketsu.65.732","url":null,"abstract":"Steroid usage poses a risk of Clostridioides difficile infection (CDI), but high-dose corticosteroid treatment can lead to false-negative CD toxin test results. Moreover, CDI-induced nausea can complicate administration of oral antibiotics, which are typically the primary therapy for CDI. In the present case, a 43-year-old woman diagnosed with EBV-associated T-cell post-transplant lymphoproliferative disorder developed CDI during treatment with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Following five cycles of CHOP, the patient presented with nausea and diarrhea. CT scans revealed swelling in the ileocecal to transverse area of the colon. While the glutamate dehydrogenase (GDH) antigen test result was positive, the CD toxin test result was negative. However, the nucleic amplification test (NAAT) result was positive, confirming the diagnosis of CDI. Oral treatment with fidaxomicin was initially impractical due to persistent nausea. Instead, treatment began with intravenous metronidazole, and was later switched to fidaxomicin pills. Symptoms improved notably within 10 days, and the patient ultimately made a complete recovery. This case underscores the significance of exploring alternative approaches to CDI management, particularly in immunosuppressed patients.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"65 8","pages":"732-736"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Current state and future prospects of off-the-shelf allogeneic CAR NK therapy]. [现成的同种异体 CAR NK 疗法的现状和未来前景]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.668

Chihaya Imai

引用次数: 0

[Immunodeficiency-related intravascular large B-cell lymphoma diagnosed by random skin biopsy manifesting as transverse myelitis].

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.1381

Eriko Kawamura, Kazuto Togitani, Daisuke Kuzume, Yoshiki Uemura

{"title":"[Immunodeficiency-related intravascular large B-cell lymphoma diagnosed by random skin biopsy manifesting as transverse myelitis].","authors":"Eriko Kawamura, Kazuto Togitani, Daisuke Kuzume, Yoshiki Uemura","doi":"10.11406/rinketsu.65.1381","DOIUrl":"https://doi.org/10.11406/rinketsu.65.1381","url":null,"abstract":"The patient was a 65-year-old woman with rheumatoid arthritis who was receiving methotrexate. Lumbar disc herniation was suspected due to development of low back pain and bilateral lower limb numbness, and progression of urinary retention and gait disturbances. Laminectomy was performed, but her condition progressed to complete paraplegia. MRI-T2-weighted imaging showed hyperintense lesions in the cervical to thoracic spinal cord. Methylprednisolone (mPSL) pulse therapy and plasmapheresis were performed based on a presumptive diagnosis of transverse myelitis, but produced no clinical improvement. Due to high levels of LDH and soluble interleukin-2 receptor (sIL2R), a random skin biopsy was performed, and intravascular large B-cell lymphoma (IVLBVL) was diagnosed. With R-CHOP, high-dose methotrexate, and intrathecal chemotherapy, LDH, sIL2R, and MRI findings improved, but paraplegia of the lower limbs and urinary retention remained. In patients with unexplained transverse myelitis-like symptoms accompanied by elevated LDH and sIL2R, it is necessary to diagnose IVLBCL at an early stage by random skin biopsy before development of irreversible pathologies such as spinal cord infarction, and to start chemotherapy promptly to improve the neuroprognosis.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"65 11","pages":"1381-1387"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Update on treatment strategies for mantle cell lymphoma]. [套细胞淋巴瘤治疗策略的最新进展]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.1012

Suguru Fukuhara

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.1245

引用次数: 0

[Genetic abnormalities in bone marrow failure]. [骨髓衰竭的遗传异常]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2024-01-01 DOI: 10.11406/rinketsu.65.1277

Kohei Hosokawa

{"title":"[Genetic abnormalities in bone marrow failure].","authors":"Kohei Hosokawa","doi":"10.11406/rinketsu.65.1277","DOIUrl":"https://doi.org/10.11406/rinketsu.65.1277","url":null,"abstract":"Bone marrow (BM) failure is a condition characterized by peripheral pancytopenia resulting from decreased hematopoiesis in the BM. It includes congenital disorders such as Fanconi anemia (FA), as well as acquired conditions such as acquired aplastic anemia (AA), myelodysplastic syndrome (MDS), and paroxysmal nocturnal hemoglobinuria (PNH). AA presents with pancytopenia and BM hypoplasia, primarily triggered by an autoimmune mechanism involving T cells that damage hematopoietic stem cells (HSCs). Genomic investigations utilizing next-generation sequencing or SNP arrays have revealed that clonal hematopoiesis by HSCs with genetic aberrations, including PIGA, DNMT3A, ASXL1, BCOR/BCORL1, copy-number neutral LOH of chromosome 6p (6pLOH), and somatic mutations in HLA class I alleles are prevalent in AA patients. Recent studies have identified somatic mutations in genes associated with the JAK-STAT and MAPK pathways in T cells of AA patients. Genomic abnormalities in AA differ from those observed in MDS and age-related clonal hematopoiesis. Notably, the presence of PNH-type cells and HLA class I allele-lacking cells represent two major instances of escape hematopoiesis, which indicate the presence of HSCs evading autoimmune T cell attacks. These findings provide crucial insights into the immune pathophysiology of BM failure.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"65 10","pages":"1277-1284"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0