Bulletin Du Cancer最新文献

{"title":"Endocrine testing after radiotherapy of brain or head and neck tumors, a snapshot on current practice","authors":"Marion Tonneau , Jordan Bouter , Shakeel Sumodhee , Valerie Bernier , Juliette Thariat","doi":"10.1016/j.bulcan.2025.03.010","DOIUrl":"10.1016/j.bulcan.2025.03.010","url":null,"abstract":"","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 1060-1061"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vécu de l’implantation des infirmières en pratique avancée mention oncologie hémato-oncologie en milieu hospitalier","authors":"Léa Toletti , Raphaël Alluin , Katie Galois , Johann Laangry","doi":"10.1016/j.bulcan.2025.02.021","DOIUrl":"10.1016/j.bulcan.2025.02.021","url":null,"abstract":"<div><h3>Introduction</h3><div>Les progrès de l’oncologie ont modifié le pronostic de certains cancers, transformant les parcours de soins. En France, l’émergence de la profession d’infirmière en pratique avancée offre une réponse innovante aux nouveaux besoins d’accompagnement des patients. Pourtant, la transition de rôle de ces soignantes s’avère être parfois une phase complexe. Ce travail explore le vécu des infirmières ayant fait le choix de se former à la pratique avancée.</div></div><div><h3>Méthode</h3><div>Cette recherche qualitative a été menée par le biais de cinq entretiens semi-directifs réalisés à la suite d’un échantillonnage théorique auprès d’infirmières en pratique avancée diplômées en oncologie et exerçant en milieu hospitalier. Une analyse thématique avec double codage a été réalisée.</div></div><div><h3>Résultats</h3><div>La transition de rôle a été décrite comme une période difficile à vivre pour certaines des soignantes avec un impact délétère sur leur bien-être, une remise en question de leur identité professionnelle et un sentiment d’isolement. Des manques préalables à cette transition ont été identifiés comme une formation incomplète et une mauvaise compréhension des nouvelles missions par les collègues. Au contraire, la construction d’un poste répondant aux attentes de l’infirmière, le soutien hiérarchique et des équipes médicales étaient des éléments positifs.</div></div><div><h3>Discussion</h3><div>La mise en place d’un programme de parrainage entre pairs, un mentorat médical ou encore une communication renforcée sur ce nouveau métier seraient des outils facilitant l’implantation des infirmières en pratique en avancée et favorisant une transition de rôle vécue positivement.</div></div><div><h3>Introduction</h3><div>Advances in oncology have altered the prognosis of certain cancers, transforming care pathways. In France, the emergence of the advanced practice nurse profession offers an innovative response to the new needs of patient support. However, the role transition for these nurses is sometimes a complex phase. This study explores the experiences of nurses who chose to train in advanced practice.</div></div><div><h3>Methods</h3><div>This qualitative research was conducted through five semi-structured interviews based on theoretical sampling with advanced practice nurses specialized in oncology, who are currently working in hospital settings. A thematic analysis with double coding was carried out.</div></div><div><h3>Results</h3><div>The role transition was described as a challenging period for some nurses, with a detrimental impact on their well-being, questioning of their professional identity, and a sense of isolation. Identified barriers to this transition included incomplete training and poor understanding of the new responsibilities by colleagues. Conversely, factors such as the development of a role aligned with the nurse's expectations, hierarchical and medical team support were perceived positively.</div></","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 976-987"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High expression and regulatory mechanisms of ANGPT1 and HOXA3 in acute myeloid leukemia","authors":"Fan Xuan,&nbsp;Na Liu,&nbsp;Bao-Xi Zhang,&nbsp;Wen-Xiao Wen,&nbsp;Yong-Cai Wang,&nbsp;Hui-Feng Zhang,&nbsp;Xiao-Li Wu","doi":"10.1016/j.bulcan.2025.01.014","DOIUrl":"10.1016/j.bulcan.2025.01.014","url":null,"abstract":"<div><h3>Objective</h3><div>Acute Myeloid Leukemia (AML) is a type of leukemia characterized by the malignant clonal proliferation of hematopoietic stem cells in the bone marrow. This study aims to investigate the role of ANGPT1 and HOXA3 in the leukemia cell line KG-1a.</div></div><div><h3>Methods</h3><div>The expression patterns of ANGPT1 and HOXA3 in AML patients were determined by analyzing the TCGA database and clinical samples. Experiments were conducted using the KG-1a cell line, including flow cytometry and SA-β-Gal staining, to knock down ANGPT1 and HOXA3 and evaluate their functions.</div></div><div><h3>Results</h3><div>ANGPT1 and HOXA3 were found to be highly expressed in AML patients. Knocking down ANGPT1 and HOXA3 promoted apoptosis and senescence in KG-1a cells by inhibiting proliferation-related genes and upregulating apoptosis-related genes. There is a reciprocal regulatory relationship between ANGPT1 and HOXA3, forming a positive feedback loop. Treatment with ATRA downregulated the expression of HOXA3 and induced apoptosis in KG-1a cells, highlighting the importance of HOXA3 as a therapeutic target in AML.</div></div><div><h3>Conclusion</h3><div>ANGPT1 and HOXA3 are highly expressed in AML, and knocking them down can promote apoptosis and senescence in leukemia cells. They exhibit a mutual regulatory relationship, forming a positive feedback loop. These findings contribute to a better understanding of the functional roles and regulatory mechanisms of ANGPT1 and HOXA3, and provide new scientific evidence for the treatment and prognosis improvement of AML patients.</div></div>","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 948-960"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Réponse des auteurs à la lettre à la rédaction « À la recherche (scientifique) des facteurs de risques connus »","authors":"Jérôme Barrière ,&nbsp;Jacques Robert","doi":"10.1016/j.bulcan.2025.08.001","DOIUrl":"10.1016/j.bulcan.2025.08.001","url":null,"abstract":"","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 1058-1060"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enjeux éthiques du suivi à long terme des cancers pédiatriques","authors":"Agathe Camus ,&nbsp;Julie Henry ,&nbsp;Claire Berger ,&nbsp;Amandine Bertrand ,&nbsp;Agnès Dumas ,&nbsp;Marine Da Silva Sé ,&nbsp;Sabine Heinrich ,&nbsp;Tanguy Leprince ,&nbsp;Gérard Michel ,&nbsp;Christelle Riberon ,&nbsp;Charlotte Demoor-Goldschmidt","doi":"10.1016/j.bulcan.2024.12.018","DOIUrl":"10.1016/j.bulcan.2024.12.018","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;L’avancée des connaissances sur les risques de complications et séquelles appelle la mise en place d’un suivi à long terme après la fin des traitements de cancers pédiatriques. Se pose alors la question des enjeux éthiques liés à l’information des anciens patients et aux sollicitations médicales visant à leur proposer une consultation de suivi à long terme.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Méthode&lt;/h3&gt;&lt;div&gt;Nous avons mené une étude qualitative en deux volets : (1) Une enquête par entretiens semi-directifs visant à explorer le vécu des anciens patients à l’égard des sollicitations médicales de suivi ; (2) La constitution d’un groupe de réflexion éthique pluridisciplinaire visant à faire émerger les enjeux éthiques liés à la systématisation du suivi.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Résultats&lt;/h3&gt;&lt;div&gt;L’étude a fait émerger cinq enjeux liés aux sollicitations médicales et à la mise en place du suivi : (1) Les besoins et les attentes des anciens patients en termes d’information ; (2) La temporalité de l’après-cancer ; (3) L’ambivalence des catégorisations au regard de la pluralité du vécu de l’après-cancer ; (4) Le rôle des différents professionnels et la responsabilité du suivi ; (5) La pluralité des besoins et propositions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;Au regard de ces enjeux, cinq points de vigilance émergent : (1) Informer sur un risque dans une vie &lt;em&gt;après&lt;/em&gt; la maladie ; (2) Quand proposer un suivi après cancer ? (3) Les « anciens patients », une catégorie en question ? (4) Qui peut/doit endosser le rôle et la responsabilité du suivi ? (5) La pluralité du suivi : entre homogénéisation et appui sur réseaux informels.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Advances in knowledge about late effects of childhood cancer treatments have led to implement long-term follow-up care. This raises the question of the ethical issues involved in providing information to survivors, and in proposals for long-term follow-up consultations.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;We conducted a two-part qualitative study: (1) A semi-directive interview survey to explore survivors’ experiences of medical proposals for follow-up consultations; (2) The creation of a multidisciplinary ethical reflection group aimed at identifying the ethical issues associated with the systematization of follow-up care.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The study identified five key issues related to medical requests and the implementation of follow-up care: (1) The needs and expectations of former patients regarding information; (2) The temporality of after-cancer; (3) The ambivalence of categorizations in light of the diversity of post-cancer experiences; (4) The role of various professionals and the responsibility for follow-up; (5) The plurality of needs and proposed approaches.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;In light of these issues, five areas of concern emerge: (1) Provide information about a risk in life after the disease? (2) When should follow-u","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 996-1007"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Évaluation de la pertinence des outils de diagnostic de la dénutrition chez les patients atteints de cancer des voies aérodigestives supérieures","authors":"Guillaume Buiret ,&nbsp;Ghislain Riffard ,&nbsp;Laurence Chenevier ,&nbsp;Lisa Meniscus ,&nbsp;Claire Combe","doi":"10.1016/j.bulcan.2025.02.016","DOIUrl":"10.1016/j.bulcan.2025.02.016","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;La dénutrition est un facteur pronostic majeur en cancérologie des voies aérodigestives supérieures. La Haute Autorité de Santé recommande plusieurs méthodes pour diagnostiquer la dénutrition. L’objectif principal de cette étude était de déterminer si les méthodes de diagnostics de dénutrition avant traitement appliquées par la diététicienne, l’enseignant d’activité physique adaptée et l’impédancemétrie étaient complémentaires ou redondants.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Méthode&lt;/h3&gt;&lt;div&gt;Soixante-six patients âgés de dix-huit à 70 ans, atteints d’un cancer des voies aérodigestives supérieures et ayant bénéficié d’une évaluation nutritionnelle selon les trois méthodes, avant le traitement de leur cancer ont été inclus de manière rétrospective. L’âge moyen état de 54,9 ans. La localisation la plus fréquente était les cancers oropharyngés.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Résultats&lt;/h3&gt;&lt;div&gt;Trente-quatre patients étaient dénutris au moment du diagnostic de leur cancer des voies aérodigestives supérieures selon au moins un des tests (52,3 %). Les spécificités des différents tests utilisés variaient entre 3,3 et 55,2 %, celles de chaque méthode (diététique, activité physique adaptée et impédancemétrie) entre 48,4 et 64,7 %. Les diagnostics de dénutrition par deux des trois méthodes ont été concordants dans 26,1 % à 38,5 % des cas et par les trois méthodes dans 2,9 % des cas de dénutrition (le diagnostic de dénutrition a été porté par les trois méthodes chez un seul patient).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;L’utilisation combinée de l’évaluation par une diététicienne, un enseignant d’activité physique adaptée et de l’impédancemétrie offre une approche plus complète, complémentaire et non redondante pour le diagnostic de la dénutrition chez les patients atteints d’un cancer des voies aérodigestives supérieures, probablement généralisable à l’ensemble des patients atteints de cancer solide ou hématologique.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Malnutrition is a major prognostic factor in head and neck cancers. The French National Authority for Health recommends several methods for diagnosing malnutrition. The main aim of this study was to determine whether the methods used to diagnose malnutrition prior to any treatment by the dietician, the adapted physical activity teacher and impedancemetry were complementary or redundant.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;Sixty-six patients aged 18 to 70 with head and neck cancer who had undergone nutritional assessment using the three methods prior to cancer treatment were retrospectively included. The mean age was 54.9 years. The most frequent location was oropharyngeal cancer.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Thirty-four patients were malnourished at the time of diagnosis of their head and neck cancer according to at least one of the tests (52.3%). The specificities of the different tests used ranged from 3.3 to 55.2%, and those of each method (diet, adapted physical activity and impedan","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 969-975"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amivantamab en association au lazertinib – cancers bronchiques non à petites cellules métastatiques avec délétion de l’exon 19 ou mutations L858R de l’EGFR","authors":"Marie Adou ,&nbsp;Florian Guisier","doi":"10.1016/j.bulcan.2025.02.024","DOIUrl":"10.1016/j.bulcan.2025.02.024","url":null,"abstract":"","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 931-933"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nous avons des yeux qui nous servent à pleurer","authors":"Jean Galtier","doi":"10.1016/j.bulcan.2025.07.005","DOIUrl":"10.1016/j.bulcan.2025.07.005","url":null,"abstract":"","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 946-947"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haute Autorité de santé et cancérologie de demain","authors":"Bachir Dahmani ,&nbsp;Sophie Albert ,&nbsp;Alicia Amigou ,&nbsp;Cédric Carbonneil ,&nbsp;Pierre Cochat ,&nbsp;Lionel Collet","doi":"10.1016/j.bulcan.2025.07.004","DOIUrl":"10.1016/j.bulcan.2025.07.004","url":null,"abstract":"","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Pages 934-936"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ours redaction EDB","authors":"","doi":"10.1016/S0007-4551(25)00313-3","DOIUrl":"10.1016/S0007-4551(25)00313-3","url":null,"abstract":"","PeriodicalId":9365,"journal":{"name":"Bulletin Du Cancer","volume":"112 9","pages":"Page i"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}