{"title":"What is the Relationship between Marijuana Use and Generalized Anxiety Disorder (GAD) Among Young Adults Aged 18–29 in the United States?","authors":"Eliza Brail","doi":"10.15695/vurj.v12i1.5293","DOIUrl":"https://doi.org/10.15695/vurj.v12i1.5293","url":null,"abstract":"Marijuana use is on the rise in the United States, with 18-29-year-old people being the most likely age group to indulge in the illegal drug’s use (Hrynowski, 2019). Similarly, generalized anxiety disorder (GAD) has increased in recent decades for those aged 18 and older (Goodwin et al., 2020). Little research has been conducted to establish a link between these two trends of growth, although researchers have tested THC doses in animals, which proved to elicit anxiety-related responses (Sharpe et al., 2020). Research by de Dios et al. (2010) regarding the correlation indicates that there is a statistically significant relationship between increased marijuana use and symptoms of generalized anxiety disorder in young adults, specifically when there is a third party mediator of tension reduction expectancies. Further systematic review and analysis on marijuana use in Seattle students implies that regular marijuana use throughout teenage years leads to cannabis use disorder by age 33 with stronger symptoms of anxiety than use of other recreational drugs (Guttmannova et al., 2017). The results of this research portray the growing necessity to educate young adults on the long term effects of regular marijuana use, as individuals may believe they are alleviating their GAD symptoms short term, but over time, they are likely facing dangers of worsening their anxiety by increasing dependency on the drug. The following research addresses the question, “What is the relationship between marijuana use and generalized anxiety disorder (GAD) among young adults aged 18–29 in the United States?”","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42377313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"False Freedom: Union Paternalistic Attitudes in Nashville’s Contraband Camps during the Civil War","authors":"Indraneel Pai","doi":"10.15695/vurj.v12i1.5274","DOIUrl":"https://doi.org/10.15695/vurj.v12i1.5274","url":null,"abstract":" As Union forces continued to secure victories in the Western Theatre of the American Civil War and reclaim, by force, the seceded lands of the Confederacy, one question persisted, particularly in Tennessee: what was to be done with the liberated slaves? Slaves would not be formally freed in Tennessee until the Battle of Nashville in 1864, and even then, the integration of freedmen into the rebuilding South proved to be a daunting task. Most prominent and immediate movement towards that end was the development of contraband camps -- so named because slaves were still considered by the Union to be “contraband” confiscated from the South during the war. However, with the chronic underfunding and lack of care put into these camps, the contraband slaves in Tennessee suffered an existence so miserable at the refugee encampments that freedmen were little better off with the Union forces than they were in Southern plantations. This paper seeks to show how, although the Union’s treatment of the freedmen was marginally better than that of the Southern plantation owners, their failures to adequately provide blacks in contraband camps with the necessary help to integrate them into American society was directly responsible for the asymmetric development of black and white communities in Tennessee. ","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48953823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What is the Effect of Topical Breast Milk Application on Umbilical Cord Separation among Healthy Newborn Babies in the Middle East?","authors":"Mary Awopileda","doi":"10.15695/vurj.v12i1.5273","DOIUrl":"https://doi.org/10.15695/vurj.v12i1.5273","url":null,"abstract":"Umbilical cord care is variable all over the world and is informed by firm traditional practices that are passed down as culture. Breast milk has been proposed as a topical substance to the umbilicus as it is full of antibacterial properties. The analysis of four studies revealed a strong correlation between the use of topical breast milk and umbilical cord separation time among newborns in the Middle East. Comparing the results of the studies included in this review, breast milk is not only effective in shortening the separation time of the umbilical cord over dry cord care but is just as effective in reducing signs of infection as the antimicrobial chlorhexidine. These findings designate breast milk as an affordable, easy, and practical method of umbilical cord care. This is particularly useful in developing countries, where the risk of neonatal death due to infection is higher. The result is generalizable to healthy neonates born in a hospital setting, so more research about its practicality in rural areas as well as among sick neonates is suggested.","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44286883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discordance between Emergency Department Electronic Health Record and Patient Self-Reported Data","authors":"Mira C. Patel, Catherine Hobbs","doi":"10.15695/vurj.v12i1.5290","DOIUrl":"https://doi.org/10.15695/vurj.v12i1.5290","url":null,"abstract":"Electronic Health Records (EHRs) have many clinical, financial, and logistical benefits, yet the extent of their accuracy is unknown. We compared patient self-reported data at emergency department (ED) presentations with the corresponding EHR, focusing on key demographics, physical characteristics, and social history. Emphasis was placed on understanding whether major life stressors were noted on patients’ charts and how that could impact quality of care. Life stressors are defined as life-altering and emotionally demanding or traumatic events. We enrolled a convenience sample of 357 ambulatory, English speaking, adult patients at the Vanderbilt University Medical Center Emergency Department, an urban, academic, tertiary care ED (annual census 70,000). We compared the EHR with self-reported data from bedside patient interviews, including information on demographics (age, sex, race, ethnicity), physical characteristics (height, weight), and life history (smoking, life stressors). Data was described using median and percent frequency, and it was analyzed using Cohen kappa statistics and Bland-Altman plots. Between EHR and patient-reports, sex and age matched in 99%, and race/ethnicity matched in 90%. Race was more discordant when the patient self-identified as multiple races, as it was only reflected in 24% of those patients’ EHRs. Weight, height, and smoking were similar between patient interviews and EHR. Of 281 self-reported life stressors, only 75 were recorded in the EHR. Although most demographic and clinical data were concordant, life stressors were frequently absent from the EHR which suggests a discrepancy in data collection and maintenance. ","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":"52 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41305023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Mystery of Evil and the Hiddenness of God: Understanding Mystery in Christian Theodicy","authors":"S. Liu","doi":"10.15695/vurj.v12i1.5294","DOIUrl":"https://doi.org/10.15695/vurj.v12i1.5294","url":null,"abstract":"Mysterium iniquitatis, the “mystery of evil,” constitutes the unresolved theological, philosophical, and pastoral debates over the pervasion of evil and suffering that contradicts a world under the providence of the omnipotent, omniscient, and benevolent God of Christianity. At the same time, the idea of mystery not only characterizes the conundrum of evil but also the hiddenness of God that formulates the relationship between creature, creator, and the pervasion of suffering that spans Christian scriptural and theological thought. The paper aims to construct a comparative exegesis of three works concerned with the meaning and significance of mystery in Christian theodical thought. Explicating the Grand Inquisitor from Fyodor Dostoevsky’s The Brothers Karamazov, the paper begins with highlighting a cynical view of mystery as a tool for the authority of liturgical institutions that ultimately offers no pastoral consolation within the framework of Christian theology. Then, drawing on Karen Kilby’s critique of Post-Enlightenment theodicy and its shortcoming in understanding the creator and the divine and Gustav Gutiérrez’s idea of divine love and gratuitousness, I propose understanding mystery as a destabilizing opening in the practice of theodicy that constellates ways to engage theologically with the mystery of the divine and translating it into an ethical understanding of, instead of a justification for, the pervasion of evil and injustice.","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48901514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"COVID-19 Vaccine Hesitancy in Adult Emergency Department Patients","authors":"Catherine Hobbs, Mira C. Patel","doi":"10.15695/vurj.v12i1.5270","DOIUrl":"https://doi.org/10.15695/vurj.v12i1.5270","url":null,"abstract":"Introduction \u0000Vaccine hesitancy is a nationally resonant issue that must be evaluated to address the spread and overwhelming complications of COVID-19 in the United States. Emergency departments (EDs) often serve disadvantaged populations who may experience disproportionate pandemic complications. We sought to gain an updated understanding of vaccine hesitancy levels in a single ED, especially following wide-scale distribution of COVID-19 vaccines and during the spread of the Delta COVID-19 variant. \u0000Methods \u0000We surveyed a convenience sample of non-COVID positive ED patients at an urban level 1 trauma center to measure patients’ vaccine rates for COVID-19 and influenza. We obtained demographics and perspectives by interview on reasons why COVID-19 vaccination was or was not obtained utilizing previously published instruments. \u0000Results \u0000Among 100 patients enrolled, 78% were vaccinated against COVID-19 and 22% were unvaccinated. The sample of participants was majority white, middle-aged, educated beyond high school, and medically-insured. Vaccine hesitancy was not significantly linked to any demographic groups, other than a slightly significant relationship with those with lower education levels and those who identified as white. Of the unvaccinated participants, the most frequent reason for refusing the vaccine was concern about the side effects or safety. \u0000Conclusion \u0000Our data suggests vaccine hesitancy persists in about 1 out of 5 emergency department patients. Education on COVID-19 vaccine safety may improve uptake.","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47544548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Adverse Cardiovascular Effects of Bruton Tyrosine Kinase Inhibitors on the Mouse Model","authors":"Dev Patel","doi":"10.15695/vurj.v12i1.5263","DOIUrl":"https://doi.org/10.15695/vurj.v12i1.5263","url":null,"abstract":"Bruton Tyrosine Kinase (BTK) inhibitors have revolutionized the treatment of several hematologic malignancies. However, treatment of cancers such as Chronic Lymphocytic Leukemia (CLL) with BTK inhibitors has led to many adverse cardiovascular side effects. These side effects include atrial fibrillation (AF), myocardial fibrosis, and left atrial enlargement. In this study, a mouse model was used in order to see if the cardiovascular side effects caused by BTK inhibitors resolved upon discontinuation of treatment. Echocardiograms, electrophysiology studies, and histology analyses were utilized in order to determine if these side effects were resolved. Our results showed that while there was a decrease in the adverse cardiovascular effects after recovery there was still a significant difference in phenotypes between the control and experimental groups.","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45512320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derrian Wright, Simone Kennard, Galina N Antonova, I. Jaffe, E. B. Chantemèle, Jessica L. Faulkner
{"title":"Endothelial Mineralocorticoid Receptor Deletion Ablates Leptin-Induced Preeclampsia Characteristics in Pregnancy","authors":"Derrian Wright, Simone Kennard, Galina N Antonova, I. Jaffe, E. B. Chantemèle, Jessica L. Faulkner","doi":"10.21633/ISSN.2380.5064/S.2021.04.01.42","DOIUrl":"https://doi.org/10.21633/ISSN.2380.5064/S.2021.04.01.42","url":null,"abstract":"Obesity increases the risk for preeclampsia (PE), a hypertensive syndrome of pregnancy. Obese PE patients demonstrate increases in plasma leptin levels in midgestation. We have shown that pregnancy increases endothelial mineralocorticoid receptor (ECMR) expression and that ECMR mediates leptin-induced endothelial dysfunction and hypertension in non-pregnant females. We, therefore, hypothesized that ECMR deletion (ECMR-/-) protects from the development endothelial dysfunction, hypertension and fetal growth restriction in leptin-infused pregnant mice. Pregnant ECMR+/+ and ECMR-/mice were infused with leptin by osmotic minipump from gestation day (GD)11-18 and thoracic aortas assessed for vascular function by wire myography or implanted with radiotelemeters for systolic blood pressure (BP) measurement. Leptin decreased pup weight and placental efficiency indicating fetal growth restriction, which was restored in ECMR-/mice infused with leptin. Leptin infusion increased BP and ablated circadian rhythm in ECMR+/+, but not ECMR-/pregnant mice. ECMR deletion protected pregnant mice from leptin-induced impairment in acetylcholine (endothelial-dependent dilator) and phenylephrine (α1receptor-mediated constriction) in aortas. Relaxation to acetylcholine with nitric oxide (NO) synthase inhibitor (LNAME) showed restoration of endothelial function in ECMR-/-+leptin mice was NO-dependent. These data indicate that ECMR deletion improves BP, vascular function and fetal growth in an obesity-associated, leptininfusion model of PE. Received: 02/15/2021 Accepted: 03/30/2021 Correspondence: Derrian Wright, Augusta University, 1120 15 St. Augusta, GA 30912, derwright@augusta.edu","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":"71 1","pages":"42-42"},"PeriodicalIF":0.0,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73258623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring Jeffrey Dahmer’s Sexual Development","authors":"F. Anwar, Michael Holman","doi":"10.21633/ISSN.2380.5064/S.2021.04.01.03","DOIUrl":"https://doi.org/10.21633/ISSN.2380.5064/S.2021.04.01.03","url":null,"abstract":"","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":"7 1","pages":"3-3"},"PeriodicalIF":0.0,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81858535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Children, Philosophy, and Early Education","authors":"Elyse Garrett, L. Maynard","doi":"10.21633/ISSN.2380.5064/S.2021.04.01.14","DOIUrl":"https://doi.org/10.21633/ISSN.2380.5064/S.2021.04.01.14","url":null,"abstract":"","PeriodicalId":93630,"journal":{"name":"Vanderbilt undergraduate research journal : VURJ","volume":"73 1","pages":"14-14"},"PeriodicalIF":0.0,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86806153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}