Interventional pulmonology (Middletown, Del.)最新文献_第7页

Cryobiopsy – a diagnostic breakthrough for peripheral pulmonary lesions - 低温活检-外周肺病变的诊断突破

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa313

Y. Matsumoto, Midori Tanaka, T. Nakai, T. Tsuchida, Y. Ohe

引用次数: 0

Safety and Feasibility of Metered CryoSpray (MCS) for Patients with Chronic Bronchitis in COPD: 9 Month Results 计量冷冻喷雾(MCS)治疗慢性支气管炎患者的安全性和可行性:9个月的结果

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa5172

J. Garner, C. Orton, Cielo Caneja, D. Sin, T. Shaipanich, K. Klooster, J. Hartman, J. Thornton, D. Slebos, P. Shah

{"title":"Safety and Feasibility of Metered CryoSpray (MCS) for Patients with Chronic Bronchitis in COPD: 9 Month Results","authors":"J. Garner, C. Orton, Cielo Caneja, D. Sin, T. Shaipanich, K. Klooster, J. Hartman, J. Thornton, D. Slebos, P. Shah","doi":"10.1183/13993003.congress-2019.oa5172","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.oa5172","url":null,"abstract":"Background: No current medication counteracts the excessive mucus secretion or reverses the airway metaplasia of Chronic Bronchitis (CB) in COPD. Metered Cryospray (RejuvenAir® System) is a novel procedure delivering liquid N2 to the bronchial airways to target mucus overproduction, ablate abnormal epithelium, reduce chronic airway inflammation and promote regeneration of a healthy mucosal lining. Methods: This is a prospective, multicenter single-arm study of CB patients with an FEV1 of 30-80% predicted. Primary outcomes were safety and feasibility; secondary outcomes, SGRQ and 6MWT, were measured. Results: We included 35 subjects with Gold Grade II (31.4%) and III (68.6%) COPD (mean age 67.2+7.0 years, FEV1% 50.2±14.5, 54% male). Full treatment was accomplished of intended lobes with median times of 34 (right lower), 30 (left lower) and 41 minutes (upper lobes + trachea) during 3 separate outpatient visits. Approximately 1800 doses of MCS were delivered without inducing pneumothorax or unanticipated device-related serious adverse events (SAEs). Efficacy data showed clinically meaningful improvements of SGRQ-symptom score of -9.5±22.0 (95% CI; -17.7 to -1.3; p=0.025), SGRQ-impact score of -10.2±19.4 (95% CI: -17.5 to -3.0; p=0.007) and SGRQ-total score of -7.9±16.8 (95% CI: -14.2 to -1.6; p=0.008); most pronounced when baseline SGRQ-total ≥50 points (n=19). 6MWT significantly improved by 28 meters (95% CI: 3.0 to 62.0; Wilcoxon signed rank, p=0.034; n=25). Conclusions: These data indicate MCS treatment is safe, feasible and associated with clinically significant improvements in health-related quality of life in COPD patients with CB over 9 months.","PeriodicalId":93455,"journal":{"name":"Interventional pulmonology (Middletown, Del.)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73251323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Visual diagnosis of tuberculous pleuritis: diagnostic utility of miliary nodules on pleura and their correlation with tissue Xpert MTB/Rif assay and AFB culture 结核性胸膜炎的视觉诊断:胸膜军事性结节的诊断价值及其与组织Xpert MTB/Rif检测和AFB培养的相关性

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa3392

K. Khan, N. Akhter, D. Chawla, N. Rizvi

引用次数: 0

Clinical outcomes of radial probe endobronchial ultrasound using a guide sheath for peripheral lung lesions in patients with pulmonary emphysema 引导鞘桡动脉支气管内超声检查肺气肿周围肺病变的临床效果

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.CONGRESS-2019.PA318

Kyu Min Lee, J. Eom, M. Lee, Insu Kim, Seyeon Park, H. Chung, J. Roh

引用次数: 0

Comparison of dexmedetomidine to propofol for sedation of endobronchial ultrasound-guided transbronchial needle aspiration 右美托咪定与异丙酚在超声引导下支气管穿刺镇静作用的比较

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa320

Ting-Yu Lin, C. Kuo, F. Chung, Y. Lo

引用次数: 1

The value of endosonographic criteria of lymph nodes in the differential diagnosis of the mediastinal lymphadenopathy 淋巴结超声诊断标准在纵隔淋巴结病鉴别诊断中的价值

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4775

I. Zaitcev, I. Vasilev, Peter Ermakov, P. Yablonskii

{"title":"The value of endosonographic criteria of lymph nodes in the differential diagnosis of the mediastinal lymphadenopathy","authors":"I. Zaitcev, I. Vasilev, Peter Ermakov, P. Yablonskii","doi":"10.1183/13993003.congress-2019.pa4775","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4775","url":null,"abstract":"The results of a prospective study. Introduction: morphological diagnosis of lymphadenopathy of the mediastinum by aspiration biopsy data presents known difficulties. The search for specific endosonographic patterns for the diagnosis of mediastinal lymph node pathology is relevant. Objective: to study the role of endosonographic patterns in the differential diagnosis of the mediastinal lymphadenopathy. Material and methods: prospective non-randomized one-center. Duration of the study: 01/01/2017 - 12/31/2017. Inclusion criteria: patients with lymphadenopathy of the mediastinum, age over 18 years, the absence of any verified cancer and tuberculosis in history, the patient’s consent to the inclusion. Exclusion criteria: the presence of contraindications to general anesthesia, the refusal to conduct the study. In accordance with the inclusion criteria, 29 patients were enrolled in the study, who underwent endobronchial sonography with subsequent analysis of endosonographic scans by the modified scheme Lei Wang, 2015. Results: as a result of statistical analysis, none of the analyzed factors had a significant effect on the form of the pathological lymphatic lesion, or on the result of the biopsy. The factor: Form p=0,249, Edges - 0,009, Echogenicity - 0,567, Presence of central structure - 0,265, Necrosis sign - 0,326, The presence of the vessel - 0,198, Calcification - 0,612, Matting - 0,368, Vascular patterns - 0,399. Edge: Pearson Correlation -0.248. Conclusion: the use of endosonographic patterns for the differential diagnosis of mediastinal lymphadenopathy and the refusal to perform a biopsy in these patients is currently not possible.","PeriodicalId":93455,"journal":{"name":"Interventional pulmonology (Middletown, Del.)","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84141591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary function before and early after endobronchial valve placement in patients with chronic cavitary tuberculosis 慢性腔型结核患者支气管内瓣膜置入术前后肺功能的变化

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa3151

M. Chushkin, L. Popova, E. Shergina, N. Karpina, I. Shabalina, T. Bagdasaryan, N. Chernykh, O. Lovacheva, O. Ots

引用次数: 0

Endobronchial ultrasound trans-bronchial needle aspiration (EBUS-TBNA) in Malta – improving diagnostic yield in a low volume centre 马耳他支气管内超声经支气管针吸(EBUS-TBNA) -提高低容量中心的诊断率

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4782

M. P. Bardon, I. Said-Huntingford, Christopher Zammit, Sharon Psaila Balzan, G. Saliba, S. Montefort, D. Bilocca

{"title":"Endobronchial ultrasound trans-bronchial needle aspiration (EBUS-TBNA) in Malta – improving diagnostic yield in a low volume centre","authors":"M. P. Bardon, I. Said-Huntingford, Christopher Zammit, Sharon Psaila Balzan, G. Saliba, S. Montefort, D. Bilocca","doi":"10.1183/13993003.congress-2019.pa4782","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4782","url":null,"abstract":"EBUS-TBNA at Mater Dei Hospital (MDH), which serves a population of about 432000, was audited over a 2 year period. Our aim was to assess results obtained and factors associated with improved diagnostic yield. All patients who underwent EBUS-TBNA at MDH were included and data was collected retrospectively. 71 EBUS TBNA procedures were performed on 70 patients. Sensitivity for malignancy was 93% (40/43) and sensitivity for granulomatous disease was 72% (16/22). The overall diagnostic sensitivity was 84.5% (60/71). Sampling multiple stations as opposed to a single station was associated with a better histology diagnostic yield (90.3% vs 60% p=0.004) as well as a better yield on cytology (83.9% vs 50% p=0.003). It also led to an improved overall combined diagnostic yield (93.5% vs 77.5%) although this narrowly missed statistical significance (p=0.06). Targeting multiple stations also correlated with obtaining an adequate histology sample (96.8% vs 82.5% p=0.05). This effect was even more pronounced for granulomatous disease with improved diagnostic histology yield (100% vs 43.8% p=0.005) diagnostic cytology yield (89% vs 25% p=0.002) and overall combined diagnostic yield (100% vs 62.5% p=0.035) Increasing lesion size was predictive of obtaining an adequate tissue sample (p=0.03) histology diagnostic yield (p=0.05) and overall diagnostic yield (p=0.04) but there was no correlation between lesion size and yield on cytology (p=0.389). Sampling multiple stations and targeting larger lesions led to an improved diagnostic yield; the effect of targeting multiple stations was even more pronounced in granulomatous disease.","PeriodicalId":93455,"journal":{"name":"Interventional pulmonology (Middletown, Del.)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73404291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Needle based confocal laser endomicroscopy (nCLE) for the real-time diagnosis of mediastinal lymph nodes involved in sarcoidosis 针基共聚焦激光内镜(nCLE)实时诊断结节病纵隔淋巴结

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa3399

T. Kramer, L. Wijmans, M. D. Bruin, P. Bonta, J. Annema

{"title":"Needle based confocal laser endomicroscopy (nCLE) for the real-time diagnosis of mediastinal lymph nodes involved in sarcoidosis","authors":"T. Kramer, L. Wijmans, M. D. Bruin, P. Bonta, J. Annema","doi":"10.1183/13993003.congress-2019.pa3399","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa3399","url":null,"abstract":"Introduction: In patients with mediastinal lymphadenopathy a distinction between malignancy and granulomatous disorders is essential. Confocal laser endomicroscopy (CLE) enables real-time microscopic analysis during endososonography. CLE criteria of malignant lymph nodes have been proposed but are lacking for granulomas. Aim: To identify CLE criteria for real-time in-vivo recognition of granulomas on CLE imaging during endosonography (EUS). Methods: In patients with suspected sarcoidosis stage I-II, mediastinal lymph nodes were imaged with CLE through a 19 G needle in-vivo under EUS control, followed by fine needle aspiration. CLE videos were reviewed and compared to the final diagnoses based on cytology and clinical-radiological follow-up. Results: EUS-nCLE-FNA was performed in 17 patients (n=16 sarcoidosis, n=1 tuberculosis) and 29 lymph nodes were imaged. No adverse events occurred. On CLE imaging the granulomas appeared like oval, well-demarcated, lighter-toned lesions (Figure). Tuberculoid necrosis could be identified on CLE as a loss of contact signal. Conclusion: In suspected sarcoidosis patients, real-time in-vivo EUS-guided nCLE imaging is feasible and safe. Granulomas show a distinct CLE pattern different from malignant CLE-criteria previously described. nCLE provides real-time pathology feedback and can therefore potentially improve diagnostics of mediastinal and lung lesions.","PeriodicalId":93455,"journal":{"name":"Interventional pulmonology (Middletown, Del.)","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82555783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Widening the scope of Cryobiopsy for ILD– Pulmonary Hypertension (PH) may not necessarily be a contraindication 扩大ILD -肺动脉高压(PH)冷冻活检的范围不一定是禁忌

Interventional pulmonology (Middletown, Del.) Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.oa1621

R. Bhat, P. Bajaj, H. Kalpakam, S. Salimath, R. Mehta

引用次数: 2