International journal of health research and innovation最新文献_第9页

Bacteriological pattern of wound swab isolates in patients with chronic leg ulcer 慢性腿部溃疡患者伤口拭子分离菌的细菌学特征

International journal of health research and innovation Pub Date : 2010-06-09 DOI: 10.4314/IJHR.V1I4.55375

A. Fadeyi, I. Adigun, G. Rahman

{"title":"Bacteriological pattern of wound swab isolates in patients with chronic leg ulcer","authors":"A. Fadeyi, I. Adigun, G. Rahman","doi":"10.4314/IJHR.V1I4.55375","DOIUrl":"https://doi.org/10.4314/IJHR.V1I4.55375","url":null,"abstract":"PURPOSE: To determine the pattern of bacterial \u0000pathogens and their antibiotic sensitivity profile in patients with infected chronic leg ulceration. METHODS: Sixty swab specimens obtained from chronic leg ulcer (CLU) patients were cultured aerobically and the antibiotic sensitivity pattern of the recovered organisms determined by the modified Kirby- Bauer disc-diffusion method. \u0000RESULTS: 47 (78.3%) of the ulcers were infected out of \u0000which 39 (83.0%) were culture positive. Most of the \u0000culture positive ulcers were on the distal third of the leg. \u0000The isolated bacteria from the wounds were Pseudomonas aeruginosa (33%), Staphylococcus aureus (24%), Proteus spp (15%), Klebsiella spp (13%), Citrobacter spp (13%) and Escherichia coli (2%). None \u0000of the patient without clinical evidence of wound infection \u0000had bacterial positive wound swab culture. All isolates \u0000were sensitive to third generation cephalosporin and \u0000floroquinolones but majority were resistant to ampicillin. \u0000CONCLUSION: Pseudomonas aeruginosa, Staphylococcus \u0000aureus. Proteus spp, Klebsiella spp, Citrobacter spp and Escherichia coli sensitive to third generation cephalosporin and floroquinolones have been recovered \u0000from 78% of patients with chronic leg ulcers in a tertiary \u0000health facility in Nigeria. \u0000 \u0000Keywords: Bacteriology; Chronic leg ulcer; Wound swab","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90171947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Knowledge and perception of e-health and telemedicine among health professionals in Lautech teaching hospital, Osogbo, Nigeria 尼日利亚奥索博Lautech教学医院保健专业人员对电子保健和远程医疗的知识和看法

International journal of health research and innovation Pub Date : 2010-06-09 DOI: 10.4314/IJHR.V2I1.55388

O. Abodunrin, T. Akande

{"title":"Knowledge and perception of e-health and telemedicine among health professionals in Lautech teaching hospital, Osogbo, Nigeria","authors":"O. Abodunrin, T. Akande","doi":"10.4314/IJHR.V2I1.55388","DOIUrl":"https://doi.org/10.4314/IJHR.V2I1.55388","url":null,"abstract":"Purpose: To assess the knowledge and perception of \u0000health professionals in LAUTECH Teaching Hospital \u0000(LTH), Osogbo on e-health and telemedicine Methods: In a cross-sectional descriptive survey, 110 different health professionals were selected by proportional multi-stage sampling in LTH, Osogbo using self-administered, semi-structured questionnaire to assess their knowledge and perception of e-health and telemedicine. Results: Only 34.1% had good knowledge of what ehealth \u0000and telemedicine entails and only 13% of the respondents have attended any relevant workshop. \u0000Respondents’ profession and attendance in workshop \u0000affected their knowledge. Although as much as 91.6% \u0000were in support of introduction of e-health practice in \u0000Nigeria, most of them believed that financial implication, illiteracy and poor infrastructure, such as electric power supply and internet services, could limit its full application. \u0000Conclusion: Although the knowledge of the health \u0000professionals on e-health and telemedicine was poor, \u0000majority of them were in support of the services. There \u0000is therefore the need to intensify training workshops for \u0000health professionals and improve electricity and \u0000Electronic communications. \u0000 \u0000Keywords: E-Health; Health professionals; Knowledge; Perception; Telemedicine; Nigeria.","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90565758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Gastroretentive drug delivery systems: a patent perspective 胃保留性药物输送系统:专利视角

International journal of health research and innovation Pub Date : 2010-06-09 DOI: 10.4314/IJHR.V2I1.55385

M. H. G. Dehghan, F. Kha

引用次数: 54

Effects of root extract of Withania somnifera in 3- Nitropropionic Acid-Induced Cognitive Dysfunction and Oxidative Damage in Rats 苦参根提取物对3-硝基丙酸致大鼠认知功能障碍和氧化损伤的影响

International journal of health research and innovation Pub Date : 2010-06-08 DOI: 10.4314/IJHR.V1I3.55359

Puneet Kumar, Anil Kumar

{"title":"Effects of root extract of Withania somnifera in 3- Nitropropionic Acid-Induced Cognitive Dysfunction and Oxidative Damage in Rats","authors":"Puneet Kumar, Anil Kumar","doi":"10.4314/IJHR.V1I3.55359","DOIUrl":"https://doi.org/10.4314/IJHR.V1I3.55359","url":null,"abstract":"Purpose: To investigate the possible modulatory role of root extract of Withania somnifera (WS) in 3-Nitroproiponic acid (3-NP)-induced cognitive impairment and altered level of oxidative defense in discrete areas of rat brain. Methods: 3-NP was administered in a dose of 10 mg/kg for 14 days where as WS root extract (100 and 200 mg/kg) was administered orally along with 3-NP. Cognitive dysfunctions were assessed in Morris water maze and plus-maze performance task paradigms. On \u000015th day the animals were scarified and reduced glutathione, total glutathione, oxidized glutathione (GSSG), glutathione-S-transferase (GST) and acetylcholinesterase enzyme levels were estimated in \u0000the striatum, cortex and hippocampus of the rat brian. \u0000Results: Chronic WS root extract (100, 200 mg/kg) treatment for a period of 14 days significantly improved 3-NP-induced cognitive impairment in Morris water and plus maze tests (p<0.05). Further, WS root extract treatment significantly restored GSH, total glutathione, oxidized glutathione, GST and attenuated acetylcholinesterase levels in striatum, cortex and hippocampus regions of brain. Conclusion: There is possible neuroprotective effect of WS root extract against a 3-NP- induced neurotoxicity in rats. \u0000 \u0000Key words: Huntington’s disease, 3-Nitropropionic acid, Oxidative stress, Withania somnifera","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86691154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Tuberculous otomastoiditis: A case report 结核性耳乳突炎1例

International journal of health research and innovation Pub Date : 2010-06-08 DOI: 10.4314/IJHR.V1I3.55350

S. Subha, P. Puraviappan, Abd Majid Nasir, Narayanan Prepageran

引用次数: 0

Advances in iontophoresis for drug delivery 离子电泳给药研究进展

International journal of health research and innovation Pub Date : 2010-06-08 DOI: 10.4314/IJHR.V1I3.55353

M. Dehghan, Md. Ismail Mouzam

引用次数: 13

Evaluation of Hepatoprotective Activity of the Fruits of Coccinia grandis Linn 大球虫果实的保肝活性评价

International journal of health research and innovation Pub Date : 2010-06-08 DOI: 10.4314/IJHR.V1I3.55366

R. Vadivu, A. Krithika, C. Biplab, P. Dedeepya, N. Shoeb, Lakshmi Ks

{"title":"Evaluation of Hepatoprotective Activity of the Fruits of Coccinia grandis Linn","authors":"R. Vadivu, A. Krithika, C. Biplab, P. Dedeepya, N. Shoeb, Lakshmi Ks","doi":"10.4314/IJHR.V1I3.55366","DOIUrl":"https://doi.org/10.4314/IJHR.V1I3.55366","url":null,"abstract":"Purpose: To evaluate the hepatoprotective activity of \u0000alcoholic extract of the fruits of Coccinia grandis Linn \u0000(Curcubitaceae) using carbon tetra chloride (CCl4)- \u0000induced hepatotoxicity in rats. Methods: The levels of serum glutamate oxaloacetate transminase (SGOT), serum glutamate pyruate transminase (SGPT), alkaline phosphatase (ALP), total protein, total and direct bilirubin were evaluated in experimental rats (with or without CCl4-induced hepatotoxicity) following administration of alcoholic extract of the fruits of C. grandis using standard \u0000procedures. The potency of the extract was compared \u0000with standard silymarin at a dose of 100 mg/kg p.o. \u0000Histopathology of the liver tissues of the animals treated \u0000with the extract was also studied. Results: At a dose level of 250 mg/kg, the alcoholic extract significantly (p<0.05) decreased the activities of serum enzymes (SGOT, SGPT, and ALP) and bilirubin which were comparable to that of silymarin. Conclusion: Alcoholic extract of the fruits of C. grandis offers protective effect against CCl4-induced hepatotoxicity in experimental rats. \u0000 \u0000Keywords: CCL4-induced hepatotoxicity; Coccinia \u0000grandis; hepatoprotective effect; silymarin","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75855446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 66

Method development and validations: characterization of critical elements in the development of pharmaceuticals 方法开发和验证:药物开发中关键元素的表征

International journal of health research and innovation Pub Date : 2010-06-08 DOI: 10.4314/IJHR.V1I1.55342

R. Putheti, R. N. Okigbo, S. Patil, -. MadhusoodansaiAd, vanapu, R. Leburu

{"title":"Method development and validations: characterization of critical elements in the development of pharmaceuticals","authors":"R. Putheti, R. N. Okigbo, S. Patil, -. MadhusoodansaiAd, vanapu, R. Leburu","doi":"10.4314/IJHR.V1I1.55342","DOIUrl":"https://doi.org/10.4314/IJHR.V1I1.55342","url":null,"abstract":"This review discusses the conceptual aspects of method \u0000validation, its management, processes and schemes and \u0000highlights method validation key performance characteristics. Although a thorough validation cannot rule out all potential problems, the process of method development and validation should address the most common ones. Examples of typical problems that can be minimized or avoided are synthesis impurities that co-elute with the analyte peak in an HPLC assay; a particular type of column that no longer produces the separation needed because the supplier of the column has changed the manufacturing process; an assay method that is transferred to a second laboratory \u0000where they are unable to achieve the same detection \u0000limit; and a quality assurance audit of a validation report \u0000that finds no documentation on how the method was performed during the validation. Problems increase as additional people, laboratories, and equipment are used to perform the method. When the method is used in the developer's laboratory, a small adjustment can usually be made to make the method work, but the flexibility to change it is lost once the method is transferred to other laboratories or used for official product testing. This is especially true in the pharmaceutical industry, where methods are submitted to regulatory agencies and changes may require formal approval before they can be implemented for official testing. The best way to minimize method problems is to perform adequate validation experiments during development. \u0000 \u0000Keywords: Method validation, method development, pharmaceutical analysis","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90937844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Mathematical analysis of corneal oxygenation 角膜氧合的数学分析

International journal of health research and innovation Pub Date : 2010-06-08 DOI: 10.4314/IJHR.V1I3.55356

R. Avtar, D. Tandon

{"title":"Mathematical analysis of corneal oxygenation","authors":"R. Avtar, D. Tandon","doi":"10.4314/IJHR.V1I3.55356","DOIUrl":"https://doi.org/10.4314/IJHR.V1I3.55356","url":null,"abstract":"Purpose: To develop a quasi steady state model for the time course concentration profile describing the oxygen diffusion and consumption in a multilayered corneal tissue and investigate the effect of various model parameters on the oxygen concentration for open and closed eyes. \u0000Method: A simple mathematical model for the oxygen transport in multilayered corneal tissue was developed using Fick’s law of diffusion and Michaelis-Menten kinetics of metabolism. A Crank-Nicoloson finite difference scheme of the equation describing the oxygen diffusion and consumption was written, in which spatial diffusive terms were approximated by central differences while the temporal terms were approximated by average of forward and backward time differences. A system of linear equations obtained from the Crank-Nicholoson finite \u0000differences schemes was solved by the Thomos Algorithm. \u0000Result: The model predict that oxygen tension without \u0000contact lens for an open and closed eye increases along the distance from the aqueous side in each of the layers and the partial pressure gradient in the stroma is higher than that in the epithelium and endothelium layers. It is also observed that the oxygen tension with contact lens in the steady and transient stares, in case of low oxygen permeability of lens decreases along the distance from the aqueous side to the stroma, whereas, at higher oxygen permeability of the lens it increases along the distance for open and closed eyes. Conclusion: Oxygen tension as observed in the cornea of an open eye with or without contact lens is higher than that in closed eye. Also at a high oxygen permeability of contact lens \u0000enhance the oxygen tension significantly than that of low \u0000oxygen permeability. \u0000 \u0000Keywords: Oxygen transport, finite difference, metabolism, \u0000oxygen consumption, pressure gradient.","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90894471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparative determination of chlorpromazine hydrochloride content in multi-sourced chlorpromazine tablets in Nigeria 尼日利亚多源氯丙嗪片中盐酸氯丙嗪含量的比较测定

International journal of health research and innovation Pub Date : 2010-06-08 DOI: 10.4314/IJHR.V1I1.55344

H. Okeri, P. Alonge, E. Etareri

{"title":"Comparative determination of chlorpromazine hydrochloride content in multi-sourced chlorpromazine tablets in Nigeria","authors":"H. Okeri, P. Alonge, E. Etareri","doi":"10.4314/IJHR.V1I1.55344","DOIUrl":"https://doi.org/10.4314/IJHR.V1I1.55344","url":null,"abstract":"Purpose: Although different brands or unbranded chlorpromazine tablets from multiple sources are available in Nigeria today, they must all contain the same active principle and satisfy the standards of quality, efficacy and safety. This study is designed to check for possible faking and adulteration of chlorpromazine tablets and also establish the possibility of inter-brand substitution based on drug content (chemical equivalence). Method: The determination of the chlorpromazine hydrochloride \u0000content was carried using non-aqueous titrimetric and \u0000spectrophotometric methods. Glacial acetic acid and acetone were used as the non-aqueous solvent and equivalence points were determined using visual indicators and potentiometer. Results: The results obtained showed that all the brands analyzed met the specification of the British Pharmacopoeia and so contain acceptable amounts of chlorpromazine drug content thus enabling possible brand substitution. Statistical comparison showed no significant difference between \u0000the results obtained by determining end-point using \u0000visual indicators and the potentiometer. Conclusion: The use of the visual indicator method is recommended \u0000for fast and accurate routine laboratory analytical work especially in developing nations. \u0000 \u0000Keywords: Chlorpromazine, non-aqueous titration, spectrophotometric determination, potentiometry","PeriodicalId":93450,"journal":{"name":"International journal of health research and innovation","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86364402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1