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[Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid]. [马来海松酸酰胺和臭氧分解产物的合成和药理活性]。
Bioorganicheskaia khimiia Pub Date : 2010-11-01
O B Kazakova, E V Tret'iakova, O S Kukovinets, G A Tolstikov, T I Nazyrov, I V Chudov, A F Ismagilova
{"title":"[Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid].","authors":"O B Kazakova,&nbsp;E V Tret'iakova,&nbsp;O S Kukovinets,&nbsp;G A Tolstikov,&nbsp;T I Nazyrov,&nbsp;I V Chudov,&nbsp;A F Ismagilova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synthesis of a new group of maleopimaric acid amides containing fragments of the methyl esters of amino acids, aliphatic amines, imidazole and N-methylpiperazine was carried out. Ozonolysis of methyl maleopimarate flows through the cleavage of double bond C18(19) and the disclosure of anhydrous cycle with formation of secotriacid. As a result of screening of anti-inflammatory and antiulcer activity of maleopimaric acid derivatives new effective compounds such as methyl esters of maleopimaric acid and product of ozonolysis - diterpenic secotriacid, maleopimaric acid amide with L-leucine were revealed. An important advantage of the compounds studied is the low toxicity and the presence of bidirectional activity in the absence of adverse effects on the animal.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 6","pages":"832-40"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29669442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthesis and antiviral evaluation against Vaccinia virus of new N¹-oxide analogues of 5'-noraristeromycin]. [5'-去甲马霉素N¹-氧化物类似物的合成及对牛痘病毒的抗病毒评价]。
Bioorganicheskaia khimiia Pub Date : 2010-11-01
E S Matiugina, K L Seley-Radtke, V L Andronova, G A Galegov, S N Kochetkov, A L Khandazhinskaia
{"title":"[Synthesis and antiviral evaluation against Vaccinia virus of new N¹-oxide analogues of 5'-noraristeromycin].","authors":"E S Matiugina,&nbsp;K L Seley-Radtke,&nbsp;V L Andronova,&nbsp;G A Galegov,&nbsp;S N Kochetkov,&nbsp;A L Khandazhinskaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>New N¹-benzyl esters of N¹-oxide analogues of 5'-noraristeromycin were synthesized and tested as potential inhibitors of S-adenosyl-L-homocysteine hydrolase in Vaccinia virus infected cell systems.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 6","pages":"797-801"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29669438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Three new polyhydroxysteroids from the tropical starfish Asteropsis carinifera]. [从热带海星Asteropsis carinifera中提取的三种新的多羟基类固醇]。
Bioorganicheskaia khimiia Pub Date : 2010-11-01
T V Maliarenko, A A Kicha, N V Ivanchina, A I Kalinovskiĭ, P S Dmitrenok, A V Smirnov
{"title":"[Three new polyhydroxysteroids from the tropical starfish Asteropsis carinifera].","authors":"T V Maliarenko,&nbsp;A A Kicha,&nbsp;N V Ivanchina,&nbsp;A I Kalinovskiĭ,&nbsp;P S Dmitrenok,&nbsp;A V Smirnov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirteen steroidal compounds including three new polyhydroxysteroids, (24R,25S)-24-methyl-5α-cholestane-3β,6α,8,15β,16β,26-hexaol, (22E,24R,25S)-24-methyl-5α-cholest-22-ene-3β,6α,8,15β,16β,26-hexaol and (22E,24R,25S)-24-methyl-5α-cholest-22-ene-3β,4β,6α,8,15β,16β,26-heptaol, have been isolated along with the previously known ten polyhydroxysteroids from the tropical starfish Asteropsis carinifera collected near the coast of Vietnam. The structures of new compounds were elucidated by spectroscopic methods (mainly 2D NMR and ESI-mass-spectrometry).</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 6","pages":"825-31"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29668819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunochemical characteristics of synthetic peptides incorporating T- and B-cell epitopes nonspecific porins of pathogenic Yersinia]. [结合致病性耶尔森菌T和b细胞表位非特异性孔蛋白的合成肽的免疫化学特性]。
Bioorganicheskaia khimiia Pub Date : 2010-11-01
O Iu Portniagina, O V Sidorova, O D Novikova, O P Vostrikova, V A Khomenko, T F Solov'eva
{"title":"[Immunochemical characteristics of synthetic peptides incorporating T- and B-cell epitopes nonspecific porins of pathogenic Yersinia].","authors":"O Iu Portniagina,&nbsp;O V Sidorova,&nbsp;O D Novikova,&nbsp;O P Vostrikova,&nbsp;V A Khomenko,&nbsp;T F Solov'eva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multiple antigenic peptides (MAPs), a sequence which include common antigenic epitopes of outer membrane porins (OM) bacteria of the genus Yersinia (Y. pseudotuberculosis, Y. enterocolitica, Y. pestis), pathogenic for humans have been synthesized. After immunization of BALB/c mice the antiserum to the peptide have been obtained. With the help of ELISA we showed that these sera interact with porins isolated from OM pathogenic Yersinia, and MAP interact with antibodies in sera from rabbits immunized with individual porins, and with antibodies in sera of patients with intestinal yersiniosis and pseudotuberculosis.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 6","pages":"779-88"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29669439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Subtyping of influenza virus A hemagglutinine with hybridization microarray]. 流感病毒A型血凝素的杂交芯片分型研究
Bioorganicheskaia khimiia Pub Date : 2010-11-01
V A Riabinin, E V Kostina, G A Maksakova, A N Siniakov
{"title":"[Subtyping of influenza virus A hemagglutinine with hybridization microarray].","authors":"V A Riabinin,&nbsp;E V Kostina,&nbsp;G A Maksakova,&nbsp;A N Siniakov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An oligonucleotide microarray for influenza A hemagglutinine subtyping was presented. The number of probes for determination of each subtype hemagglutinine (H1-H13, H15, H16, pandemic flu H1N1)varied from 13 to 28. When testing of the microarray using 40 type A influenza virus isolates the hemagglutinin subtypes were unambiguously determined for 36 specimens.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 6","pages":"849-52"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29669445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Monoclonal antibody based enzyme-linked immunosorbent assay for aminoglycoside antibiotic kanamycin in foodstuff]. [基于单克隆抗体的食品中氨基糖苷类抗生素卡那霉素的酶联免疫吸附测定]。
Bioorganicheskaia khimiia Pub Date : 2010-11-01
I A Gal'vidis, M A Burkin
{"title":"[Monoclonal antibody based enzyme-linked immunosorbent assay for aminoglycoside antibiotic kanamycin in foodstuff].","authors":"I A Gal'vidis,&nbsp;M A Burkin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monoclonal antibodies to aminoglycoside antibiotic kanamycin (KM) were raised as a result of mice complex immunization with glutaraldehyde conjugates BSA with KM, tobramycin (TM) and gentamicin. Using antibodies an indirect competitive enzyme-linked immunosorbent assay was developed. This method allows to determine antibiotic up to 1.2 ng/ml in water solutions, milk and eggs and up to 2.5 ng/ml in honey. The recovery rate from these products spiked with KM was 83, 84 and 96% respectively. The assay of KM based on homologous and heterologous solid-phase conjugates were estimated. The cross-reactivity with TM could vary from 7 to 54%. The same indexes for of amikacin were more constant and reached 7-8%. The other aminoglycosides showed no inhibitory activity.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 6","pages":"789-96"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29669437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses]. [合成三萜酰化物——一种有效抑制甲型H1N1流感病毒和乳头瘤病毒繁殖的物质]。
Bioorganicheskaia khimiia Pub Date : 2010-11-01
O B Kazakova, N I Medvedeva, I P Baĭkova, G A Tolstikov, T V Lopatina, M S Iunusov, L Zaprutko
{"title":"[Synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses].","authors":"O B Kazakova,&nbsp;N I Medvedeva,&nbsp;I P Baĭkova,&nbsp;G A Tolstikov,&nbsp;T V Lopatina,&nbsp;M S Iunusov,&nbsp;L Zaprutko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synthesis of a new group of triterpenoid acylates on the basis of oleanolic, glycyrrhetic and ursolic acids and betulin is described. In studying the activity of the synthesized compounds in relation to reproduction of virus pathogens of respiratory infections 28-O-methoxycynnamoylbetulin shows high activity against influenza type A (H1N1) the selectivity index SI > 100. The high activity of 3,28-dinicotinoylbetulin against papilloma virus (strain HPV-11) was detected, the selectivity index SI was 35.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 6","pages":"841-8"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29669444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Oligoglycine surface structures: molecular dynamics simulation]. [寡甘氨酸表面结构:分子动力学模拟]。
Bioorganicheskaia khimiia Pub Date : 2010-09-01
O A Gus'kova, P G Khalatur, A R Khokhlov, A A Chinarev, S V Tsygankova, N V Bovin
{"title":"[Oligoglycine surface structures: molecular dynamics simulation].","authors":"O A Gus'kova,&nbsp;P G Khalatur,&nbsp;A R Khokhlov,&nbsp;A A Chinarev,&nbsp;S V Tsygankova,&nbsp;N V Bovin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The full-atomic molecular dynamics (MD) simulation of adsorption mode for diantennary oligoglycines [H-Gly4-NH(CH2)5]2 onto graphite and mica surface is described. The resulting structure of adsorption layers is analyzed. The peptide second structure motives have been studied by both STRIDE (structural identification) and DSSP (dictionary of secondary structure of proteins) methods. The obtained results confirm the possibility of polyglycine II (PGII) structure formation in diantennary oligoglycine (DAOG) monolayers deposited onto graphite surface, which was earlier estimated based on atomic-force microscopy measurements.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 5","pages":"622-9"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29457289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The dependence of cytotoxicity and antioxidant activity of ammonii derivatives of alkylphenols upon percularities of their structure]. [烷基酚的氨衍生物的细胞毒性和抗氧化活性取决于其结构的复杂性]。
Bioorganicheskaia khimiia Pub Date : 2010-07-01
U N Rotskaia, L P Ovchinnikova, E A Vasiunina, O I Sinitsina, O I Diubchenko, N V Kandalintseva, A E Prosenko, G A Nevinskiĭ
{"title":"[The dependence of cytotoxicity and antioxidant activity of ammonii derivatives of alkylphenols upon percularities of their structure].","authors":"U N Rotskaia,&nbsp;L P Ovchinnikova,&nbsp;E A Vasiunina,&nbsp;O I Sinitsina,&nbsp;O I Diubchenko,&nbsp;N V Kandalintseva,&nbsp;A E Prosenko,&nbsp;G A Nevinskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Effect of seven structurally similar N, N-dimethyl-(4-hydroxyaryl)alkylammonium chlorides in the presence and in the absence of hydrogen peroxide on the survival of E. coli cells AB1157 and its isogenic strain BH910 defective in genes of repair enzymes has been analyzed. Among the studied compounds only chloride of N,N-dimethyl-(3,5-dimethyl-4-hydroxybenzyl)ammonium (C1) has no cytotoxic properties and increases the survive of the cells of both strains in the presence of H2O2 better than trolox (water soluble analog of alpha-tocopherol). C1 analogs: 3-methyl-(5-di(tert-butyl)-4-hydroxybenzyl) and 3-(3,5-di(tert-butyl)-4-hydroxyphenyl)propyl)amines derivatives effectively protected from H2O2 only mutant cells BH910. Among the structural analogs of C1 cytotoxicity increases at substitution of methyl groups in aromatic cycle by tert-butyl and cyclohexyl groups. Only C1 among the seven new compounds is the most promising antioxidant for the subsequent more detailed analysis.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 4","pages":"563-9"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29291615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antiviral activity of 2,3-secotriterpenic hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type]. [狼烷和19 -，28-环氧-18 -齐墩烷型2,3-二萜腙的抗病毒活性]。
Bioorganicheskaia khimiia Pub Date : 2010-07-01
N V Galaĭko, I A Tolmacheva, V V Grishko, L V Volkova, E N Prevozchikova, S A Pestereva
{"title":"[Antiviral activity of 2,3-secotriterpenic hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type].","authors":"N V Galaĭko,&nbsp;I A Tolmacheva,&nbsp;V V Grishko,&nbsp;L V Volkova,&nbsp;E N Prevozchikova,&nbsp;S A Pestereva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Novel hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type have been synthesized via interaction of 2,3-secotriterpenic aldehydonitriles with substituted hydrazines. As a result of investigation of 2,3-secotriterpenic hydrazones antiviral activity to the strain \"Indiana\" of vesicular stomatitis virus on two models of mammal's line cell infection, acetylhydrazone 1-cyano-2,3-seco-19beta,28-epoxy-18alpha-olean-3-al has been found to have a high prophylactic activity 0.00016 microg/ml to vesicular stomatitis virus and to inhibit a virus reproduction in primarily infected cells in 0.21 microg/ml concentration.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"36 4","pages":"556-62"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29291618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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