流感病毒A型血凝素的杂交芯片分型研究

Bioorganicheskaia khimiia Pub Date : 2010-11-01

V A Riabinin, E V Kostina, G A Maksakova, A N Siniakov

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引用次数: 0

摘要

提出了一种甲型流感血凝素亚型的寡核苷酸芯片。检测各亚型血凝素(H1-H13、H15、H16、大流行性流感H1N1)的探针数量从13个到28个不等。当使用40种A型流感病毒分离物对微阵列进行检测时，36种标本的血凝素亚型得到了明确的确定。

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[Subtyping of influenza virus A hemagglutinine with hybridization microarray].

An oligonucleotide microarray for influenza A hemagglutinine subtyping was presented. The number of probes for determination of each subtype hemagglutinine (H1-H13, H15, H16, pandemic flu H1N1)varied from 13 to 28. When testing of the microarray using 40 type A influenza virus isolates the hemagglutinin subtypes were unambiguously determined for 36 specimens.

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Bioorganicheskaia khimiia

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