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In vitro delivery of curcumin with cholesterol-based cationic liposomes. 姜黄素与胆固醇基阳离子脂质体的体外递送。
Bioorganicheskaia khimiia Pub Date : 2013-07-01
N Apiratikul, T Penglong, K Suksen, S Svasti, A Chairoungdua, B Yingyongnarongkula
{"title":"In vitro delivery of curcumin with cholesterol-based cationic liposomes.","authors":"N Apiratikul,&nbsp;T Penglong,&nbsp;K Suksen,&nbsp;S Svasti,&nbsp;A Chairoungdua,&nbsp;B Yingyongnarongkula","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new cholesterol-based cationic lipid was synthesized; liposomes prepared on its basis were evaluated as drug delivery vehicles for curcumin. Free and liposome-encapsulated curcumin cytotoxicity against HeLa, A549, HepG2, K562 and 1301 cell lines was assessed. Liposomal curcumin with ED50 values ranging from 2.5-10 microM exhibited 2-8 times higher cytotoxicity than free curcumin. The synthetic cholesterol-based cationic lipid also enhanced cellular uptake of curcumin into tested cells. Cationic liposome alone showed low cytotoxicity at high doses with ED50 values of 90-210 microM.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 4","pages":"497-503"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32242042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Glycosilated derivatives of substituted hydroxylamine. II. Phase transfer synthesis and investigation of glycosyl transfer reaction of glucosaminides of substituted hydroxylavine]. 取代羟胺的糖硅氧烷化衍生物。2取代羟基丙烷氨基葡萄糖的相转移合成及糖基转移反应研究[j]。
Bioorganicheskaia khimiia Pub Date : 2013-07-01 DOI: 10.7868/s0132342313030081
V O Kur'ianov, A A Lushchik, T A Chupakhina
{"title":"[Glycosilated derivatives of substituted hydroxylamine. II. Phase transfer synthesis and investigation of glycosyl transfer reaction of glucosaminides of substituted hydroxylavine].","authors":"V O Kur'ianov,&nbsp;A A Lushchik,&nbsp;T A Chupakhina","doi":"10.7868/s0132342313030081","DOIUrl":"https://doi.org/10.7868/s0132342313030081","url":null,"abstract":"<p><p>1-(2-Acetamido-3,4,6,-tri-O-acetyl-2-deoxy-beta-D-glucopyranosyloxy)-benzotriazole reacted in boiling dichloromethane, in the presence of Luis acids as a promotors with primary and secondary aliphatic and cycloaliphatic alcohols and diisopropilidene galactose with alkyl-O-1,2-trans-glucosaminides formation. It was shown that the other glucosaminides of substituted hydroxylamine are not participated in this reaction. Structures of glucosaminides were identify by 1H-NMR-spectroscopy and comparison with known compounds.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 4","pages":"477-85"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32241114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A compact microarray for sub-typing of influenza A virus]. [用于甲型流感病毒分型的紧凑型微阵列]。
Bioorganicheskaia khimiia Pub Date : 2013-05-01 DOI: 10.7868/s0132342313030123
V A Riabinin, E V Kostina, A N Siniakov
{"title":"[A compact microarray for sub-typing of influenza A virus].","authors":"V A Riabinin,&nbsp;E V Kostina,&nbsp;A N Siniakov","doi":"10.7868/s0132342313030123","DOIUrl":"https://doi.org/10.7868/s0132342313030123","url":null,"abstract":"<p><p>A universal oligonucleotide hybridazation microchip 6 x 5 spot (4 x 4 mm) for influenza A virus subtyping was suggested, functioning on a principle one spot--one subtype. This microchip with additional printing quality control is a prototype of a biosensor for detection of influenza A virus and typing of 15 subtypes of hemagglutinin and 9 subtypes of neuraminidase.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 3","pages":"378-80"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32007036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthesis of aminopropylaminoderivatives of betulinic and oleanolic acids]. [白桦酸和齐墩果酸的氨基丙基氨基衍生物的合成]。
Bioorganicheskaia khimiia Pub Date : 2013-05-01 DOI: 10.7868/s0132342313020061
G V Giniiatullina, O B Kazakova, N I Medvedeva, I V Sorokina, N A Zhukova, T G Tolstikova, G A Tolstikov
{"title":"[Synthesis of aminopropylaminoderivatives of betulinic and oleanolic acids].","authors":"G V Giniiatullina,&nbsp;O B Kazakova,&nbsp;N I Medvedeva,&nbsp;I V Sorokina,&nbsp;N A Zhukova,&nbsp;T G Tolstikova,&nbsp;G A Tolstikov","doi":"10.7868/s0132342313020061","DOIUrl":"https://doi.org/10.7868/s0132342313020061","url":null,"abstract":"<p><p>On the basis of betulinic and oleanolic acids triterpenoids with different with different amine fragments: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, (3-aminopropyl)-4-aminosulfonyl-4-phenylamino- at positions C3 and C28 were synthesized. It is shown that betulonic acid amide with 4,4'-diaminodiphenylsulfonic substituent don't render antitumor effect in mice with transplantable Lewis lung carcinoma, but possess significant anti-inflammatory activity.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 3","pages":"369-77"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32006157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections. 新型螺旋衍生物的合成及其对癣感染的协同加性抑制作用。
Bioorganicheskaia khimiia Pub Date : 2013-05-01
Gajanand Sharma, Richa Sharma, Anshu Dandia, Preeti Bansal
{"title":"Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections.","authors":"Gajanand Sharma,&nbsp;Richa Sharma,&nbsp;Anshu Dandia,&nbsp;Preeti Bansal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-DHPs) incorporating 2-oxindole/piperidines is performed in 5-8 min with reasonable purity in 80-90% yield under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermatophytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment of dermatophytosis or ringworm infections.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 3","pages":"358-68"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32006156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Synthetic conformational antigen, simulating the extracellular part of M2-muscarinic receptor and its reactivity with sera from patients with idiopathic arrhythmias]. [合成构象抗原，模拟m2 -毒蕈碱受体细胞外部分及其与特发性心律失常患者血清的反应性]。
Bioorganicheskaia khimiia Pub Date : 2013-05-01 DOI: 10.7868/s013234231303010x
M E Pal'keeva, M V Sidorova, A S Molokoedov, A A Az'muko, Zh D Bespalova, T V Sharf, E N Mamochkina, E E Efremov, M M Rogova, N A Mironova, K A Zykov, S P Golitsyn
{"title":"[Synthetic conformational antigen, simulating the extracellular part of M2-muscarinic receptor and its reactivity with sera from patients with idiopathic arrhythmias].","authors":"M E Pal'keeva,&nbsp;M V Sidorova,&nbsp;A S Molokoedov,&nbsp;A A Az'muko,&nbsp;Zh D Bespalova,&nbsp;T V Sharf,&nbsp;E N Mamochkina,&nbsp;E E Efremov,&nbsp;M M Rogova,&nbsp;N A Mironova,&nbsp;K A Zykov,&nbsp;S P Golitsyn","doi":"10.7868/s013234231303010x","DOIUrl":"https://doi.org/10.7868/s013234231303010x","url":null,"abstract":"<p><p>Linear peptides corresponding to fragment 83-98 of the first loop and fragments 168-192 and 171-182 of the second extracellular loops of M2-muscarinic receptor (marker of early cardiac disorders and arrhythmias) were synthesized by Fmoc-SPPS method. A new conformational antigen was synthesized by method of selective ligation of linear peptides by disulfide bond with native localization. Peptides were studied in reaction with sera from patients with idiopathic arrhythmias. A new conformational antigen was recognized by sera from patients with idiopathic arrhythmias with high reactivity.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 3","pages":"285-92"},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32006208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluation of novel isoxazolo[4,3-e]indoles as antibacterial agents. 新型异恶唑[4,3-e]吲哚类抗菌药物的合成及生物学评价。
Bioorganicheskaia khimiia Pub Date : 2013-03-01
Mehdi Pordel, Amin Abdollahi, Bahareh Razavi
{"title":"Synthesis and biological evaluation of novel isoxazolo[4,3-e]indoles as antibacterial agents.","authors":"Mehdi Pordel,&nbsp;Amin Abdollahi,&nbsp;Bahareh Razavi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The synthesis of a new series of 8-bromo-6-alkyl-1-aryl-6H-isoxazolo[4,3-e]indole derivatives is described. All the newly synthesized compounds were screened for their antibacterial activity against Escherichia coli HB101, Staphylococcuse aureus pathogens (methicillin resistant S. aureus and methicillin susceptible S. aureus), Pseudomonas aeruginosa, and Bacillus subtilis; also MIC values of these compounds were determined.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 2","pages":"240-3"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31673145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Unusual amidation reaction of Asn-containing glycopeptide antibiotics using the coupling reagent PyBOP]. [偶联剂PyBOP对含砷糖肽抗生素的异常酰胺化反应]。
Bioorganicheskaia khimiia Pub Date : 2013-03-01 DOI: 10.7868/s0132342313020097
E N Olsuf'eva, S E Solov'eva, M I Reznikova, A M Korolev, M N Preobrazhenskaia
{"title":"[Unusual amidation reaction of Asn-containing glycopeptide antibiotics using the coupling reagent PyBOP].","authors":"E N Olsuf'eva,&nbsp;S E Solov'eva,&nbsp;M I Reznikova,&nbsp;A M Korolev,&nbsp;M N Preobrazhenskaia","doi":"10.7868/s0132342313020097","DOIUrl":"https://doi.org/10.7868/s0132342313020097","url":null,"abstract":"<p><p>The coupling reagent PyBOP is widely used for the synthesis of different peptides and their amides, particularly for carboxamides of glycopeptide antibiotics of vancomycin or teicoplanin groups. The amidation reaction of the peptide core of the glycopeptide antibiotic eremomycin (I) with highly reactive amines in the presence of PyBOP is usually not accompanied by the formation of side products. However, the amidation of I with bulky amines (e.g., decyl amine and adamantyl amine) in the presence of PyBOP and Et3N or di-(i-Pr)2EtN (pH - 8.5) yielded N-unsubstituted carboxamide of eremomycin (Ia) as an admixture. The reaction of (I) or vancomycin (II) with an excess of PyBOP and Et3N (pH - 8.5) without addition of an amine or ammonia gave a mixture of products which contained higher amounts of the corresponding N-unsubstituted carboxamides (-20%). The structures of the samples of Ia and vancomycin amide (IIa) were proved by 1H NMR and ESI MS methods and confirmed by comparing with the authentic samples.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 2","pages":"141-50"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31673254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Investigation of fluorescent components of drug "heparin" and its complexing with phenylalanine, tyrosine and tryptophan]. [药物“肝素”的荧光成分及其与苯丙氨酸、酪氨酸和色氨酸络合的研究]。
Bioorganicheskaia khimiia Pub Date : 2013-01-01 DOI: 10.7868/s0132342313010090
S S Astakhov, V M Iunusov, M V Sultanbaev, G Kh Akhmadeeva, M S Iunusov
{"title":"[Investigation of fluorescent components of drug \"heparin\" and its complexing with phenylalanine, tyrosine and tryptophan].","authors":"S S Astakhov,&nbsp;V M Iunusov,&nbsp;M V Sultanbaev,&nbsp;G Kh Akhmadeeva,&nbsp;M S Iunusov","doi":"10.7868/s0132342313010090","DOIUrl":"https://doi.org/10.7868/s0132342313010090","url":null,"abstract":"<p><p>Using spectral-luminescent and spectrophotometric methods a composition of aminoacidic (AA) and protein components of commercial drug of heparin (Hep) as well as its interaction with Trp, Tyr and Phe was studied. The impurities of aromatic aminoacids Phe, Tyr and elastin protein was revealed in drug of heparin. The quenching of fluorescence (FL) of Trp, Tyr and Phe with heparin was studied and the Stern-Volmer Constants (K) showing the stability of its complexes with aminoacids were determined. The stability of complexes AA...Hep increases in the series K (Trp...Hep) = 19 +/- 2 M(-1) < K (Tyr...Hep) = 39 +/- 3 M(-1) < K (Phe...Hep) = 710 +/- 70 M(-1), that, probably, determines dominating contribution of Phe impurity in heparin and the absence of that of tryptophan. It was assumed, that animal elastin, which is different from human one can provoke allergic reactions up to anaphylactic shock.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31571951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bacterial pigment prodigiosin and its genotoxic effects]. 细菌色素prodigiosin及其基因毒性作用。
Bioorganicheskaia khimiia Pub Date : 2013-01-01 DOI: 10.7868/s0132342312060048
I D Gur'ianov, N S Karamova, D V Iusupova, O I Gnezdilov, L A Koshkarova
{"title":"[Bacterial pigment prodigiosin and its genotoxic effects].","authors":"I D Gur'ianov,&nbsp;N S Karamova,&nbsp;D V Iusupova,&nbsp;O I Gnezdilov,&nbsp;L A Koshkarova","doi":"10.7868/s0132342312060048","DOIUrl":"https://doi.org/10.7868/s0132342312060048","url":null,"abstract":"<p><p>The prodigiosin preparation was isolated and purified from Serratia marcescens ATCC 9986, using chromatographic methods. The analysis of the preparation by TLC, NMR-spectrometry and mass-spectrometry allowed to confirm the red pigment fraction as the prodigiosin and detect its purity. Originally, the specific features of the toxic and genotoxic effects of prodigiosin and the possibility of induction of mutations by pigment in the cells of Salmonella typhimurium TA 100 (Ames test) and chromosome damage of mammalian erythroblasts have been determined.</p>","PeriodicalId":9325,"journal":{"name":"Bioorganicheskaia khimiia","volume":"39 1","pages":"121-8"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31572896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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