新型异恶唑[4,3-e]吲哚类抗菌药物的合成及生物学评价。

Bioorganicheskaia khimiia Pub Date : 2013-03-01
Mehdi Pordel, Amin Abdollahi, Bahareh Razavi
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引用次数: 0

摘要

报道了一系列新的8-溴-6-烷基-1-芳基-6- h -异恶唑[4,3-e]吲哚衍生物的合成。新合成的化合物对大肠杆菌HB101、金黄色葡萄球菌病原菌(耐甲氧西林金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌)、铜绿假单胞菌和枯草芽孢杆菌的抑菌活性进行了筛选;测定了这些化合物的MIC值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and biological evaluation of novel isoxazolo[4,3-e]indoles as antibacterial agents.

The synthesis of a new series of 8-bromo-6-alkyl-1-aryl-6H-isoxazolo[4,3-e]indole derivatives is described. All the newly synthesized compounds were screened for their antibacterial activity against Escherichia coli HB101, Staphylococcuse aureus pathogens (methicillin resistant S. aureus and methicillin susceptible S. aureus), Pseudomonas aeruginosa, and Bacillus subtilis; also MIC values of these compounds were determined.

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