Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections.

Bioorganicheskaia khimiia Pub Date : 2013-05-01
Gajanand Sharma, Richa Sharma, Anshu Dandia, Preeti Bansal
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引用次数: 0

Abstract

An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-DHPs) incorporating 2-oxindole/piperidines is performed in 5-8 min with reasonable purity in 80-90% yield under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermatophytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment of dermatophytosis or ringworm infections.

新型螺旋衍生物的合成及其对癣感染的协同加性抑制作用。
在微波辐射下,以KSF蒙脱土为无机固体载体,在5 ~ 8 min内合成了含2-氧吲哚/哌啶的各种螺-1,4-二氢吡啶(1,4- dhps),纯度合理,产率为80 ~ 90%。对于各种环羰基化合物,如环己酮、取代吲哚-2,3-二酮和哌啶酮衍生物,发现该反应是普遍的。在我们的研究中,这些化合物也被发现对皮肤真菌和其他真菌生物有效。我们的结果表明,新的螺旋衍生物可用于治疗皮肤癣或癣感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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