British journal of pharmaceutical research最新文献

{"title":"Development of Anti-bacterial Ointment from Two Extracts of Curcuma longa L. and Aloe vera L.","authors":"Abdulkarim K. Y. Alzomor, N. Noman, Lamia'a Al-Akhali, Ahmed Al-Qubati, Ahmed Al-Shawafi, Adnan Al-Serry, Sadam Al-Zedaar","doi":"10.9734/BJPR/2017/33737","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33737","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"30 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80128428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General Anaesthesia for Cesarean Section in a Parturient with Long QT Syndrome: A Case Report and a Review of Literature","authors":"N. Kayacan, B. Karsli, U. Ince","doi":"10.9734/bjpr/2017/31699","DOIUrl":"https://doi.org/10.9734/bjpr/2017/31699","url":null,"abstract":"Long QT syndrome patients are at high risk of developing ventricular arrhythmia and cardiac arrest, so that the anesthetic technique used for these patients must avoid anything that will induce an arrhythmia such as tachycardia, hypotension or increased catecholamine release by pain or stress. A 28 -yr-old woman was scheduled for an elective, repeat cesarean section at 36 weeks gestation. She was diagnosed long QT syndrome at age 22 and an automatic implantable cardiac defibrillator (AICD) was implanted. During her pregnancy, parturient was hospitalized at 35 weeks gestation because of fetal bradycardia and obstetrician scheduled cesarean section at 36 weeks gestation. Before induction of anaesthesia, esmolol 200mcg.kg.min -1 was started for prevention of ventricular dysrhythmia during laryngoscopy and tracheal intubation. After preoxygenation, anaesthesia was induced with fentanyl 100mcg, propofol 200mg, rocuronium 100 mg and trachea was intubated at 45 seconds. Esmolol infusion rate was reduced gradually to parturient’s Case Study Kayacan et al.; BJPR, 15(2): 1-7, 2017; Article no.BJPR.31699 2 haemodynamic parameters during surgery and was stopped at end of the surgery. At 4 minutes of the surgery, fetus was deliveried but there is no heart rate and breathing of baby. Following cardiac compression for 45 seconds, heart rate and breathing of baby returned. Anaesthesia was maintained with 1 MAC sevoflurane and 100 mcg fentanyl. Parturient’s blood pressure and heart rate remained within normal limits during surgery. Consequently, if parturient does not accept regional anaesthesia, in case of an emergency cesarean section, general anaesthesia can be safely used with optimized preoperative evaluation, close monitoring and carefully anaesthetic management.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"26 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86946973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Chemical Constituent Analysis, in vitro Antioxidant and Antimicrobial Activity of Whole Plant Methanol Extracts of Ulva lactuca Linn","authors":"Vijayalingam Alagan, R. Valsala, K. Rajesh","doi":"10.9734/BJPR/2017/31818","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31818","url":null,"abstract":"Aims: To analyse the bioactive chemical constituents and evaluate in vitro antioxidant and antimicrobial activities of whole plant methanol extracts of Ulva lactuca Linn. Study Design: Preliminary phytochemical screening, Gas Chromatography-Mass Spectrometry (GC-MS) analysis, evaluation of antioxidant and antimicrobial activities. Place and Duration of Study: Veterinary University Training and Research Centre, Ramanathapuram-623503, Department of Botany, A.V.V.M Sri Pushpam college, Poondi, Thanjavur-613503 and K.M.C.H college of pharmacy, Kovai Estate, Kalapatti Road, Coimbatore641048. The studies were carried out during August-December 2016. Methodology: Phytochemical constituents were identified by qualitative and GC-MS analysis. Original Research Article Alagan et al.; BJPR, 15(1): 1-14, 2017; Article no.BJPR.31818 2 In vitro antioxidant activity of the extracts were studied using DPPH radical scavenging assay, total phenol and total flavonoid content determination assays. Antimicrobial activity was investigated by disc diffusion technique. Results: Phytochemical screening of methanol extracts showed positive results for alkaloids, flavonoids, phenols, tannins, terpenoids, glycosides, steroids, proteins and negative results for saponins and cardiac glycosides. GC-MS analysis revealed the presence of 10 compounds in Ulva lactuca methanolic extracts and some of the phytocomponents screened were terpenoids, fatty acid derivatives and aliphatic hydrocarbons and many of them have antioxidant, anti-inflammatory, antimicrobial and anticancer actions. Methanolic plant extract showed significant antioxidant activity under DPPH free radical scavenging activity, total phenol and total flavonoid content determination assay. In disc diffusion technique among six bacterial species, methanol extract showed potent activity against three Gram positive (Bacillus subtilis, Corynebacterium diphtheriae and Staphylococcus aureus) and three Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella paratyphi). The extracts were more potent towards fungal isolates (Aspergillus niger and Aspergillus fumigatus) and no activity reported in Candida albicans. Conclusion: The results demonstrate that methanolic extracts of whole plant of U. lactuca can be used as a potential source of antioxidant and antimicrobial agent.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"13 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90281067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and Characterization of β-Sitosterol-3-O-β-D-glucoside from the Extract of the Flowers of Viola odorata","authors":"Tania Peshin, H. Kar","doi":"10.9734/BJPR/2017/33160","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33160","url":null,"abstract":"Isolation from the ethanol extract of the flowers of Viola odorata resulted in the isolation of βSitosterol-β-D-glucoside. This compound has not been previously isolated or reported from the flowers of this variety. The isolated β-Sitosterol-3-O-β-D-glucosidewas characterized on the basis of spectroscopic techniques viz. infrared and nuclear magnetic resonance spectroscopy. A tetra acetyl derivative of β-Sitosterol-3-O-β-D-glucoside was synthesized and characterized. On hydrolysis of β-Sitosterol-β-D-glucoside, β-sitosterol was obtained and characterized.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"238 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77015536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifilarial Activity of Cucurbita pepo ovifera var ovifera (Cucurbitaceae) on Onchocerca ochengi Adult Worms","authors":"Justin Kalmobé, D. Ndjonka, J. Dikti, E. Liebau","doi":"10.9734/BJPR/2017/33381","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33381","url":null,"abstract":"One of the strategies for developing novel pharmaceutical drugs is to use natural sources such as plants for therapeutic treatment. Plant extracts are a cocktail of compounds which act synergically and can improve treatment effectiveness, reduce therapeutic duration and resistance. The ethanolic extracts of leaves and seeds of Cucurbita pepo ovifera var ovifera from Sudano-Guinean and Sudano-Sahelian zones of Cameroon were evaluated on the cattle parasite nematode Onchocerca ochengi. Worms were incubated with different concentrations of the plant extracts in RPMI-1640 supplemented with streptomycin and gentamicin. Mortality at 37°C was monitored after 24, 48 and 72 h. Ivermectin was used as positive control and DMSO as negative. Plant extracts Original Research Article Kalmobé et al.; BJPR, 17(2): 1-8, 2017; Article no.BJPR.33381 2 from the two ecological zones showed anthelminthic activities on O. ochengi after 72 h with LC50 varying from 20 to 1090 μg /mL. The highest antifilarial activity in Sudano-Guinean zone was obtained with leave extract of C. pepo ovifera (LC50 of 20 μg/mL), while highest antifilarial activity in Sudano-Sahelian zone was obtained with seed extracts of the plant with LC50 value of 17 μg/mL after 72 h. These results show that anthelmintic activity depends on the part of the plant and the ecological zones. Additionally, the plant is not toxic. These results on the ethanolic extracts of leaves and seeds of C. pepo ovifera var ovifera confirmed the use of this plant in traditional medicine in Cameroon to treat disease due to nematodes. The plants could be used as alternative anthelmintic to fight against Human and Bovine onchocerciasis.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"109 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82497353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrimethamine Based Anti-protozoan Agents from Isostere and Heuristic Structure-similarity Search","authors":"Ronald Bartzatt","doi":"10.9734/BJPR/2017/33205","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33205","url":null,"abstract":"Aims: To generate new medicaments for control and treatment of the parasitic protozoan Toxoplasma gondii. Study Design: Structure similarity search and isostere search was conducted over a broad range of structure categories. Correlation and highest similarity scores were implemented to select the best drug candidates.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"9 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72820732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Commercially Used Antibacterial Agents against Oral Bacteria Associated with HIV/AIDS Patients in South Western Uganda","authors":"J. Ezeonwumelu, M. Ntale, S. Ogbonnia, Ezera Agwu, J. Tanayen, Dr. Keneth Iceland Kasozi, Ambrose Amamchukwu Akunne, C. Okonkwo, F. Byarugaba","doi":"10.9734/BJPR/2017/33211","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33211","url":null,"abstract":"Aims: This was to determine efficacy and resistance profiles against commonly used commercial antibacterial agents in Uganda in the management of oral pathogens in HIV/AIDS patients. Study Design: This was an experimental study. Place and Duration of Study: Microbiology Laboratory, Mbarara University of Science and Technology, Mbarara, Uganda between September 2015 and February 2016. Methodology: Bacterial isolates were tested against commercial antibacterial agents in Uganda. Drug shops, pharmacies and hospitals were purposively and conveniently sampled. Drugs commonly used for the management of opportunistic infections amongst HIV/AIDS patients were purchased and used in the laboratory for susceptibility, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using standard protocols. Results: All the bacterial isolates showed mean total resistance above 60% against erythromycin [85 isolates (69.7%)] and cotrimoxazole [79 isolates, (64.8%)]; with injectable gentamicin [97 isolates (79.5%)] and ceftriaxone [105 isolates (86.0%)] displaying high susceptibility; and ciprofloxacin [65 isolates (53.3%)] showing moderate susceptibility. This shows that national policy on effective regulation of these antibacterial agents needs to be revised to ensure that the situation is reversed. Gentamicin showed increased significant mean activity (P***< .005, ANOVA, multiple comparisons) in MIC and MBC when compared with the other antimicrobial agents. Conclusion: Gentamicin was highly efficacious in this study and resistance of these oral bacteria to common commercial antibacterial agents is a major public health burden especially among Uganda HIV/AIDS patients. Improving drug regulation activities will reduce antibacterial resistance and treatment failures. We recommend a survey on the reasons for efficacy of gentamicin against all the commercially available antimicrobials used in this study.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"126 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75968847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical and Antimicrobial Properties of Tiliacora triandra Stem Bark","authors":"Md. Mahbubur Rahman, Md Shamsuzzaman, M. Khatun, Md. Mostafijur Rahman, A. S. Hossain, A. Alam, A. Mosaddik, M. I. I. Wahed","doi":"10.9734/BJPR/2017/34059","DOIUrl":"https://doi.org/10.9734/BJPR/2017/34059","url":null,"abstract":"Aim: Tiliacora triandra (T. triandra), a species of Menispermaceae family, has folkloric reputation for the treatment of several diseases including infectious diseases in Thailand and neighboring countries. The present study aimed at screening the stem bark of T. triandra for its phytochemical constituents and its antimicrobial potential against selected bacteria and fungi. Materials and Methods: The dried stem bark of T. triandra was extracted with methanol and qualitative phytochemical analysis was performed. The antimicrobial activity was determined by disc diffusion assay method against some bacteria and fungi. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by serial dilution method to establish the antimicrobial potential of the extract. Results: Qualitative phytochemical analysis revealed the presence of phenolics, flavonoids, Original Research Article Rahman et al.; BJPR, 17(2): 1-9, 2017; Article no.BJPR.34059 2 terpenoids, alkaloids, saponins and cardiac glycosides. Susceptibility testing by disc diffusion assay showed significant antimicrobial activity against the tested pathogens. The highest antibacterial activity was observed against a Gram-negative bacterium Escherichia coli (E. coli) where the zones of inhibition were 15 mm and 21 mm at the potencies of 250 and 500 μg/disc, respectively. The stem bark extract also showed moderate activity against Shigella sonnei (14 mm), Shigella dysenteriae (13 mm), Agrobacterium spp (13 mm) bacteria and fungus, Aspergillus niger (14 mm) at 250 μg/disc. The results also revealed equal MIC and MBC values of 62.5ug/mL against E. coli. Conclusions: Our findings revealed that the methanol extract of T. triandra possesses potent antimicrobial activity which may be attributed to the identified phytochemical components of the plant extract.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"66 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74353505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validated Stability – Indicating Methods for Determination of Oseltamivir Phosphate","authors":"N. Rashed, O. Abdallah, Noha S. Said","doi":"10.9734/BJPR/2017/33044","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33044","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"15 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80187945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of Efficiency of Dissolved Air Flotation in Removal Penicillin G Potassium from Aqueous Solutions","authors":"S. Ahmadi, F. Mostafapour","doi":"10.9734/BJPR/2017/31180","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31180","url":null,"abstract":"Antibiotics are a large group of pharma compounds which are stable in environment. Antibiotics are considered among the major pollutants in water environments. The aim of this study was to evaluate the efficiency of the dissolved air flotation in removal penicillin G potassium from aqueous solutions. This study was an empirical-lab study which the dissolved air flotation was applied in laboratory scale. After determination of the optimal condition of pH and the dosage of poly aluminum, the effect of the effective parameters including the concentration of the coagulant (20, 50, 75, 100 mg/L), penicillin G (25, 50, 100,200), flotation time (5, 10, 15 and 20 sec), saturation pressure (3, 3.5, 4 and 4.5 atm) on the removal efficiency of the penicillin G and COD by dissolve air flotation was studied. The results showed that the dissolved air flotation can reduce COD and Original Research Article penicillin G up to 70.41% and 67.45%, respectively. initial concentration of penicillin G saturation pressure= 4 atm and PAC concentration = 20 mg/L. Also, the results showed that the removal efficiency is reduced by increasing the turbidity in the flotation process. study revealed that the dissolved air flotation process can be effective method to remove the penicillin G from aqueous solution.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"20 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84911602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}