{"title":"Pyrimethamine Based Anti-protozoan Agents from Isostere and Heuristic Structure-similarity Search","authors":"Ronald Bartzatt","doi":"10.9734/BJPR/2017/33205","DOIUrl":null,"url":null,"abstract":"Aims: To generate new medicaments for control and treatment of the parasitic protozoan Toxoplasma gondii. Study Design: Structure similarity search and isostere search was conducted over a broad range of structure categories. Correlation and highest similarity scores were implemented to select the best drug candidates.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"9 1","pages":"1-12"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of pharmaceutical research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/BJPR/2017/33205","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Aims: To generate new medicaments for control and treatment of the parasitic protozoan Toxoplasma gondii. Study Design: Structure similarity search and isostere search was conducted over a broad range of structure categories. Correlation and highest similarity scores were implemented to select the best drug candidates.