British journal of pharmaceutical research最新文献_第4页

A Cross Section Study to Probe Self-prescribing Trends among the Population of Faisalabad- Pakistan 巴基斯坦费萨拉巴德人口自我处方趋势的横断面研究

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/32240

U. Saleem, M. Manan, Maryam Farrukh, B. Ahmad

引用次数: 0

Study on the Chemical Constituents and Anti-inflammatory Activity of Essential Oil of Petiveria alliacea L. 葱韭挥发油化学成分及抗炎活性研究。

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/31331

Aderoju Oluwa, O. Avoseh, O. Omikorede, I. Ogunwande, O. A. Lawal

{"title":"Study on the Chemical Constituents and Anti-inflammatory Activity of Essential Oil of Petiveria alliacea L.","authors":"Aderoju Oluwa, O. Avoseh, O. Omikorede, I. Ogunwande, O. A. Lawal","doi":"10.9734/BJPR/2017/31331","DOIUrl":"https://doi.org/10.9734/BJPR/2017/31331","url":null,"abstract":"Aims: To study and report the chemical constituents and anti-inflammatory activity of essential oil of Petiveria alliacea L (Phytolaccaceae) from Nigeria. Study Design: The study involves the distillation of essential oil from the leaf of P. alliacea, characterization of the chemical constituents of the essential oil and the evaluation of its antiinflammatory potential. Place and Duration of Study: Leaves of P. alliacea were collected at Ijede, Ikorodu, Lagos state, Nigeria, in June 2016. Male Wistar rats were obtained and accommodated at the animal facility of Biochemistry Department Lagos state University, Ojo, Nigeria. The experiment lasted till October 2016. Original Research Article Oluwa et al.; BJPR, 15(1): 1-8, 2017; Article no.BJPR.31331 2 Methodology: Essential oils were obtained by hydrodistillation of air-dried and pulverized leaves of P. alliacea. The distilled colourless oil was analysed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The anti-inflammatory activity was determined on fresh egg albumins over 4 h by measurement of rat paw edema according to established procedure. Results: Eleven compounds representing 99.1% of the oil content were identified in the essential oil of P. alliacea. The main constituents were phytol (56.1%), citronellol (16.0%) and (Z, Z)-αfarnesol (14.6%). In the egg albumin-induced edema, essential oils of P. alliacea induced time dependent in paw edema. The anti-inflammatory activity was non-significant (P= .05) from the 1st h to the 3rd h after egg albumin injection at 1 mL of 2% dose level while the maximum inhibition (P < .001) was observed after 4 h. At this hour, the inhibition was more pronounced than Diclofenac sodium injection. Conclusion: The chemical constituents of P. alliacea essential oil were found to differ from previous studies. The potent anti-inflammatory activity of essential oils of P. alliacea may provide further information on the biological uses of P. alliacea.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"51 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74718615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Hypoglycemic, Hypolipidemic and Antibacterial Activity of Ficus racemosa Fruit Extract 总状无花果果实提取物的降血糖、降血脂和抗菌活性

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/33056

N. Hasan, F. Shirin, Khan, Mamun, Belal, Hasan, A. Islam, Naoshia Tasnin, Karim, Asaduzzaman, Islam, Tabassum Ara, K. Rahman, Rahman, Mohammad K. Islam

引用次数: 7

Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female Rats 香蒲煎剂对汽油蒸气致雌性大鼠生殖毒性的影响

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/32895

C. Ekpenyong

{"title":"Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female Rats","authors":"C. Ekpenyong","doi":"10.9734/BJPR/2017/32895","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32895","url":null,"abstract":"Aims: Recent research indicates that plant molecules, particularly those that are rich with antioxidant, anti-inflammatory and immune modulatory constituents, can modify and prevent the detrimental effects of gasoline compounds on reproductive endpoints. However, whether C. citratus decoction can alleviate gasoline vapour (GV)-induced derangement of female reproductive hormones has not yet been documented. In this study, the capacity of C. citratus decoction was evaluated for its ability to alleviate GV-induced reproductive toxicity in female rats. Study Design: Seventy-two female Wistar albino rats weighing 185 ± 11.2 g were placed into six groups (n = 12 per group): the control (group 1, G1), GV alone (G2), GV plus C. citratus decoction (500 mg/kg; G3), (1000 mg/kg; G4), (1500 mg/kg; G5), and GV plus vitamin C (200 mg/kg; G6). Place and Duration of Study: Department of Physiology, University of Uyo, Uyo, Akwa Ibom State, Nigeria. All groups were treated for 35 days. Methodology: Serum levels of the female reproductive hormones progesterone (P3) estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) as well as superoxide dismutase (SOD) and malondialdehyde (MDA; an oxidative stress marker) in the animals were assessed using standard procedures. Results: The results showed that GV significantly (p < 0.05) decreased serum levels of P3, E2, LH, Original Research Article Ekpenyong; BJPR, 15(6): 1-8, 2017; Article no.BJPR.32895 2 FSH, SOD and increased serum MDA levels compared to the levels in the control animals. However, co-administration of C. citratus at different doses to the animals in G3, G4, and G5 and vitamin C to the animals in G6 dose-dependently significantly (p < 0.05) increased the levels of the GV-reduced reproductive hormones and antioxidant enzyme and decreased the GV-increased oxidative stress marker levels to levels similar to those in the control group. Conclusion: Thus, C. citratus decoction has an ameliorative effect on GV-induced reproductive dysfunction and oxidative stress.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"61 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78584228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Animal Model for Hypoglycemic Studies Using Albino Rats 白化大鼠低血糖研究的动物模型

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/bjpr/2017/31666

A. J. Alhassan, I. Muhammad, A. Imam, A. Wudil, A. Idi, A. Mohammed, A. Nasir, I. Alexander

引用次数: 0

Thaumatococcus daniellii Extract Modulates Glibenclamide Activity and Ameliorates Heamatological Disorders, Oxidative Stress and Dyslipidemia Associated with Diabetes Mellitus in Rats 丹尼尔球菌提取物调节格列本脲活性并改善与糖尿病相关的血液系统疾病、氧化应激和血脂异常

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/33134

Adedosu Ot, Badmus Jelili Abiodun, G. Adeleke, G. O. Olalere

引用次数: 1

In vitro Evaluation of Antidiabetic and Anti-Inflammatory Activity of Ethanolic and Methanolic Extracts of Ceropegia juncea 荆芥乙醇和甲醇提取物抗糖尿病和抗炎活性的体外评价

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/32020

M. Saraswathy, K. Kalimuthu, V. Chinnadurai, Y. Juliet

引用次数: 3

Effect of Ethanolic Leaf Extract of Psidium guajava Linn. (Guava) in Alloxan-Induced Diabetic Rats 番石榴叶乙醇提取物的作用。四氧嘧啶诱导的糖尿病大鼠

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/31987

P. Ofoha, R. Nimenibo-Uadia

引用次数: 1

Impact of Socioeconomic and Risk Factors on Cardiovascular Diseases among People in Bangladesh: A Cross-sectional Health Survey 社会经济因素和风险因素对孟加拉国人心血管疾病的影响:一项横断面健康调查

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/bjpr/2017/32024

Haque, M. Khatun, S. Barik, Islam

引用次数: 0

Hepatoprotective Activity of Macrotyloma uniflorum (Lam.) Verdc. Seeds Extracts Against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats 单花大叶草的保肝作用Verdc。对乙酰氨基酚种子提取物对Wistar白化大鼠肝毒性的影响

British journal of pharmaceutical research Pub Date : 2017-01-10 DOI: 10.9734/BJPR/2017/32457

Mohgana Ramasamy, Anbu Jeba Sunilson John Samuel, Anandarajagopal Kalusalingam, Krupavaram Bethala

{"title":"Hepatoprotective Activity of Macrotyloma uniflorum (Lam.) Verdc. Seeds Extracts Against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats","authors":"Mohgana Ramasamy, Anbu Jeba Sunilson John Samuel, Anandarajagopal Kalusalingam, Krupavaram Bethala","doi":"10.9734/BJPR/2017/32457","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32457","url":null,"abstract":"Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used as a folklore medicine for treatment of jaundice in Andhra Pradesh, India. Aim: The present study was aimed to find out the therapeutic potentials of M. uniflorum seeds Original Research Article Mohgana et al.; BJPR, 15(5): 1-9, 2017; Article no.BJPR.32457 2 extract against paracetamolinduced hepatotoxicity and also to scientifically prove its traditional claim. Methodology: Hepatotoxicity was induced in wistar albino rats by the oral administration of paracetamol (400 mg/kg b.wt.) for 10 days. The ethanolic extract and water extract (400 mg/kg b.wt.) were orally administered to the respective group once daily for 10 days. Silymarin (20 mg/kg b.wt.) was used as standard. Biochemical parameters such as ASAT, ALAT, ALP, TP, albumin, globulin, total bilirubin and GGT were determined to assess the hepatoprotective effect. Results: The oral administration of both ethanolic and water extracts significantly (P<0.001) restored the biochemical parameters in the hepatotoxicated rats which were well compared with standard drug silymarin. The hepatoprotective activity of ethanolic extract provides therapeutically better efficacy which was further supported by histopathological examination. The phytochemical screening reveals the presence of phytoconstituents such as phenolic compounds, flavonoids and alkaloids which might be responsible for the hepatoprotective activity. Conclusion: The scientific establishment of the M. uniflorum was traditionally claimed by folklore medicine was validated.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"23 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74699250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1