{"title":"香蒲煎剂对汽油蒸气致雌性大鼠生殖毒性的影响","authors":"C. Ekpenyong","doi":"10.9734/BJPR/2017/32895","DOIUrl":null,"url":null,"abstract":"Aims: Recent research indicates that plant molecules, particularly those that are rich with antioxidant, anti-inflammatory and immune modulatory constituents, can modify and prevent the detrimental effects of gasoline compounds on reproductive endpoints. However, whether C. citratus decoction can alleviate gasoline vapour (GV)-induced derangement of female reproductive hormones has not yet been documented. In this study, the capacity of C. citratus decoction was evaluated for its ability to alleviate GV-induced reproductive toxicity in female rats. Study Design: Seventy-two female Wistar albino rats weighing 185 ± 11.2 g were placed into six groups (n = 12 per group): the control (group 1, G1), GV alone (G2), GV plus C. citratus decoction (500 mg/kg; G3), (1000 mg/kg; G4), (1500 mg/kg; G5), and GV plus vitamin C (200 mg/kg; G6). Place and Duration of Study: Department of Physiology, University of Uyo, Uyo, Akwa Ibom State, Nigeria. All groups were treated for 35 days. Methodology: Serum levels of the female reproductive hormones progesterone (P3) estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) as well as superoxide dismutase (SOD) and malondialdehyde (MDA; an oxidative stress marker) in the animals were assessed using standard procedures. Results: The results showed that GV significantly (p < 0.05) decreased serum levels of P3, E2, LH, Original Research Article Ekpenyong; BJPR, 15(6): 1-8, 2017; Article no.BJPR.32895 2 FSH, SOD and increased serum MDA levels compared to the levels in the control animals. However, co-administration of C. citratus at different doses to the animals in G3, G4, and G5 and vitamin C to the animals in G6 dose-dependently significantly (p < 0.05) increased the levels of the GV-reduced reproductive hormones and antioxidant enzyme and decreased the GV-increased oxidative stress marker levels to levels similar to those in the control group. Conclusion: Thus, C. citratus decoction has an ameliorative effect on GV-induced reproductive dysfunction and oxidative stress.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"61 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female Rats\",\"authors\":\"C. Ekpenyong\",\"doi\":\"10.9734/BJPR/2017/32895\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aims: Recent research indicates that plant molecules, particularly those that are rich with antioxidant, anti-inflammatory and immune modulatory constituents, can modify and prevent the detrimental effects of gasoline compounds on reproductive endpoints. However, whether C. citratus decoction can alleviate gasoline vapour (GV)-induced derangement of female reproductive hormones has not yet been documented. In this study, the capacity of C. citratus decoction was evaluated for its ability to alleviate GV-induced reproductive toxicity in female rats. Study Design: Seventy-two female Wistar albino rats weighing 185 ± 11.2 g were placed into six groups (n = 12 per group): the control (group 1, G1), GV alone (G2), GV plus C. citratus decoction (500 mg/kg; G3), (1000 mg/kg; G4), (1500 mg/kg; G5), and GV plus vitamin C (200 mg/kg; G6). Place and Duration of Study: Department of Physiology, University of Uyo, Uyo, Akwa Ibom State, Nigeria. All groups were treated for 35 days. Methodology: Serum levels of the female reproductive hormones progesterone (P3) estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) as well as superoxide dismutase (SOD) and malondialdehyde (MDA; an oxidative stress marker) in the animals were assessed using standard procedures. Results: The results showed that GV significantly (p < 0.05) decreased serum levels of P3, E2, LH, Original Research Article Ekpenyong; BJPR, 15(6): 1-8, 2017; Article no.BJPR.32895 2 FSH, SOD and increased serum MDA levels compared to the levels in the control animals. However, co-administration of C. citratus at different doses to the animals in G3, G4, and G5 and vitamin C to the animals in G6 dose-dependently significantly (p < 0.05) increased the levels of the GV-reduced reproductive hormones and antioxidant enzyme and decreased the GV-increased oxidative stress marker levels to levels similar to those in the control group. Conclusion: Thus, C. citratus decoction has an ameliorative effect on GV-induced reproductive dysfunction and oxidative stress.\",\"PeriodicalId\":9320,\"journal\":{\"name\":\"British journal of pharmaceutical research\",\"volume\":\"61 1\",\"pages\":\"1-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British journal of pharmaceutical research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.9734/BJPR/2017/32895\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of pharmaceutical research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/BJPR/2017/32895","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of Cymbopogon citratus Decoctions on Gasoline Vapour-induced Reproductive Toxicity in Female Rats
Aims: Recent research indicates that plant molecules, particularly those that are rich with antioxidant, anti-inflammatory and immune modulatory constituents, can modify and prevent the detrimental effects of gasoline compounds on reproductive endpoints. However, whether C. citratus decoction can alleviate gasoline vapour (GV)-induced derangement of female reproductive hormones has not yet been documented. In this study, the capacity of C. citratus decoction was evaluated for its ability to alleviate GV-induced reproductive toxicity in female rats. Study Design: Seventy-two female Wistar albino rats weighing 185 ± 11.2 g were placed into six groups (n = 12 per group): the control (group 1, G1), GV alone (G2), GV plus C. citratus decoction (500 mg/kg; G3), (1000 mg/kg; G4), (1500 mg/kg; G5), and GV plus vitamin C (200 mg/kg; G6). Place and Duration of Study: Department of Physiology, University of Uyo, Uyo, Akwa Ibom State, Nigeria. All groups were treated for 35 days. Methodology: Serum levels of the female reproductive hormones progesterone (P3) estradiol (E2), luteinizing hormone (LH), and follicle stimulating hormone (FSH) as well as superoxide dismutase (SOD) and malondialdehyde (MDA; an oxidative stress marker) in the animals were assessed using standard procedures. Results: The results showed that GV significantly (p < 0.05) decreased serum levels of P3, E2, LH, Original Research Article Ekpenyong; BJPR, 15(6): 1-8, 2017; Article no.BJPR.32895 2 FSH, SOD and increased serum MDA levels compared to the levels in the control animals. However, co-administration of C. citratus at different doses to the animals in G3, G4, and G5 and vitamin C to the animals in G6 dose-dependently significantly (p < 0.05) increased the levels of the GV-reduced reproductive hormones and antioxidant enzyme and decreased the GV-increased oxidative stress marker levels to levels similar to those in the control group. Conclusion: Thus, C. citratus decoction has an ameliorative effect on GV-induced reproductive dysfunction and oxidative stress.