Bone最新文献

{"title":"Femoral bowing in the coronal plane: A computed tomography analysis of 1313 femurs","authors":"Arun Aneja ,&nbsp;Jeffrey A. Foster ,&nbsp;Jarod T. Griffin ,&nbsp;Maaz Muhammad ,&nbsp;Bernhard Hofstätter ,&nbsp;Eben A. Carroll ,&nbsp;Thuan V. Ly ,&nbsp;David C. Landy","doi":"10.1016/j.bone.2025.117620","DOIUrl":"10.1016/j.bone.2025.117620","url":null,"abstract":"<div><h3>Introduction</h3><div>Appreciation of femoral bowing in the sagittal plane has led to optimization of implant design and placement techniques. However, little is known about femoral bowing in the coronal plane. The objective of this study was to describe coronal bowing of the femur and how demographic characteristics were associated with bowing.</div></div><div><h3>Methods</h3><div>Three-dimensional models of 1313 left femurs taken from the Stryker Orthopaedic Modeling and Analytics database were analyzed. Coronal bowing was measured via radius of curvature in centimeters (cm) and classified as straight (&gt;300 cm), mild-to-moderate (150 to 300 cm), and severe (&lt;150 cm). Univariable analyses were performed to detect associations between demographics and coronal bowing. Multivariable analyses including sex-specific Spearman correlation coefficients were also undertaken.</div></div><div><h3>Results</h3><div>In total, 236 femurs (18 %) had mild-to-moderate lateral bowing, 46 (4 %) had severe lateral bowing, 35 (3 %) had mild-to-moderate medial bowing, and 2 (&lt;1 %) had severe medial bowing. Univariable analyses revealed coronal bowing had significant associations with age (p &lt; 0.001), sex (p &lt; 0.001), and ethnicity (p = 0.002) but not with body mass index (p = 0.54). Multivariable analyses found the correlation of age with coronal bowing to be moderate positive in females (Spearman's Rho = 0.42, p &lt; 0.001) compared to weak positive in males (Spearman's Rho = 0.21, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Three-dimensional analysis of 1313 femurs demonstrated that 24 % of femurs had coronal bowing which had significant associations with age, sex, and ethnicity. Coronal bowing had a positive correlation with age that was stronger in females. By acknowledging variations in femoral morphology, these findings highlight the utility of examining radiographs of the injured and uninjured femurs in multiple planes during preoperative planning.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117620"},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture patterns and outcomes in children and adolescents aged 5–19 years with type 1 diabetes: Analysis of data from the US nationwide inpatient sample, 2005–2020","authors":"Kai Yuan Cheng,&nbsp;Chen Yu Yang,&nbsp;Shih Chia Liu","doi":"10.1016/j.bone.2025.117617","DOIUrl":"10.1016/j.bone.2025.117617","url":null,"abstract":"<div><h3>Background</h3><div>Despite the high prevalence of type 1 diabetes mellitus (T1DM) and fractures in pediatric populations, little is known about fracture patterns and T1DM-specific outcomes. This study aimed to investigate differences in fracture patterns and T1DM-specific outcomes between children and adolescents with/without T1DM.</div></div><div><h3>Methods</h3><div>This retrospective observational study assessed differences in fracture patterns and outcomes among hospitalized children and adolescents (ages 5–19) with and without T1DM using the United State (US) Nationwide Inpatient Sample (NIS). Children and adolescents treated for limb fractures via closed/open reduction or debridement were analyzed. Propensity score matching (PSM) balanced baseline characteristics, yielding 295 T1DM patients and 2950 non-T1DM controls. Outcomes were examined using in-hospital outcomes from the NIS database.</div></div><div><h3>Results</h3><div>Among 135,981 children and adolescents (mean age: 13; 68.1 % male), tibia/fibula fractures were most common (28.6 %), and 52.3 % underwent open reduction and internal fixation (ORIF). No significant differences in fracture site were found between T1DM and non-T1DM groups. However, children and adolescents with T1DM had higher odds of venous thromboembolism (VTE) (adjusted odds ratio [aOR]: 2.20; 95 % CI: 1.07–4.52) and acute kidney injury (AKI) (aOR: 4.59; 95 % CI: 2.02–10.44). Age-stratified analysis revealed elevated VTE risk (aOR: 5.25) and prolonged ventilation (aOR: 2.02) in T1DM children and adolescents aged 10–14, and higher AKI risk (aOR: 3.42) in those aged 15–19. Among T1DM patients, VTE risk was highest with upper limb fractures (aOR: 7.73), while AKI risk increased with lower limb fractures (aOR: 9.83).</div></div><div><h3>Conclusions</h3><div>Children and adolescents with T1DM do not differ in fracture patterns but are at higher risk for complications, particularly VTE and AKI. These findings highlight the need for vigilant perioperative care and further studies with detailed clinical data and long-term follow-up to guide management strategies.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117617"},"PeriodicalIF":3.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A reliable micro-CT-based method reveals dynamic changes to alveolar bone and tooth root following ligature-induced periodontal injury in the mouse","authors":"Yu Fu ,&nbsp;Wasif Qayyum ,&nbsp;Parsa Shafiei ,&nbsp;Farah Eaton ,&nbsp;Maria Alexiou ,&nbsp;Daniel Graf","doi":"10.1016/j.bone.2025.117619","DOIUrl":"10.1016/j.bone.2025.117619","url":null,"abstract":"<div><div>This study presents a method development and evaluation framework for assessing longitudinally the dynamic alveolar bone changes in a murine periodontal injury model using 3D Slicer software. Accurate and reproducible measurement of bone loss is crucial for periodontal research, yet traditional two-dimensional (2D) histological approaches lack the ability to capture three-dimensional (3D) alterations, while inconsistencies in image alignment, region of interest (ROI) selection, and segmentation have limited the widespread adoption of 3D micro-CT analysis in small animal models. Here, we present a standardized workflow, incorporating defined criteria for ROI selection, scan alignment, and segmentation suitable for live micro-CT scanning. We validated this method using the ligature-induced periodontal injury model in mice. Multiple micro-CT scans were performed over 35 days to evaluate changes to alveolar bone and tooth roots. Quantitative analysis highlighted significant bone loss and early-stage remodeling within the first two weeks. Following ligature removal at 3 weeks, bone loss largely resolved by the end of week 5. However, we find that although the total bone volume mostly recovers, permanent changes at the alveolar crest persist, and additional cementum was formed at the apical tooth root. By enhancing methodological consistency, this standardized protocol improves the accuracy and comparability of longitudinal studies and minimizes variability in small animal studies, providing a reliable framework for functional investigations. Through its application, we show for the first time that, beyond alveolar bone regeneration, cementum apposition at the root apex is also observed. This opens up studies investigating how root loss at the apex could be restored.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"201 ","pages":"Article 117619"},"PeriodicalIF":3.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic opportunistic osteoporosis screening using chest X-ray images via deep neural networks","authors":"Jun Tang ,&nbsp;Xiang Yin ,&nbsp;Jiangyuan Lai ,&nbsp;Keyu Luo ,&nbsp;Dongdong Wu","doi":"10.1016/j.bone.2025.117618","DOIUrl":"10.1016/j.bone.2025.117618","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis is a bone disease characterized by reduced bone mineral density and quality, which increases the risk of fragility fractures. The current diagnostic gold standard, dual-energy X-ray absorptiometry (DXA), faces limitations such as low equipment penetration, high testing costs, and radiation exposure, restricting its feasibility as a screening tool.</div></div><div><h3>Method</h3><div>To address these limitations, we retrospectively collected data from 1995 patients who visited Chongqing Daping Hospital between January 2019 and August 2024. We have developed an opportunistic screening method using chest X-rays and designed three innovative deep neural network models using transfer learning: Inception v3, VGG16, and ResNet50. These models were evaluated for their classification performance of osteoporosis using chest X-ray images and validated through an external dataset.</div></div><div><h3>Results</h3><div>The ResNet50 model demonstrated superior performance, achieving average accuracies of 87.85 % and 90.38 % in the internal test dataset across two experiments, with AUC values of 0.945 and 0.957, respectively. These results outperformed traditional convolutional neural networks. In the external validation, the ResNet50 model achieved an AUC of 0.904, accuracy of 89 %, sensitivity of 90 %, and specificity of 88.57 %, demonstrating strong generalization ability. And the model shows robust performance despite concurrent pulmonary pathologies.</div></div><div><h3>Conclusions</h3><div>This study provides an automatic screening method for osteoporosis using chest X-rays, without additional radiation exposure or cost. The ResNet50 model's high performance supports clinicians in the early identification and treatment of osteoporosis patients.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"201 ","pages":"Article 117618"},"PeriodicalIF":3.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between cognitive impairment and bone mineral density reduction in aging populations: A systematic review and meta-analysis of osteoporosis, osteopenia, and bone mineral content","authors":"Hasti Nasiri ,&nbsp;Tina Ghandali ,&nbsp;Faezeh Yazdani ,&nbsp;Mahsa Amiri ,&nbsp;Saleh Usefinezhad ,&nbsp;Sara Yahyavi ,&nbsp;Maryam Talebi Moghaddam ,&nbsp;Mehdi Karimi ,&nbsp;Mahmood Moosazadeh","doi":"10.1016/j.bone.2025.117616","DOIUrl":"10.1016/j.bone.2025.117616","url":null,"abstract":"<div><div>Osteoporosis is a skeletal disorder characterized by reduced bone mineral density (BMD), increasing fracture risk. Cognitive disorders (CD), including Alzheimer's disease, dementia, and mild cognitive impairment (MCI), cause cognitive decline and are prevalent among older adults. This systematic review and meta-analysis explores the bidirectional association between cognitive impairment and bone health, specifically low BMD, osteopenia, and osteoporosis. Comprehensive searches were performed in PubMed, Scopus, and the Cochrane Library through August 15, 2024. Eligible observational studies assessing the association between cognitive impairment and BMD were included. Two reviewers independently evaluated studies, with data analyzed using fixed and random-effects models in STATA 17. Risk of bias was assessed with the Newcastle-Ottawa Scale and AHRQ checklist. Fifteen studies involving 93 to 47,579 participants were analyzed. Results showed individuals with cognitive impairment had a significantly higher risk of osteoporosis (log RR: 0.59, 95 % CI: 0.27–0.92, <em>p</em> &lt; 0.001) and a higher risk of osteopenia (log RR: -0.18, 95 % CI: −0.41–0.05). Conversely, those with osteoporosis were more likely to develop cognitive impairment (log RR: 0.34, 95 % CI: 0.19–0.48, <em>p</em> &lt; 0.001). Comparing mean BMD between cognitively impaired individuals and controls revealed lower BMD in the cognitive impairment group: spine (Cohen's d: -0.26, 95 % CI: −0.57–0.04) and femur (Cohen's d: -0.39, 95 % CI: −0.63–-0.16). These findings underscore the importance of bone health monitoring in patients with cognitive impairment and preventing cognitive decline in those with osteoporosis. Longitudinal studies with larger, diverse populations are warranted to confirm these results.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117616"},"PeriodicalIF":3.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporotic fractures among foreign-born individuals registered in Sweden before and after the age of 30 years","authors":"Per Wändell ,&nbsp;Xinjun Li ,&nbsp;Axel C. Carlsson ,&nbsp;Jan Sundquist ,&nbsp;Kristina Sundquist","doi":"10.1016/j.bone.2025.117614","DOIUrl":"10.1016/j.bone.2025.117614","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyse risk of osteoporotic fractures in foreign-born individuals migrating to Sweden at different ages, compared to Swedish-born individuals.</div></div><div><h3>Methods</h3><div>This was a nationwide open cohort study including individuals ≥30 years of age at baseline (<em>N</em> = 4,715,081). Foreign-born individuals were divided as having arrived to and being registered in Sweden from the ages 0–30 years of age or &gt;30 years of age. Osteoporotic fractures were defined as at least one registered diagnosis of fractures in the hip, humerus, forearm, vertebrae, or pelvis, in the National Patient Register between January 1, 1998, and December 31, 2018. Cox regression analysis was used to estimate relative risk (hazard ratios (HR) with 99 % confidence intervals (CI)) of incident osteoporotic fractures in foreign-born compared to Swedish-born individuals. Cox regression models were stratified by sex and adjusted for age, co-morbidities, and sociodemographic status.</div></div><div><h3>Results</h3><div>Totally 304,462 fractures (men <em>n</em> = 82,992, and women <em>n</em> = 221,470) were registered, with hip fractures dominating (54.0 % among men, 42.6 % among women). Fully adjusted HRs (99 % CI) were for foreign-born men registered at the age 0–30 years 0.81 (0.78–0.85) and 0.73 (0.69–0.78) for foreign-born men above 30 years, respectively. The corresponding risk for foreign-born women registered at the age 0–30 years was 0.92 (0.90–0.95) and 0.84 (0.80–0.88) for foreign-born women registered above 30 years.</div></div><div><h3>Conclusions</h3><div>We found slightly different risks of osteoporotic fractures among immigrants, but with no statistically significant interaction between risks for those being registered in Sweden at the age above 30 years vs those registered until this age.</div></div><div><h3>Summary</h3><div>In this national study of osteoporotic fractures in foreign-born individuals, the fracture risk did not differ by age at immigration.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117614"},"PeriodicalIF":3.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteocyte-lacuna shape and canaliculi architecture dictate fluid flow around osteocyte, and strain of cell and bone matrix: implications for cell mechanobiology and bone fragility","authors":"Asier Muñoz,&nbsp;Annalisa De Paolis,&nbsp;Luis Cardoso,&nbsp;Alessandra Carriero","doi":"10.1016/j.bone.2025.117613","DOIUrl":"10.1016/j.bone.2025.117613","url":null,"abstract":"<div><div>Osteocytes, the most abundant cells in bone, play a critical role in maintaining bone quality by sensing mechanical loads and orchestrating bone modeling and remodeling. These cells are housed in lacunae and connected by a complex network of canaliculi, through which interstitial fluid flows in response to mechanical loading. Osteocyte-lacuna shape can vary from elongated in healthy lamellar bones subjected to directional loading to more spherical shapes, often seen in flat bones, or in aging and diseases. Additionally, canaliculi can be star-shaped or run perpendicular to the lacunar major axis. The morphology of the osteocyte-lacunar-canalicular system is believed to impact fluid flow and mechanical strain on cell influencing osteocyte signaling, and strains on bone affecting bone fragility. However, the mechanical implications of these geometrical variations are not yet fully understood. This study uses fluid-structure interaction (FSI) models of osteocytes within bone blocks to investigate how changes in lacunar shape, canalicular orientation and number influence bone strain, interstitial fluid velocity and cell deformation caused by mechanical loading-induced convection-driven fluid flow. Our results demonstrate that spherical lacunae, and canaliculi oriented perpendicular to the lacunar major axis result in high bone strain concentrations but low osteocyte strain, increasing bone fragility and impairing cell mechanosensation. In contrast, elongated lacunae, and many and/or star-shaped canaliculi result in low bone strain and high interstitial fluid flow and osteocyte strain, fostering a more anabolic mechanical environment and nutrient transport. Our findings offer new insights into how osteocyte-lacuna morphology and canalicular arrangement affect bone fragility and cell mechanobiology, particularly in aging and diseases.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117613"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower limb deformity correction in X-linked hypophosphatemia (XLH) with intramedullary nails: A strategy to reduce deformity recurrence and improve limb function","authors":"Gregor Toporowski ,&nbsp;Adrien Frommer ,&nbsp;Robert Roedl ,&nbsp;Georg Gosheger ,&nbsp;Andrea Laufer ,&nbsp;Henning Tretow ,&nbsp;Bjoern Vogt","doi":"10.1016/j.bone.2025.117611","DOIUrl":"10.1016/j.bone.2025.117611","url":null,"abstract":"<div><h3>Purpose</h3><div>X-linked hypophosphatemia (XLH) is a rare metabolic disorder leading to impaired bone mineralization and rickets. Severely affected patients often develop complex, three-dimensional lower limb deformities, resulting in pain and reduced mobility. Although various surgical approaches have been described, deformity recurrence remains common. This study retrospectively analyzed the outcomes of multilevel deformity correction using intramedullary nails (IN) in patients with XLH.</div></div><div><h3>Methods</h3><div>Between 2002 and 2022, 45 lower limb reconstructions involving 165 osteotomies were performed in 26 XLH patients using femoral IN (retrograde) and tibial IN (antegrade). Each leg required two to five osteotomies. The age at surgery was 24 ± 13.8 years. Clinical and radiographic evaluations were conducted pre- and postoperatively.</div></div><div><h3>Results</h3><div>The follow-up was 76.7 ± 49.2 months. Mechanical axis deviation improved significantly from 54.3 ± 31.0 mm to 12.8 ± 8.9 mm (<em>p</em> &lt; 0.0001). The mechanical lateral distal femoral angle improved from 99.0° ± 10.9° to 90.5° ± 4.4° (<em>p</em> &lt; 0.0001), the medial proximal tibial angle from 80.7° ± 8.0° to 87.4° ± 3.1° (<em>p</em> &lt; 0.001), and the posterior proximal tibial angle from 76.7° ± 9.0° to 80.4° ± 4.2° (<em>p</em> = 0.018). Lower Extremity Functional Scale scores improved from 45 ± 12 to 55 ± 12 (<em>p</em> &lt; 0.01). Deformity recurrence occurred in 2/43 limbs (4.7 %), both revised. Complications arose in 17/45 limbs (37.8 %), of which 14 (31.1 %) required revision surgery, primarily screw removal or osteophyte resection (8/45, 17.8 %). Malunion occurred in 2/45 (4.4 %), implant-related infections in 3/45 (6.7 %).</div></div><div><h3>Conclusion</h3><div>IN-based deformity correction of lower limbs in XLH provides effective, long-term correction with low recurrence. Despite frequent complications, most patients experience functional improvement. Nail retention is recommended to prevent fractures and recurrences.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117611"},"PeriodicalIF":3.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Moderate-intensity exercise attenuates bone loss in hyperuricemic nephropathic mice” [Bone 200 (November 2025) 117603]","authors":"Liang Chen ,&nbsp;Rong Xie ,&nbsp;Zuxi Cen ,&nbsp;Jun Zou ,&nbsp;Buping Liu ,&nbsp;Gang Liu ,&nbsp;Ying Zhang ,&nbsp;Yu Yuan ,&nbsp;Lin Yang","doi":"10.1016/j.bone.2025.117608","DOIUrl":"10.1016/j.bone.2025.117608","url":null,"abstract":"","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117608"},"PeriodicalIF":3.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related changes in bone mineral density of the scaphoid and distal radius: A quantitative computed tomography study","authors":"Ryutaro Iwasaki ,&nbsp;Yusuke Matsuura ,&nbsp;Takahiro Yamazaki ,&nbsp;Kaoru Kitsukawa ,&nbsp;Aya Kanazuka ,&nbsp;Seiji Ohtori","doi":"10.1016/j.bone.2025.117612","DOIUrl":"10.1016/j.bone.2025.117612","url":null,"abstract":"<div><h3>Background</h3><div>Scaphoid fractures predominantly occur in young males, while distal radius fractures occur in elderly females, despite similar injury mechanisms. We hypothesized that age-related bone mineral density (BMD) changes differ between these bones, explaining their distinct fracture patterns. This study compared age-related BMD changes between the scaphoid and distal radius using quantitative computed tomography (qCT).</div></div><div><h3>Methods</h3><div>We analyzed 167 cases (110 males, 57 females; mean age 45.2 ± 18.1 years) who underwent qCT including forearm and carpal bones. Exclusion criteria included fractures, arthritis, and implants. BMD was measured separately for cortical and cancellous bone in both the scaphoid and distal radius using phantom-corrected Hounsfield values. Correlations between age and BMD were evaluated using Pearson correlation coefficients.</div></div><div><h3>Results</h3><div>The distal radius showed significant negative correlation with age in overall BMD (<em>r</em> = −0.44) and cancellous BMD (<em>r</em> = −0.40), while the scaphoid showed no significant correlation. Females demonstrated significantly stronger negative correlations than males in both bones. Age-related BMD decline occurred predominantly in cancellous bone. The radius/scaphoid BMD ratio decreased with age (<em>r</em> = −0.51), indicating relatively greater BMD decline in the radius.</div></div><div><h3>Conclusion</h3><div>The distal radius exhibits stronger age-related BMD decline than the scaphoid, particularly in cancellous bone. This differential aging pattern may explain why scaphoid fractures predominate in young individuals while distal radius fractures are more common in the elderly.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"200 ","pages":"Article 117612"},"PeriodicalIF":3.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}