Bone最新文献

{"title":"The independent and joint association between physical activity, sleep duration and daily sitting time with bone mineral density: A real world study from NHANES 2007–2018.","authors":"Hongjiang Yang ,&nbsp;Bo Li ,&nbsp;Hailiang Li ,&nbsp;Mi Zhou ,&nbsp;Baicao Li ,&nbsp;Junrui Guo ,&nbsp;Hao Zhong ,&nbsp;Song Liu ,&nbsp;Qi Zhang ,&nbsp;Cong Xing ,&nbsp;Guangzhi Ning","doi":"10.1016/j.bone.2024.117264","DOIUrl":"10.1016/j.bone.2024.117264","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the independent and joint effect of physical activity, sleep duration, and daily sitting time on bone mineral density (BMD), based on National Health and Nutrition Examination Survey (NHANES) 2007–2018.</div></div><div><h3>Design</h3><div>Cross-sectional design.</div></div><div><h3>Methods</h3><div>The primary outcome was risk of low BMD. All associations between lifestyle factors and the prevalence of low BMD were based on logistic regression, and dose-response relationships were further explored by restricted cubic spline (RCS). Finally, multiplicative and additive interaction was examined by P _interaction and relative excess risk due to interaction (RERI).</div></div><div><h3>Results</h3><div>10,346 individuals (N _{normal BMD} = 6353; N _{Low BMD} = 3993) were analyzed. Multivariate logistic regression indicated low intensity physical activity (odds ratio [OR] 0.84; 95 % confidence interval [95%CI] 0.78–0.90) and high intensity physical activity (0.67, 0.56–0.78) had protective impact on risk of low BMD, whereas short sleep (1.41, 1.20–1.64), long sleep (1.36, 1.03–1.79) and prolonged daily sitting (1.58, 1.32–1.88) had harmful effect. RCS revealed dose-response associations between physical activity (J-shaped), sleep duration (U-shaped), daily sitting time (positive-associated) and risk of low BMD. Multiplicative interaction between sleep duration and physical activity was observed (P _interaction = 0.003), while not between daily sitting time and physical activity (P _interaction = 0.600). Notably, negative additive interactions indicated that physical activity mitigated the increased risk of low BMD associated with irregular sleep patterns and prolonged sedentary behavior.</div></div><div><h3>Conclusion</h3><div>Increasing physical activity was presented as a modulating factor, potentially altering the relationship between independent variables that have deleterious effects on BMD like sleep duration and sedentary behavior. The study underscores the importance of lifestyle modifications in the prevention of early onset low BMD.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117264"},"PeriodicalIF":3.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-traumatic osteoarthritic-mediated changes in condylar shape do not covary with changes in the internal microstructure of the bone","authors":"Zach Skabelund ,&nbsp;Dakshina Acharya ,&nbsp;Jonathan Banks,&nbsp;Minahil Chaudhry,&nbsp;Chun-Chieh Huang,&nbsp;Christina Nicholas,&nbsp;David Reed","doi":"10.1016/j.bone.2024.117263","DOIUrl":"10.1016/j.bone.2024.117263","url":null,"abstract":"<div><div>Post-traumatic osteoarthritis (PTOA) in the temporomandibular joint (TMJ) is associated with remodeling of the subchondral bone. This remodeling changes both the external appearance of the condylar bone and the internal bony microstructure. The external geometry can be quantified using shape, a multivariate mathematical measurement that contains all of the structure's geometric information with location, scale, and rotation effects removed. There is an important gap in knowledge related to how TMJ PTOA affects the shape of the mandible and if the external shape covaries with the internal bony microstructure. To evaluate these gaps, TMJ PTOA was induced in male and female skeletally mature mice using a surgical destabilization procedure. After four weeks, tissues were collected and characterized using a high-resolution μCT scanner. Shape was calculated from surface reconstructions of the mandibular condyle, and the internal bony microstructure was characterized by the region of interest including the subchondral trabeculae. The covariance of shape with and without corrections for allometric scaling and internal bony microstructure was calculated using a Procrustes ANOVA. The data illustrate that PTOA significantly alters the shape of the condyle in a sex-independent manner. PTOA does alter some aspects of the internal bony microstructure in a sex-dependent manner. Allometric scaling was a significant factor in the variance of shape. Shape including the effects of allometric scaling significantly covaries with some internal bony microstructure variables in both sexes. Shape scaled to remove the effects of allometric scaling does not covary with internal bony microstructure in either sex. These findings indicate that PTOA progression is associated with changes in the size and shape of the condyle but variance in trabecular bone remodeling is only associated with size related shape change. Thus, the allostatic response of subchondral bone is multimodal, coordinating two independent biological processes controlling size and shape. Since subchondral bone participates in and guides the progression of PTOA, these findings have implications for identifying select and specific mechanisms contributing to the progression and pathophysiology of the PTOA in the TMJ.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117263"},"PeriodicalIF":3.5,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive effects of transcutaneous CO2 application on disuse osteoporosis and muscle atrophy in a rat hindlimb suspension model","authors":"Ryota Nishida ,&nbsp;Tomoaki Fukui ,&nbsp;Takahiro Niikura ,&nbsp;Yohei Kumabe ,&nbsp;Ryo Yoshikawa ,&nbsp;Kyohei Takase ,&nbsp;Yuya Yamamoto ,&nbsp;Ryosuke Kuroda ,&nbsp;Keisuke Oe","doi":"10.1016/j.bone.2024.117262","DOIUrl":"10.1016/j.bone.2024.117262","url":null,"abstract":"<div><p>We previously demonstrated that transcutaneous CO₂ application promotes muscle fiber-type switching, fracture healing, and osteogenesis by increasing blood flow and angiogenesis. Here, we aimed to investigate the preventive effects of transcutaneous CO₂ application on disuse osteoporosis and muscle atrophy in a rat hindlimb suspension model. Eleven-week-old male Sprague-Dawley rats were divided into hindlimb suspension (HS), HS with transcutaneous CO₂ application (HSCO₂), and control groups. HSCO₂ rats were administered transcutaneous 100 % CO₂ gas in their bilateral hindlimbs, five times a week for 20 min. After 3 weeks, we harvested the gastrocnemius, femur, and tibia for assessment. Histological analysis revealed a significant decrease in the gastrocnemius myofiber cross-sectional area in HS rats compared to the control rats, whereas HSCO₂ rats exhibited a significant increase compared to HS rats. Micro-computed tomography showed significant bone atrophy in the trabecular and cortical bones of the femur in HS rats compared to those of the control rats, whereas significant improvement was noted in HSCO₂ rats. Histological analysis of the proximal tibia revealed more marrow adipose tissue in the HS rats than in the control rats. However, in the HSCO₂ rats, fewer marrow adipose tissue and osteoclasts were observed. Moreover, HSCO₂ rats had more osteoblasts and higher expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and vascular endothelial growth factor (VEGF) than the HS rats. The gastrocnemius and distal femur of HSCO₂ rats also exhibited elevated PGC-1α and VEGF expression and upregulation of the myogenesis markers and osteogenesis markers compared to those of HS rats. This treatment effectively prevented disuse osteoporosis and muscle atrophy by promoting local angiogenesis and blood flow. PGC-1α is crucial for promoting this angiogenic pathway. Transcutaneous CO₂ application may be a novel preventive procedure for disuse osteoporosis and muscle atrophy, complementing medication and rehabilitation.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117262"},"PeriodicalIF":3.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae","authors":"Ting Yu ,&nbsp;Manci Chen ,&nbsp;Jing Wen ,&nbsp;Juan Liu ,&nbsp;Ke Li ,&nbsp;Lei Jin ,&nbsp;Jiang Yue ,&nbsp;Zheqiong Yang ,&nbsp;Jinlei Xi","doi":"10.1016/j.bone.2024.117261","DOIUrl":"10.1016/j.bone.2024.117261","url":null,"abstract":"<div><div>Glucocorticoids (GCs) are extensively used as anti-inflammatory and immunosuppressive medications in the long-term treatment of rheumatic disorders, respiratory diseases, renal diseases, and organ transplantation. Prolonged use of GCs can reduce bone mineral density, leading to osteoporosis (Glucocorticoid Induced Osteoporosis, GIOP) and fracture. All-trans retinoic acid (ATRA) is an active vitamin A metabolite that regulates embryonic development and adult organ function. ATRA has been found in studies to enhance osteogenesis. To examine the interventional effects of ATRA on GIOP and the mechanisms of ATRA activities, we first performed bioinformatic analysis to identify potential gene targets of ATRA. Zebrafish larvae were recruited as experimental animals, and the frequently used GC, prednisolone, was administered to larvae to construct a GIOP model. We evaluated the influence of exogenous ATRA on the activities of bone metabolic enzymes, the expression of genes linked to osteoblasts and osteoclasts, and the restoration of bone mineral density and bone mass in GIOP zebrafish larvae. Furthermore, we studied the influence of RBM14, a transcriptional coactivator and negative reciprocal factor of ATRA, on the regulation of osteoblastic gene expression during the anti-GIOP process of ATRA using the morpholino knockdown approach. The findings of bone metabolic enzyme activity (alkaline phosphatase, ALP and tartrate-resistant acid phosphatase, TRAP) and expression assays of osteoblastic marker genes (Runx2a, Runx2b, SP7, Csf1a, RANKL, and CTSK) indicated that ATRA had bidirectional effects on osteogenesis. However, in the GIOP model, ATRA reversed the GIOP-induced osteoporosis phenotype by inhibiting the GIOP-induced suppression of osteoblastic metabolic enzyme (ALP) activities and osteoblastic marker gene expression (Runx2a, Runx2b, and SP7), and this antagonism was concentration-dependent. We also observed that ATRA inhibited RBM14 expression in zebrafish larvae, while ATRA alone and RBM14 knockdown showed a consistent induction of osteoblast marker gene expression, implying that ATRA's inhibitory effect on RBM14 expression may underlie ATRA's osteogenic effects. Based on these data, we postulated that ATRA may ameliorate GIOP by decreasing RBM14 expression, thereby enhancing osteoblastic marker gene expression.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117261"},"PeriodicalIF":3.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoas muscle cross sectional area relates to bone density and microarchitecture in candidates for spine fusion surgery","authors":"Joseph Raphael,&nbsp;Giavanna D'Erasmo,&nbsp;Jeri Nieves,&nbsp;Sravisht Iyer,&nbsp;Ryan Breighner,&nbsp;Alexander Dash,&nbsp;Emma Billings,&nbsp;Junho Song,&nbsp;Han Jo Kim,&nbsp;Sheeraz Qureshi,&nbsp;Matthew Cunningham,&nbsp;Emily Stein","doi":"10.1016/j.bone.2024.117259","DOIUrl":"10.1016/j.bone.2024.117259","url":null,"abstract":"<div><p>Prior studies demonstrate that muscle and bone health are integrally related, and both independently impact orthopedic surgery outcomes. However, relationships between bone density<em>, in vivo</em> microarchitecture, and muscle area have not been previously investigated in orthopedic surgery patients. This study assessed associations between psoas cross sectional area (CSA), bone mineral density (BMD), and microstructure in a cohort undergoing spine fusion. Pre-operatively, bilateral psoas CSA was measured on axial lumbar spine CT in the L3-L4 disc space. To adjust for body size, Psoas Muscle Index (PMI) was calculated (CSA divided by the square of patient height). High resolution peripheral quantitative CT (HR-pQCT, XtremeCT2) assessed volumetric BMD (vBMD), cortical (Ct) and trabecular (Tb) microarchitecture at the distal radius and tibia. Areal BMD (aBMD) was measured by DXA at the lumbar spine (LS), total hip (TH), femoral neck (FN), and the 1/3 radius (1/3R). Pearson correlations related psoas CSA and bone imaging parameters before and after correcting for height and weight. Among 88 patients included, mean age was 63 ± 12 years, BMI was 28 ± 7 kg/m², 47 (53 %) were female. Larger psoas CSA was associated with higher vBMD, greater Ct thickness and better Tb microarchitecture (higher Tb number and lower Tb separation) at the tibia and radius. Larger psoas CSA was also associated with greater aBMD at TH and FN bilaterally and 1/3R (r 0.33 to 0.61; <em>p</em> &lt; 0.002 for all comparisons). Psoas CSA was not associated with aBMD at the LS. Similar results were observed when relating PMI, and adjusting for age, height and weight to HR-pQCT and DXA measurements. Investigation of subgroups by sex demonstrated that relationships were similar magnitude among women but not the men. Patients who underwent primary compared to revision spine surgery had similar associations. Our results demonstrate a link between psoas muscle size and peripheral bone microarchitecture among patients undergoing posterior lumbar spinal fusion. Given the importance of both muscle and skeletal integrity to the success of spine surgery, further study regarding the associations between measurements of psoas muscle, bone microarchitecture, and surgical outcomes is warranted.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117259"},"PeriodicalIF":3.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclophilin D, regulator of the mitochondrial permeability transition, impacts bone development and fracture repair","authors":"Rubens Sautchuk Jr ,&nbsp;John Martinez ,&nbsp;Sarah E. Catheline ,&nbsp;Roman A. Eliseev","doi":"10.1016/j.bone.2024.117258","DOIUrl":"10.1016/j.bone.2024.117258","url":null,"abstract":"<div><p>Mitochondrial Permeability Transition Pore (MPTP) and its key positive regulator, Cyclophilin D (CypD), control activity of cell oxidative metabolism important for differentiation of stem cells of various lineages including osteogenic lineage. Our previous work (Sautchuk et al., 2022) showed that CypD gene, <em>Ppif</em>, is transcriptionally repressed during osteogenic differentiation by regulatory Smad transcription factors in BMP canonical pathway, a major driver of osteoblast (OB) differentiation. Such a repression favors closure of the MPTP, priming OBs to higher usage of mitochondrial oxidative metabolism. The physiological role of CypD/MPTP regulation was demonstrated by its inverse correlation with BMP signaling in aging and bone fracture healing in addition to the negative effect of CypD gain-of-function (GOF) on bone maintenance. Here we show evidence that CypD GOF also negatively affects bone development and growth as well as fracture healing in adult mice. Developing craniofacial and long bones presented with delayed ossification and decreased growth rate, respectively, whereas in fracture, bony callus volume was diminished. Given that Genome Wide Association Studies showed that <em>PPIF</em> locus is associated with both body height and bone mineral density, our new data provide functional evidence for the role of <em>PPIF</em> gene product, CypD, and thus MPTP in bone growth and repair.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117258"},"PeriodicalIF":3.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Interaction of high lipogenic states with titanium on osteogenesis” [Bone 188 (2024) 117242]","authors":"T.S. Pinto ,&nbsp;B.C. van der Eerden ,&nbsp;M. Schreuders-Koedam ,&nbsp;J. van de Peppel ,&nbsp;I. Ayada ,&nbsp;Q. Pan ,&nbsp;M.M. Verstegen ,&nbsp;L.J. van der Laan ,&nbsp;G.M. Fuhler ,&nbsp;W.F. Zambuzzi ,&nbsp;M.P. Peppelenbosch","doi":"10.1016/j.bone.2024.117256","DOIUrl":"10.1016/j.bone.2024.117256","url":null,"abstract":"","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117256"},"PeriodicalIF":3.5,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S875632822400245X/pdfft?md5=046c2f39e6546759fff2453ad1c51004&pid=1-s2.0-S875632822400245X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of endurance trainability phenotype, sex, and interval running training on bone collagen synthesis in adult rats","authors":"Rita Civil ,&nbsp;Matthew S. Brook ,&nbsp;Lívia Santos ,&nbsp;Ian Varley ,&nbsp;Kirsty J. Elliott-Sale ,&nbsp;Sanna Lensu ,&nbsp;Juha P. Ahtiainen ,&nbsp;Heikki Kainulainen ,&nbsp;Lauren G. Koch ,&nbsp;Steven L. Britton ,&nbsp;Daniel J. Wilkinson ,&nbsp;Kenneth Smith ,&nbsp;Philip J. Atherton ,&nbsp;Craig Sale","doi":"10.1016/j.bone.2024.117257","DOIUrl":"10.1016/j.bone.2024.117257","url":null,"abstract":"<div><div>Bone is influenced by many factors such as genetics and mechanical loading, but the short-term physiological effects of these factors on bone (re)modelling are not well characterised. This study investigated the effects of endurance trainability phenotype, sex, and interval running training (7-week intervention) on bone collagen formation in rats using a deuterium oxide stable isotope tracer method. Bone samples of the femur diaphysis, proximal tibia, mid-shaft tibia, and distal tibia were collected after necropsy from forty-six 9 ± 3-month male and female rats selectively bred for yielding low (LRT) or high (HRT) responses to endurance training. Bone collagen proteins were isolated and hydrolysed, and fractional synthetic rates (FSRs) were determined by the incorporation of deuterium into protein-bound alanine via GC-pyrolysis-IRMS. There was a significant large main effect of phenotype at the femur site (<em>p</em> &lt; 0.001; η²_<em>g</em> = 0.473) with HRT rats showing greater bone collagen FSRs than LRT rats. There was a significant large main effect of phenotype (<em>p</em> = 0.008; η²_<em>g</em> = 0.178) and a significant large main effect of sex (<em>p</em> = 0.005; η²_<em>g</em> = 0.196) at the proximal site of the tibia with HRT rats showing greater bone collagen FSRs than LRT rats, and male rats showing greater bone collagen FSRs compared to female rats. There was a significant large main effect of training at the mid-shaft site of the tibia (<em>p</em> = 0.012; η²_<em>g</em> = 0.159), with rats that underwent interval running training having greater bone collagen FSRs than control rats. Similarly, there was a significant large main effect of training at the distal site of the tibia (<em>p</em> = 0.050; η²_<em>g</em> = 0.156), with rats in the interval running training group having greater bone collagen FSRs compared to rats in the control group. Collectively, this evidence highlights that bone responses to physiological effects are site-specific, indicating that interval running training has positive effects on bone collagen synthesis at the tibial mid-shaft and distal sites, whilst genetic factors affect bone collagen synthesis at the femur diaphysis (phenotype) and proximal tibia (phenotype and sex) in rats.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117257"},"PeriodicalIF":3.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002461/pdfft?md5=4763be6fb79818a98ab2f75996879995&pid=1-s2.0-S8756328224002461-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BDNF sensitizes bone and joint afferent neurons at different stages of MIA-induced osteoarthritis","authors":"Michael Morgan ,&nbsp;Vida Nazemian ,&nbsp;Jenny Thai ,&nbsp;Irene Lin ,&nbsp;Susan Northfield ,&nbsp;Jason J. Ivanusic","doi":"10.1016/j.bone.2024.117260","DOIUrl":"10.1016/j.bone.2024.117260","url":null,"abstract":"<div><div>There is emerging evidence that Brain Derived Neurotrophic Factor (BDNF), and one of its receptors TrkB, play important roles in the pathogenesis of osteoarthritis (OA) pain. Whilst these studies clearly highlight the potential for targeting BDNF/TrkB signaling to treat OA pain, the mechanism for how BDNF/TrkB signaling contributes to OA pain remains unclear. In this study, we used an animal model of mono-iodoacetate (MIA)-induced OA, in combination with electrophysiology, behavioral testing, Western blot analysis, and retrograde tracing and immunohistochemistry, to identify roles for BDNF/TrkB signaling in the pathogenesis of OA pain. We found that: 1) TrkB is expressed in myelinated medium diameter neurons that innervate the knee joint and bone in naïve animals; 2) peripheral application of BDNF increases the sensitivity of Aδ, but not C knee joint and bone afferent neurons, in response to mechanical stimulation, in naïve animals; 3) BDNF expression increases in synovial tissue in early MIA-induced OA, when pathology is confined to the joint, and in the subchondral bone in late MIA-induced OA, when there is additional damage to the surrounding bone; and 4) TrkB inhibition reverses MIA-induced changes in the sensitivity of Aδ but not C knee joint afferent neurons early in MIA-induced OA, and Aδ but not C bone afferent neurons late in MIA-induced OA. Our findings suggest that BDNF/TrkB signaling may have a role to play in the pathogenesis of OA pain, through effects on knee joint afferent neurons early in disease when there is inflammation confined to the joint, and bone afferent neurons late in disease when there is involvement of damage to subchondral bone. Targeted manipulation of BDNF/TrkB signaling may provide therapeutic benefit for the management of OA pain.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117260"},"PeriodicalIF":3.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of biological age in osteoporosis risk among middle-aged and older adults: A nationwide perspective","authors":"Guomao Zhu ,&nbsp;Buyu Guo ,&nbsp;Jinqian Liang","doi":"10.1016/j.bone.2024.117255","DOIUrl":"10.1016/j.bone.2024.117255","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to investigate the association between biological age acceleration and osteoporosis (OP) risk in middle-aged and older adults using data from the National Health and Nutrition Examination Survey (NHANES). The research focused on analyzing the relationship between two biological aging metrics, Klemera-Doubal Method Age (KDMAge) and Phenotypic Age (PhenoAge), and OP risk.</p></div><div><h3>Methods</h3><p>The study analyzed data from NHANES, which included 6550 participants aged 50 and above from survey cycles 2005–2010 and 2017–2018. Linear and logistic regression were used to investigate the relationship between biological age acceleration (KDMAgeAccel and PhenoAgeAccel) and OP. Subgroup analysis was performed by age, gender and other factors. Multivariable Cox regression analysis yielded Hazard Ratios (HRs) relating biological age acceleration to mortality were evaluated. The study also considered the mediating roles of body mass index (BMI).</p></div><div><h3>Results</h3><p>KDMAgeAccel (odds ratio [OR] = 2.34, 95 % CI, 1.72–3.18) and PhenoAgeAccel (OR = 2.03, 95 % CI, 1.48–2.78) were significantly associated with increased OP risk and reduced bone mineral density (BMD). Specifically, higher KDMAgeAccel and PhenoAgeAccel were linked to higher OP prevalence and lower BMD at multiple sites. Subgroup analyses indicated that the association between accelerated biological age acceleration and OP risk was consistent across different demographics. Mediation analysis revealed that BMI partially mediated the relationship between accelerated biological age and OP, although other mechanisms are likely involved. Statistical analysis indicated that individuals with higher biological age metrics had increased mortality risk related to OP.</p></div><div><h3>Conclusion</h3><p>The findings suggest that accelerated biological age is a robust predictor of OP risk and related mortality. KDMAgeAccel and PhenoAgeAccel could serve as valuable biomarkers for identifying individuals at high risk for OP, guiding preventive strategies.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117255"},"PeriodicalIF":3.5,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}