Bone最新文献

{"title":"Klotho senses mechanical stimuli and modulates tension-induced osteogenesis","authors":"Xinrui Men,&nbsp;Wei-Cho Chiou,&nbsp;Xingjian Li,&nbsp;Qiming Li,&nbsp;Xinyi Chen,&nbsp;Kaiwen Zhang,&nbsp;Xiaoge Jiang,&nbsp;Song Chen","doi":"10.1016/j.bone.2025.117464","DOIUrl":"10.1016/j.bone.2025.117464","url":null,"abstract":"<div><div>Delicate external mechanosensing, efficient intracellular mechanotransduction and effective alveolar bone remodeling lay the foundation of orthodontic tooth movement (OTM). Periodontal ligament stem cells (PDLSCs) are thought to be the primary cells that withstand mechanical stimuli and respond to biomechanical signals during orthodontic treatment. Nevertheless, the cellular and molecular mechanisms of orthodontic force-induced mechanosignaling and osteogenesis in PDLSCs still remain unclear. In the present study, we hypothesize that the ageing suppressor, Klotho, is correlated with orthodontic force-triggered mechanical signaling cascades, further contributing to alveolar bone remodeling. This study reveals that Klotho expression is notably upregulated via cytoskeletal-nuclei-mediated epigenetic modifications, consistent with osteogenic differentiation on the tension side during OTM. Additionally, Klotho deficiency undermines tensile force-induced new bone formation in NFκB- and PI3K/Akt-dependent manners. Notably, RNA sequencing (RNA-seq) results and targeted force application experiments unveil that Klotho not only functions as a downstream effector of external stress but also acts as an upstream regulator in mechanical signaling for the first time. In summary, we identify the indispensable role of Klotho in mechanotransduction and alveolar bone formation, which provide a latent target of linking cell senescence to mechanical force in future studies and offer novel insights into orthodontic force-induced tooth movement and bone remodeling.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117464"},"PeriodicalIF":3.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of nuclear magnetic resonance-based metabolomics with bone health in the UK Biobank","authors":"Jie Cai ,&nbsp;Huan Huang ,&nbsp;Huaying Hu ,&nbsp;Lu Qi ,&nbsp;Tao Zhou","doi":"10.1016/j.bone.2025.117460","DOIUrl":"10.1016/j.bone.2025.117460","url":null,"abstract":"<div><h3>Objectives</h3><div>The study aimed to explore associations of metabolomic data based on nuclear magnetic resonance (NMR) with the risk of fractures and bone mineral density (BMD).</div></div><div><h3>Methods</h3><div>We included 69,963 participants without fractures at baseline in the UK Biobank. Cox proportional hazard models were used to estimate the associations of metabolomic biomarkers measured by NMR technology with the risk of all fractures and hip fracture. We used principal component analysis (PCA) to obtain uncorrelated principal components (PC), which were further used to estimate the associations of each PC with BMD, all fractures, and hip fracture separately.</div></div><div><h3>Results</h3><div>During a median follow-up of 12.6 years, 3840 incidents of all fractures and 666 incidents of hip fracture were documented. Ninety-four of the 143 metabolomic biomarkers were significantly associated with incident all fractures, and 81 were significantly associated with incident hip fracture. The very low-density lipoprotein (VLDL) subclasses in different lipid constituents were associated with increased BMD at multiple sites, whereas high-density lipoprotein (HDL) subclasses were associated with decreased BMD. Higher concentrations of small (HR per SD increment: 0.92; 95 % CI: 0.88–0.97), medium (HR per SD increment: 0.91; 95 % CI: 0.88–0.94), and large (HR per SD increment: 0.93; 95 % CI: 0.90–0.96) low-density lipoprotein (LDL) particles were associated with a lower risk of all fractures. Similarly, higher VLDL subclasses (excluding very small VLDL particles) were associated with a lower risk of all fractures. Besides, higher levels of lipid constituents (including total lipids, cholesteryl esters, cholesterol, and free cholesterol) of very large and large HDL were associated with an increased risk of all fractures. PC1 (mainly contributed by lipid subclasses of LDL and VLDL), which explained the most variance of individual biomarkers, showed a negative association with the risk of all fractures (<em>P</em> = 7.80E-08). Similar associations were observed for hip fracture.</div></div><div><h3>Conclusions</h3><div>Higher levels of large and very large HDL were associated with an increased risk of fractures, whereas higher lipid subclasses of LDL and VLDL were associated with a lower risk of fracture. Higher levels of VLDL subclasses in different lipid constituents were associated with increased BMD at multiple sites, while higher level of HDL was associated with decreased BMD.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117460"},"PeriodicalIF":3.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mapping of articular cartilage CXCR4 expression after ACL injury via a novel small molecule-based probe","authors":"Michael D. Newton ,&nbsp;Mackenzie M. Fleischer ,&nbsp;Howard W.T. Matthew ,&nbsp;Tristan Maerz","doi":"10.1016/j.bone.2025.117463","DOIUrl":"10.1016/j.bone.2025.117463","url":null,"abstract":"<div><h3>Purpose</h3><div>Molecular imaging is a powerful modality to spatially resolve molecular changes across tissues, but application to articular cartilage remains limited. CXCR4 is an established marker of chondrocyte hypertrophy and potential therapeutic target for osteoarthritis. The purpose of this study was to develop and apply a CXCR4-targeted, near-infrared fluorescent (NIR) probe to a rat model of post-traumatic osteoarthritis (PTOA).</div></div><div><h3>Methods</h3><div>A CXCR4-targeted, small molecule-based NIR probe (“Cy7-AMD”) was synthesized. Sensitivity and specificity of Cy7-AMD to CXCR4 was validated in vitro (HUVECs), and ex vivo (rat osteochondral explants). To induce PTOA, female Lewis rats underwent noninvasive anterior cruciate ligament (ACL) rupture. At 7- and 28-days post-injury, injured/contralateral femora and tibiae were dissected, incubated in Cy7-AMD vs a non-targeting control, and imaged via NIR imaging, as well as conventional and contrast-enhanced micro-computed tomography. Imaging datasets were co-registered, cartilage tissue volumes were segmented, and paired cartilage thickness and NIR signal maps were generated and analyzed for PTOA-relevant changes.</div></div><div><h3>Results</h3><div>Compared to a non-targeting control probe, in vitro and ex vivo assays confirm sensitivity and specificity of Cy7-AMD to CXCR4. Flow cytometry confirmed high correspondence between Cy7-AMD- and antibody-based measurement of CXCR4 expression. Cy7-AMD rapidly equilibrated within cartilage, and fluorescent histology confirmed full-thickness penetration. Injured femoral cartilage exhibited heterogeneous CXCR4 expression, with increased signal deviation compared to contralateral femora. Spatial CXCR4 expression patterns correlated to cartilage thickness patterns; high CXCR4 expression at boundaries of low-thickness lesions suggests an association between CXCR4 expression and cartilage loss.</div></div><div><h3>Conclusions</h3><div>Small molecule-based probes are advantageous for mapping spatial patterns of molecular expression in rodent articular cartilage, deepening our understanding of PTOA progression.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117463"},"PeriodicalIF":3.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limb lengthening in individuals with achondroplasia: Analysis of an international survey","authors":"Christoph Beger ,&nbsp;Inês Alves ,&nbsp;Patricia Carl-Innig ,&nbsp;Marco Sessa ,&nbsp;Klaus Mohnike ,&nbsp;Moira S. Cheung","doi":"10.1016/j.bone.2025.117462","DOIUrl":"10.1016/j.bone.2025.117462","url":null,"abstract":"<div><h3>Background</h3><div>Limb lengthening surgery is a contentious option for individuals with achondroplasia. This study aimed to assess real-world experiences, outcomes, and perspectives on limb lengthening in a multinational cohort of individuals with achondroplasia.</div></div><div><h3>Methods</h3><div>A cross-sectional, international online survey on limb lengthening experiences and perspectives was conducted in 11 languages across 16 countries from May until July 2024.</div></div><div><h3>Results</h3><div>Out of 467 responders (229 self-responders, 238 parents/caregivers), 90 (19.3 %) reported undergoing limb lengthening (LL) surgery. The mean age at first surgery was 10.5 years (SD 4.5). On average, respondents underwent 3.7 (SD 2.9) procedures, resulting in 14.5 cm (SD10.4) added and final adult height of 137.1 cm in females and 142.1 cm in males. Significant improvements were described in activities such as car driving, bathing, brushing hair, and wiping after toileting for those who underwent both arm and leg lengthening (<em>p</em> ≤ 0.001). Among respondents, 23 % would recommend the procedure to others and 28 % would not recommend LL. Nearly half of respondents (49 %) was uncertain about recommending LL.</div></div><div><h3>Conclusions</h3><div>This is the largest international survey on LL in achondroplasia with results highlighting some of the differences in perspectives and choices of the individual with achondroplasia and their families, providing real-world evidence of the outcomes of this intervention. While significant functional improvements were reported, a reduced percentage of respondents recommended LL intervention. The findings underscore the existence of a triad when considering limb lengthening in achondroplasia as individual choices and life experiences, socio-cultural environment and access to clinical options.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117462"},"PeriodicalIF":3.5,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between total volume and intensity of moderate-to-vigorous physical activity and incidence of osteoporosis","authors":"Yuting Li ,&nbsp;Yiyi Yang ,&nbsp;Cui Guo ,&nbsp;Honglin Cai","doi":"10.1016/j.bone.2025.117461","DOIUrl":"10.1016/j.bone.2025.117461","url":null,"abstract":"<div><div>It is unclear whether moderate-to-vigorous physical activity (MVPA) and its proportion by vigorous physical activities (VPA) would decrease the risk of osteoporosis. This study aimed to examine a dose-response association between MVPA, VPA ratio, and incident osteoporosis in a large prospective cohort. We conducted a longitudinal analysis using data on MVPA, VPA, and osteoporosis from the UK Biobank prospective cohort study. A total of 368,553 eligible participants were included at baseline. Cox proportional hazard models were used to explore the association of MVPA and VPA with the incidence of osteoporosis for men and women, and trend tests were applied to assess the dose-response relationship between them. During a median follow-up of 12.56 years, 11,788 incident cases of osteoporosis (2016 in men and 9772 in women) were identified. The multivariate-adjusted HR (95%CI) of osteoporosis in the highest compared with lowest quartile of MVPA was 0.61 (0.54–0.69); P-trend &lt; 0.001 for men and 0.84 (0.79–0.89); P-trend &lt; 0.001 for women. In the analyses of proportions of VPA and the risk of osteoporosis, the highest tertile of VPA proportion was associated with the lowest risk of osteoporosis with a HR (95%CI) of 0.74 (0.63–0.86); P-trend &lt; 0.001 for men and 0.80 (0.75–0.86); P-trend &lt; 0.001 for women. A higher MVPA and VPA proportion were associated with decreasing osteoporosis risk in a dose-response manner, respectively, among British aged between 37 and 73 years.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117461"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vascular calcifications on the risk of fractures in patients with chronic kidney disease","authors":"Alejandro Godoy ,&nbsp;Maria Paula Dionisi ,&nbsp;Anyelo Cardozo ,&nbsp;Pehuén Fernández ,&nbsp;Daniela Porta ,&nbsp;Aldo Tabares ,&nbsp;Carlos Chiurchiu ,&nbsp;Javier de Arteaga ,&nbsp;Jorge de la Fuente ,&nbsp;Walter Douthat ,&nbsp;María Angélica Rivoira","doi":"10.1016/j.bone.2025.117455","DOIUrl":"10.1016/j.bone.2025.117455","url":null,"abstract":"<div><h3>Background</h3><div>The decline in kidney function adversely affects mineral and bone disease, leading to decreased bone mass, increased fractures, and vascular calcifications (VC), particularly in advanced CKD stage 5. This study aimed to identify VC markers to eventually develop personalized therapeutic and preventive strategies in Argentina, where data is limited.</div></div><div><h3>Methods</h3><div>A prospective, observational study included 101 patients on dialysis or pre-dialysis, eligible for kidney transplant at the Private University Hospital of Córdoba from June 2019 to December 2020. Clinical, laboratory, and imaging assessments were conducted, measuring bone mineral density (BMD), pulse wave velocity (PWV), and VC presence. Patients were grouped based on VC status for comparative analysis.</div></div><div><h3>Results</h3><div>VC was found in 28 % of patients, correlating significantly with age, BMI, time on dialysis, deceased donor type, and PWV (<em>p</em> &lt; 0.01). PTH showed a direct correlation with total alkaline phosphatase (ALP), bone-specific alkaline phosphatase, P1NP, osteocalcin, and telopeptides. ALP was significantly higher in the VC group (median = 149.5, range [62–964] vs. median = 106, range [28–449]; <em>p</em> &lt; 0.01). Patients without VC had higher serum albumin levels (OR = 0.16; <em>p</em> = 0.002; CI = 0.05–0.52). Fracture prevalence was 32.1 % in the VC group compared to 13.1 % without VC (<em>p</em> &lt; 0.02), with logistic regression showing VC increased fracture risk threefold (OR = 3.09; <em>p</em> = 0.01; CI = 1.22–7.83).</div></div><div><h3>Conclusion</h3><div>This study highlights the high prevalence of VC and increased fracture risk in CKD stage 5 patients. ALP is a potential serum marker for bone metabolism, while lower serum albumin levels suggest chronic inflammation may contribute to VC development.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117455"},"PeriodicalIF":3.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DXA-based 3D finite element models predict hip fractures better than areal BMD in elderly women","authors":"Lorenzo Grassi ,&nbsp;Sami P. Väänänen ,&nbsp;Antti Voss ,&nbsp;Tomi Nissinen ,&nbsp;Reijo Sund ,&nbsp;Heikki Kröger ,&nbsp;Hanna Isaksson","doi":"10.1016/j.bone.2025.117457","DOIUrl":"10.1016/j.bone.2025.117457","url":null,"abstract":"<div><div>Bone strength is a major contributor to fracture risk. Areal bone mineral density (aBMD) obtained from dual-energy X-ray absorptiometry (DXA) is used as a surrogate for bone strength in fracture risk prediction. 3D finite element (FE) models predict bone strength better than aBMD but need 3D computed tomography and are not automated. We have earlier developed a method to automatically reconstruct the 3D hip anatomy from a 2D hip DXA image, followed by subject-specific FE-based prediction of proximal femoral strength. In this study, we evaluate the method's ability to predict incident hip fractures in a population-based cohort of women (OSTPRE). We used a sub-cohort including 46 cases with a hip fracture (&lt;10 years from DXA scan) and 2 healthy controls to each hip fracture case, matched by age, height, and body mass index. We automatically reconstructed the 3D hip anatomy and predicted proximal femoral strength using FE analysis for all the subjects of the sub-cohort. The FE-predicted proximal femoral strength was a significantly better predictor of incident hip fractures than aBMD (difference in area under the receiver operating characteristics curve, ΔAUROC = 0.10). This is the first time that 3D FE models obtained from a 2D hip DXA scan outperform aBMD in predicting incident hip fractures in a population-based prospectively followed cohort of women. Our approach provided an improved fracture risk prediction in a clinically feasible manner (only one single DXA image is needed) and without additional costs compared to the current clinical approach.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117457"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superiority of 68Ga-DOTA-FAPI-04 PET/CT to 18F-FDG PET/CT in the evaluation of different cancers with bone metastases","authors":"Rui Guo ,&nbsp;Fei Wang ,&nbsp;Hua Su ,&nbsp;Xiangxi Meng ,&nbsp;Qing Xie ,&nbsp;Wei Zhao ,&nbsp;Zhi Yang ,&nbsp;Nan Li","doi":"10.1016/j.bone.2025.117426","DOIUrl":"10.1016/j.bone.2025.117426","url":null,"abstract":"<div><h3>Background</h3><div>⁶⁸Ga-DOTA-FAPI-04 is a new positron imaging agent, and its application in bone metastasis has been limited. The purpose of this retrospective study was to compare the diagnostic ability of ⁶⁸Ga-DOTA-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT to detect bone metastases in patients with different types of cancer.</div></div><div><h3>Methods</h3><div>A total of 293 patients with pathologically confirmed primary malignancies were examined with ⁶⁸Ga-DOTA-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT within one week. Using pathological examination or follow-up CT or MRI scan as the gold standard, the diagnostic efficacy of the two methods in differentiating bone metastases was compared (p &lt; 0.05, with statistical significance). The maximum standard uptake value (SUVmax) of the two methods for different types of bone metastasis was further compared. The SUVmax was used to compare the differences between the two methods in detecting bone metastases in different tumor types and different sites.</div></div><div><h3>Results</h3><div>A total of 48 patients were diagnosed with bone metastasis, and 245 patients without bone metastasis. There were 376 bone metastases and 243 benign bone lesions. ⁶⁸Ga-DOTA-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT detected 376 and 228 metastases, respectively. Sensitivity, specificity, positive and negative predictive value (PPV and NPV) and accuracy of ⁶⁸Ga-DOTA-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT were 100.0 % vs 60.6 %, 93.8 % vs 99.2 %, 96.2 % vs 99.2 %, 100.0 % vs 62.0 % and 97.6 % vs 75.8 %, respectively. Compared with ¹⁸F-FDG, ⁶⁸Ga-DOTA-FAPI-04 uptake was significantly increased in both benign bone lesions and metastases (p = 0.001). The uptake of ⁶⁸Ga-DOTA-FAPI-04 for osteoblastic metastasis was also significantly higher than that of ¹⁸F-FDG (p &lt; 0.001). In bone metastasis of lung cancer and gastric cancer, ⁶⁸Ga-DOTA-FAPI-04 uptake was higher than that of ¹⁸F-FDG PET/CT (p &lt; 0.05). Using SUVmax = 4.1 and SUVmax = 6.2 as the cutoff value by ⁶⁸Ga-DOTA-FAPI-04 PET/CT and ¹⁸F-FDG PET/CT, it was possible to predict the occurrence of metastases (AUC = 0.817,95 % CI: 0.791–0.923 vs AUC =0.751,95%CI:0.626–0.875).</div></div><div><h3>Conclusions</h3><div>⁶⁸Ga-DOTA-FAPI-04 as a novel imaging agent, can detect more bone metastases and has a higher tracer uptake level than ¹⁸F-FDG. Especially for lung and gastric cancer, ⁶⁸Ga-DOTA-FAPI-04 PET/CT may be a more reliable means to detect bone metastases.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"196 ","pages":"Article 117426"},"PeriodicalIF":3.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Period prevalence and timing of contralateral hip fractures: An eighteen year retrospective cohort study, systematic review and meta-analysis of the literature","authors":"David Morris ,&nbsp;Tim Cheok ,&nbsp;Thomas Smith ,&nbsp;Jonghoo Sung ,&nbsp;Ruurd Jaarsma ,&nbsp;Luke Johnson","doi":"10.1016/j.bone.2025.117453","DOIUrl":"10.1016/j.bone.2025.117453","url":null,"abstract":"<div><h3>Purpose</h3><div>Second contralateral hip fractures (SCHF) are relatively uncommon. The overall prevalence of this is poorly reported in literature.</div></div><div><h3>Methods</h3><div>We performed a single centre retrospective cohort study in patients &gt;50 years old who sustained a SCHF between 1st of January 2005 and 30th of April 2023. A systematic search of the literature was then performed by searching PubMed, Embase, and Web of Science from the date of inception of each database through to the 22nd of February 2024. A meta-analysis was conducted to estimate the prevalence of SCHF and hip fracture pattern symmetry, incorporating both our results and that previously reported in literature.</div></div><div><h3>Results</h3><div>Our cohort study showed a period prevalence of 1.7 % within 1 year and 2.8 % within 2 years following a hip fracture. 65 studies were identified using our search strategy. The overall prevalence of SCHF was 7.3 % [95 % CI: 6.3–8.4]. Meta-regression suggested that studies conducted in Europe and North America showed higher prevalence than studies conducted in Asia. A similar fracture pattern was seen in 72.1 % [95 % CI: 69.7–74.4] of patients with SCHF.</div></div><div><h3>Conclusion</h3><div>SCHF are relatively uncommon. When they do occur, it is usually within 2 years of the index fracture. Asian populations had lower prevalence of SCHF when compared to their European and North American counterparts. Hip fracture pattern is symmetrical in most patients with a SCHF.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117453"},"PeriodicalIF":3.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis","authors":"Keisuke Uemura ,&nbsp;Sotaro Kono ,&nbsp;Kazuma Takashima ,&nbsp;Kazunori Tamura ,&nbsp;Ryo Higuchi ,&nbsp;Hirokazu Mae ,&nbsp;Nobuo Nakamura ,&nbsp;Yoshito Otake ,&nbsp;Yoshinobu Sato ,&nbsp;Nobuhiko Sugano ,&nbsp;Seiji Okada ,&nbsp;Hidetoshi Hamada","doi":"10.1016/j.bone.2025.117456","DOIUrl":"10.1016/j.bone.2025.117456","url":null,"abstract":"<div><h3>Background</h3><div>Accurately evaluating bone mineral density (BMD) in patients with unilateral hip osteoarthritis (OA) is crucial for diagnosing osteoporosis and selecting implants for hip arthroplasty. Our goal was to measure the BMD differences between sides, examine contributing factors, and identify the optimal side for BMD assessment in these patients.</div></div><div><h3>Methods</h3><div>We analyzed 108 women with unilateral hip OA. Bilateral hip BMD was assessed automatically through quantitative CT (QCT) utilizing a validated, deep-learning-based approach. We evaluated BMD variations between the OA and healthy hips across total, neck, and distal regions. To determine their contributions, we analyzed factors, including patient demographics, Crowe classification, Bombelli classification, knee OA status, hip functional score, and gluteal muscle volume and density. Furthermore, we examined how side-to-side BMD differences influenced osteoporosis diagnosis using T-scores based on QCT.</div></div><div><h3>Results</h3><div>The average BMD on the OA side was 6.9 % lower in the total region, 14.5 % higher in the neck region, and 9.4 % lower in the distal region than on the healthy side. Contributing factors to the reduced BMD in the OA hip included younger age, Bombelli classification (atrophic type), and significant gluteal muscle atrophy. Diagnoses from the OA side revealed lower sensitivity (61 %) than those from the healthy side (88 %).</div></div><div><h3>Conclusions</h3><div>Analysis on one side alone yields a more precise osteoporosis diagnosis from the healthy side. Nonetheless, bilateral BMD assessment remains crucial, particularly in younger individuals and those with atrophic OA types. Although based on QCT, our findings support bilateral analysis by dual-energy X-ray absorptiometry for these patients.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"195 ","pages":"Article 117456"},"PeriodicalIF":3.5,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}