Bone最新文献

{"title":"Calcium kinetic rates in Caucasian males and females from birth to adulthood","authors":"Niklas Hartung ,&nbsp;Steven A. Abrams ,&nbsp;Wilhelm Huisinga ,&nbsp;Karin Weisser","doi":"10.1016/j.bone.2024.117254","DOIUrl":"10.1016/j.bone.2024.117254","url":null,"abstract":"<div><p>Calcium plays an important role in bone physiology and its kinetics change over lifetime. The analysis of calcium deposition and release through stable isotope techniques has guided recommendations on nutritional uptake for overall health. In addition, calcium kinetics have great relevance for toxicokinetic studies of bone-seeking elements (e.g, aluminium and lead) since these elements use common uptake and release pathways. While the impact of many factors on calcium kinetics have been investigated individually, a consolidated age- and sex-dependent kinetic description amenable for toxicokinetic modeling, however, is still lacking. Motivated by this need, we systematically reviewed the existing literature on calcium kinetics and assembled a large and consistent dataset. Then, building on the work of O'Flaherty in the 1990s, we formulated age- and sex-dependent functions describing calcium deposition, release, net retention, and mass. This description represents the current knowledge on calcium kinetics in a reference individual of Caucasians as most data was from this population.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117254"},"PeriodicalIF":3.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of age-dependent sexual dimorphism in paediatric vertebral size and density using a statistical shape and statistical appearance modelling approach","authors":"Natalia M. Castoldi ,&nbsp;Dermot O'Rourke ,&nbsp;Maria Antico ,&nbsp;Vittorio Sansalone ,&nbsp;Laura Gregory ,&nbsp;Peter Pivonka","doi":"10.1016/j.bone.2024.117251","DOIUrl":"10.1016/j.bone.2024.117251","url":null,"abstract":"<div><p>This work focuses on the growth patterns of the human fourth lumbar vertebra (L4) in a paediatric population, with specific attention to sexual dimorphism. The study aims to understand morphological and density changes in the vertebrae through age-dependent statistical shape and statistical appearance models, which can describe full three-dimensional anatomy. Results show that the main growth patterns are associated with isotropic volumetric vertebral growth, a decrease in the relative size of the vertebral foramen, and an increase in the length of the transverse processes. Moreover, significant sexual dimorphism was demonstrated during puberty. We observe significant age and sex interaction in the anterior vertebral body height (<em>P</em> = 0.005), where females exhibited an earlier increase in rates of vertebral height evolution. Moreover, we also observe an increase in cross-sectional area (CSA) with age (<em>P</em> = 0.020), where the CSA is smaller in females than in males (significant sex effect <em>P</em> = 0.042). Finally, although no significant increase in trabecular bone density with age is observed (<em>P</em> = 0.363), a trend in the statistical appearance model suggests an increase in density with age.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117251"},"PeriodicalIF":3.5,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002400/pdfft?md5=326eea364020ae4b2ddeef656abe33d9&pid=1-s2.0-S8756328224002400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional and national trends in the burden of low bone mineral density from 1990 to 2030: A Bayesian age-period-cohort modeling study","authors":"Jiaying Li ,&nbsp;Hongyu Jia ,&nbsp;Zhenqiu Liu ,&nbsp;Kelin Xu","doi":"10.1016/j.bone.2024.117253","DOIUrl":"10.1016/j.bone.2024.117253","url":null,"abstract":"<div><p>Low bone mineral density (LBMD) remains a global public health concern. To provide deeper insights, we retrieved and calibrated LBMD death and Disability-Adjusted Life Years (DALYs) data from the Global Burden of Disease 2021 (GBD 2021) database. We calculated the age-standardized rate (ASR) and estimated annual percentage change (EAPC) to delineate LBMD trends across sexes, age groups, Sociodemographic Index (SDI) regions, and countries. Spearman rank order correlation analysis was used to explore the relationship between SDI and ASR. Additionally, we constructed Bayesian age-period-cohort (BAPC) models to predict future trends in LBMD up to 2030, with the mean absolute percentage error (MAPE) used to evaluate prediction accuracy. Our analyses revealed that global deaths related to LBMD nearly doubled, from 250,930 in 1990 to 463,010 in 2021, and are projected to rise to 473,690 by 2030. However, the ASR exhibited an opposite trend, decreasing from 17.91 per 100,000 in 1990 to 15.77 per 100,000 in 2021, and is expected to further decline to 13.64 per 100,000 by 2030. The EAPC indicated descending trends in 1990–2021 and 2022–2030. Trends in LBMD varied across different subgroups by sex, age, and location. Males are projected to continue experiencing higher death numbers than females, though the gap is narrowing. The 90 to 94 age group consistently had the highest ASR from 1990 to 2030. Lower SDI remains a critical factor contributing to the higher burden of LBMD. Spearman rank order correlation analysis showed a negative correlation between SDI and ASR. We categorized 6 distinct trends in ASR across different countries, with most expected to experience a decline by 2030. The MAPE value (0.038 &lt; 0.1) indicated that the BAPC model produced reliable predictions even under the COVID-19 pandemic.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117253"},"PeriodicalIF":3.5,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific effects of a Mediterranean diet on lower limb bone strength in Polish children","authors":"Daria Masztalerz-Kozubek,&nbsp;Monika A. Zielinska-Pukos,&nbsp;Jadwiga Hamulka","doi":"10.1016/j.bone.2024.117252","DOIUrl":"10.1016/j.bone.2024.117252","url":null,"abstract":"<div><p>Lifestyle factors have the potential to influence bone health in various ways, whether positively or negatively. As osteoporosis is believed to originate in early years, it is therefore essential to indicate factors that may positively affect bone health during childhood. The aim of our study was to investigate the effects of early and current diet, vitamin D supplementation, and BMI z-score on bone properties in a group of children aged 3–7 years. A cross-sectional sample of 205 preschoolers and their parents participated in the study. Dietary assessment was made using a modified version of the Polish-adapted Mediterranean Diet score (MVP-aMED) on the basis of the data from food frequency questionnaire (FFQ), filled out by the parents. Quantitative ultrasound (QUS) was used in the assessment of bone properties. In the sex-stratified analysis, significant associations were observed between MVP-aMED score (β = 0.193, 95 % CI: 0.005, 0.237; <em>p</em> = 0.04), BMI z-score (β = −0.318, 95 % CI: −1.455, −0.039; p = 0.04) and QUS z-score, exclusively among girls. After adjustment, only the relationship with diet remained significant (β = 0.209, 95 % CI: 0.007, 0.255; <em>p</em> = 0.04), suggesting that a higher adherence to the Mediterranean Diet may be associated with better bone properties in girls aged 3–7 years old. Our results emphasize the importance of fostering healthy dietary habits and maintaining proper weight in children in order to promote optimal bone development.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117252"},"PeriodicalIF":3.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002412/pdfft?md5=ccc822044a6438f81f7dc3081e001aa6&pid=1-s2.0-S8756328224002412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls","authors":"Kounosuke Watanabe ,&nbsp;Ko Chiba ,&nbsp;Kazuteru Shiraishi ,&nbsp;Takeshi Iida ,&nbsp;Naoki Iwamoto ,&nbsp;Akihiko Yonekura ,&nbsp;Atsushi Kawakami ,&nbsp;Makoto Osaki","doi":"10.1016/j.bone.2024.117250","DOIUrl":"10.1016/j.bone.2024.117250","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate which joint microarchitectural parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) serve as imaging markers for rheumatoid arthritis (RA).</p></div><div><h3>Methods</h3><p>The second and third metacarpophalangeal (MCP) joints of 50 patients with RA and 50 healthy controls (HCs) (aged 50–79 years, all females) were scanned using a HR-pQCT. Joint space, trabecular bone microarchitecture, and erosion were measured and compared between RA patients and HCs.</p></div><div><h3>Results</h3><p>There were no differences in joint space parameters between RA patients and HCs.</p><p>For bone microarchitecture, RA patients had lower trabecular bone mineral density (127 vs. 167 mg/cm³), thinner trabecular thickness (0.20 vs. 0.21 mm), fewer trabecular number (1.49 vs. 1.55 /mm), more rod-like structure (1.68 vs. 1.23), and poorer trabecular connectivity (4.51 vs. 5.72 /mm³) than HCs.</p><p>Regarding erosion, RA patients had a higher number of erosions per joint (36/100 vs. 18/100), larger volume (4.62 vs. 1.89 mm³), and longer width (2.40 vs. 1.82 mm) and longer length (2.34 vs. 1.64 mm) than HCs.</p><p>Most of the erosions in HCs were &lt;5 mm³ in volume (95 %) and located on the radial side (85 %). When erosions &lt;5 mm³ were compared between RA patients and HCs, there were no differences in their location or morphology.</p></div><div><h3>Conclusions</h3><p>Deterioration of bone microarchitecture and existences of erosions &gt;5 mm³ in the MCP joints are sensitive imaging markers of RA. Erosions &lt;5 mm³ in RA patients may include not only early pathological erosion but also physiological erosion because even HCs can have erosions &lt;5 mm³.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117250"},"PeriodicalIF":3.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of high lipogenic states with titanium on osteogenesis","authors":"T.S. Pinto ,&nbsp;B.C. van der Eerden ,&nbsp;M. Schreuders-Koedam ,&nbsp;J. van de Peppel ,&nbsp;I. Ayada ,&nbsp;Q. Pan ,&nbsp;M.M. Verstegen ,&nbsp;L.J. van der Laan ,&nbsp;G.M. Fuhler ,&nbsp;W.F. Zambuzzi ,&nbsp;M.P. Peppelenbosch","doi":"10.1016/j.bone.2024.117242","DOIUrl":"10.1016/j.bone.2024.117242","url":null,"abstract":"<div><p>As obesity rates continue to rise, the prevalence of metabolic dysfunction and alcohol-associated steatotic liver disease (MetALD), a new term for Nonalcoholic Fatty Liver Disease (NAFLD), also increases. In an aging population, it is crucial to understand the interplay between metabolic disorders, such as MetALD, and bone health. This understanding becomes particularly significant in the context of implant osseointegration. This study introduces an <em>in vitro</em> model simulating high lipogenesis through the use of human Mesenchymal Stroma Cells-derived adipocytes, 3D intrahepatic cholangiocyte organoids (ICO), and Huh7 hepatocytes, to evaluate the endocrine influence on osteoblasts interacting with titanium. We observed a significant increase in intracellular fat accumulation in all three cell types, along with a corresponding elevation in metabolic gene expression compared to the control groups. Notably, osteoblasts undergoing mineralization in this high-lipogenesis environment also displayed lipid vesicle accumulation. The study further revealed that titanium surfaces modulate osteogenic gene expression and impact cell cycle progression, cell survival, and extracellular matrix remodeling under lipogenic conditions. These findings provide new insights into the challenges of implant integration in patients with obesity and MetALD, offering a deeper understanding of the metabolic influences on bone regeneration and implant success.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117242"},"PeriodicalIF":3.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between changes in serum bone metabolism markers and bone microarchitecture changes during basic combat training – The ARMI study","authors":"Jennifer C. Coulombe ,&nbsp;Brittany N. Bozzini ,&nbsp;Katelyn I. Guerriere ,&nbsp;Stephen A. Foulis ,&nbsp;Marinaliz Reynoso ,&nbsp;Leila A. Walker ,&nbsp;Jeffery S. Staab ,&nbsp;Mary L. Bouxsein ,&nbsp;Julie M. Hughes ,&nbsp;Kristin L. Popp","doi":"10.1016/j.bone.2024.117241","DOIUrl":"10.1016/j.bone.2024.117241","url":null,"abstract":"<div><h3>Importance</h3><p>U.S. Army Basic Combat Training (BCT) improves tibial volumetric bone mineral density (BMD) and structure in most, but not all soldiers. Few studies have investigated whether changes in serum bone biomarkers during BCT are associated with changes in tibial BMD and bone structure following BCT.</p></div><div><h3>Objective</h3><p>To characterize bone biomarker changes during BCT and to investigate the relationship between changes in bone biomarkers and changes in tibial BMD and bone structure.</p></div><div><h3>Methods</h3><p>We enrolled 235 trainees entering BCT in this ten-week prospective observational study. Trainees provided fasted blood samples and questionnaires weekly throughout BCT. Procollagen type 1 N-terminal propeptide (PINP) and C-terminal telopeptide of type 1 collagen (CTX) were measured by enzyme-linked immunoabsorbent assays every two weeks during BCT. We evaluated body composition and mass via dual-energy X-ray absorptiometry and bone structure, microarchitecture, and mineral density at the distal tibia via high-resolution peripheral quantitative computed tomography at baseline and post-BCT.</p></div><div><h3>Results</h3><p>Both male (<em>n</em> = 110) and female trainees (<em>n</em> = 125) were young (20.9 ± 3.7 and 20.7 ± 4.3 years, respectively), with normal to overweight BMIs (25.2 ± 4.1 and 24.2 ± 3.6 kg/m², respectively). In female trainees, PINP increased during and post-BCT compared to baseline, with the greatest increase in PINP at week four (45.4 % ± 49.6, <em>p</em> &lt; 0.0001), whereas there were no changes in CTX. PINP also increased in male trainees, but only at weeks two and four (21.9 % ± 24.5, <em>p</em> = 0.0027 and 35.9 % ± 35.8, <em>p</em> &lt; 0.0001, respectively). Unlike female trainees, in males, CTX was lower than baseline at weeks four, eight, and post-BCT. The change in PINP from baseline to week four of BCT was positively associated with changes in tibial BMD, Tb.BMD, Tb.Th, Tb.BV/TV, Ct.Th, Ct.Ar, and Ct.Po from the baseline to post-BCT.</p></div><div><h3>Conclusion</h3><p>The bone formation marker PINP increases during U.S. Army BCT, especially during the first four weeks. Increases in PINP, but not CTX, were correlated with improved BMD and bone structure in the distal tibia.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117241"},"PeriodicalIF":3.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cluster set resistance training on bone mineral density and markers of bone metabolism in older hemodialysis subjects: A pilot study","authors":"Bruno Magalhães de Castro ,&nbsp;Thiago dos Santos Rosa ,&nbsp;Thaís Branquinho de Araújo ,&nbsp;Hugo de Luca Corrêa ,&nbsp;Lysleine Alves de Deus ,&nbsp;Rodrigo Vanerson Passos Neves ,&nbsp;Andrea Lucena Reis ,&nbsp;Rafael Lavarini dos Santos ,&nbsp;Jéssica Mycaelle da Silva Barbosa ,&nbsp;Fernando de Sousa Honorato ,&nbsp;Vitória Marra da Motta Vilalva Mestrinho ,&nbsp;Milton Rocha de Moraes ,&nbsp;Carmen Tzanno-Martins ,&nbsp;Jonato Prestes","doi":"10.1016/j.bone.2024.117240","DOIUrl":"10.1016/j.bone.2024.117240","url":null,"abstract":"<div><p>Chronic kidney disease (CKD) is associated with a series of mineral bone disturbances due to increased production of parathormone which increases the activity of osteoclasts, removing calcium and phosphorous from the bones. However, the literature lacks investigations on the feasibility of different resistance training (RT) methods, such as cluster-sets, in this population. Thus, the aim of the present study was to compare traditional versus cluster-set RT protocols on bone mineral density (BMD) T-score, BMD Total, femur BMD, L3-L4 BMD, femoral neck BMD, Klotho, FGF23, Klotho - FGF23 ratio, Sclerostin, vitamin D, phosphorous and calcium in older subjects with CKD. Seventy-eight older subjects (age: 57.55 ± 4.06 years, body mass: 72.26 ± 13.96 kg, body mass index: 26.73 ± 2.97 kg/m2) with CKD undergoing maintenance hemodialysis were randomly divided into control group (CG, <em>n</em> = 26), traditional RT (RT, n = 26) and cluster-set RT (RT-CS, n = 26) groups. Subjects completed 24 weeks of RT three times per week, 1 h and 30 min before the hemodialysis session, and each training lasted around 60 to 80 min. There was a group×time interaction for total BMD, femur BMD, L3-L4 BMD, and femoral neck BMD, revealed by improvements for RT and RT-CS groups (pre versus post). Only femur BMD displayed differences as compared with the CG. Minimum clinically important difference (MCID) values revealed more responsive subjects in the RT-CS group for total BMD, femur BMD, klotho, FGF23, sclerostin, Vitamin D and calcium. In conclusion, RT can be used as a non-pharmacological complementary strategy for the treatment of CKD. RT-CS may be useful for these subjects as more responders were found for this type of training.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117240"},"PeriodicalIF":3.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the link between gut microbiome and bone mineral density: The role of genetic factors","authors":"Ningxin Gao ,&nbsp;Yue Zhuang ,&nbsp;Yi Zheng ,&nbsp;Yucan Li ,&nbsp;Yawen Wang ,&nbsp;Sibo Zhu ,&nbsp;Min Fan ,&nbsp;Weizhong Tian ,&nbsp;Yanfeng Jiang ,&nbsp;Yingzhe Wang ,&nbsp;Mei Cui ,&nbsp;Chen Suo ,&nbsp;Tiejun Zhang ,&nbsp;Li Jin ,&nbsp;Xingdong Chen ,&nbsp;Kelin Xu","doi":"10.1016/j.bone.2024.117239","DOIUrl":"10.1016/j.bone.2024.117239","url":null,"abstract":"<div><p>Osteoporosis is a complex metabolic bone disease that severely undermines the quality of life and overall health of the elderly. While previous studies have established a close relationship between gut microbiome and host bone metabolism, the role of genetic factors has received less scrutiny. This research aims to identify potential taxa associated with various bone mineral density states, incorporating assessments of genetic factors. Fecal microbiome profiles from 605 individuals (334 females and 271 males) aged 55–65 from the Taizhou Imaging Study with osteopenia (<em>n</em> = 270, 170 women) or osteoporosis (<em>n</em> = 94, 85 women) or normal (<em>n</em> = 241, 79 women) were determined using shotgun metagenomic sequencing. The linear discriminant analysis was employed to identify differentially enriched taxa. Utilizing the Kyoto Encyclopedia of Genes and Genomes for annotation, functional pathway analysis was conducted to identify differentially metabolic pathways. Polygenic risk score for osteoporosis was estimated to represent genetic susceptibility to osteoporosis, followed by stratification and interaction analyses. Gut flora diversity did not show significant differences among various bone mineral groups. After multivariable adjustment, certain species, such as <em>Clostridium leptum</em>, <em>Fusicatenibacter saccharivorans</em> and <em>Roseburia hominis,</em> were enriched in osteoporosis patients. Statistically significant interactions between the polygenic risk score and taxa <em>Roseburia faecis, Megasphaera elsdenii</em> were observed (<em>P</em> for interaction = 0.005, 0.018, respectively). Stratified analyses revealed a significantly negative association between <em>Roseburia faecis</em> and bone mineral density in the low-genetic-risk group (β = −0.045, <em>P</em> &lt; 0.05), while <em>Turicimonas muris</em> was positively associated with bone mineral density in the high-genetic-risk group (β = 4.177, <em>P</em> &lt; 0.05) after multivariable adjustments. Functional predictions of the gut microbiome indicated an increase in pathways related to structural proteins in high-genetic-risk patients, while low-genetic-risk patients exhibited enrichment in enzyme-related pathways. This study emphasizes the association between gut microbes and bone mass, offering new insights into the interaction between genetic background and gut microbiome.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117239"},"PeriodicalIF":3.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 public health restrictions on fall-related hip fracture hospitalizations: An interrupted time series analysis","authors":"Seigo Mitsutake ,&nbsp;Reidar P. Lystad ,&nbsp;Janet C. Long ,&nbsp;Jeffrey Braithwaite ,&nbsp;Rebecca Mitchell","doi":"10.1016/j.bone.2024.117237","DOIUrl":"10.1016/j.bone.2024.117237","url":null,"abstract":"<div><h3>Purpose</h3><p>There is limited evidence regarding the impact of public health restrictions on hip fracture hospitalization by place of fracture occurrence. This study aimed to examine the impact of COVID-19 public health restrictions on fall-related hip fracture hospitalization rates by place of occurrence.</p></div><div><h3>Methods</h3><p>This retrospective cohort study was conducted using hospitalization data in New South Wales, Australia, between January 2014 and June 2022. Older adults aged ≥65 years admitted to hospital following a fall-related hip fracture. An interrupted time-series analysis using autoregressive integrated moving average models evaluated the impact of public health restrictions on fall-related hip fracture hospitalization by place of fracture occurrence (home/residence, residential aged care facility (RACF), or away from usual residence).</p></div><div><h3>Results</h3><p>The mean observed fall-related hip fracture hospitalization rate during COVID-19 public health restrictions (36.3 per 100,000 people per month) was 13.4 % lower than the forecasted rate (41.1 per 100,000 people per month). The mean observed hospitalization rates for fall-related hip fractures at home/residence, at a RACF, and away from the usual residence were 3.8 %, 18.5 %, and 40.1 % lower than the forecasted rates, respectively. Level changes in the fall-related hip fracture hospitalization rates at RACFs and away from usual residences were −0.9 per 100,000 people per month (95 % CI −1.6 to −0.2) and −1.7 per 100,000 people per month (95 % CI −2.5 to −0.9), respectively.</p></div><div><h3>Conclusions</h3><p>There was a decline in fall-related hip fracture hospitalization rates among older adults, where the fracture occurred at RACFs and away from a person's usual residence during COVID-19 public health restrictions.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117237"},"PeriodicalIF":3.5,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002266/pdfft?md5=8b49ebfd16a64d1489873e83f5c1f234&pid=1-s2.0-S8756328224002266-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}