Bone最新文献

{"title":"Complications following hip fracture surgery in end-stage kidney disease patients receiving dialysis: A systematic review and meta-analysis of cohort studies","authors":"Lewis Weeda ,&nbsp;Saiuj Bhat ,&nbsp;Katie Wang ,&nbsp;Ben Chia ,&nbsp;Nick Calvert ,&nbsp;Hannah Seymour ,&nbsp;Revathy Manickavasagar ,&nbsp;Lucy Kilshaw","doi":"10.1016/j.bone.2025.117728","DOIUrl":"10.1016/j.bone.2025.117728","url":null,"abstract":"<div><h3>Aims</h3><div>Hip fracture patients have significant morbidity and mortality, with worse outcomes in end-stage kidney disease (ESKD) patients receiving dialysis. This study evaluates and quantifies the risk of mortality and complications in dialysis patients undergoing surgery for hip fractures.</div></div><div><h3>Methods</h3><div>A systematic review of studies investigating complications after surgery for hip fractures in ESKD patients receiving dialysis was performed across various databases. Mortality (30-day or longer) was the primary outcome.</div></div><div><h3>Results</h3><div>Thirty studies encompassing 23,024 dialysis patients were included, most of which had a low risk of bias (<em>n</em> = 26; 87 %). Thirty-day (RR 2.2; CI 95 %: 1.5, 3.2 and HR 2.3; CI 95 %: 1.7, 3.0) and overall mortality (RR 1.9; CI 95 %: 1.6, 2.2) were two-fold greater in dialysis patients. There was also an increased risk of surgical site infection (RR 1.6. CI 95 %: 1.3, 2.0), major adverse cardiac events (RR 1.9. CI 95 %: 1.3, 3.0), and sepsis (RR 1.9. CI: 1.5, 2.2) in this cohort compared to a non-dialysis cohort.</div></div><div><h3>Conclusion</h3><div>Patients receiving dialysis experience approximately two-fold greater mortality after hip fracture surgery compared to patients not receiving dialysis. Dialysis patients face higher rates of complications after surgery, notably wound infection, major adverse cardiac events, and sepsis. Results from this study provide quantitative estimates for perioperative counselling of patients alongside families. While some tools aid in predicting post-operative outcomes, further research may refine risk stratification in this cohort. Additional evidence is required to establish evidence-based models of care that optimise the peri-operative health of dialysis patients.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117728"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145515262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related response to 12-month romosozumab in treatment-naïve Japanese women aged 55–100 years with primary osteoporosis","authors":"Takaomi Kobayashi ,&nbsp;Tomonori Kobayakawa ,&nbsp;Yukio Nakamura","doi":"10.1016/j.bone.2025.117708","DOIUrl":"10.1016/j.bone.2025.117708","url":null,"abstract":"<div><div>This study aimed to investigate the age-related bone mineral density (BMD) response to romosozumab. A prospective cohort study was conducted on 221 treatment-naïve women aged 55–100 years with primary osteoporosis who initiated a 12-month romosozumab therapy. Percent changes in lumbar spine (LS), total hip (TH), and femoral neck (FN) BMD and bone turnover markers were assessed at 6 and 12 months. Associations between age and treatment efficacy were analyzed using multivariate regression, adjusting for potential confounders. Sensitivity analyses were conducted according to the baseline 25-hydroxyvitamin D (25OHD) status (&lt;20 vs. ≥20 ng/mL). Restricted cubic spline curves were applied to assess the potential non-linear associations between age and the BMD response, adjusting for the same covariates. Multivariate regression showed that younger age is independently associated with higher percent changes in LS BMD at 6 (regression coefficient [<em>β</em>], −0.31; 95 % confidence interval [CI], −0.45 to −0.18) and 12 months (<em>β</em>, −0.19; 95 % CI, −0.36 to −0.02). Sensitivity analyses confirmed the association between age and percent gains in the LS BMD at 6 months but not at 12 months. No evidence of non-linearity was found at 6 (<em>p</em> for non-linearity = 0.874) and 12 months (<em>p</em> for non-linearity = 0.686). No significant associations were observed for TH or FN BMD or the bone turnover markers. An inverse linear relationship was observed between age and percent change of the LS BMD at 6 months; however, the relationship was not robust at 12 months.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117708"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world safety and age-dependent effectiveness of vosoritide in achondroplasia: A single-center retrospective analysis of transition from growth hormone to vosoritide","authors":"Takaaki Shimada ,&nbsp;Hirofumi Nakayama ,&nbsp;Ikumi Ueda ,&nbsp;Takeshi Ishimi ,&nbsp;Chieko Yamada ,&nbsp;Yukako Nakano ,&nbsp;Kenichi Yamamoto ,&nbsp;Makoto Fujiwara ,&nbsp;Taichi Kitaoka ,&nbsp;Keiichi Ozono ,&nbsp;Takuo Kubota ,&nbsp;Yasuhisa Ohata ,&nbsp;Yasuji Kitabatake","doi":"10.1016/j.bone.2025.117722","DOIUrl":"10.1016/j.bone.2025.117722","url":null,"abstract":"<div><div>Achondroplasia (ACH), a skeletal dysplasia, is characterized by disproportionate short stature and impaired quality of life. In Japan, growth hormone (GH) therapy has been available since 1997, and vosoritide, a C-type natriuretic peptide analog, was approved in 2022. Although clinical trials have demonstrated vosoritide's efficacy, real-world comparative data in Japan are scarce. We conducted a retrospective study of 22 children with ACH treated with vosoritide for over 6 months at a single institution between February 2018 and May 2025. Patients were divided into two groups: GH-naïve group (Group A, <em>n</em> = 13), receiving vosoritide alone, and a switch group (Group B, <em>n</em> = 9), who transitioned from prior GH treatment. Growth outcomes included annualized growth velocity (AGV) and height standard deviation scores (HT-SDS) calculated using Japanese and ACH-specific (HT-SDS_ACH) references. Group A (median age: 2.10 years) demonstrated significant improvements in HT-SDS_ACH at years 3 (<em>p</em> = 0.0022), 4 (<em>p</em> = 0.0004), 5 (<em>p</em> = 0.007), and 6 (<em>p</em> = 0.0012). Group B (median age: 10.1 years), with a median of 6.10 years of GH exposure, showed significant increases at 1 year (<em>p</em> = 0.047) and 2.5 years (<em>p</em> = 0.0054) after switching. In Group B, HT-SDS_ACH remained stable among patients starting vosoritide before age 4, but improved significantly in those beginning later. Injection site pain occurred in three patients, leading to one discontinuation. Vosoritide improves linear growth in children with ACH, including those previously treated with GH, showing greater benefit when started at ≥4 years, though earlier use may offer advantages.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117722"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145515251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-supported opportunistic detection of vertebral fractures on routine CT scans: Diagnostic performance and clinical relevance","authors":"Martina Behanova ,&nbsp;Anton Sokhan ,&nbsp;Judith Haschka ,&nbsp;Shahin Zandieh ,&nbsp;Christoph Salzlechner ,&nbsp;Richard Ljuhar ,&nbsp;Jochen Zwerina ,&nbsp;Roland Kocijan","doi":"10.1016/j.bone.2025.117735","DOIUrl":"10.1016/j.bone.2025.117735","url":null,"abstract":"<div><h3>Background</h3><div>Vertebral fractures (VFs) are among the most common osteoporotic fractures, yet they are frequently underdiagnosed and left untreated. The use of an artificial intelligence (AI) tool may support improved detection rates. This study aimed to evaluate the diagnostic performance of the AI-based software (IB Lab FLAMINGO) in identifying VFs on thoracic and abdominal CT scans, using radiologist assessment as the reference standard.</div></div><div><h3>Methods</h3><div>This was a monocentric, retrospective cross-sectional study. 205 patients with CT scans performed for non-skeletal indications were randomly selected. Sensitivity, specificity, and accuracy were calculated at the vertebra and patient level. We examined the proportion of false positive AI-identified fractures that might represent overlooked fractures upon re-evaluation.</div></div><div><h3>Results</h3><div>Among 205 patients (59 % male; mean age 67.9 ± 9.5 years), VFs were initially identified in 11.2 % by the radiologist, most frequently at the thoracolumbar junction. Females showed more thoracic (T4–T7) fractures, while males more commonly had lumbar (L1–L4) fractures. The AI analyzed 190 patients (92.7 %), detecting fractures in 24.7 %. At the patient level, IB Lab FLAMINGO showed 81 % accuracy, 74 % sensitivity and 82 % specificity. Vertebra-level performance (<em>N</em> = 3040) demonstrated high accuracy (97 %) and specificity (97 %). As a result of re-evaluation, fractures were confirmed in 29 of 30 AI-positively flagged patients, increasing sensitivity to 88.5 %, specificity to 99.3 %, and the overall presence of VFs to 25 %.</div></div><div><h3>Discussion</h3><div>The performance metrics support potential use of AI IB Lab FLAMINGO as a screening aid and as a quality assurance tool, taking into account the proportion of missed diagnoses by the radiologist.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117735"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145590360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric pQCT-derived tibial bone mineral density estimates: A systematic review and meta-regression","authors":"Anna Maria Markarian ,&nbsp;Dennis R. Taaffe ,&nbsp;Daniel A. Galvão ,&nbsp;Jodie Cochrane Wilkie ,&nbsp;Carolyn J. Peddle-McIntyre ,&nbsp;Mark Markarian ,&nbsp;Daniel J. Schiferl ,&nbsp;Robert U. Newton","doi":"10.1016/j.bone.2025.117720","DOIUrl":"10.1016/j.bone.2025.117720","url":null,"abstract":"<div><h3>Background</h3><div>Assessing bone mineral density (BMD) in children and adolescents is essential for detecting skeletal deficits and fracture risk. Peripheral quantitative computed tomography (pQCT) has gained increasing attention as a valuable imaging tool due to its ability to assess bone quality. Unlike dual-energy x-ray absorptiometry, pQCT provides volumetric BMD measurements and distinguishes between cortical and trabecular compartments. Despite these advantages, its clinical adoption remains limited due to the lack of reference data and standardized protocols.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in CINAHL, Embase, PubMed, SPORTDiscus, and Web of Science from inception to November 2024. Studies reporting pQCT-derived tibial BMD in healthy children and adolescents (&lt;19 years old) were included. Meta-regression models using natural cubic splines were applied to estimate age-specific BMD values for trabecular and cortical bone. Potential moderators, such as sex, race, reference line location, limb, and pQCT device, were evaluated to assess their influence on BMD outcomes.</div></div><div><h3>Results</h3><div>Eighty-three studies (18,531 participants) were included in this review. The meta-regression models demonstrated a non-linear relationship between BMD and age, best described using natural cubic splines. Moderator analysis indicated that sex, race, and reference line location significantly influenced cortical BMD, while trabecular BMD was affected by reference line location and pQCT device. The choice of limb assessed (dominant vs non-dominant) had minimal impact on BMD outcomes.</div></div><div><h3>Conclusion</h3><div>We present pQCT-derived BMD estimates from a diverse cohort of healthy children and adolescents and identify key moderators. Our findings provide a foundation for improved understanding and future standardization, laying the groundwork for enhancing the clinical utility of pQCT.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117720"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Familial determinants of bone health parameters – a dual X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT)-based parent and offspring study in rural Indian children” [Bone (2026), volume 202, article 117685]","authors":"Sharvani Patil ,&nbsp;Nikhil Shah ,&nbsp;Alex Ireland ,&nbsp;Vivek Patwardhan ,&nbsp;Neha Sanwalka ,&nbsp;Neha Kajale ,&nbsp;Chidvilas More ,&nbsp;Ketan Gondhalekar ,&nbsp;Anuradha Khadilkar","doi":"10.1016/j.bone.2025.117707","DOIUrl":"10.1016/j.bone.2025.117707","url":null,"abstract":"","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117707"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain intensity in patients with genetic metabolic bone diseases: an observational study","authors":"Mattia Morri ,&nbsp;Morena Tremosini ,&nbsp;Cristiana Forni ,&nbsp;Elena Pedrini ,&nbsp;Alice Moroni ,&nbsp;Maria Gnoli ,&nbsp;Alessia Di Cecco ,&nbsp;Luca Sangiorgi","doi":"10.1016/j.bone.2025.117736","DOIUrl":"10.1016/j.bone.2025.117736","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to describe the intensity of the pain in patients with genetic metabolic bone disease and to identify possible risk factors.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>The patients were recruited through the outpatient register of the Centre for Rare Skeletal Diseases between 2017 and 2022 from a dedicated orthopedic hospital in northern Italy.</div></div><div><h3>Subjects</h3><div>All patients with a diagnosis of genetic metabolic bone disease were enrolled. The diagnosis of the pathology was based on the clinical data and the outcome of any genetic tests.</div></div><div><h3>Methods</h3><div>Pain intensity (0-10) at the first exam was collected and two comparison groups were made: no/ mild pain and moderate/severe pain. Through medical and nursing clinical records, a set of clinical data was collected.</div></div><div><h3>Results</h3><div>The analysis was performed on 68 patients. The median age was 32.1 years, osteogenesis imperfecta was present in 72.1 % of cases and the median pain score was 2. Logistic regression showed that the independent risk factors of pain were age with a 5 % increase in risk for each year of age (<em>p</em> value = 0.010), a previous surgical intervention (OR = 10.16; CI95%: 2.07–49.89) and the presence of muscle anomalies (OR = 5.91; CI95% 1.09–31.88). The median pain score in the osteogenesis imperfecta group was 1, whereas in the other group it was 2, with a non-significant difference.</div></div><div><h3>Conclusions</h3><div>In genetic metabolic bone diseases, pain is a relevant symptom. Increased age, surgical intervention and the presence of muscular problems are risk factors in determining higher levels of pain and require targeted treatments.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117736"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone morphogenetic protein-2-independent bone formation by human iPSC-derived megakaryocytes and platelets","authors":"Norichika Mizuki ,&nbsp;Michiaki Mukai ,&nbsp;Yasuhiro Shiga ,&nbsp;Naoya Takayama ,&nbsp;Sou Nakamura ,&nbsp;Kentaro Kosaka ,&nbsp;Si Jing Chen ,&nbsp;Sudip Kumar Paul ,&nbsp;Takahito Arai ,&nbsp;Susumu Tashiro ,&nbsp;Masashi Sato ,&nbsp;Masaki Fukuyo ,&nbsp;Bahityar Rahmutulla ,&nbsp;Ikuko Tajiri ,&nbsp;Kazuhide Inage ,&nbsp;Miyako Suzuki-Narita ,&nbsp;Yawara Eguchi ,&nbsp;Sumihisa Orita ,&nbsp;Atsushi Kaneda ,&nbsp;Koji Eto ,&nbsp;Seiji Ohtori","doi":"10.1016/j.bone.2025.117703","DOIUrl":"10.1016/j.bone.2025.117703","url":null,"abstract":"<div><div>Bone regeneration (BR) is an ongoing challenge in biomedical research. While recombinant human bone morphogenetic protein-2 (rhBMP-2) is available for clinical use, its side effects remain a concern. Patient-derived platelet-rich plasma has been proposed as an alternative, but its heterogeneity poses a major hurdle to standardization. Here, we evaluated the effectiveness of induced pluripotent stem cell (iPSC)-derived megakaryocytes and platelets (iMPs) and recombinant human bone morphogenetic protein-2 (rhBMP-2) as potential BR therapy in a rat lumbar bone graft model. We implanted artificial bones with iMPs and/or rhBMP-2 and performed computed tomography and histological analysis to assess new bone formation. iMPs and rhBMP-2 showed comparable efficacy in vivo, but rhBMP-2 induced significant inflammation. In vitro, iMPs promoted human bone marrow mesenchymal stem cell (BM-MSC) proliferation and migration, while rhBMP-2 enhanced osteodifferentiation. RNA sequencing revealed cell cycle-related gene upregulation by iMPs. Altogether, these findings suggest iMPs, alone or in combination with rhBMP-2, as a promising BR therapy for enhancing clinical efficacy.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117703"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteocyte differentiation requires glucose metabolism, but mature osteocytes display metabolic flexibility","authors":"Matthew Prideaux ,&nbsp;Mathilde Palmier ,&nbsp;Yukiko Kitase ,&nbsp;Yuika Sone ,&nbsp;Lynda F. Bonewald ,&nbsp;Thomas M. O'Connell","doi":"10.1016/j.bone.2025.117694","DOIUrl":"10.1016/j.bone.2025.117694","url":null,"abstract":"<div><div>Recent research has identified metabolic pathways which play key roles in the differentiation and function of osteoblasts and osteoclasts. However, the mechanisms by which osteocytes, the most numerous cells in bone, meet their energetic demands are still unknown. To address this, we used the IDG-SW3 osteocyte cell line to examine changes in metabolism during differentiation from late osteoblasts to mature osteocytes. There was a significant increase in the expression of glycolysis genes (including <em>Pkm</em> and <em>Ldha</em>), glucose consumption and lactate production during late differentiation of these cells. This was concurrent with the onset of the expression of mature osteocyte markers. Inhibition of glucose metabolism using the glucose analogue 2-deoxy-<span>d</span>-glucose (2-DG) inhibited IDG-SW3 cell mineralization and differentiation into osteocytes. To examine the effect of glucose metabolism inhibition on mature osteocytes, we treated differentiated IDG-SW3 cells and long bone osteocytes with 2-DG, which resulted in decreased expression of the bone formation inhibitor <em>Sost</em> and mineralization inhibitor <em>Fgf23</em>. Concurrently, there was an increase in genes associated with lipolysis (<em>Lpl</em>) fatty acid β-oxidation (<em>Pparδ</em> and <em>Cpt1a</em>). Treatment of differentiated IDG-SW3 cells with the unsaturated fatty acid oleic acid increased <em>Cpt1a</em> expression and downregulated <em>Sost</em> and <em>Fgf23</em>. Application of mechanical stress to IDG-SW3 cells resulted in upregulation of oxidative metabolism, <em>Pparδ</em> and <em>Cpt1a</em> expression. Long and short chain acylcarnitines were increased in the cortical bone of axially loaded tibiae compared to non-loaded controls, indicative of increased β-oxidation. Overall, our data suggests that while glucose metabolism is essential for osteocyte differentiation, mature osteocytes are metabolically flexible. Furthermore, β-oxidation may play an important role in the osteocyte response to mechanical stress.</div></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117694"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author response to letter to the editor, “Comment on “Impact of baseline PINP on the BMD increase with romosozumab, teriparatide, and denosumab in treatment-naïve primary osteoporosis: A retrospective cohort study””","authors":"Yuki Etani ,&nbsp;Takaaki Noguchi ,&nbsp;Toshitaka Yukishima ,&nbsp;Tomonori Kobayakawa ,&nbsp;Masafumi Kashii ,&nbsp;Gensuke Okamura ,&nbsp;Atsushi Goshima ,&nbsp;Makoto Hirao ,&nbsp;Taihei Miura ,&nbsp;Takuya Kurihara ,&nbsp;Yuji Fukuda ,&nbsp;Atsushi Sugimoto ,&nbsp;Seiji Okada ,&nbsp;Ken Nakata ,&nbsp;Kosuke Ebina","doi":"10.1016/j.bone.2025.117727","DOIUrl":"10.1016/j.bone.2025.117727","url":null,"abstract":"","PeriodicalId":9301,"journal":{"name":"Bone","volume":"203 ","pages":"Article 117727"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}