Nanoscale最新文献_第8页

Time-lapsed nanoscale maps of the elastic modulus of collagen during cross-linking by bimodal AFM 双峰AFM交联过程中胶原弹性模量的延时纳米尺度图

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-24 DOI: 10.1039/d5nr01313e

Clara Garcia-Sacristan, Ricardo Garcia

{"title":"Time-lapsed nanoscale maps of the elastic modulus of collagen during cross-linking by bimodal AFM","authors":"Clara Garcia-Sacristan, Ricardo Garcia","doi":"10.1039/d5nr01313e","DOIUrl":"https://doi.org/10.1039/d5nr01313e","url":null,"abstract":"Collagen is the most abundant structural protein in mammals. Collagen in tissues is exposed to cross-linking processes such as glycation which might cause progressive tissue stiffening. Tissue stiffening might be considered a landmark of aging. Yet a quantitative characterization of the elastic modulus of collagen nanofibers under different cross-linking processes and stages is not available. Bimodal AFM was applied to generate time-lapsed maps of Young's modulus of type I collagen nanoribbons under two cross-linking processes associated, respectively, with the presence of ribose and glutaraldehyde in the solution. Elastic modulus maps were acquired for different incubation times (0, 30 min, 12 h, 24 h and 1 week). The experiments were performed in liquid. The Young's modulus showed an initial sharp increase after an incubation time of 30 min, from a few MPa (native) to 100 MPa. From then onwards we measured a monotonic increase until a saturation value of about 2 GPa was reached after one week. We did not observe a dependence on the elastic modulus evolution using ribose versus glutaraldehyde. The saturation value was very similar to that measured on dry collagen nanoribbons.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"26 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic metal-organic frameworks as an antisense delivery platform and their performance in a cell-free protein expression system. 磁性金属-有机框架作为反义传递平台及其在无细胞蛋白表达系统中的性能。

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-24 DOI: 10.1039/d5nr00788g

Maria Yakovtseva,Anastasia Kurtova,Roman Melikov,Nikita Chernov,Artem Sizikov,Victoria Shipunova,Maxim Nikitin

{"title":"Magnetic metal-organic frameworks as an antisense delivery platform and their performance in a cell-free protein expression system.","authors":"Maria Yakovtseva,Anastasia Kurtova,Roman Melikov,Nikita Chernov,Artem Sizikov,Victoria Shipunova,Maxim Nikitin","doi":"10.1039/d5nr00788g","DOIUrl":"https://doi.org/10.1039/d5nr00788g","url":null,"abstract":"Nanosized metal-organic frameworks (nMOF) have become one of the most promising classes of drug delivery vehicles due to their high load capacity, controllable drug release, and potential for transporting multiple payloads. Magnetic nMOFs, composed of a magnetic core and MOF coating, can further enhance their functionality through remote control using an external magnetic field. However, only a few studies have investigated the potential toxicity of magnetic nMOFs and the effects of their degradation on cellular machinery and the translation process. Here we show magnetic MOFs that: (i) regulate gene expression through antisense payload delivery; (ii) do not inhibit protein synthesis. We harness a cell-free protein system, CFPS, to investigate gene expression under more controlled conditions compared to traditional cell-based systems. Our findings demonstrate that magnetic nMOFs, with a magnetite core and a MIL-100(Fe) shell, do not inhibit protein translation upon degradation, and nMOFs loaded with antisense oligonucleotides can suppress protein translation by up to 87%. Furthermore, the magnetic nature of nMOFs ensured the fine-tuning of gene expression through remote control via a magnetic field without any additions to the CFPS system, thus offering an additional modality for the \"on/off\" control of cell-free protein synthesis. Considering the promising characteristics of nMOFs as delivery systems with minimal side effects, we anticipate their use in cutting-edge synthetic biology, biomedical applications, and the creation of the next generation of theranostic agents.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"19 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical analysis of flexible symmetric supercapacitors using WSe2@graphite thin film electrodes under different pH conditions. 利用WSe2@graphite薄膜电极对柔性对称超级电容器在不同pH条件下的电化学分析。

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-24 DOI: 10.1039/d5nr01328c

Akshay Tomar,Nitesh Choudhary,Radhika Jain,Dushyant Chaudhary,Gaurav Malik,Sheetal Issar,Ramesh Chandra

{"title":"Electrochemical analysis of flexible symmetric supercapacitors using WSe2@graphite thin film electrodes under different pH conditions.","authors":"Akshay Tomar,Nitesh Choudhary,Radhika Jain,Dushyant Chaudhary,Gaurav Malik,Sheetal Issar,Ramesh Chandra","doi":"10.1039/d5nr01328c","DOIUrl":"https://doi.org/10.1039/d5nr01328c","url":null,"abstract":"A key focus of this research is to investigate the influence of electrolyte pH on the supercapacitive performance of a flexible symmetric supercapacitor (SS) based on WSe2@graphite composite electrodes. To represent distinct pH environments, three aqueous electrolytes, namely H2SO4 (acidic), NaOH (basic), and Na2SO4 (neutral), were selected. A range of standard characterization methods, including X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and energy-dispersive X-ray spectroscopy (EDX), were employed to validate the successful fabrication and integrity of the supercapacitive electrode. Electrochemical performance was evaluated through cyclic voltammetry (CV), galvanostatic charge-discharge (GCD) and electrochemical impedance spectroscopy (EIS), elucidating the charge storage behaviour of the device at different pH levels. As a result, the fabricated SS device exhibited an impressive electrochemical potential window of 2 V (0 to +2 V) across all electrolytic systems, demonstrating excellent operational stability and pH adaptability. Among the tested electrolytes, the acidic H2SO4 electrolyte demonstrated the highest performance, achieving a high areal capacitance of 123.73 mF cm-2 and an energy density of 68.73 μWh cm-2 at a current density of 1 mA cm-2. Furthermore, the device demonstrated reliable cycling stability, retaining approximately 78.69% of its initial capacitance after 5000 consecutive GCD cycles. These results highlight the critical role of electrolyte pH in tailoring supercapacitor performance and provide valuable insights into the design of high-performance, flexible symmetric supercapacitors through strategic electrolyte selection.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"101 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene Oxide/Niobium Carbide MXene Composite-Based Functional Nanocomposite Scaffold for Artificial Cornea 基于氧化石墨烯/碳化铌MXene复合材料的人工角膜功能纳米复合支架

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-24 DOI: 10.1039/d5nr01312g

Li Peng, Wei Ma, Liwei Zhang, Siming Liu, Kai Han, Baihua Chen

{"title":"Graphene Oxide/Niobium Carbide MXene Composite-Based Functional Nanocomposite Scaffold for Artificial Cornea","authors":"Li Peng, Wei Ma, Liwei Zhang, Siming Liu, Kai Han, Baihua Chen","doi":"10.1039/d5nr01312g","DOIUrl":"https://doi.org/10.1039/d5nr01312g","url":null,"abstract":"Artificial cornea offers the only hope to end-stage cornea disease patient. A highly desirable artificial cornea requires high mechanical strength, good biocompatibility, sufficient durability to withstand hostile environment and possesses specific biological activities. This study reports the physical characteristics, cytocompatibility, and biocompatibility of nanocomposite by graphene oxide and niobium carbide MXene (GO/Nb2C) used in normal rabbit cornea and corneal alkali burn model. Nanoindentation and long-term corrosion assay in combination with atomic force and scanning electron microscopy were used to study mechanical properties and corrosion resistance. In vitro biocompatibility was evaluated based on the survival, proliferation, and attachment of human corneal stromal cells. In vivo stability and host tissue responses were conducted using GO/Nb2C scaffolds implanted inside rabbit corneas and in a vivo corneal alkali burn model. Fibrosis index Hsp47, FN, and a-SMA were negative. Furthermore, IL-2 and IL-6 were downregulated, along with oxidative stress indices in the rabbit cornea after implanting GO/Nb2C scaffolds. In vivo corneal alkali burns model, IF indicated GO/ Nb2C scaffolds decreased CD11b expression around surgical area. The GO/Nb2C scaffolds have significantly high biocompatibility with biological activity, safety, efficacy, antioxidative stress, and anti-inflammatory property. This promising bioactivity corneal scaffold provides new ideas for constructing a functional scaffold of artificial cornea.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"21 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanometrology assisted chemical fabrication: direct laser writing of porphyrins onto complex surfaces. 纳米计量辅助化学制造：直接激光在复杂表面上书写卟啉。

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-24 DOI: 10.1039/d5nr00765h

Baptiste Maillot, Haroon Rashid, Roxanne Bercy, Jean Frédéric Audibert, Manuel J. Llansola-Portoles, Isabelle LERAY, Fabien Miomandre, Vitor Brasiliense

{"title":"Nanometrology assisted chemical fabrication: direct laser writing of porphyrins onto complex surfaces.","authors":"Baptiste Maillot, Haroon Rashid, Roxanne Bercy, Jean Frédéric Audibert, Manuel J. Llansola-Portoles, Isabelle LERAY, Fabien Miomandre, Vitor Brasiliense","doi":"10.1039/d5nr00765h","DOIUrl":"https://doi.org/10.1039/d5nr00765h","url":null,"abstract":"The association of operando monitoring methodologies with micro and nanoscale surface modification strategies has recently been shown to enable the preparation of complex yet highly precise organic functional surfaces. While promissing, such demonstrations have so far been limited to model systems, consisting on minimally functionalized aryl radicals. With a growing demand for more sophisticated surfaces, bearing multiple functions, a demonstration of the generality of the strategy to chemically complex moieties and surfaces is deeply needed. In this work, we aim to fill this gap by preparing tetraphenyl porphyrin derivatives modified to become radical precursors that can be activated with light. Operando optical monitoring is used to non-invasively analyze their grafting behavior in different conditions, optimizing the routes to enable modification of inert glass surfaces with high precision (30 atto L). We demonstrate that the methodology is compatible with direct laser writing technologies, and use it to prepare photophysically active surfaces with high resolution. We demonstrate that the instrinsic emissive properties of Tetraphenylporphyrin derivatives are well preserved, and that several surface modifing steps can be sequentially stacked, leading to the preparation of surfaces with mulitple functions. By controlling the microscale distribution of chemical groups with different photophysical properties, we demonstrate that complex chemical designs can be readily and reliably implemented. This work therefore shows that light activated radical pathways can be broadly used to modify surfaces, opening interesting new perspectives for the implementation of functional materials.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"636 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoscale Chemical Characterization of Functionalized Graphene by Heterodyne AFM-IR and Chemical Force Microscopy 外差AFM-IR和化学力显微镜表征功能化石墨烯的纳米尺度化学性质

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-24 DOI: 10.1039/d5nr01862e

Reiji Kumagai, Mariko Takahashi, Nozomu Suzuki, Kenji Hirai, Hirohmi Watanabe, Hiroshi Uji-i, Yasuhiko Fujita

{"title":"Nanoscale Chemical Characterization of Functionalized Graphene by Heterodyne AFM-IR and Chemical Force Microscopy","authors":"Reiji Kumagai, Mariko Takahashi, Nozomu Suzuki, Kenji Hirai, Hirohmi Watanabe, Hiroshi Uji-i, Yasuhiko Fujita","doi":"10.1039/d5nr01862e","DOIUrl":"https://doi.org/10.1039/d5nr01862e","url":null,"abstract":"Nanoscale analysis is of critical importance for understanding and engineering the functional properties of advanced materials, particularly in applications requiring precise control of surface chemistry. In this work, we present a powerful strategy to probe the nanoscale heterogeneity of chemical functional species on graphene by combining heterodyne AFM-based infrared (AFM-IR) microscopy and chemical force microscopy (CFM). AFM-IR provides nanoscale-resolved chemical fingerprint information, enabling direct characterization of surface functional species, while complementary CFM reveals specific surface chemical interaction at the nanoscale with surface morphology. This combined approach successfully visualizes the nanoscale heterogeneity of chemical functional species on graphene introduced by a liquid-phase photoinduced covalent modification (PICM) method. Specifically, our results reveal that oxidative functional groups such as carboxyl, hydroxyl, and epoxide groups are relatively uniformly distributed across the PICM-modified regions. In contrast, methoxy groups form nanosized domains concentrated at the center of the PICM regions. This study represents the first successful molecular fingerprint visualization of nanoscale heterogeneity in functional groups introduced on graphene surfaces. As this method is fundamentally applicable to a wide range of sample systems—including other 2D atomic layer materials, polymers, and biological samples—, our work provides significant implications for both basic science and industrial applications.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"32 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of Localized Charge Accumulation on Photocurrent Dynamics in Metal-MoS2 Contacts 局部电荷积累对金属- mos2触点光电流动力学的影响

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-24 DOI: 10.1039/d4nr04610b

Deogkyu Choi, Seungho Bang, Juchan Lee, Chaewon Lee, jieun Jo, Young Joo Yu, Chan Kwon, Hayoung Ko, Ki Kang Kim, Jin Ho Ahn, Eun Kyu Kim, Mun Seok Jeong

{"title":"Impacts of Localized Charge Accumulation on Photocurrent Dynamics in Metal-MoS2 Contacts","authors":"Deogkyu Choi, Seungho Bang, Juchan Lee, Chaewon Lee, jieun Jo, Young Joo Yu, Chan Kwon, Hayoung Ko, Ki Kang Kim, Jin Ho Ahn, Eun Kyu Kim, Mun Seok Jeong","doi":"10.1039/d4nr04610b","DOIUrl":"https://doi.org/10.1039/d4nr04610b","url":null,"abstract":"Monolayer molybdenum disulfide (1L-MoS2) has attracted a lot of attention due to its excellent electrical and optoelectronic properties. However, the challenge remains the instability of the metal-semiconductor junction, which greatly affects the performance of the drain/source contacts. Despite the promising potential offered by 1L-MoS2 as an ultrathin two-dimensional semiconductor, its optoelectronic performance is often compromised by contact issues at the metal-semiconductor junctions. Especially, the localized charge accumulation (LCA) can cause barrier height fluctuation, which affects carrier transport and activated trap states. In this study, we use photocurrent mapping to investigate photocurrent reduction and its optoelectronic properties depending on device position. The results show a significant reduction in the photoresponsivity and photodetectivity of the LCA region compared to the channel. Moreover, the decay time of the LCA region was approximately twice as long compared to the channel, indicating the presence of deep traps leading to slow switching. This investigation highlights the significant role of photo-generated LCA region affecting metal-semiconductor junctions in degrading optoelectronics performance. It also provides a critical understanding necessary for engineering next-generation optoelectronics based on 2D semiconductors.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"17 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient photochemical production of H2O2 on carbon nitride photocatalysts with optimized multi-synergistic effect of enhanced visible-light absorption, charge separation, and surface kinetics 在氮化碳光催化剂上高效光化学生产H2O2，增强可见光吸收、电荷分离和表面动力学的优化多重协同效应

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-23 DOI: 10.1039/d5nr01427a

Jiaqiao Hu, Xing Wang, Xingang Kong, Shinobu Uemura, Takafumi Kusunose, Yasuhiro Tanaka, Qi Feng

{"title":"Efficient photochemical production of H2O2 on carbon nitride photocatalysts with optimized multi-synergistic effect of enhanced visible-light absorption, charge separation, and surface kinetics","authors":"Jiaqiao Hu, Xing Wang, Xingang Kong, Shinobu Uemura, Takafumi Kusunose, Yasuhiro Tanaka, Qi Feng","doi":"10.1039/d5nr01427a","DOIUrl":"https://doi.org/10.1039/d5nr01427a","url":null,"abstract":"Photochemical production of hydrogen peroxide (H2O2) using visible-light response photocatalysts offers a sustainable green strategy. In this study, the g-C3N4-based (CN) photocatalysts for the photochemical production of H2O2were facilely synthesized through multi-step calcination and alkali metal ion intercalation processes. The n-π* electronic transition was achieved by disrupting the symmetrical planar of the heptazine layers to enhance visible-light absorption. The alkali metal ion intercalations greatly enhanced photocatalytic activities of CN by redshift in the π-π* electronic transitions in visible-light and introduction of cyano groups into the photocatalysts. In the alkali metal ion intercalated photocatalysts, the K+-intercalated photocatalyst demonstrates the greatest photocatalytic efficiency because of its effective introduction of cyano groups into the CN structure, which enhances the kinetics of O2 reduction reaction on the photocatalyst surface by reducing the interfacial charge-transfer resistance. A gradient energy band structure was introduced into the photocatalyst by a gradient K+-doping, which improved the charge separation efficiency. The photocatalyst with the optimized multi-synergistic effect of improved visible-light absorption, charge separation, and surface kinetics achieved a H2O2 production rate of 2720 µM/h under simulated sunlight, which is 64 times higher than that of the photocatalyst prepared by traditional thermal decomposition process. This study offers a straightforward approach to designing of high-efficiency CN photocatalysts for the photochemical H2O2 production.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"50 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144341326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in outermost surface engineering for solar panels 太阳能电池板外表面工程的最新进展

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-23 DOI: 10.1039/d5nr00621j

Yicai Wang, Junhui He

引用次数: 0

A smart nanocomposite system for controlled insulin release and glucose sensing in diabetes management 一种在糖尿病管理中控制胰岛素释放和葡萄糖传感的智能纳米复合系统

IF 6.7 3区材料科学

Nanoscale Pub Date : 2025-06-23 DOI: 10.1039/d5nr01437a

Dan Wang, Yaoyao Wang, Wilson Dumisani Gamuchirai Dube, Jiarong Zhang, Jie Gao, Xue Tang, Gisèle Ineza Urujeni, Yajie Zhang, Linjie Zhao, Hua He, Deli Xiao, Pierre Dramou

{"title":"A smart nanocomposite system for controlled insulin release and glucose sensing in diabetes management","authors":"Dan Wang, Yaoyao Wang, Wilson Dumisani Gamuchirai Dube, Jiarong Zhang, Jie Gao, Xue Tang, Gisèle Ineza Urujeni, Yajie Zhang, Linjie Zhao, Hua He, Deli Xiao, Pierre Dramou","doi":"10.1039/d5nr01437a","DOIUrl":"https://doi.org/10.1039/d5nr01437a","url":null,"abstract":"Diabetes is a global health challenge, driving the need for novel solutions in glucose monitoring and insulin delivery. Here, we present a next-generation glucose-responsive nanocomposite, ZIF-8@Ins-GOx/AuNCs, designed for simultaneous controlled insulin release and real-time glucose sensing. This dual-functional system synergistically integrates zeolite imidazolate framework-8 (ZIF-8), glucose oxidase (GOx), and gold nanoclusters (AuNCs), creating a highly efficient platform for personalized diabetes management. The nanocomposite exhibits an impressive glucose detection range (2.50–200 mM) with high sensitivity (LOD = 0.80 mM), offering unprecedented accuracy for early diagnosis and monitoring. In addition, it demonstrates a glucose-triggered insulin release profile with exceptional encapsulation efficiency (90%) and sustained release under hyperglycemic conditions. Comprehensive in vitro studies reveal excellent biocompatibility, with cell viability greater than 80% at concentrations up to 22.2 mM, highlighting the safety for potential clinical use. This work represents a significant leap forward in the development of adaptive drug delivery systems, offering a versatile, scalable platform with the potential to revolutionize not only diabetes treatment but also broader biomedical applications demanding precise, self-regulated therapeutic interventions.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"269 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144341325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0