Journal of human virology & retrovirology最新文献_第10页

Chigungunya Disease: A Review of a Global Pandemic 基孔肯雅病:全球大流行回顾

Journal of human virology & retrovirology Pub Date : 2016-06-20 DOI: 10.15406/jhvrv.2016.03.00096

G. Gossius

引用次数: 0

HIV: Problems and Perspectives 艾滋病毒:问题和观点

Journal of human virology & retrovirology Pub Date : 2016-06-17 DOI: 10.15406/JHVRV.2016.03.00095

Bogoyavlenskiy Ap

引用次数: 0

Prevalence of Hepatitis B and Hepatitis C Infection among Patients Undergoing Dialysis 透析患者乙型和丙型肝炎感染的流行情况

Journal of human virology & retrovirology Pub Date : 2016-06-06 DOI: 10.15406/JHVRV.2016.03.00094

K. Anwar, M. Imran, F. Shahzad, Mamoona Noreen, M. Atif, Fayyaz Ahmed, A. Waqar

{"title":"Prevalence of Hepatitis B and Hepatitis C Infection among Patients Undergoing Dialysis","authors":"K. Anwar, M. Imran, F. Shahzad, Mamoona Noreen, M. Atif, Fayyaz Ahmed, A. Waqar","doi":"10.15406/JHVRV.2016.03.00094","DOIUrl":"https://doi.org/10.15406/JHVRV.2016.03.00094","url":null,"abstract":"Hepatitis B and Hepatitis C are the major causes of morbidity and mortality in Pakistani population and their influence is considerable in patients suffering from kidney diseases and undergoing dialysis (Haemodialysis/ Peritoneal). This study considered the total number of dialysis a patient received and the number of dialysis in a week with the chances of Hepatitis C and Hepatitis B infection. This cross sectional study was conducted to determine the frequency of hepatitis B and hepatitis C in patients undergoing either haemodialysis or peritoneal dialysis. Serum sample was extracted from the blood of 60 patients. All the patients were suffering from either chronic kidney disease or acute renal failure. Screening was performed by strip method, which is based on Immuno-chromatographic technique for the detection of antibodies against HBsAg and HCV in patients on dialysis (haemodialysis/ peritoneal dialysis). The patients undergoing haemodialysis or peritoneal dialysis were randomly selected, out of which 43 were males and 17 were females. The association of HCV and HBV infection was calculated in relation to frequency per week of dialysis and total number of dialysis. There is significant correlation between HCV infection and total numbers of haemodialysis a patient has. Increase in the frequency of HCV infection was observed as the number of dialysis increased.","PeriodicalId":92670,"journal":{"name":"Journal of human virology & retrovirology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67075314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Levels of Antiviral Therapy 抗病毒治疗水平

Journal of human virology & retrovirology Pub Date : 2016-06-01 DOI: 10.15406/jhvrv.2016.03.00093

A. Bogoyavlenskiy, A. Turmagambetova, V. Berezin

{"title":"Levels of Antiviral Therapy","authors":"A. Bogoyavlenskiy, A. Turmagambetova, V. Berezin","doi":"10.15406/jhvrv.2016.03.00093","DOIUrl":"https://doi.org/10.15406/jhvrv.2016.03.00093","url":null,"abstract":"The problem of the treatment and prevention of acute infectious diseases, especially viral remains relevant for practical health care, despite the wide variety of currently available drugs in the pharmaceutical market. The processes caused by a viral infection largely determine the nature of the flow of infectious process and its outcome. The degree of viremia directly correlates with the manifestations of toxicity, a fever, a reaction of the immune system and the severity of the patient's condition. An important biological feature of viruses is the ability to persistence in the organism and the development of chronic or latent viral infection. The persistence of viruses causes defects of the immune reactivity and creates favorable conditions for the bacterial infection. Thus the priority in the selection of antiviral drugs is at the polling suppression of virus reproduction without significant disturbances of vital activity of host cells. The article describes main levels of antiviral therapy.This review summarized information on the antiviral preparations currently used in clinical as well as in experimental settings. It is shown that the effect of antiviral preparations is possibly at any stage of viral replication.","PeriodicalId":92670,"journal":{"name":"Journal of human virology & retrovirology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67075302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotyping of Dengue Virus from Deadly Outbreaks of Pakistan 巴基斯坦致命疫情中登革热病毒的血清分型

Journal of human virology & retrovirology Pub Date : 2016-05-12 DOI: 10.15406/jhvrv.2016.03.00092

M. Atif, Ummar Raheel, F. Alam, H. Arshad, Fayyaz-ul-Hassan Baloch, M. Imran, N. S. Zaidi, A. Waqar

{"title":"Serotyping of Dengue Virus from Deadly Outbreaks of Pakistan","authors":"M. Atif, Ummar Raheel, F. Alam, H. Arshad, Fayyaz-ul-Hassan Baloch, M. Imran, N. S. Zaidi, A. Waqar","doi":"10.15406/jhvrv.2016.03.00092","DOIUrl":"https://doi.org/10.15406/jhvrv.2016.03.00092","url":null,"abstract":"Dengue virus (DENV) belonging to the family Flaviviridae consists of 4 serotypes (DEN-1, 2, 3 & 4) causing severe illnesses like dengue fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Dengue fever has become an emerging disease in Pakistan during the past 5-7 years with an increase in the number of cases every year since 2006. The current study aimed at identifying the serotypes of dengue virus involved in 2011 outbreak of Pakistan. Samples were collected from all provinces of Pakistan. Patients were confirmed in the hospital by antibody captured Enzyme linked immunosorbent assay (ELISA). These ELISA positive serum samples were inoculated on HeLa cell line to raise the viral titer of dengue virus and then RT-PCR was done for serotyping of dengue virus. Initially D1, D2 primers were tried for serotyping of dengue virus but poor results were obtained. \u0000 \u0000 Then serotype specific primers were designed having equal fragment length targeting NS1 gene. This approach was successful in serotyping of dengue virus from Pakistani population. On Real time RT-PCR, Dengue virus (DENV) was detected in 43.33% (n=26) patientsout of 60 analyzed samples. Among 26 positive cases, 76.9% (n=20) were children and 23.1% (n=6) were adultsand 46.1% (n=12) were male and 53.8 % (n=14) were females. ELISA results of26 PCR positive cases show that 53.8% (n=14) were positive for IgM, 15.4 % (n=4) were positive for IgG and 30.8 % (n=8) were positive for both IgG and IgM. In this study DEN-2 was detected in 13.3% (n=8) patients, DEN-3 was detected in 16.67% (n=10) patients and DEN-2 & DEN-3 coinfection was detected in 13.3% (n=8) patients. We did not detected DEN-1 & DEN-4 in 2011 outbreak of Pakistan in 60 analyzed samples. By this study we can conclude that DEN-2 and DEN-3 were the main serotypes involved in 2011 outbreaks in Pakistan.","PeriodicalId":92670,"journal":{"name":"Journal of human virology & retrovirology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67075258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Dengue Virus: Host-Pathogen Interactions and Emerging Role of DNA Vaccines 登革病毒:宿主-病原体相互作用和DNA疫苗的新作用

Journal of human virology & retrovirology Pub Date : 2016-05-04 DOI: 10.15406/JHVRV.2016.03.00091

M. Atif, Ummar Raheel, M. Imran, H. Arshad, Fayyaz-ul-Hassan Baloch, F. Alam, Sadia Irshad Leghari, Fayyaz Ahmad, Z. Fatima, Y. Qi, S. Manzoor, N. S. Zaidi, A. Waqar

{"title":"Dengue Virus: Host-Pathogen Interactions and Emerging Role of DNA Vaccines","authors":"M. Atif, Ummar Raheel, M. Imran, H. Arshad, Fayyaz-ul-Hassan Baloch, F. Alam, Sadia Irshad Leghari, Fayyaz Ahmad, Z. Fatima, Y. Qi, S. Manzoor, N. S. Zaidi, A. Waqar","doi":"10.15406/JHVRV.2016.03.00091","DOIUrl":"https://doi.org/10.15406/JHVRV.2016.03.00091","url":null,"abstract":"Dengue virus infections are a major cause of mortality and morbidity in Southeast Asia, South and Central America with 24’000 deaths annually. Two factors are accountable for the severe outcomes of Dengue Hemorrhagic Fever (DHF); one is the virulence of the virus and second is the cross-reactivity of various dengue serotypes with the immune system of the host. Rapid rise in the levels of various cytokines, particularly Tumor Necrosis Factor-alpha (TNF-α), Interleukin-2 (IL-2), Interleukin-6 (IL-6), Interleukin-8 (IL-8) have a major role in inducing distinctive clinical presentations of DHF. These range from simple plasma leakage to hemorrhagic problems and even shock. Another hallmark of DHF is the presence of cross reactive primary antibodies which produce an intense immune response in secondary infection resulting in immune mediated pathology seen in DHF. There have been many attempts made in the past for the development of a suitable vaccine for dengue fever. Vaccination using plasmid DNA against dengue fever is an active area of research. In this review the role of different cells in the multiplication of dengue virus and viral interactions with the immune system have been discussed. Special emphasis is given to the nature of DNA vaccines in general developmental efforts of a dengue fever vaccine.","PeriodicalId":92670,"journal":{"name":"Journal of human virology & retrovirology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67075247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Zika and Other Brain Parenchyma Viruses: Is Nanomedicine the Answer? 寨卡病毒和其他脑实质病毒:纳米医学是答案吗?

Journal of human virology & retrovirology Pub Date : 2016-04-19 DOI: 10.15406/JHVRV.2016.03.00090

Wagilla Osman, Nye Mary Katherine, Brown TonyL

引用次数: 0

Construction of Mammalian Expression Vector of Core Gene of HCV of Pakistani Isolate Genotype 1a 巴基斯坦1a型HCV分离株核心基因哺乳动物表达载体的构建

Journal of human virology & retrovirology Pub Date : 2016-04-19 DOI: 10.15406/JHVRV.2016.03.00089

B. Khubaib, M. Idrees, Abrar Hussain

引用次数: 0

Humanized NSG Mouse Models of HIV-1 Infection and Pathogenesis 人源化NSG小鼠HIV-1感染模型及其发病机制

Journal of human virology & retrovirology Pub Date : 2016-04-14 DOI: 10.15406/JHVRV.2016.03.00088

O. Latinovic, S. MedinaMoreno, Lauren M. Hippler, J. Zapata, R. Redfield

引用次数: 2

The Role of Oncogenic Infectious Agents in Causing Liver, Stomach, Urinary Bladder, Head and Neck and Cervical Cancers 致瘤性感染因子在肝癌、胃癌、膀胱癌、头颈癌和子宫颈癌中的作用

Journal of human virology & retrovirology Pub Date : 2016-04-05 DOI: 10.15406/JHVRV.2016.03.00087

R. Shabrawy, A. Abdelateef, Ahmed Abdel Reheem Al Nagar, A. Salem

{"title":"The Role of Oncogenic Infectious Agents in Causing Liver, Stomach, Urinary Bladder, Head and Neck and Cervical Cancers","authors":"R. Shabrawy, A. Abdelateef, Ahmed Abdel Reheem Al Nagar, A. Salem","doi":"10.15406/JHVRV.2016.03.00087","DOIUrl":"https://doi.org/10.15406/JHVRV.2016.03.00087","url":null,"abstract":"Background: Understanding the pathogenesis and predisposing factors for cancer is a major concern. Several studies have elucidated the role of infection in developing certain malignancies. \u0000 Aim: The aim of this work was to assess the role of infectious agents in causing liver, stomach, urinary bladder, head and neck and cervical cancers. \u0000 Methods: This case-control study included 181, diagnosis of several infectious agents included genetic and serological tests in both groups. The relative risk of each infectious agent was then calculated. \u0000 Results: Oncogenic infectious agents cause 81.2% of studied cancers. HCV was detected in 92.2% of HCC with a relative risk of 4.6, HBV was detected in 5% of cases and relative risk of 4.8, H. pylori DNA was found in 77% of gastric cancer and a relative risk of 1.2 and S. heamatobium was found in 37.5% of urinary bladder cases with a relative risk of 31. Finally, HPV16 DNA was detected in 56.2% of head and neck cancer and 66.6% of cervical cancer with a relative risk of 3.12 and 3.7 respectively. \u0000 Conclusion: Infections play an important role in the pathogenesis of cancer. Better attention to Infection prevention and control programs must be adapted to decrease the burden of malignant diseases.","PeriodicalId":92670,"journal":{"name":"Journal of human virology & retrovirology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67075136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1