抗病毒治疗水平

A. Bogoyavlenskiy, A. Turmagambetova, V. Berezin
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引用次数: 0

摘要

尽管目前医药市场上可获得的药物种类繁多,但治疗和预防急性传染病,特别是病毒性疾病的问题仍然与实际保健有关。由病毒感染引起的过程在很大程度上决定了感染过程流动的性质及其结果。病毒血症的程度与毒性表现、发烧、免疫系统反应和患者病情的严重程度直接相关。病毒的一个重要生物学特征是能够在生物体中持续存在并发展成慢性或潜伏的病毒感染。病毒的持续存在导致免疫反应性的缺陷,为细菌感染创造了有利条件。因此,在选择抗病毒药物时,优先考虑的是在不显著干扰宿主细胞重要活动的情况下抑制病毒繁殖。本文介绍了抗病毒治疗的主要水平。本文综述了目前在临床和实验环境中使用的抗病毒制剂的信息。这表明抗病毒制剂可能在病毒复制的任何阶段起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Levels of Antiviral Therapy
The problem of the treatment and prevention of acute infectious diseases, especially viral remains relevant for practical health care, despite the wide variety of currently available drugs in the pharmaceutical market. The processes caused by a viral infection largely determine the nature of the flow of infectious process and its outcome. The degree of viremia directly correlates with the manifestations of toxicity, a fever, a reaction of the immune system and the severity of the patient's condition. An important biological feature of viruses is the ability to persistence in the organism and the development of chronic or latent viral infection. The persistence of viruses causes defects of the immune reactivity and creates favorable conditions for the bacterial infection. Thus the priority in the selection of antiviral drugs is at the polling suppression of virus reproduction without significant disturbances of vital activity of host cells. The article describes main levels of antiviral therapy.This review summarized information on the antiviral preparations currently used in clinical as well as in experimental settings. It is shown that the effect of antiviral preparations is possibly at any stage of viral replication.
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