O. Latinovic, S. MedinaMoreno, Lauren M. Hippler, J. Zapata, R. Redfield
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Humanized NSG Mouse Models of HIV-1 Infection and Pathogenesis
J Hum Virol Retrovirol 2016, 3(2): 00087 Another alternative approach has been to implant human stem cells (HSC) into newborn NSG mice. Both models provide a suitable environment in which to partially reconstitute the human immune system. With adequate numbers of target cells, HIV-1 can replicate without interference from the mouse immune system. The NSG mouse transplantation/engraftment models are the best currently available, as they provide the highest level of human HSC engraftment compared with other immunodeficient strains [1,2].
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