{"title":"Levels of Antiviral Therapy","authors":"A. Bogoyavlenskiy, A. Turmagambetova, V. Berezin","doi":"10.15406/jhvrv.2016.03.00093","DOIUrl":null,"url":null,"abstract":"The problem of the treatment and prevention of acute infectious diseases, especially viral remains relevant for practical health care, despite the wide variety of currently available drugs in the pharmaceutical market. The processes caused by a viral infection largely determine the nature of the flow of infectious process and its outcome. The degree of viremia directly correlates with the manifestations of toxicity, a fever, a reaction of the immune system and the severity of the patient's condition. An important biological feature of viruses is the ability to persistence in the organism and the development of chronic or latent viral infection. The persistence of viruses causes defects of the immune reactivity and creates favorable conditions for the bacterial infection. Thus the priority in the selection of antiviral drugs is at the polling suppression of virus reproduction without significant disturbances of vital activity of host cells. The article describes main levels of antiviral therapy.This review summarized information on the antiviral preparations currently used in clinical as well as in experimental settings. It is shown that the effect of antiviral preparations is possibly at any stage of viral replication.","PeriodicalId":92670,"journal":{"name":"Journal of human virology & retrovirology","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of human virology & retrovirology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/jhvrv.2016.03.00093","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The problem of the treatment and prevention of acute infectious diseases, especially viral remains relevant for practical health care, despite the wide variety of currently available drugs in the pharmaceutical market. The processes caused by a viral infection largely determine the nature of the flow of infectious process and its outcome. The degree of viremia directly correlates with the manifestations of toxicity, a fever, a reaction of the immune system and the severity of the patient's condition. An important biological feature of viruses is the ability to persistence in the organism and the development of chronic or latent viral infection. The persistence of viruses causes defects of the immune reactivity and creates favorable conditions for the bacterial infection. Thus the priority in the selection of antiviral drugs is at the polling suppression of virus reproduction without significant disturbances of vital activity of host cells. The article describes main levels of antiviral therapy.This review summarized information on the antiviral preparations currently used in clinical as well as in experimental settings. It is shown that the effect of antiviral preparations is possibly at any stage of viral replication.